ES2038560B1 - Procedimiento para preparar ginkgolida b. - Google Patents
Procedimiento para preparar ginkgolida b.Info
- Publication number
- ES2038560B1 ES2038560B1 ES9200747A ES9200747A ES2038560B1 ES 2038560 B1 ES2038560 B1 ES 2038560B1 ES 9200747 A ES9200747 A ES 9200747A ES 9200747 A ES9200747 A ES 9200747A ES 2038560 B1 ES2038560 B1 ES 2038560B1
- Authority
- ES
- Spain
- Prior art keywords
- ginkgolida
- hydroxy
- resulting
- procedure
- ginkgolide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229930184727 ginkgolide Natural products 0.000 abstract 2
- -1 THIOCARBONYL ESTER Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- SQOJOAFXDQDRGF-ZMVGXLHTSA-N ginkgolide b Chemical group O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13[C@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]21O SQOJOAFXDQDRGF-ZMVGXLHTSA-N 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919107425A GB9107425D0 (en) | 1991-04-09 | 1991-04-09 | Preparation of ginkgolide b |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2038560A1 ES2038560A1 (es) | 1993-07-16 |
| ES2038560B1 true ES2038560B1 (es) | 1994-02-16 |
Family
ID=10692881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9200747A Expired - Fee Related ES2038560B1 (es) | 1991-04-09 | 1992-04-08 | Procedimiento para preparar ginkgolida b. |
Country Status (33)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3490276A (en) * | 1968-04-29 | 1970-01-20 | Earl B Maxwell | Automobile road testing device |
| US3826129A (en) * | 1972-08-15 | 1974-07-30 | J Wiss | Automotive vehicular dynamometer |
| KR0136986B1 (ko) * | 1993-12-31 | 1998-04-25 | 김준웅 | 신규 징코라이드 유도체와 이의 제조방법 |
| GB9408044D0 (en) * | 1994-04-22 | 1994-06-15 | Sod Conseils Rech Applic | Conversion of ginkgolide c to ginkgolide b |
| AU692401B2 (en) * | 1995-06-23 | 1998-06-04 | Craig Thomas Marriott | Improved docking apparatus |
| KR970032857A (ko) * | 1995-12-29 | 1997-07-22 | 김준웅 | 약제 조성물 |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| FR2777280B1 (fr) * | 1998-04-10 | 2001-04-20 | Centre Nat Rech Scient | Derives de ginkgolides, leur procede de preparation et compositions pharmaceutiques les contenant |
| US6946283B2 (en) * | 2001-01-05 | 2005-09-20 | William Marsh Rice University | Ginkgo biloba levopimaradiene synthase |
| US7238514B2 (en) * | 2001-01-05 | 2007-07-03 | William Marsh Rice University | Diterpene-producing unicellular organism |
| FR2823116B1 (fr) * | 2001-04-10 | 2004-11-19 | Sod Conseils Rech Applic | Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| US20090156668A1 (en) * | 2004-03-19 | 2009-06-18 | The Trustees Of Columbia University In The City Of New York | Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof |
| CN103450217B (zh) * | 2013-09-02 | 2015-12-02 | 北京绿科天成生物科技有限公司 | 粗毛韧革菌菌体在制备银杏内酯b中的应用 |
| CN105367582B (zh) * | 2014-08-11 | 2019-06-25 | 广东东阳光药业有限公司 | 银杏内酯b衍生物及其在药物中的应用 |
| KR102105451B1 (ko) | 2015-12-18 | 2020-04-28 | 청두 바이위 징코라이드 파마슈티컬즈 컴퍼니 리미티드 | 징코라이드b 유도체, 그 제조 방법 및 응용 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8418424D0 (en) * | 1984-07-19 | 1984-08-22 | Scras | Inhibition of platelets aggregation |
| KR940002795B1 (ko) * | 1989-06-16 | 1994-04-02 | 주식회사 선경인더스트리 | 은행잎에서 징코라이드를 분리 및 정제하는 방법 |
-
1991
- 1991-04-09 GB GB919107425A patent/GB9107425D0/en active Pending
-
1992
- 1992-03-24 GR GR920100118A patent/GR1001019B/el unknown
- 1992-03-25 AT AT0060992A patent/AT401059B/de not_active IP Right Cessation
- 1992-03-25 TW TW081102301A patent/TW223076B/zh active
- 1992-03-25 NL NL9200549A patent/NL9200549A/nl active Search and Examination
- 1992-03-30 US US07/860,165 patent/US5241084A/en not_active Expired - Lifetime
- 1992-03-30 IN IN285DE1992 patent/IN178153B/en unknown
- 1992-03-31 ZA ZA922352A patent/ZA922352B/xx unknown
- 1992-03-31 CH CH1028/92A patent/CH684193A5/fr not_active IP Right Cessation
- 1992-04-01 NZ NZ242188A patent/NZ242188A/en unknown
- 1992-04-01 GB GB9207131A patent/GB2254612B/en not_active Expired - Fee Related
- 1992-04-01 AR AR92322062A patent/AR247568A1/es active
- 1992-04-03 BE BE9200313A patent/BE1005089A3/fr not_active IP Right Cessation
- 1992-04-03 IT ITMI920807A patent/IT1255636B/it active IP Right Grant
- 1992-04-03 JP JP04082362A patent/JP3131494B2/ja not_active Expired - Fee Related
- 1992-04-04 MY MYPI92000585A patent/MY108426A/en unknown
- 1992-04-07 MA MA22778A patent/MA22497A1/fr unknown
- 1992-04-07 TN TNTNSN92028A patent/TNSN92028A1/fr unknown
- 1992-04-07 LU LU88094A patent/LU88094A1/xx unknown
- 1992-04-07 FI FI921523A patent/FI921523A7/fi not_active Application Discontinuation
- 1992-04-07 CA CA002065501A patent/CA2065501C/en not_active Expired - Fee Related
- 1992-04-08 DK DK047492A patent/DK171400B1/da not_active IP Right Cessation
- 1992-04-08 KR KR1019920005828A patent/KR100232068B1/ko not_active Expired - Fee Related
- 1992-04-08 IE IE921118A patent/IE69326B1/en not_active IP Right Cessation
- 1992-04-08 SE SE9201125A patent/SE9201125L/xx not_active Application Discontinuation
- 1992-04-08 ES ES9200747A patent/ES2038560B1/es not_active Expired - Fee Related
- 1992-04-08 DZ DZ920034A patent/DZ1569A1/fr active
- 1992-04-08 AU AU14704/92A patent/AU647350B2/en not_active Ceased
- 1992-04-08 NO NO921388A patent/NO300215B1/no unknown
- 1992-04-08 PT PT100363A patent/PT100363A/pt not_active Application Discontinuation
- 1992-04-09 DE DE4212019A patent/DE4212019C2/de not_active Expired - Fee Related
- 1992-04-09 FR FR9204337A patent/FR2675145B1/fr not_active Expired - Fee Related
- 1992-04-09 OA OA60182A patent/OA09695A/fr unknown
-
1996
- 1996-03-21 HK HK48296A patent/HK48296A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20101018 |