ES2058059T3 - Derivados de benzazepina. - Google Patents
Derivados de benzazepina.Info
- Publication number
- ES2058059T3 ES2058059T3 ES86117264T ES86117264T ES2058059T3 ES 2058059 T3 ES2058059 T3 ES 2058059T3 ES 86117264 T ES86117264 T ES 86117264T ES 86117264 T ES86117264 T ES 86117264T ES 2058059 T3 ES2058059 T3 ES 2058059T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- aryl
- alkoxy
- heteroaryl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar un compuesto que tiene la fórmula o una de sus sales farmacéuticamente aceptables, en la que: R y R1 son cada uno de ellos hidrógeno o alquilo C1-10, R es hidrógeno y R1 es alquilo C1-10, alquenilo C2-10, alquinilo C2-10, arilo, o cicloalquilo C3-7; R2 y R3 son cada uno de ellos independientemente alquilo C1-10 o cicloalquilo C3-7, oR2 y R3 junto con el átomo de nitrógeno al que están unidos son pirrolidinilo, piperidinilo, o morfolinilo; R4 y R5 son cada uno de ellos independientemente hidrógeno, halógeno, alquilo C1-10, alcoxiC1-10, ariloxi, aril alcoxi C1-10, aril alquilo C1-10, hidroxi, alcanoil (C2-11) -oxi, O k { O{C{NX1X4 , di-fl uorometoxi, trifluorometilo, NX3X4, -S(O)m alquilo C1-10 o -S(O)marilo; n es2ó 3; m es0, 1 ó 2; X1 y X2 son cada uno de ellos independientemente hidrógeno, alquilo C1-10, arilo o heteroarilo, o X1 y X2 junto con el átomo de nitrógeno al que están unidos forman un heteroarilo que contiene nitrógeno; X3 y X4 son cada uno de ellos independientemente hidrógeno, alquilo C1-10, alcanoílo C2-11, arilcarbonilo, heteroarilcarbonilo, o carbamoílo; con la condición de que si R4 es un grupo alquilo en la posición 7, el mismo ha de tener un átomo de carbono terciario unido al anillo; donde el término \arilo" se refiere a grupos fenilo y fenilo sustituido con 1, 2 ó 3 grupos amino, alquilamino, dialquilamino, nitro, halógeno, hidroxilo,trifluorometilo,alquilode1 a 4 átomos de carbono, alcoxi de1 a 4 átomos de carbono, alcanoiloxi, carbamoílo, o carboxilo; el término \heteroarilo" se refiere a piridinilo, pirrolilo, imidazolilo, furilo, tienilo, o tiazolilo; y la expresión \heteroarilo que contiene nitrógeno" se refiere a piridinilo, pirrolilo, imidazolilo o tiazolilo, procedimiento que comprende hacer reaccionar un compuesto que tiene la fórmula con un compuesto que tiene la fórmula halógeno (CH2)n NR2R3 y convertir opcionalmente el producto en una sal farmacéuticamente aceptable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80818385A | 1985-12-12 | 1985-12-12 | |
US91713086A | 1986-10-09 | 1986-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058059T3 true ES2058059T3 (es) | 1994-11-01 |
Family
ID=27123095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86117264T Expired - Lifetime ES2058059T3 (es) | 1985-12-12 | 1986-12-11 | Derivados de benzazepina. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0229329B1 (es) |
JP (1) | JPH0686435B2 (es) |
KR (1) | KR900001177B1 (es) |
CN (1) | CN1017894B (es) |
AU (1) | AU591726B2 (es) |
CA (2) | CA1271748C (es) |
CZ (1) | CZ278686B6 (es) |
DE (1) | DE3688788T2 (es) |
DK (1) | DK163731C (es) |
ES (1) | ES2058059T3 (es) |
FI (1) | FI83775C (es) |
HU (2) | HU199806B (es) |
IE (1) | IE61757B1 (es) |
IL (2) | IL80668A0 (es) |
NO (1) | NO168820C (es) |
NZ (1) | NZ218292A (es) |
PL (2) | PL151569B1 (es) |
PT (1) | PT83917B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4752645A (en) * | 1986-10-09 | 1988-06-21 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4771047A (en) * | 1987-07-27 | 1988-09-13 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4774239A (en) * | 1987-08-26 | 1988-09-27 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
DE3807922A1 (de) * | 1988-03-10 | 1989-09-21 | Boehringer Mannheim Gmbh | Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
US4946840A (en) * | 1989-04-06 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
WO2001054677A2 (en) * | 2000-01-26 | 2001-08-02 | Warner-Lambert Company | Ace inhibitor-vasopressin antagonist combinations |
US20030008860A1 (en) | 2002-05-09 | 2003-01-09 | Bakker-Arkema Rebecca Guggemos | Treatment of congestive heart failure |
JP2022055368A (ja) * | 2019-02-19 | 2022-04-08 | 株式会社三和化学研究所 | ベンゾアゼピン誘導体の製造方法及びその中間体 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3075967A (en) | 1961-06-12 | 1963-01-29 | Olin Mathieson | Benzothiazines |
US3330823A (en) | 1964-12-16 | 1967-07-11 | Squibb & Sons Inc | N-amino-loweralkylene-benzo-lactams |
CA1271747C (en) | 1985-06-12 | 1990-07-17 | BENZAZEPINE DERIVATIVES |
-
1986
- 1986-11-13 CA CA522913A patent/CA1271748C/en not_active Expired
- 1986-11-14 NZ NZ218292A patent/NZ218292A/xx unknown
- 1986-11-17 AU AU65303/86A patent/AU591726B2/en not_active Ceased
- 1986-11-17 IL IL80668A patent/IL80668A0/xx not_active IP Right Cessation
- 1986-12-10 CZ CS869154A patent/CZ278686B6/cs unknown
- 1986-12-10 IE IE322486A patent/IE61757B1/en not_active IP Right Cessation
- 1986-12-11 DE DE86117264T patent/DE3688788T2/de not_active Expired - Fee Related
- 1986-12-11 EP EP86117264A patent/EP0229329B1/en not_active Expired - Lifetime
- 1986-12-11 ES ES86117264T patent/ES2058059T3/es not_active Expired - Lifetime
- 1986-12-11 PL PL1986271723A patent/PL151569B1/pl unknown
- 1986-12-11 DK DK595686A patent/DK163731C/da not_active IP Right Cessation
- 1986-12-11 KR KR1019860010579A patent/KR900001177B1/ko not_active IP Right Cessation
- 1986-12-11 PL PL1986262928A patent/PL150461B1/pl unknown
- 1986-12-11 JP JP61296504A patent/JPH0686435B2/ja not_active Expired - Lifetime
- 1986-12-11 FI FI865056A patent/FI83775C/fi not_active IP Right Cessation
- 1986-12-11 HU HU885684A patent/HU199806B/hu not_active IP Right Cessation
- 1986-12-11 NO NO865012A patent/NO168820C/no unknown
- 1986-12-11 HU HU865179A patent/HU196760B/hu unknown
- 1986-12-12 PT PT83917A patent/PT83917B/pt unknown
- 1986-12-12 CN CN86108530A patent/CN1017894B/zh not_active Expired
-
1990
- 1990-04-04 CA CA000615691A patent/CA1294617C/en not_active Expired - Lifetime
- 1990-09-07 IL IL95607A patent/IL95607A0/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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