ES2061632T5 - Kluyveromyces como celula hospedante. - Google Patents
Kluyveromyces como celula hospedante.Info
- Publication number
- ES2061632T5 ES2061632T5 ES88201632T ES88201632T ES2061632T5 ES 2061632 T5 ES2061632 T5 ES 2061632T5 ES 88201632 T ES88201632 T ES 88201632T ES 88201632 T ES88201632 T ES 88201632T ES 2061632 T5 ES2061632 T5 ES 2061632T5
- Authority
- ES
- Spain
- Prior art keywords
- kluyveromyces
- endogenous
- product
- hospitalizing
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01108—Lactase (3.2.1.108)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
LA INVENCION PROPORCIONA HUESPEDES DE KLUYVEROMYCES Y CASETTES DE EXPRESION DE DNA PARA SU EMPLEO EN KLUYVEROMICES PARA LA TRANSCRIPCION DE DNA ENDOGENO Y/O EXOGENO Y PRODUCCION DE PEPTIDOS, PARA MEJORAR LA PRODUCCION DE UN PRODUCTO ENDOGENO O PARA PRODUCIR UN PRODUCTO EXOGENO. LOS HUESPEDES DE KLUYVEROMYCES SON PARTICULARMENTE UTILES PARA LA SECRECION DE UN PRODUCTO PEPTIDICO DESEADO, EN LAS QUE LAS SECUENCIAS SEÑAL PUEDEN SER NATIVAS DEL PEPTIDO O SER PROPORCIONADAS A PARTIR DE SECUENCIAS SEÑAL ENDOGENAS O EXOGENAS, QUE INCLUYEN SECUENCIAS SINTETICAS, FUNCIONALES EN LOS KLUYVEROMYCES. LE PROPORCIONA TAMBIEN UN PROCEDIMIENTO PARA TRANSFORMAR KLUYVEROMYCES DE FORMA EFICAZ.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/078,539 US4943529A (en) | 1982-05-19 | 1987-07-28 | Kluyveromyces as a host strain |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2061632T3 ES2061632T3 (es) | 1994-12-16 |
ES2061632T5 true ES2061632T5 (es) | 2000-12-16 |
Family
ID=22144683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88201632T Expired - Lifetime ES2061632T5 (es) | 1987-07-28 | 1988-07-28 | Kluyveromyces como celula hospedante. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0301670B2 (es) |
JP (1) | JPH02476A (es) |
KR (1) | KR970007024B1 (es) |
CN (1) | CN1026994C (es) |
AR (1) | AR247761A1 (es) |
AT (1) | ATE97446T1 (es) |
AU (1) | AU628018B2 (es) |
CA (1) | CA1323850C (es) |
DE (1) | DE3885668T3 (es) |
DK (1) | DK175203B1 (es) |
ES (1) | ES2061632T5 (es) |
FI (1) | FI107939B (es) |
GR (1) | GR3034358T3 (es) |
HU (1) | HU208553B (es) |
IE (1) | IE62458B1 (es) |
IL (1) | IL87258A (es) |
NO (1) | NO302485B1 (es) |
NZ (1) | NZ225597A (es) |
PT (1) | PT88133B (es) |
ZA (1) | ZA885536B (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
FR2649991B2 (fr) * | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
CA2017176A1 (en) * | 1989-05-22 | 1990-11-22 | Yoshitomi Pharmaceutical Industries Ltd. | Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin |
FR2650598B1 (fr) * | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
FR2677996B1 (fr) * | 1991-06-21 | 1993-08-27 | Rhone Poulenc Rorer Sa | Vecteurs de clonage et/ou d'expression preparation et utilisation. |
FR2678636A1 (fr) * | 1991-07-02 | 1993-01-08 | Rhone Poulenc Rorer Sa | Procede de production de proteines recombinantes et cellules hote utilisees. |
IT1251435B (it) * | 1991-09-04 | 1995-05-09 | Sclavo Spa | Vettore genetico per la integrazione multipla stabile di sequenze di dna nel genoma dei lieviti kluyveromyces lactis e saccharomyces cerevisiae e plasmidi che lo contengono. |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
FR2692907B1 (fr) * | 1992-06-25 | 1995-06-30 | Rhone Poulenc Rorer Sa | Levures kluyveromyces modifiees, preparation et utilisation. |
FR2693475B1 (fr) * | 1992-07-08 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procédé d'identification et/ou de clonage de promoteurs transcriptionnels, et utilisation de ces promoteurs pour l'expression de gènes. |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
GB9907461D0 (en) | 1999-03-31 | 1999-05-26 | King S College London | Neurite regeneration |
US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
CN1059236C (zh) * | 1997-04-24 | 2000-12-06 | 复旦大学 | 脆壁克鲁维酵母的高效转化系统 |
US8372620B2 (en) | 1998-12-23 | 2013-02-12 | Dupont Nutrition Biosciences Aps | Bacterial xylanases |
CA2405557C (en) | 2000-04-12 | 2013-09-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
GB0020498D0 (en) | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
AU2000277798B2 (en) | 2000-09-21 | 2006-06-22 | Basf Aktiengesellschaft | Talaromyces xylanases |
CA2706364A1 (en) | 2000-12-07 | 2002-06-13 | Dsm Ip Assets B.V. | Method for the prevention or reduction of haze in beverages |
