GR3015182T3 - Acceleration of clot lysis. - Google Patents
Acceleration of clot lysis.Info
- Publication number
- GR3015182T3 GR3015182T3 GR940403885T GR940403885T GR3015182T3 GR 3015182 T3 GR3015182 T3 GR 3015182T3 GR 940403885 T GR940403885 T GR 940403885T GR 940403885 T GR940403885 T GR 940403885T GR 3015182 T3 GR3015182 T3 GR 3015182T3
- Authority
- GR
- Greece
- Prior art keywords
- hapten
- clot lysis
- binding molecule
- thrombolytic agent
- preventing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Surgical Instruments (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17722288A | 1988-04-04 | 1988-04-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3015182T3 true GR3015182T3 (en) | 1995-05-31 |
Family
ID=22647707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR940403885T GR3015182T3 (en) | 1988-04-04 | 1995-02-27 | Acceleration of clot lysis. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0336693B1 (el) |
JP (1) | JP2871775B2 (el) |
KR (1) | KR100194113B1 (el) |
AT (1) | ATE114480T1 (el) |
AU (1) | AU628041B2 (el) |
CA (1) | CA1341377C (el) |
DE (1) | DE68919504T2 (el) |
DK (1) | DK174062B1 (el) |
ES (1) | ES2064435T3 (el) |
FI (1) | FI102812B (el) |
GR (1) | GR3015182T3 (el) |
HU (1) | HU207349B (el) |
NO (1) | NO301374B1 (el) |
WO (1) | WO1989009817A1 (el) |
ZA (1) | ZA892464B (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5357042A (en) * | 1984-04-23 | 1994-10-18 | The General Hospital Corporation | Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity |
US5453269A (en) * | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
US5372812A (en) * | 1988-04-04 | 1994-12-13 | The General Hospital Corporation | Composition and method for acceleration of clot lysis |
US5582862A (en) * | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5609869A (en) * | 1988-08-19 | 1997-03-11 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
US5811265A (en) * | 1988-08-19 | 1998-09-22 | The General Hospital Corporation | Hybrid immunoglobulin-thrombolytic enzyme molecules which specifically bind a thrombus, and methods of their production and use |
JPH02268694A (ja) * | 1989-04-07 | 1990-11-02 | Teijin Ltd | 血栓溶解剤 |
JP2001515345A (ja) * | 1996-09-20 | 2001-09-18 | ザ・ジェネラル・ホスピタル・コーポレイション | アルファ―2―抗プラスミンに対する抗体を用いてフィブリン溶解を増進するための組成物と方法 |
US6524675B1 (en) | 1999-05-13 | 2003-02-25 | 3M Innovative Properties Company | Adhesive-back articles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0735340B2 (ja) * | 1985-05-23 | 1995-04-19 | 帝人株式会社 | 血栓溶解促進剤 |
JPH0610139B2 (ja) * | 1986-05-15 | 1994-02-09 | エモリ ユニバーシティ | 繊維素溶解性合成物混合物及び血管内の血餅溶解用薬剤 |
-
1989
- 1989-03-15 WO PCT/US1989/001065 patent/WO1989009817A1/en active IP Right Grant
- 1989-03-15 KR KR1019890702259A patent/KR100194113B1/ko not_active IP Right Cessation
- 1989-03-15 JP JP1503381A patent/JP2871775B2/ja not_active Expired - Fee Related
- 1989-03-15 AU AU32845/89A patent/AU628041B2/en not_active Ceased
- 1989-03-15 HU HU892304A patent/HU207349B/hu not_active IP Right Cessation
- 1989-03-29 CA CA000594988A patent/CA1341377C/en not_active Expired - Fee Related
- 1989-04-04 EP EP89303293A patent/EP0336693B1/en not_active Expired - Lifetime
- 1989-04-04 ZA ZA892464A patent/ZA892464B/xx unknown
- 1989-04-04 AT AT89303293T patent/ATE114480T1/de not_active IP Right Cessation
- 1989-04-04 ES ES89303293T patent/ES2064435T3/es not_active Expired - Lifetime
- 1989-04-04 DE DE68919504T patent/DE68919504T2/de not_active Expired - Fee Related
-
1990
- 1990-10-03 NO NO904294A patent/NO301374B1/no not_active IP Right Cessation
- 1990-10-03 FI FI904867A patent/FI102812B/fi not_active IP Right Cessation
