SV1995000062A - DERIVADOS DE CICLOALCANO-INDOL Y - AZAINDOL REF. Le A 30 699 - Google Patents

DERIVADOS DE CICLOALCANO-INDOL Y - AZAINDOL REF. Le A 30 699

Info

Publication number
SV1995000062A
SV1995000062A SV1995000062A SV1995000062A SV1995000062A SV 1995000062 A SV1995000062 A SV 1995000062A SV 1995000062 A SV1995000062 A SV 1995000062A SV 1995000062 A SV1995000062 A SV 1995000062A SV 1995000062 A SV1995000062 A SV 1995000062A
Authority
SV
El Salvador
Prior art keywords
opt
substd
alkyl
phenyl
alkoxy
Prior art date
Application number
SV1995000062A
Other languages
English (en)
Inventor
Ulrich Muller
Richard Connell
Siegfried Goldmann
Rudi Grutzmann
Martin Beuck
Hilmar Bischoff
Stefan Wohlfeil
Dirk Denzer
Anke Domdey-Bette
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SV1995000062A publication Critical patent/SV1995000062A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS DERIVADOS DE CICLOALCANO-INDOL Y -AZINDOL SE PRODUCEN MEDIANTE TRANSFORMACION DE LOS ACIDOS CARBOXILICOS SUSTITUIDOS RESPECTIVOS CON AMINAS. LOS DERIVADOS DE CICLOALCANO-INDOL Y -AZAINDOL SON ADECUADOS COMO SUSTANCIA ACTIVA PARA MEDICAMENTOS, PREFERIBLEMENTE MEDICAMENTOS ANTIATEROSCLEROTICOS.
SV1995000062A 1994-10-04 1995-10-04 DERIVADOS DE CICLOALCANO-INDOL Y - AZAINDOL REF. Le A 30 699 SV1995000062A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4435477A DE4435477A1 (de) 1994-10-04 1994-10-04 Cycloalkano-indol- und -azaindol-derivate

Publications (1)

Publication Number Publication Date
SV1995000062A true SV1995000062A (es) 1996-07-10

Family

ID=6529939

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1995000062A SV1995000062A (es) 1994-10-04 1995-10-04 DERIVADOS DE CICLOALCANO-INDOL Y - AZAINDOL REF. Le A 30 699

Country Status (36)

Country Link
US (6) US5684014A (es)
EP (1) EP0705831B1 (es)
JP (1) JP3901234B2 (es)
KR (1) KR100355986B1 (es)
CN (2) CN1050605C (es)
AT (1) ATE255580T1 (es)
AU (1) AU700609B2 (es)
CA (1) CA2159546C (es)
CZ (1) CZ291348B6 (es)
DE (2) DE4435477A1 (es)
DK (1) DK0705831T3 (es)
DZ (1) DZ1934A1 (es)
EE (1) EE03527B1 (es)
ES (1) ES2211890T3 (es)
FI (2) FI113048B (es)
HK (1) HK1005139A1 (es)
HN (1) HN1995009160A (es)
HR (1) HRP950505B1 (es)
HU (1) HU225052B1 (es)
IL (3) IL129641A0 (es)
MA (1) MA23683A1 (es)
MY (1) MY117282A (es)
NO (1) NO305365B1 (es)
NZ (1) NZ280130A (es)
PH (1) PH31400A (es)
PL (1) PL183154B1 (es)
PT (1) PT705831E (es)
RU (1) RU2157803C2 (es)
SG (1) SG63528A1 (es)
SI (1) SI0705831T1 (es)
SK (1) SK284260B6 (es)
SV (1) SV1995000062A (es)
TN (1) TNSN95098A1 (es)
TW (1) TW448175B (es)
UA (1) UA44700C2 (es)
ZA (1) ZA958297B (es)

