ES2148600T3 - Derivados de indol sustituidos. - Google Patents

Derivados de indol sustituidos.

Info

Publication number
ES2148600T3
ES2148600T3 ES96100761T ES96100761T ES2148600T3 ES 2148600 T3 ES2148600 T3 ES 2148600T3 ES 96100761 T ES96100761 T ES 96100761T ES 96100761 T ES96100761 T ES 96100761T ES 2148600 T3 ES2148600 T3 ES 2148600T3
Authority
ES
Spain
Prior art keywords
substituted indol
derivatives
indol derivatives
indol
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96100761T
Other languages
English (en)
Inventor
Matthias Dr Muller-Gliemann
Ulrich Dr Muller
Martin Dr Beuck
Sigfried Dr Zaiss
Christoph Dr Gerdes
Anke Dr Domdey-Bette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19513716A external-priority patent/DE19513716A1/de
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2148600T3 publication Critical patent/ES2148600T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE OBTIENEN DERIVADOS SUSTITUIDOS DE INDOL HACIENDO REACCIONAR LOS CORRESPONDIENTES ACIDOS CARBOXILICOS, OPCIONALMENTE EN PRESENCIA DE ADYUVANTES, CON LAS CORRESPONDIENTES AMINAS. LOS DERIVADOS SUSTITUIDOS DE INDOL SON MUY APROPIADOS COMO PRINCIPIOS ACTIVOS EN MEDICAMENTOS, ESPECIALMENTE EN MEDICAMENTOS PARA EL TRATAMIENTO DE LA ARTERIOESCLEROSIS Y RESTENOSIS.
ES96100761T 1995-02-01 1996-01-19 Derivados de indol sustituidos. Expired - Lifetime ES2148600T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19503159 1995-02-01
DE19513716A DE19513716A1 (de) 1995-02-01 1995-04-11 Substituierte 2-Phenylindol-Derivate

Publications (1)

Publication Number Publication Date
ES2148600T3 true ES2148600T3 (es) 2000-10-16

Family

ID=26012026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96100761T Expired - Lifetime ES2148600T3 (es) 1995-02-01 1996-01-19 Derivados de indol sustituidos.

Country Status (25)

Country Link
US (1) US5607962A (es)
EP (1) EP0725061B1 (es)
JP (1) JPH08253451A (es)
CN (1) CN1067987C (es)
AR (1) AR002271A1 (es)
AT (1) ATE193701T1 (es)
AU (1) AU708784B2 (es)
BG (1) BG62807B1 (es)
CA (1) CA2168320A1 (es)
CZ (1) CZ28996A3 (es)
DK (1) DK0725061T3 (es)
DZ (1) DZ1985A1 (es)
EE (1) EE9600021A (es)
ES (1) ES2148600T3 (es)
FI (1) FI960424A7 (es)
GR (1) GR3034245T3 (es)
HR (1) HRP960015B1 (es)
HU (1) HUP9600231A2 (es)
IL (1) IL116956A (es)
MA (1) MA23795A1 (es)
NO (1) NO305119B1 (es)
NZ (1) NZ280906A (es)
PL (1) PL312545A1 (es)
PT (1) PT725061E (es)
SK (1) SK13896A3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19924818A1 (de) 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
DE10044792A1 (de) * 2000-09-11 2002-04-04 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide und ihre Verwendung
GB0208642D0 (en) 2002-04-16 2002-05-22 Accentus Plc Metal implants
GB0405680D0 (en) 2004-03-13 2004-04-21 Accentus Plc Metal implants
AU2008306596B2 (en) 2007-10-03 2013-04-04 Accentus Plc Method of manufacturing metal with biocidal properties

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
DE4221009A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
DE4304455A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
US5358959A (en) * 1993-02-18 1994-10-25 President And Fellows Of Harvard University Methods for treating arteriosclerosis
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe

Also Published As

Publication number Publication date
FI960424L (fi) 1996-08-02
GR3034245T3 (en) 2000-12-29
NO960413D0 (no) 1996-01-31
NZ280906A (en) 1996-10-28
HUP9600231A3 (en) 1997-05-28
PL312545A1 (en) 1996-08-05
AU4224196A (en) 1996-08-08
NO960413L (no) 1996-08-02
DZ1985A1 (fr) 2002-10-15
MA23795A1 (fr) 1996-10-01
JPH08253451A (ja) 1996-10-01
ATE193701T1 (de) 2000-06-15
FI960424A7 (fi) 1996-08-02
FI960424A0 (fi) 1996-01-30
HUP9600231A2 (en) 1997-05-28
BG62807B1 (bg) 2000-08-31
DK0725061T3 (da) 2000-10-02
CZ28996A3 (en) 1996-08-14
US5607962A (en) 1997-03-04
NO305119B1 (no) 1999-04-06
EP0725061B1 (de) 2000-06-07
CN1067987C (zh) 2001-07-04
EE9600021A (et) 1996-08-15
BG100325A (bg) 1996-08-30
SK13896A3 (en) 1996-10-02
HRP960015B1 (en) 2000-12-31
HRP960015A2 (en) 1997-10-31
AR002271A1 (es) 1998-03-11
IL116956A (en) 2000-02-17
IL116956A0 (en) 1996-05-14
PT725061E (pt) 2000-11-30
HU9600231D0 (en) 1996-03-28
EP0725061A1 (de) 1996-08-07
AU708784B2 (en) 1999-08-12
CN1137520A (zh) 1996-12-11
CA2168320A1 (en) 1996-08-02

Similar Documents

Publication Publication Date Title
ES2065691T3 (es) Derivados de quinuclidina.
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
MX9301634A (es) Quinuclidinas peptidicas.
ES2191192T3 (es) Tienopirimidinas.
ES2096312T3 (es) Derivado de quinuclidina como antagonista de la sustancia p.
ECSP941122A (es) Derivados de 5-arilindoles
ES2132223T3 (es) Derivados de indol condensados en calidad de antagonistas del receptor 5-ht4.
ES2161290T3 (es) Derivados de quinazolina.
SV1995000062A (es) DERIVADOS DE CICLOALCANO-INDOL Y - AZAINDOL REF. Le A 30 699
ES2074867T3 (es) Derivados de quinazolina para potenciar la actividad antitumoral.
AR009507A1 (es) Utilizacion de retinoides
ES2170884T3 (es) Acidos alfa-iminohidroxamicos y carboxilicos n-sustituidos, ciclicos y heterociclicos.
ES2040838T3 (es) Compuestos piperazinil-heterociclicos.
CR10370A (es) Derivados sustituidos de pirrolo-pirazol inhibidores de quinasa (divisional exp. 7880)
BR8707672A (pt) Pirazolinas inseticidas
DE69623899D1 (de) Behandlung von Tinnitus mit neuroprotektiven Wirkstoffen
ES2147320T3 (es) Derivados de n-(3-benzofuranil)urea.
ES2066278T3 (es) Derivados del alcoxipirimidina contra la migraña.
ES2089687T3 (es) 4-fenil-piridonas y 4-fenil-2-alcoxipiridinas sustituidas como inhibidores de la hmg-coa-reductasa.
ES2084339T3 (es) Tetrahidropiridinas e hidroxipiperidinas sustituidas utiles como agentes para el sistema nervioso central.
MX9301197A (es) Derivados de indol.
AR002272A1 (es) Uso de amidas de fenilciclohexilcarboxilicos
ES2148600T3 (es) Derivados de indol sustituidos.
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ES2124861T3 (es) Derivados de aminoacidos y su utilizacion como inhibidores de la encefalinasa.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 725061

Country of ref document: ES