ES2059380T3 - Metodo para el cultivo de bordetella pertussis, toxoide de la tos ferina y vacuna contra la tos ferina. - Google Patents

Metodo para el cultivo de bordetella pertussis, toxoide de la tos ferina y vacuna contra la tos ferina.

Info

Publication number
ES2059380T3
ES2059380T3 ES87306165T ES87306165T ES2059380T3 ES 2059380 T3 ES2059380 T3 ES 2059380T3 ES 87306165 T ES87306165 T ES 87306165T ES 87306165 T ES87306165 T ES 87306165T ES 2059380 T3 ES2059380 T3 ES 2059380T3
Authority
ES
Spain
Prior art keywords
toxoid
bordetella pertussis
pertussic
whole cough
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87306165T
Other languages
English (en)
Inventor
Masashi Chazono
Iwao Yoshida
Takeo Konobe
Juichiro Osame
Keisuke Takaku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation for Microbial Diseases of Osaka University BIKEN
Original Assignee
Research Foundation for Microbial Diseases of Osaka University BIKEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation for Microbial Diseases of Osaka University BIKEN filed Critical Research Foundation for Microbial Diseases of Osaka University BIKEN
Application granted granted Critical
Publication of ES2059380T3 publication Critical patent/ES2059380T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/22—Processes using, or culture media containing, cellulose or hydrolysates thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE LA INVENCION A UN METODO PARA CULTIVAS BORDETELLA PERTUSSIS EN PRESENCIA DE CELULOSA O DE DERIVADOS CELULOSICOS. EL METODO ES UTIL PARA OBTENER UN ANTIGENO MIXTO QUE CONTIENE TOXINA PERTUSICA Y HEMAGLUTININA FILAMENTOS EN UNA GRAN CANTIDAD, A BAJO COSTE. A PARTIR DEL ANTIGENO SE PUEDE OBTENER UN TOXOIDE PERTUSICO ESTABLE Y EFECTIVO PARA SU EMPLEO EN VACUNAS PERTUSICAS. TAMBIEN SE REFIERE LA INVENCION A UNA VACUNA QUE CONTIENE EL TOXOIDE PERTUSICO COMO INGREDIENTE ACTIVO Y GELATINA O DERIVADOS DE GELATINA COMO AGENTES ESTABILIZANTE. LA VACUNA ES MUY ESTABLE Y PUEDE SER ALMACENADA DURANTE UN PERIODO DE TIEMPO PROLONGADO.
ES87306165T 1987-04-24 1987-07-13 Metodo para el cultivo de bordetella pertussis, toxoide de la tos ferina y vacuna contra la tos ferina. Expired - Lifetime ES2059380T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10236087 1987-04-24

Publications (1)

Publication Number Publication Date
ES2059380T3 true ES2059380T3 (es) 1994-11-16

Family

ID=14325294

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87306165T Expired - Lifetime ES2059380T3 (es) 1987-04-24 1987-07-13 Metodo para el cultivo de bordetella pertussis, toxoide de la tos ferina y vacuna contra la tos ferina.

Country Status (10)

