ES2052907T3 - Derivados de tiazolidinodiona como agentes hipoglucemicos. - Google Patents

Derivados de tiazolidinodiona como agentes hipoglucemicos.

Info

Publication number
ES2052907T3
ES2052907T3 ES89303086T ES89303086T ES2052907T3 ES 2052907 T3 ES2052907 T3 ES 2052907T3 ES 89303086 T ES89303086 T ES 89303086T ES 89303086 T ES89303086 T ES 89303086T ES 2052907 T3 ES2052907 T3 ES 2052907T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
derivatives
fenil
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303086T
Other languages
English (en)
Inventor
David Alan Clark
Steven Wayne Goldstein
Bernard Hulin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2052907T3 publication Critical patent/ES2052907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Treatment Of Fiber Materials (AREA)

Abstract

DERIVADOS TIAZOLIDINE-2,4-DIONE HIPOGLICEMICOS DE LA FORMULA EN DONDE LAS LINEAS DOTADAS REPRESENTAN UN ENLACE O NO; V ES -CH=CH-, -N=CH-, -CH=N-, S, O OR NR; W ES S, SO, SO2, SO2NR1, NR1SO2, CONR1 O NR1CO; X ES S, O, NR2, -CH=NO -N=CH; Y ES CH O N; Z ES HIDROGENO, ALQUIL (C1-C7), CICLOALQUIL(C3-C7), FENIL, PIRIDIL, FURIL, TIENIL O FENIL MONO- O DISUSTITUIDO CON EL MISMO O DIFERENTES GRUPOS QUE SON ALQUIL(C1-C3), TRIFLUOROMETIL, ALCOXI(C1-C3), FLUORO, CLORO O BROMO; Z1 ES HIDROGENO O ALQUIL(C1-C3); R, R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O (C1-C4); Y N ES 1, 2 O 3; UNA SAL CATIONICA DE ELLO ACEPTABLE FARMACEUTICAMENTE; O UNA SAL DE ADICCION DE ACIDO DE ELLO ACEPTABLE FARMACEUTICAMENTE CUANDO EL COMPONENTE CONTIENE UN NITROGENO BASICO.
ES89303086T 1988-03-08 1989-03-29 Derivados de tiazolidinodiona como agentes hipoglucemicos. Expired - Lifetime ES2052907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/000745 WO1989008652A1 (en) 1988-03-08 1988-03-08 Thiazolidinedione derivatives as hypoglycemic agents

Publications (1)

Publication Number Publication Date
ES2052907T3 true ES2052907T3 (es) 1994-07-16

Family

ID=22208591

Family Applications (3)

Application Number Title Priority Date Filing Date
ES89302872T Expired - Lifetime ES2052906T3 (es) 1988-03-08 1989-03-22 Aparato y metodo de flotador segmentado configurable.
ES89303086T Expired - Lifetime ES2052907T3 (es) 1988-03-08 1989-03-29 Derivados de tiazolidinodiona como agentes hipoglucemicos.
ES89303667T Expired - Lifetime ES2052910T3 (es) 1988-03-08 1989-04-13 Metodo de inspeccion para detectar y distinguir las caras de un tejido.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES89302872T Expired - Lifetime ES2052906T3 (es) 1988-03-08 1989-03-22 Aparato y metodo de flotador segmentado configurable.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES89303667T Expired - Lifetime ES2052910T3 (es) 1988-03-08 1989-04-13 Metodo de inspeccion para detectar y distinguir las caras de un tejido.

Country Status (17)

Country Link
EP (1) EP0389699B1 (es)
JP (1) JPH01299289A (es)
KR (1) KR910000734B1 (es)
CN (1) CN1026234C (es)
AU (1) AU594899B2 (es)
CA (1) CA1328265C (es)
DK (1) DK108789A (es)
ES (3) ES2052906T3 (es)
FI (1) FI92696C (es)
HU (1) HU217432B (es)
IL (1) IL89481A (es)
MY (1) MY103837A (es)
NO (1) NO178068C (es)
NZ (1) NZ228247A (es)
PT (1) PT89922B (es)
WO (1) WO1989008652A1 (es)
ZA (1) ZA891681B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008651A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
GB8919417D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
DE69106714T2 (de) * 1990-08-23 1995-05-11 Pfizer Hypoglykämische hydroxyharnstoffderivate.
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
JPH08157473A (ja) * 1994-10-06 1996-06-18 Nissan Chem Ind Ltd ピラゾール系チアゾリジン類
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
JP3906935B2 (ja) * 1995-12-18 2007-04-18 杏林製薬株式会社 Ｎ−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法
WO1997032863A1 (fr) * 1996-03-08 1997-09-12 Torii Pharmaceutical Co., Ltd. Derives de thiazolidine-2,4-dione
DE19711616A1 (de) 1997-03-20 1998-09-24 Boehringer Mannheim Gmbh Verbessertes Verfahren zur Herstellung von Thiazolidindionen
WO2000008018A1 (fr) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Derives de benzothiepine, leur procede de preparation et leurs utilisations
CA2380206A1 (en) 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Pharmaceutical compositions exhibiting thrombopoietin receptor agonism
JP4316787B2 (ja) * 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
DE10029077A1 (de) 2000-06-13 2001-12-20 Bayer Ag Thiazolylsubstituierte Heterocyclen
US20040063764A1 (en) * 2001-01-26 2004-04-01 Hiroshi Takemoto Halogen compounds having thrombopoietin receptor agonism
EP1357116A4 (en) * 2001-02-02 2005-06-01 Yamanouchi Pharma Co Ltd 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF
DE10331675A1 (de) 2003-07-14 2005-02-10 Bayer Cropscience Ag Hetarylsubstituierte Pyrazolidindion-Derivate
US8492428B2 (en) 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
GB2465890A (en) * 2008-12-05 2010-06-09 Scynexis Inc 2-Arylazole derivatives as antiprotozoal agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
HU210339B (en) * 1985-05-21 1995-03-28 Pfizer Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物

Also Published As

Publication number Publication date
CA1328265C (en) 1994-04-05
PT89922B (pt) 1995-03-01
AU3107789A (en) 1989-09-14
IL89481A0 (en) 1989-09-10
JPH0585551B2 (es) 1993-12-07
FI92696B (fi) 1994-09-15
HUT54680A (en) 1991-03-28
FI92696C (fi) 1994-12-27
MY103837A (en) 1993-09-30
NZ228247A (en) 1990-05-28
NO178068B (no) 1995-10-09
EP0389699A1 (en) 1990-10-03
FI904413A0 (fi) 1990-09-07
NO903863D0 (no) 1990-09-05
DK108789A (da) 1989-09-09
HU882181D0 (en) 1991-01-28
ZA891681B (en) 1990-10-31
DK108789D0 (da) 1989-03-07
EP0389699B1 (en) 1994-05-11
PT89922A (pt) 1989-11-10
ES2052906T3 (es) 1994-07-16
JPH01299289A (ja) 1989-12-04
WO1989008652A1 (en) 1989-09-21
KR890014534A (ko) 1989-10-24
IL89481A (en) 1993-02-21
CN1036572A (zh) 1989-10-25
KR910000734B1 (ko) 1991-02-06
NO178068C (no) 1996-01-17
ES2052910T3 (es) 1994-07-16
NO903863L (no) 1990-09-05
AU594899B2 (en) 1990-03-15
HU217432B (hu) 2000-01-28
CN1026234C (zh) 1994-10-19

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