DK1339837T3 (da) | 2000-12-07 | 2008-06-09 | Dsm Ip Assets Bv | Prolyl-endoprotease fra Aspergillus Niger |
GB0116453D0 (en) | 2001-07-05 | 2001-08-29 | Imp College Innovations Ltd | Method |
CN101724075B (zh) | 2001-10-10 | 2014-04-30 | 诺和诺德公司 | 肽的重构和糖缀合 |
EP2292273A3 (en) | 2001-10-10 | 2011-11-23 | BioGeneriX AG | Remodeling and glycoconjugation of peptides |
WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
EP1511835B9 (en) | 2002-06-07 | 2015-02-25 | DSM IP Assets B.V. | Improved method for the prevention or reduction of haze in beverages |
TWI328612B (en) | 2002-07-25 | 2010-08-11 | Dsm Ip Assets Bv | Genes and their encoded polypeptides involved in the biosynthetic pathway of vitamin b12, vectors and host cells comprising the genes, and process for producing vitamin b12 |
GB0403864D0 (en) | 2004-02-20 | 2004-03-24 | Ucl Ventures | Modulator |
ES2246175B1 (es) * | 2004-07-30 | 2007-03-16 | Felix Claverie Martin | "procedimiento para producir quimosina caprina recombinante para la coagulacion de la leche de cabra en la fabricacion de queso". |
WO2007060247A2 (en) | 2005-11-28 | 2007-05-31 | Dsm Ip Assets B.V. | Enzyme preparations yielding a clean taste |
GB0600406D0 (en) | 2006-01-10 | 2006-02-15 | Univ Bath | Crystal |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
NZ571699A (en) | 2006-04-13 | 2011-07-29 | Dsm Ip Assets Bv | Liquid composition comprising an aspartic protease |
NZ578882A (en) | 2007-02-20 | 2012-01-12 | Dsm Ip Assets Bv | Sialidase from the fungus Penicilium chrysogenum |
ES2608033T3 (es) | 2007-03-22 | 2017-04-05 | Dsm Ip Assets B.V. | Nuevas lisil oxidasas |
JP5435657B2 (ja) * | 2008-03-18 | 2014-03-05 | 国立大学法人山口大学 | 凝集性酵母、及びその作製法 |
WO2011101339A2 (en) | 2010-02-18 | 2011-08-25 | Dsm Ip Assets B.V. | Fermentation broth and filtration filter cake and uses thereof |
WO2012007445A1 (en) | 2010-07-13 | 2012-01-19 | Dsm Ip Assets B.V. | Mutarotase in crystallization |
WO2012007446A1 (en) | 2010-07-13 | 2012-01-19 | Dsm Ip Assets B.V. | Use of a mutarotase in the production of dried powders |
CN115806889B (zh) * | 2022-09-28 | 2024-06-11 | 山东大学 | 一种提高基因表达水平的酿酒酵母工程菌及其构建方法与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL66614A (en) * | 1981-08-28 | 1985-09-29 | Genentech Inc | Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it |
MX197183A (es) * | 1982-05-05 | 1994-02-28 | Genentech Inc | Activador de plasminogeno de tejido humano |
EP0096910B1 (en) * | 1982-05-19 | 1989-04-19 | Unilever N.V. | Yeast of the genus kluyveromyces modified for the expression of preprothaumatin or its various allelic and modified forms or their maturation forms |
DE3382547D1 (de) * | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
IT1203758B (it) * | 1986-03-27 | 1989-02-23 | Univ Roma | Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori |
-
1988
- 1988-07-28 CA CA000573343A patent/CA1323850C/en not_active Expired - Lifetime
- 1988-07-28 DE DE3885668T patent/DE3885668T3/de not_active Expired - Fee Related
- 1988-07-28 NO NO883347A patent/NO302485B1/no not_active IP Right Cessation
- 1988-07-28 ES ES88201632T patent/ES2061632T5/es not_active Expired - Lifetime
- 1988-07-28 JP JP63189551A patent/JPH02476A/ja active Pending
- 1988-07-28 IE IE231488A patent/IE62458B1/en not_active IP Right Cessation
- 1988-07-28 AT AT88201632T patent/ATE97446T1/de not_active IP Right Cessation
- 1988-07-28 DK DK198804221A patent/DK175203B1/da not_active IP Right Cessation
- 1988-07-28 AR AR88311535A patent/AR247761A1/es active
- 1988-07-28 KR KR1019880009551A patent/KR970007024B1/ko not_active IP Right Cessation
- 1988-07-28 AU AU20148/88A patent/AU628018B2/en not_active Ceased
- 1988-07-28 NZ NZ225597A patent/NZ225597A/xx unknown
- 1988-07-28 FI FI883540A patent/FI107939B/fi not_active IP Right Cessation
- 1988-07-28 PT PT88133A patent/PT88133B/pt not_active IP Right Cessation
- 1988-07-28 IL IL8725888A patent/IL87258A/en not_active IP Right Cessation
- 1988-07-28 EP EP88201632A patent/EP0301670B2/en not_active Expired - Lifetime
- 1988-07-28 ZA ZA885536A patent/ZA885536B/xx unknown
- 1988-07-28 HU HU884020A patent/HU208553B/hu not_active IP Right Cessation
- 1988-07-28 CN CN88104676A patent/CN1026994C/zh not_active Expired - Fee Related
-
2000
- 2000-09-06 GR GR20000402046T patent/GR3034358T3/el not_active IP Right Cessation
Also Published As
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