Country Link
US (1) US4849358A (es)
EP (1) EP0287732B1 (es)
KR (1) KR900007644B1 (es)
AT (1) ATE96036T1 (es)
CA (1) CA1337859C (es)
DE (1) DE3787887T2 (es)
DK (1) DK365287A (es)
ES (1) ES2059380T3 (es)
FI (1) FI86959C (es)
NO (1) NO172188C (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2596413B1 (fr) * 1986-03-27 1988-06-10 Merieux Inst Nouveaux milieux de culture de bacteries appartenant au genre bordetella, contenant des derives etherifies de polymeres de d-glucose, et leur application
US5101019A (en) * 1987-05-22 1992-03-31 Takeda Chemical Industries, Ltd. Method for removing pertussis endotoxin, a pertussis toxoid and its production
JP2849632B2 (ja) * 1988-04-08 1999-01-20 社団法人北里研究所 ワクチン製剤
US5000952A (en) * 1988-08-02 1991-03-19 The Board Of Trustees Of The Leland Stanford, Jr. University Polypeptide pertussis toxin vaccine
CA1341123C (en) * 1988-10-27 2000-10-17 David A. Relman Filamentous hemagglutinin of b. pertussis
JP2706792B2 (ja) * 1988-11-29 1998-01-28 財団法人化学及血清療法研究所 百日咳毒素のトキソイド化法
US5578308A (en) * 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
US5474900A (en) * 1990-03-16 1995-12-12 Sekisui Chemical Co., Ltd. Process for preparing purified syphilis antigen from Treponema palljdum
US5718909A (en) * 1991-02-18 1998-02-17 Medscand Ab Sheet containing carbohydrate derivative for removal of E. coli
AU2088992A (en) * 1992-05-05 1993-11-11 Research Foundation For Microbial Diseases Of Osaka University, The Stabilized live vaccine
CN1147259A (zh) * 1994-04-28 1997-04-09 武田药品工业株式会社 分离百日咳杆菌保护性组分的方法
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB512196A (en) * 1937-08-19 1939-08-30 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
US2359388A (en) * 1941-02-13 1944-10-03 Lederle Lab Inc Method of preparing pertussis toxin and toxoid
DE2461439C3 (de) * 1974-12-24 1980-03-20 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines schützenden Antigens von Bordetella Pertussis sowie jenes enthaltendes Mittel
FR2356429A1 (fr) * 1976-06-28 1978-01-27 Bertoye Renee Procede de preparation d'endo-antigenes de bordetella pertussis et bordetella parapertussis utiles notamment au traitement de la coqueluche
EP0004137B1 (en) * 1978-02-17 1981-11-11 National Research Development Corporation Immunogenic cell envelope preparations
US4247452A (en) * 1978-03-01 1981-01-27 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Purification of pertussis haemagglutinins
JPS5647167A (en) * 1979-09-26 1981-04-28 Ricoh Co Ltd Facsimile transmitter
JPS581482B2 (ja) * 1980-06-11 1983-01-11 中松 義郎 無加熱反射ライト
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
US4500639A (en) * 1981-10-15 1985-02-19 Teijin Limited Culturing Bordetella in media containing etherified cyclodextrin
US4474758A (en) * 1981-11-19 1984-10-02 American Cyanamid Company Haemophilus influenzae type b and pertussis outer membrane component combined vaccine
FR2522268A1 (fr) * 1982-02-26 1983-09-02 Green Cross Corp Vaccin anti-ourlien vivant et procede pour le stabiliser
JPS58222032A (ja) * 1982-06-18 1983-12-23 Teijin Ltd 百日咳毒素のサブユニツト蛋白
JPS59110626A (ja) * 1982-12-17 1984-06-26 Kaken Pharmaceut Co Ltd Ｂ−オリゴマ−含有百日咳ワクチンおよびその製造方法
HU188847B (en) * 1983-02-22 1986-05-28 Human Oltoanyagtermeloe Es Kutato Intezet,Hu Process for producing liophylized combined vaccines
JPS59175439A (ja) * 1983-03-23 1984-10-04 Teijin Ltd 繊維状赤血球凝集素の製法
CA1213234A (en) * 1983-03-30 1986-10-28 Akihiro Ginnaga Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine
US4551429A (en) * 1983-09-15 1985-11-05 American Home Products Corporation Stimulation of antigen production by Bordetella pertussis
JPS6098988A (ja) * 1983-11-01 1985-06-01 Chemo Sero Therapeut Res Inst Ｌｐｆ−ｈａの精製法
JPS60226822A (ja) * 1984-04-25 1985-11-12 Chemo Sero Therapeut Res Inst 線維状赤血球凝集素の精製方法
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
JPS60237027A (ja) * 1984-05-07 1985-11-25 Chemo Sero Therapeut Res Inst 線維状赤血球凝集素の精製方法
JPS60218326A (ja) * 1984-04-14 1985-11-01 Chemo Sero Therapeut Res Inst 線維状赤血球凝集素の精製方法
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
JPS6176422A (ja) * 1984-09-22 1986-04-18 Chemo Sero Therapeut Res Inst 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法
GB8512972D0 (en) * 1985-05-22 1985-06-26 Univ Glasgow Vaccine production
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
FR2596413B1 (fr) * 1986-03-27 1988-06-10 Merieux Inst Nouveaux milieux de culture de bacteries appartenant au genre bordetella, contenant des derives etherifies de polymeres de d-glucose, et leur application
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
US4699786A (en) * 1986-05-09 1987-10-13 American Cyanamid Company Enhanced large scale cultivation of bordetella pertussis cells for vaccine production using lactoglobulin
JP2537042B2 (ja) * 1986-11-27 1996-09-25 社団法人北里研究所 ボルデテラ・ブロンキセプチカ感染症生菌ワクチン用原株の製造法および生菌ワクチン
JPH0628277A (ja) * 1992-07-10 1994-02-04 Nec Software Ltd ファイル転送装置
JP3240711B2 (ja) * 1992-11-11 2001-12-25 ソニー株式会社 Ｙ／ｃ分離フィルタ装置

Also Published As

Publication number Publication date
FI86959C (fi) 1992-11-10
DE3787887D1 (de) 1993-11-25
EP0287732B1 (en) 1993-10-20
FI86959B (fi) 1992-07-31
KR900007644B1 (ko) 1990-10-17
ATE96036T1 (de) 1993-11-15
KR880012238A (ko) 1988-11-26
NO872919D0 (no) 1987-07-13
DK365287D0 (da) 1987-07-14
NO172188B (no) 1993-03-08
NO872919L (no) 1988-10-25
NO172188C (no) 1993-06-16
FI873083A0 (fi) 1987-07-13
US4849358A (en) 1989-07-18
FI873083A (fi) 1988-10-25
CA1337859C (en) 1996-01-02
DK365287A (da) 1988-10-25
DE3787887T2 (de) 1994-02-10
EP0287732A1 (en) 1988-10-26

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