ES2039646T3 - Derivados de fenetanolamina. - Google Patents

Derivados de fenetanolamina.

Info

Publication number
ES2039646T3
ES2039646T3 ES198888310661T ES88310661T ES2039646T3 ES 2039646 T3 ES2039646 T3 ES 2039646T3 ES 198888310661 T ES198888310661 T ES 198888310661T ES 88310661 T ES88310661 T ES 88310661T ES 2039646 T3 ES2039646 T3 ES 2039646T3
Authority
ES
Spain
Prior art keywords
group
rent
compounds
formula
phenethanolamine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888310661T
Other languages
English (en)
Inventor
William Leonard Mitchell
Ian Frederick Skidmore
Lawrence Henry Charles Lunts
Harry Finch
Alan Naylor
David Hartley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878726586A external-priority patent/GB8726586D0/en
Priority claimed from GB888821179A external-priority patent/GB8821179D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2039646T3 publication Critical patent/ES2039646T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA(I) Y SUS SALES FISIOLOGICAMENTE ACEPTABLES Y SOLVATOS DE ESTO; DONDE AR ES EL GRUPO (A) Y Q1 ES UN GRUPO C1 - C3 ALQUILENO RECTO O RAMIFICADO Y Q2 DE LA FORMULA(B) ES UN GRUPO R3CO - R3NHCO -, R3R4NSO2 - O R5SO2, DONDE R3 Y R4 SON CADA UNO H O UN GRUPO C1 C3 ALQUILO Y R5 ES UN GRUPO C1 - C3 ALQUILO. LOS COMPUESTOS TIENEN ACCION ESTIMULANTE EN BETA 2 - ADRENORRECEPTORES Y PUEDEN SER USADOS EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON OBSTRUCCION REVERSIBLE DE VIAS RESPIRATORIAS TALES COMO ASMA Y BRONQUITIS CRONICA.
ES198888310661T 1987-11-13 1988-11-11 Derivados de fenetanolamina. Expired - Lifetime ES2039646T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878726586A GB8726586D0 (en) 1987-11-13 1987-11-13 Chemical compounds
GB888821179A GB8821179D0 (en) 1988-09-09 1988-09-09 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2039646T3 true ES2039646T3 (es) 1993-10-01

Family

ID=26293025

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888310661T Expired - Lifetime ES2039646T3 (es) 1987-11-13 1988-11-11 Derivados de fenetanolamina.

Country Status (11)

Country Link
US (4) US4997986A (es)
EP (1) EP0317206B1 (es)
JP (1) JPH0228141A (es)
AU (1) AU609209B2 (es)
DE (1) DE3880628T2 (es)
DK (1) DK633588A (es)
ES (1) ES2039646T3 (es)
GR (1) GR3008446T3 (es)
IE (1) IE883400L (es)
NZ (1) NZ226934A (es)
PT (1) PT88988B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3880628T2 (de) * 1987-11-13 1993-08-05 Glaxo Group Ltd Phenethanolamin-derivate.
GB0103630D0 (en) 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
ATE365720T1 (de) 2001-03-08 2007-07-15 Glaxo Group Ltd Agonisten von beta-adrenorezeptoren
JP4143413B2 (ja) 2001-03-22 2008-09-03 グラクソ グループ リミテッド β２−アドレナリン受容体アゴニストとしてのホルムアニリド誘導体
ES2316599T3 (es) 2001-09-14 2009-04-16 Glaxo Group Limited Derivados de fenetanolamina para el tratamiento de enfermedades respiratorias.
GB0204719D0 (en) * 2002-02-28 2002-04-17 Glaxo Group Ltd Medicinal compounds
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
GB0303396D0 (en) * 2003-02-14 2003-03-19 Glaxo Group Ltd Medicinal compounds
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2296516B1 (es) * 2006-04-27 2009-04-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320961B1 (es) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094461A (en) * 1962-03-31 1967-12-13 Degussa Amino ketones and a process for their production
FR95908E (fr) * 1963-11-09 1972-01-31 Degussa Procédé de préparation de nouvelles aminocétones et des alcools secondaires correspondants.
GB1069411A (en) * 1964-04-13 1967-05-17 Ici Ltd Naphthalene derivatives
CH556323A (de) * 1969-12-12 1974-11-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von neuen naphthylalkylaminen.
DE1962497C3 (de) * 1969-12-12 1979-09-20 C.H. Boehringer Sohn, 6507 Ingelheim Naphthylalkyl- a -hydroxyphenäthyl-amine, ihre Herstellung und diese enthaltende Arzneimittel
DE2164505A1 (de) * 1971-01-22 1972-08-31 CH. Boehringer Sohn, 6507 Ingelheim Aminoäthanolderivate
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1455116A (en) * 1972-12-15 1976-11-10 Ici Ltd Pharmaceutical compositions
US4042624A (en) * 1975-05-12 1977-08-16 Morton-Norwich Products, Inc. Antidepressant 2-[(substituted-1-naphthylmethyl)amino]-1-phenylpropanols
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
US4558051A (en) * 1983-10-11 1985-12-10 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
DK173685A (da) * 1984-04-17 1985-10-18 Glaxo Group Ltd Ethanolaminderivater
LU85856A1 (fr) * 1984-04-17 1986-06-11 Glaxo Group Ltd Composes de phenethanolamine
GB8426200D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
GB8426191D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
GB8525321D0 (en) * 1985-10-15 1985-11-20 Glaxo Group Ltd Chemical compounds
GB8525483D0 (en) * 1985-10-16 1985-11-20 Glaxo Group Ltd Chemical compounds
EP0223410A3 (en) * 1985-10-16 1987-11-19 Glaxo Group Limited Ethanolamine derivatives
US4742767A (en) * 1985-11-05 1988-05-10 Kabushiki Kaisha Toshiba Coffee maker
GB8603475D0 (en) * 1986-02-12 1986-03-19 Glaxo Group Ltd Chemical compounds
US4937268A (en) * 1987-03-12 1990-06-26 Glaxo Group Limited Chemical compounds
DE3880628T2 (de) * 1987-11-13 1993-08-05 Glaxo Group Ltd Phenethanolamin-derivate.

Also Published As

Publication number Publication date
EP0317206B1 (en) 1993-04-28
GR3008446T3 (es) 1993-10-29
US4997986A (en) 1991-03-05
AU609209B2 (en) 1991-04-26
PT88988B (pt) 1993-02-26
EP0317206A3 (en) 1990-02-07
EP0317206A2 (en) 1989-05-24
DE3880628D1 (de) 1993-06-03
IE883400L (en) 1989-05-13
US5109023A (en) 1992-04-28
JPH0228141A (ja) 1990-01-30
DK633588D0 (da) 1988-11-11
NZ226934A (en) 1991-01-29
US5099068A (en) 1992-03-24
US5283262A (en) 1994-02-01
AU2505588A (en) 1989-05-18
PT88988A (pt) 1988-12-01
DK633588A (da) 1989-05-14
DE3880628T2 (de) 1993-08-05

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