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DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19615119A1 (de) 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
DE19615265A1 (de) * 1996-04-18 1997-12-04 Bayer Ag Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
SK16332000A3 (sk) * 1998-05-01 2001-06-11 Eli Lilly And Company Ester ako inhibítor spla2
ES2213984T3 (es) 1998-10-30 2004-09-01 Eli Lilly And Company Derivados de azaindol y su uso como agentes antitrombicos.
AU4616200A (en) * 1999-05-25 2000-12-12 Yamanouchi Pharmaceutical Co., Ltd. Hydrazide derivatives
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
AU3741801A (en) * 2000-03-15 2001-09-24 Aventis Pharma Gmbh Substituted beta-carbolines with ikb-kinase inhibiting activity
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
EP2140864A3 (en) * 2001-01-31 2010-01-27 H.Lundbeck A/S Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods
CN101838218A (zh) * 2002-02-28 2010-09-22 日本烟草产业株式会社 酯化合物及其医药用途
WO2003101983A1 (fr) * 2002-05-31 2003-12-11 Yamanouchi Pharmaceutical Co., Ltd. Derive tetrahydropyrane
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US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
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US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
EP1737460A2 (en) * 2004-04-09 2007-01-03 Janssen Pharmaceutica N.V. Intermittent dosing regimen for the treatment of overweight with mtp-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
KR20070072888A (ko) * 2004-10-25 2007-07-06 니뽄 다바코 산교 가부시키가이샤 용해성 및 안정성이 개선된 고형 제제 및 그의 제조 방법
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
EP1890767A2 (en) * 2005-05-27 2008-02-27 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
EP1912968A1 (en) * 2005-08-04 2008-04-23 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
US20070088089A1 (en) * 2005-10-18 2007-04-19 Wisler Gerald L Methods for treating disorders associated with hyperlipidemia in a mammal
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
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US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
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DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
EE9500071A (et) 1996-04-15
NO953930D0 (no) 1995-10-03
SI0705831T1 (en) 2004-02-29
CZ256795A3 (en) 1996-04-17
SG63528A1 (en) 1999-03-30
FI108791B (fi) 2002-03-28
ES2211890T3 (es) 2004-07-16
MY117282A (en) 2004-06-30
US5684014A (en) 1997-11-04
JP3901234B2 (ja) 2007-04-04
US6245775B1 (en) 2001-06-12
HN1995009160A (es) 2000-04-24
DK0705831T3 (da) 2004-04-05
PL183154B1 (pl) 2002-05-31
EP0705831A3 (de) 1997-01-22
KR100355986B1 (ko) 2003-01-06
JPH08225526A (ja) 1996-09-03
US6858622B2 (en) 2005-02-22
ATE255580T1 (de) 2003-12-15
HK1005139A1 (en) 1998-12-24
DE4435477A1 (de) 1996-04-11
EE03527B1 (et) 2001-10-15
US20020055635A1 (en) 2002-05-09
US6479503B2 (en) 2002-11-12
CN1130631A (zh) 1996-09-11
CA2159546A1 (en) 1996-04-05
HU9502891D0 (en) 1995-11-28
US6265431B1 (en) 2001-07-24
HUT73240A (en) 1996-07-29
IL129641A (en) 2000-08-31
CZ291348B6 (cs) 2003-02-12
AU700609B2 (en) 1999-01-07
PH31400A (en) 1998-10-29
CN1183111C (zh) 2005-01-05
IL115493A0 (en) 1996-01-19
NO953930L (no) 1996-04-09
FI954681A0 (fi) 1995-10-02
CN1050605C (zh) 2000-03-22
TW448175B (en) 2001-08-01
CN1224715A (zh) 1999-08-04
EP0705831B1 (de) 2003-12-03
PT705831E (pt) 2004-04-30
DE59510839D1 (de) 2004-01-15
IL129641A0 (en) 2000-02-29
FI113048B (fi) 2004-02-27
KR960014126A (ko) 1996-05-22
CA2159546C (en) 2010-12-14
HU225052B1 (en) 2006-05-29
US20030149073A1 (en) 2003-08-07
SK284260B6 (sk) 2004-12-01
ZA958297B (en) 1996-05-06
NO305365B1 (no) 1999-05-18
IL115493A (en) 1999-10-28
EP0705831A2 (de) 1996-04-10
HRP950505A2 (en) 1997-08-31
FI20002693A (fi) 2000-12-08
AU3292095A (en) 1996-04-18
UA44700C2 (uk) 2002-03-15
PL310756A1 (en) 1996-04-15
RU2157803C2 (ru) 2000-10-20
MA23683A1 (fr) 1996-07-01
SK123995A3 (en) 1996-06-05
FI954681A (fi) 1996-04-05
DZ1934A1 (fr) 2002-02-17
HRP950505B1 (en) 2002-04-30
NZ280130A (en) 1996-05-28
TNSN95098A1 (fr) 1996-02-06
US20020147209A1 (en) 2002-10-10

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