GB1069411A - Naphthalene derivatives - Google Patents

Naphthalene derivatives

Info

Publication number
GB1069411A
GB1069411A GB15201/64A GB1520164A GB1069411A GB 1069411 A GB1069411 A GB 1069411A GB 15201/64 A GB15201/64 A GB 15201/64A GB 1520164 A GB1520164 A GB 1520164A GB 1069411 A GB1069411 A GB 1069411A
Authority
GB
United Kingdom
Prior art keywords
stands
formula
compound
reducing
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15201/64A
Inventor
Ralph Howe
Balbir Singh Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB15201/64A priority Critical patent/GB1069411A/en
Priority to NL6504470A priority patent/NL6504470A/xx
Priority to BE662389A priority patent/BE662389A/xx
Priority to FR24330A priority patent/FR4497M/fr
Publication of GB1069411A publication Critical patent/GB1069411A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Racemic compounds of the general formula <FORM:1069411/C2/1> (wherein R1 stands for a hydrogen atom or C1- 6 alkyl radical and R2 stands for a C1- 6 alkyl radical) and their acid addition salts are prepared by (a) reducing 2-naphthylglyoxal or its hydrate in the presence of a compound of the formula <FORM:1069411/C2/2> (wherein E stands for the CO or CHOH group); or (b) reducing a compound of the formula <FORM:1069411/C2/3> optionally followed in either case by salt formation. The compounds of the invention are useful in the treatment or prophylaxis of heart diseases and in the treatment of hypertension and phaeochromocytoma; they may be administered in the form of pharmaceutical preparations containing them together with a diluent or carrier.
GB15201/64A 1964-04-13 1964-04-13 Naphthalene derivatives Expired GB1069411A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB15201/64A GB1069411A (en) 1964-04-13 1964-04-13 Naphthalene derivatives
NL6504470A NL6504470A (en) 1964-04-13 1965-04-08
BE662389A BE662389A (en) 1964-04-13 1965-04-12
FR24330A FR4497M (en) 1964-04-13 1965-07-12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15201/64A GB1069411A (en) 1964-04-13 1964-04-13 Naphthalene derivatives

Publications (1)

Publication Number Publication Date
GB1069411A true GB1069411A (en) 1967-05-17

Family

ID=10054821

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15201/64A Expired GB1069411A (en) 1964-04-13 1964-04-13 Naphthalene derivatives

Country Status (4)

Country Link
BE (1) BE662389A (en)
FR (1) FR4497M (en)
GB (1) GB1069411A (en)
NL (1) NL6504470A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997986A (en) * 1987-11-13 1991-03-05 Glaxo Group Limited Phenethanolamine derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997986A (en) * 1987-11-13 1991-03-05 Glaxo Group Limited Phenethanolamine derivatives
US5099068A (en) * 1987-11-13 1992-03-24 Glaxo Group Limited Phenethanolamine derivatives
US5109023A (en) * 1987-11-13 1992-04-28 Glaxo Group Limited Phenethanolamine derivatives

Also Published As

Publication number Publication date
FR4497M (en) 1966-10-10
NL6504470A (en) 1965-10-14
BE662389A (en) 1965-10-12

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