ES2060149T3 - Nuevos derivados de alquilamida sustituida de teicoplanina. - Google Patents

Nuevos derivados de alquilamida sustituida de teicoplanina.

Info

Publication number
ES2060149T3
ES2060149T3 ES90904339T ES90904339T ES2060149T3 ES 2060149 T3 ES2060149 T3 ES 2060149T3 ES 90904339 T ES90904339 T ES 90904339T ES 90904339 T ES90904339 T ES 90904339T ES 2060149 T3 ES2060149 T3 ES 2060149T3
Authority
ES
Spain
Prior art keywords
teicoplanin
derivatives
new derivatives
amida
alkylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90904339T
Other languages
English (en)
Inventor
Adriano Malabarba
Pierfausto Seneci
Jurgen Kurt Kettenring
Romeo Ciabatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Application granted granted Critical
Publication of ES2060149T3 publication Critical patent/ES2060149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE DIRIGE A DERIVADOS NUEVOS DE AMIDAS DE C63 DE TEICOPLANIN EN LAS QUE SE DERIVA LA MITAD DE LA AMIDA DE UNA DIRALOS. LOS DERIVADOS SE PREPARAN HACIENDO REACCIONAR UN PRODUCTO SEMEJANTE AL TEICOPLANIN CON UN ESTER ACTIVO QUE FORMA UN REACTIVO COMO EL CLOROACETONITRILO Y, A CONTINUACION, PONIENDO EN CONTACTO DICHO ESTER ACTIVO CON LA DIPROPIADA. LOS DERIVADOS DE LA AMIDA DE LA INVENCION SON ACTIVOS FRENTE A BACTERIAS GRAM POSITIVAS Y GRAM NEGATIVAS.
ES90904339T 1989-03-29 1990-03-13 Nuevos derivados de alquilamida sustituida de teicoplanina. Expired - Lifetime ES2060149T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89105525 1989-03-29

Publications (1)

Publication Number Publication Date
ES2060149T3 true ES2060149T3 (es) 1994-11-16

Family

ID=8201144

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90904339T Expired - Lifetime ES2060149T3 (es) 1989-03-29 1990-03-13 Nuevos derivados de alquilamida sustituida de teicoplanina.

Country Status (21)

Country Link
EP (1) EP0465481B1 (es)
JP (1) JP2833716B2 (es)
KR (1) KR0137958B1 (es)
CN (1) CN1045976A (es)
AU (1) AU638977B2 (es)
CA (1) CA2046880C (es)
DE (1) DE69004685T2 (es)
DK (1) DK0465481T3 (es)
ES (1) ES2060149T3 (es)
FI (1) FI914513A0 (es)
GR (1) GR1000421B (es)
HU (1) HU217074B (es)
IE (1) IE64155B1 (es)
IL (1) IL93716A (es)
NO (1) NO300068B1 (es)
NZ (1) NZ233135A (es)
PH (1) PH27258A (es)
PT (1) PT93445B (es)
RU (1) RU2078768C1 (es)
WO (1) WO1990011300A1 (es)
ZA (1) ZA901881B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0836619T3 (da) * 1995-07-05 2004-12-06 Aventis Bulk S P A Oprensning af dalbaheptid antibiotika ved hjælp af isoelektrisk fokusering
ATE242783T1 (de) 1998-12-23 2003-06-15 Theravance Inc Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
AR021964A1 (es) * 1998-12-23 2002-09-04 Theravance Inc Un compuesto glicopeptidico, composiciones farmaceuticas que los contienen y uso de dichos compuestos glicopeptidicos para la manufactura de un medicamento antibacteriano.
ES2158770B1 (es) * 1999-02-03 2002-04-16 Smithkline Beecham Sa Nuevos glicopeptidos.
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en) 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
US20050090433A1 (en) 2002-11-18 2005-04-28 Vicuron Pharmaceuticals, Inc Dalbavancin compositions for treatment of bacterial infections
ES2278101T3 (es) * 2003-09-17 2007-08-01 Alpharma Aps Composicion de teicoplanina con actividad antibiotica mejorada.
RU2570425C1 (ru) * 2014-12-22 2015-12-10 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Химерные антибиотики на основе гликопептидов и 11,12-циклического карбоната азитромицина и способ их получения
JP2019063191A (ja) * 2017-09-29 2019-04-25 国立研究開発法人国立長寿医療研究センター 非細胞性根管充填材及び非細胞性歯組織再生促進キット

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8704847D0 (en) * 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
GB8827202D0 (en) * 1988-11-22 1988-12-29 Lepetit Spa Process for preparing 63-carboxyamides of teicoplanin antibiotics

Also Published As

Publication number Publication date
GR1000421B (el) 1992-06-30
HU902355D0 (en) 1991-12-30
AU5188390A (en) 1990-10-22
EP0465481B1 (en) 1993-11-18
NO913764D0 (no) 1991-09-25
NO913764L (no) 1991-09-25
DK0465481T3 (da) 1994-02-21
WO1990011300A1 (en) 1990-10-04
PH27258A (en) 1993-05-04
IE900808L (en) 1990-09-29
DE69004685D1 (de) 1993-12-23
JP2833716B2 (ja) 1998-12-09
ZA901881B (en) 1990-12-28
PT93445B (pt) 1996-08-30
KR920701251A (ko) 1992-08-11
PT93445A (pt) 1990-11-07
HUT58350A (en) 1992-02-28
RU2078768C1 (ru) 1997-05-10
FI914513A7 (fi) 1991-09-25
DE69004685T2 (de) 1994-05-26
NZ233135A (en) 1992-09-25
CN1045976A (zh) 1990-10-10
IL93716A (en) 1994-10-21
AU638977B2 (en) 1993-07-15
JPH04504251A (ja) 1992-07-30
EP0465481A1 (en) 1992-01-15
HU217074B (hu) 1999-11-29
FI914513A0 (fi) 1991-09-25
IE64155B1 (en) 1995-07-12
KR0137958B1 (ko) 1998-04-30
CA2046880A1 (en) 1990-09-30
IL93716A0 (en) 1990-12-23
GR900100195A (en) 1990-07-31
CA2046880C (en) 2001-12-04
NO300068B1 (no) 1997-04-01

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