ES2083374T3 - Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas. - Google Patents

Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas.

Info

Publication number
ES2083374T3
ES2083374T3 ES89122874T ES89122874T ES2083374T3 ES 2083374 T3 ES2083374 T3 ES 2083374T3 ES 89122874 T ES89122874 T ES 89122874T ES 89122874 T ES89122874 T ES 89122874T ES 2083374 T3 ES2083374 T3 ES 2083374T3
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
branched
integer
linear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89122874T
Other languages
English (en)
Inventor
Adriano Malabarba
Jurgen Kurt Kettenring
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Application granted granted Critical
Publication of ES2083374T3 publication Critical patent/ES2083374T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electric Stoves And Ranges (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADO C63-AMIDA DEL 34- DE (ACETILGLUCOSAMINIL)- 34-DEOXI-TEICOPLANINAS DONDE LA MITAD DE ANIDA ES DERIVADA DE UNA DIAMINA O POLIAMINA. LOS DERIVADOS SON PREPARADOS REACCIONANDO LAS 34- DE (ACETIL-GLUCOSAMINIL)-34- DEOXILEICOPLANINAS CON UN ESTORES ACTIVOS FORMANDO REACTIVOS TALES COMO LA CLOROACETONITRIDA Y DESPUES CONTACTANDO DICHOS ESTERES ACTIVOS CON EL APROPIADO DI O POLI-AMINA. LOS DERIVADOS DE AMIDA SON ACTIVOS FRENTE A LOS MICROSORFANIDAS GRAN-POSITIVOS EN PARTICULAR CONTRA EL GRUPO A STRECTOCOCC:
ES89122874T 1988-12-27 1989-12-12 Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas. Expired - Lifetime ES2083374T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88121708 1988-12-27

Publications (1)

Publication Number Publication Date
ES2083374T3 true ES2083374T3 (es) 1996-04-16

Family

ID=8199722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89122874T Expired - Lifetime ES2083374T3 (es) 1988-12-27 1989-12-12 Derivados amidicos en posicion c63 de 34-des(acetilglucosaminil)-34-desoxi-teicoplaninas.

Country Status (19)

Country Link
EP (1) EP0376041B1 (es)
JP (1) JPH02221298A (es)
CN (1) CN1043941A (es)
AT (1) ATE134646T1 (es)
AU (1) AU629883B2 (es)
CA (1) CA2006379A1 (es)
DE (1) DE68925806T2 (es)
DK (1) DK171404B1 (es)
ES (1) ES2083374T3 (es)
FI (1) FI91076C (es)
GR (1) GR3020070T3 (es)
HU (1) HU209939B (es)
IE (1) IE71942B1 (es)
IL (1) IL92827A (es)
NO (1) NO178664C (es)
NZ (1) NZ231863A (es)
PT (1) PT92672B (es)
RU (1) RU2068418C1 (es)
ZA (1) ZA899772B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU647122B2 (en) * 1990-05-28 1994-03-17 Gruppo Lepetit S.P.A. C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy- teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
US5750509A (en) * 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
JP3418762B2 (ja) * 1991-07-29 2003-06-23 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ 抗生物質ａ４０９２６のアミド誘導体類
ES2201825T3 (es) 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
MY123217A (en) * 1998-12-23 2006-05-31 Theravance Inc Glycopeptide derivatives and pharmaceutical compositions containing the same
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
US20050004011A1 (en) 2002-11-18 2005-01-06 Marco Cavaleri Compositions and methods for treating bacterial infections with protein-dalbavancin complexes
US7119061B2 (en) 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en) 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8522574D0 (en) * 1985-09-12 1985-10-16 Lepetit Spa Amides of teicoplanin compounds
GB8529272D0 (en) * 1985-11-28 1986-01-02 Lepetit Spa Teicoplanin derivatives
GB8704847D0 (en) * 1987-03-02 1987-04-08 Lepetit Spa Substituted alkylamides of teicoplanin compounds
GB8711066D0 (en) * 1987-05-11 1987-06-17 Lepetit Spa Teicoplanin derivatives
GB8827202D0 (en) * 1988-11-22 1988-12-29 Lepetit Spa Process for preparing 63-carboxyamides of teicoplanin antibiotics

Also Published As

Publication number Publication date
DE68925806D1 (de) 1996-04-04
HU209939B (en) 1994-12-28
ZA899772B (en) 1991-01-30
CN1043941A (zh) 1990-07-18
JPH02221298A (ja) 1990-09-04
CA2006379A1 (en) 1990-06-27
DE68925806T2 (de) 1996-09-26
GR3020070T3 (en) 1996-08-31
HUT53376A (en) 1990-10-28
NZ231863A (en) 1992-08-26
AU629883B2 (en) 1992-10-15
DK171404B1 (da) 1996-10-14
EP0376041B1 (en) 1996-02-28
IL92827A (en) 1994-08-26
NO895123L (no) 1990-06-28
PT92672A (pt) 1990-06-29
NO178664C (no) 1996-05-08
DK640489D0 (da) 1989-12-18
DK640489A (da) 1990-06-28
IE894143L (en) 1990-06-27
RU2068418C1 (ru) 1996-10-27
NO895123D0 (no) 1989-12-19
PT92672B (pt) 1996-09-30
FI91076B (fi) 1994-01-31
EP0376041A2 (en) 1990-07-04
IL92827A0 (en) 1990-09-17
FI91076C (fi) 1994-05-10
FI896199A0 (fi) 1989-12-22
AU4698489A (en) 1990-07-05
HU896772D0 (en) 1990-03-28
NO178664B (no) 1996-01-29
IE71942B1 (en) 1997-03-12
ATE134646T1 (de) 1996-03-15
EP0376041A3 (en) 1991-11-13

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