ATE173023T1 - Dna-sequenzen kodierend für das polypeptid gelonin - Google Patents
Dna-sequenzen kodierend für das polypeptid geloninInfo
- Publication number
- ATE173023T1 ATE173023T1 AT92919264T AT92919264T ATE173023T1 AT E173023 T1 ATE173023 T1 AT E173023T1 AT 92919264 T AT92919264 T AT 92919264T AT 92919264 T AT92919264 T AT 92919264T AT E173023 T1 ATE173023 T1 AT E173023T1
- Authority
- AT
- Austria
- Prior art keywords
- gelonin
- dna sequences
- polypeptide
- sequences coding
- synthetic gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75594991A | 1991-09-06 | 1991-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE173023T1 true ATE173023T1 (de) | 1998-11-15 |
Family
ID=25041367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92919264T ATE173023T1 (de) | 1991-09-06 | 1992-08-21 | Dna-sequenzen kodierend für das polypeptid gelonin |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5624827A (de) |
| EP (1) | EP0602144B1 (de) |
| JP (1) | JPH06510431A (de) |
| KR (1) | KR100270195B1 (de) |
| CN (1) | CN1047402C (de) |
| AT (1) | ATE173023T1 (de) |
| AU (1) | AU679427B2 (de) |
| CA (1) | CA2115049C (de) |
| DE (1) | DE69227519T2 (de) |
| DK (1) | DK0602144T3 (de) |
| ES (1) | ES2123008T3 (de) |
| FI (1) | FI113547B (de) |
| IL (1) | IL103057A (de) |
| NO (1) | NO317659B1 (de) |
| NZ (1) | NZ244220A (de) |
| RU (1) | RU2142015C1 (de) |
| WO (1) | WO1993005168A1 (de) |
| ZA (1) | ZA926705B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5317009A (en) * | 1991-08-26 | 1994-05-31 | New York University | Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses thereof |
| US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
| US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
| US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| ES2202310T3 (es) * | 1991-12-13 | 2004-04-01 | Xoma Corporation | Metodos y materiales para la preparacion de dominios variables de anticuerpos modificados y sus usos terapeuticos. |
| US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| JPH08510642A (ja) * | 1993-05-12 | 1996-11-12 | ゾマ コーポレイション | ゲロニンおよび抗体から成る免疫毒素 |
| US20030166169A1 (en) * | 1998-01-16 | 2003-09-04 | Padgett Hal S. | Method for constructing viral nucleic acids in a cell-free manner |
| ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| JP2004535202A (ja) * | 2001-07-17 | 2004-11-25 | リサーチ ディベロップメント ファンデーション | アポトーシス促進性蛋白質を含む治療剤 |
| WO2003105761A2 (en) * | 2002-06-12 | 2003-12-24 | Research Development Foundation | Immunotoxin as a therapeutic agent and uses thereof |
| EP1551876B1 (de) | 2002-10-16 | 2011-03-16 | Purdue Pharma L.P. | Antikörper, die an zellassoziiertes ca 125/0722p binden, und verfahren zu deren anwendung |
| EP1855724A2 (de) * | 2005-02-01 | 2007-11-21 | Research Development Foundation | Blys-fusionsproteine für targeting des blys-rezeptors und verfahren zur behandlung von proliferativen b-zell-störungen |
| KR101224828B1 (ko) * | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
| US20130109596A1 (en) | 2011-09-26 | 2013-05-02 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
| EP4029937A1 (de) | 2012-10-04 | 2022-07-20 | Research Development Foundation | Serinproteasemoleküle und therapien |
| US10563240B2 (en) | 2013-03-14 | 2020-02-18 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
| LT3557262T (lt) | 2014-12-09 | 2022-11-10 | Life Technologies Corporation | Didelio efektyvumo nukleorūgščių sintezė mažame tūryje |