- 1990-10-04 DK DK199002401A patent/DK174062B1/da not_active IP Right Cessation
-
1995
- 1995-02-27 GR GR940403885T patent/GR3015182T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2871775B2 (ja) | 1999-03-17 |
FI102812B1 (fi) | 1999-02-26 |
DE68919504T2 (de) | 1995-06-29 |
EP0336693B1 (en) | 1994-11-30 |
JPH03504717A (ja) | 1991-10-17 |
NO301374B1 (no) | 1997-10-20 |
AU3284589A (en) | 1989-11-03 |
NO904294L (no) | 1990-12-04 |
DK174062B1 (da) | 2002-05-13 |
HU892304D0 (en) | 1991-07-29 |
ZA892464B (en) | 1989-12-27 |
KR900700129A (ko) | 1990-08-11 |
FI102812B (fi) | 1999-02-26 |
HU207349B (en) | 1993-03-29 |
FI904867A0 (fi) | 1990-10-03 |
WO1989009817A1 (en) | 1989-10-19 |
ATE114480T1 (de) | 1994-12-15 |
DE68919504D1 (de) | 1995-01-12 |
ES2064435T3 (es) | 1995-02-01 |
KR100194113B1 (ko) | 1999-06-15 |
CA1341377C (en) | 2002-07-16 |
AU628041B2 (en) | 1992-09-10 |
EP0336693A2 (en) | 1989-10-11 |
EP0336693A3 (en) | 1990-03-21 |
HUT56394A (en) | 1991-08-28 |
NO904294D0 (no) | 1990-10-03 |
DK240190A (da) | 1990-10-04 |
DK240190D0 (da) | 1990-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Seitz et al. | Increased thrombin activity during thrombolysis | |
GR3020036T3 (en) | Inhibition of arterial thrombotic occlusion or thromboembolism | |
BG101647A (en) | Low molecular weight bicyclic thrombin inhibitors | |
GR3015182T3 (en) | Acceleration of clot lysis. | |
DK36991D0 (da) | Vaevsplasminoaktivator-(t-pa)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmaade til fremstilling deraf, dna-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og vaertsceller transformeret med vektoren | |
ATE126269T1 (de) | Fledermausspeichel-plasminogenaktivatoren. | |
Eisenberg | Role of new anticoagulants as adjunctive therapy during thrombolysis | |
Stassen et al. | Comparative effects of enoxaparin and heparin on arterial and venous clot lysis with alteplase in dogs | |
Jang et al. | A randomized, blinded study of two doses of Novastan®(brand of argatroban) versus heparin as adjunctive therapy to recombinant tissue plasminogen activator (accelerated administration) in acute myocardial infarction: Rationale and design of the Myocardial Infarction using Novastan® and t-PA (MINT) study | |
VI | PLATELET INHIBITORS IN ARTERIALTHROMBOSIS ANDATHEROCENESIS. | |
Preissner et al. | Influence of fibrinogen on fibrin polymerization. Ultracentrifugation studies | |
Colucci et al. | Does human protein C exert profibrinolytic activity? | |
Norman | III. INHIBITORS OF THE FIBRINOLYTIC SYSTEM | |
Mombelli et al. | Low Grade DIC in Liver Cirrhosis: Fact or Fiction?-Rebuttal | |
Diffang et al. | The effect of alpha-blocking agents on the amount of intravascular fibrin in the lungs during induced intravascular coagulation in rats | |
DK0563280T3 (da) | Vævsplasminogenaktivator substitutionsvariant | |
Fears et al. | Evidence for the progressive uptake of APSAC by human clots in vitro | |
Shafer et al. | Thrombolytic therapy. Current and potential uses. | |
LUCCHESI | New Drugs in Cardiovascular Medicine | |
WO1995030438A3 (en) | Methods and compositions to enhance endogenous fibrinolytic activity | |
TAYLOR et al. | Prolonged Clot Lysis Time and Absence of Platelet γM-globulin in Patients with Thrombasthenia | |
Ch et al. | Influence of aspirin ingestion on in-vitro formation and lysis of platelet-fibrin-thrombi | |
Morser et al. | 51 Differential effects of human platelets on plasminogen activator by tissue-plasminogen activator, urokinase and streptokinase | |
de Fouw et al. | 52 Profibrinolytic activity associated with anti-coagulation | |
IL109735A0 (en) | Tissue plasminogen activator having zymonogenic or fibrin specific properties |