DK174062B1 - Kombineret præparat til anvendelse ved en fremgangsmåde til behandling af myocardieinfarkt - Google Patents

Kombineret præparat til anvendelse ved en fremgangsmåde til behandling af myocardieinfarkt Download PDF

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Publication number
DK174062B1
DK174062B1 DK199002401A DK240190A DK174062B1 DK 174062 B1 DK174062 B1 DK 174062B1 DK 199002401 A DK199002401 A DK 199002401A DK 240190 A DK240190 A DK 240190A DK 174062 B1 DK174062 B1 DK 174062B1
Authority
DK
Denmark
Prior art keywords
fragment
antibody
thrombolytic agent
fibrin
plasmin
Prior art date
Application number
DK199002401A
Other languages
Danish (da)
English (en)
Other versions
DK240190D0 (da
DK240190A (da
Inventor
Guy L Reed
Edgar Haber
Gary Matsueda
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of DK240190D0 publication Critical patent/DK240190D0/da
Publication of DK240190A publication Critical patent/DK240190A/da
Application granted granted Critical
Publication of DK174062B1 publication Critical patent/DK174062B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Surgical Instruments (AREA)
  • External Artificial Organs (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK199002401A 1988-04-04 1990-10-04 Kombineret præparat til anvendelse ved en fremgangsmåde til behandling af myocardieinfarkt DK174062B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17722288A 1988-04-04 1988-04-04
US17722288 1988-04-04
US8901065 1989-03-15
PCT/US1989/001065 WO1989009817A1 (en) 1988-04-04 1989-03-15 Composition and method for acceleration of clot lysis

Publications (3)

Publication Number Publication Date
DK240190D0 DK240190D0 (da) 1990-10-04
DK240190A DK240190A (da) 1990-10-04
DK174062B1 true DK174062B1 (da) 2002-05-13

Family

ID=22647707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002401A DK174062B1 (da) 1988-04-04 1990-10-04 Kombineret præparat til anvendelse ved en fremgangsmåde til behandling af myocardieinfarkt

Country Status (15)

Country Link
EP (1) EP0336693B1 (es)
JP (1) JP2871775B2 (es)
KR (1) KR100194113B1 (es)
AT (1) ATE114480T1 (es)
AU (1) AU628041B2 (es)
CA (1) CA1341377C (es)
DE (1) DE68919504T2 (es)
DK (1) DK174062B1 (es)
ES (1) ES2064435T3 (es)
FI (1) FI102812B (es)
GR (1) GR3015182T3 (es)
HU (1) HU207349B (es)
NO (1) NO301374B1 (es)
WO (1) WO1989009817A1 (es)
ZA (1) ZA892464B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5609869A (en) * 1988-08-19 1997-03-11 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
US5811265A (en) * 1988-08-19 1998-09-22 The General Hospital Corporation Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use
JPH02268694A (ja) * 1989-04-07 1990-11-02 Teijin Ltd 血栓溶解剤
CA2266339A1 (en) * 1996-09-20 1998-03-26 The General Hospital Corporation Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
US6524675B1 (en) 1999-05-13 2003-02-25 3M Innovative Properties Company Adhesive-back articles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0735340B2 (ja) * 1985-05-23 1995-04-19 帝人株式会社 血栓溶解促進剤
ATE142502T1 (de) * 1986-05-15 1996-09-15 Univ Emory Injizierbares arzneimittel zum schutz vor gewebebeschädigung durch ischemie

Also Published As

Publication number Publication date
DK240190D0 (da) 1990-10-04
EP0336693A2 (en) 1989-10-11
NO301374B1 (no) 1997-10-20
GR3015182T3 (en) 1995-05-31
DE68919504T2 (de) 1995-06-29
KR900700129A (ko) 1990-08-11
DK240190A (da) 1990-10-04
EP0336693B1 (en) 1994-11-30
AU3284589A (en) 1989-11-03
ES2064435T3 (es) 1995-02-01
EP0336693A3 (en) 1990-03-21
NO904294D0 (no) 1990-10-03
CA1341377C (en) 2002-07-16
ATE114480T1 (de) 1994-12-15
JP2871775B2 (ja) 1999-03-17
HUT56394A (en) 1991-08-28
JPH03504717A (ja) 1991-10-17
FI102812B1 (fi) 1999-02-26
HU207349B (en) 1993-03-29
AU628041B2 (en) 1992-09-10
WO1989009817A1 (en) 1989-10-19
ZA892464B (en) 1989-12-27
KR100194113B1 (ko) 1999-06-15
HU892304D0 (en) 1991-07-29
DE68919504D1 (de) 1995-01-12
FI102812B (fi) 1999-02-26
NO904294L (no) 1990-12-04
FI904867A0 (fi) 1990-10-03

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