| US20180291413A1 (en) | 2015-10-06 | 2018-10-11 | Thermo Fisher Scientific Geneart Gmbh | Devices and methods for producing nucleic acids and proteins |
| US20210147830A1 (en) | 2018-06-29 | 2021-05-20 | Thermo Fisher Scientific Geneart Gmbh | High throughput assembly of nucleic acid molecules |
| GB201905303D0 (en) | 2019-04-15 | 2019-05-29 | Thermo Fisher Scient Geneart Gmbh | Multiplex assembly of nucleic acid molecules |
| EP4114972A1 (de) | 2020-03-06 | 2023-01-11 | Life Technologies Corporation | Nukleinsäuresynthese und -anordnung mit hoher sequenztreue |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888415A (en) * | 1985-03-04 | 1989-12-19 | Dana-Farber Cancer Institute, Inc. | Gelonin immunotoxin |
| US5024947A (en) * | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
| US5290914A (en) * | 1988-04-28 | 1994-03-01 | Mycogen Corporation | Hybrid diphtheria-B.t. pesticidal toxins |
| IE912716A1 (en) * | 1990-08-14 | 1992-02-26 | Res Dev Foundation | Protein Structure of the Plant Toxin Gelonin |
-
1992
- 1992-08-21 WO PCT/US1992/007066 patent/WO1993005168A1/en active IP Right Grant
- 1992-08-21 AT AT92919264T patent/ATE173023T1/de not_active IP Right Cessation
- 1992-08-21 JP JP5505226A patent/JPH06510431A/ja active Pending
- 1992-08-21 KR KR1019940700732A patent/KR100270195B1/ko not_active IP Right Cessation
- 1992-08-21 AU AU25476/92A patent/AU679427B2/en not_active Ceased
- 1992-08-21 EP EP92919264A patent/EP0602144B1/de not_active Expired - Lifetime
- 1992-08-21 CA CA002115049A patent/CA2115049C/en not_active Expired - Fee Related
- 1992-08-21 ES ES92919264T patent/ES2123008T3/es not_active Expired - Lifetime
- 1992-08-21 DE DE69227519T patent/DE69227519T2/de not_active Expired - Lifetime
- 1992-08-21 DK DK92919264T patent/DK0602144T3/da active
- 1992-08-21 RU RU94034733A patent/RU2142015C1/ru not_active IP Right Cessation
- 1992-09-04 CN CN92110105A patent/CN1047402C/zh not_active Expired - Fee Related
- 1992-09-04 ZA ZA926705A patent/ZA926705B/xx unknown
- 1992-09-04 NZ NZ244220A patent/NZ244220A/en not_active IP Right Cessation
- 1992-09-04 IL IL10305792A patent/IL103057A/en not_active IP Right Cessation
-
1994
- 1994-03-03 NO NO19940736A patent/NO317659B1/no not_active IP Right Cessation
- 1994-03-04 FI FI941048A patent/FI113547B/fi active
- 1994-10-21 US US08/327,440 patent/US5624827A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR100270195B1 (ko) | 2001-03-02 |
| NZ244220A (en) | 1994-12-22 |
| NO940736D0 (no) | 1994-03-03 |
| ES2123008T3 (es) | 1999-01-01 |
| WO1993005168A1 (en) | 1993-03-18 |
| US5624827A (en) | 1997-04-29 |
| IL103057A0 (en) | 1993-02-21 |
| EP0602144A1 (de) | 1994-06-22 |
| JPH06510431A (ja) | 1994-11-24 |
| DK0602144T3 (da) | 1999-07-19 |
| FI113547B (fi) | 2004-05-14 |
| FI941048A (fi) | 1994-03-04 |
| CA2115049A1 (en) | 1993-03-18 |
| CN1070227A (zh) | 1993-03-24 |
| RU94034733A (ru) | 1996-06-10 |
| DE69227519D1 (de) | 1998-12-10 |
| EP0602144B1 (de) | 1998-11-04 |
| NO940736L (no) | 1994-03-03 |
| NO317659B1 (no) | 2004-11-29 |
| AU2547692A (en) | 1993-04-05 |
| RU2142015C1 (ru) | 1999-11-27 |
| CN1047402C (zh) | 1999-12-15 |
| AU679427B2 (en) | 1997-07-03 |
| CA2115049C (en) | 2003-10-21 |
| DE69227519T2 (de) | 1999-06-02 |
| FI941048A0 (fi) | 1994-03-04 |
| ZA926705B (en) | 1993-04-28 |
| IL103057A (en) | 1999-09-22 |
| EP0602144A4 (de) | 1995-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |