GR1001019B - Μεθοδος παρασκευης τζινκολιδης β απο τζινκολιδη c. - Google Patents

Μεθοδος παρασκευης τζινκολιδης β απο τζινκολιδη c.

Info

Publication number
GR1001019B
GR1001019B GR920100118A GR920100118A GR1001019B GR 1001019 B GR1001019 B GR 1001019B GR 920100118 A GR920100118 A GR 920100118A GR 920100118 A GR920100118 A GR 920100118A GR 1001019 B GR1001019 B GR 1001019B
Authority
GR
Greece
Prior art keywords
gingolide
protected
degrees celsius
carried out
temperature
Prior art date
Application number
GR920100118A
Other languages
English (en)
Inventor
Teng Mr Beng-Poom
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of GR1001019B publication Critical patent/GR1001019B/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η εφεύρεση αφορά μια μέ?οδο δια την παρασκευή γκινγκολίδη Β από γκινγκολίδη C και την τοιουτοτρόπως λαμβανόμενη γκινγκολίδη Β, όπου η μέ?οδος περιλαμβάνει την ακόλου?ο σειρά τεσσάρων βα?μίδων: - προστασία της 10-υδροξυ ομάδος της γκινγκολίδης C δια μετατροπής εις ένα αλκυλεστέρα, όπου η αντίδραση διεξάγεται εντός διμε?υλοφορμαμίδης σε ?ερμοκρασία από 15 έως 50 βα?μούς κελσίου επί 4 έως 10 ώρες. - ενεργοποίηση της 7-υδροξυ ομάδος της προκυπτούσης 10- προστατευομένης γκινγκολίδης C δια μετατροπής σε ένα (R) ?ειοκαρβονυλεστέρα, όπου η ενεργοποίηση διεξάγεται υπό βασικάς συν?ήκας σε ?ερμοκρασία από 0 έως 40 βα?μούς κελσίου επί 1 έως 24 ώρες. - αποοξυγόνωση της 7-ενεργοποιημένης ομάδος εις την προκύπτουσα 10-προστατευομένη 7-ενεργοποιημένη γκινγκολίδη C δια κατεργασίας αυτής με τριβουτυλοκασσιτερουδρίδιο ή τρις (τριμε?υλοσιλυλο)σιλάνιο εντός απρωτονικού διαλύτου, παρουσία ενός παράγοντος δημιουργίας ελεύ?ερων ριζικών, όπου η αντίδραση διεξάγεται σε ?ερμοκρασία από 70 έως 110 βα?μούς κελσίου επί 15 λεπτά έως 3 ώρες υπό αδρανή ατμόσφαιρα και διάσπαση της προστατευτικής ομάδος δια να απευλευ?ερώσουμε την 10-υδροξυ ομάδα από την ανωτέρω 10- προστατευομένη γκινγκολίδη Β. ω
GR920100118A 1991-04-09 1992-03-24 Μεθοδος παρασκευης τζινκολιδης β απο τζινκολιδη c. GR1001019B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919107425A GB9107425D0 (en) 1991-04-09 1991-04-09 Preparation of ginkgolide b

Publications (1)

Publication Number Publication Date
GR1001019B true GR1001019B (el) 1993-03-31

Family

ID=10692881

Family Applications (1)

Application Number Title Priority Date Filing Date
GR920100118A GR1001019B (el) 1991-04-09 1992-03-24 Μεθοδος παρασκευης τζινκολιδης β απο τζινκολιδη c.

Country Status (33)

Country Link
US (1) US5241084A (el)
JP (1) JP3131494B2 (el)
KR (1) KR100232068B1 (el)
AR (1) AR247568A1 (el)
AT (1) AT401059B (el)
AU (1) AU647350B2 (el)
BE (1) BE1005089A3 (el)
CA (1) CA2065501C (el)
CH (1) CH684193A5 (el)
DE (1) DE4212019C2 (el)
DK (1) DK171400B1 (el)
DZ (1) DZ1569A1 (el)
ES (1) ES2038560B1 (el)
FI (1) FI921523A (el)
FR (1) FR2675145B1 (el)
GB (2) GB9107425D0 (el)
GR (1) GR1001019B (el)
HK (1) HK48296A (el)
IE (1) IE69326B1 (el)
IN (1) IN178153B (el)
IT (1) IT1255636B (el)
LU (1) LU88094A1 (el)
MA (1) MA22497A1 (el)
MY (1) MY108426A (el)
NL (1) NL9200549A (el)
NO (1) NO300215B1 (el)
NZ (1) NZ242188A (el)
OA (1) OA09695A (el)
PT (1) PT100363A (el)
SE (1) SE9201125L (el)
TN (1) TNSN92028A1 (el)
TW (1) TW223076B (el)
ZA (1) ZA922352B (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3490276A (en) * 1968-04-29 1970-01-20 Earl B Maxwell Automobile road testing device
US3826129A (en) * 1972-08-15 1974-07-30 J Wiss Automotive vehicular dynamometer
KR0136986B1 (ko) * 1993-12-31 1998-04-25 김준웅 신규 징코라이드 유도체와 이의 제조방법
GB9408044D0 (en) * 1994-04-22 1994-06-15 Sod Conseils Rech Applic Conversion of ginkgolide c to ginkgolide b
AU692401B2 (en) * 1995-06-23 1998-06-04 Craig Thomas Marriott Improved docking apparatus
KR970032857A (ko) * 1995-12-29 1997-07-22 김준웅 약제 조성물
US6030621A (en) 1998-03-19 2000-02-29 De Long; Xie Ginkgo biloba composition, method to prepare the same and uses thereof
FR2777280B1 (fr) * 1998-04-10 2001-04-20 Centre Nat Rech Scient Derives de ginkgolides, leur procede de preparation et compositions pharmaceutiques les contenant
US7238514B2 (en) * 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
US6946283B2 (en) * 2001-01-05 2005-09-20 William Marsh Rice University Ginkgo biloba levopimaradiene synthase
FR2823116B1 (fr) * 2001-04-10 2004-11-19 Sod Conseils Rech Applic Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
US20090156668A1 (en) * 2004-03-19 2009-06-18 The Trustees Of Columbia University In The City Of New York Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof
JP5937375B2 (ja) 2012-02-08 2016-06-22 株式会社 Ｍｔｇ 美容器
CN103450217B (zh) * 2013-09-02 2015-12-02 北京绿科天成生物科技有限公司 粗毛韧革菌菌体在制备银杏内酯b中的应用
CN105367582B (zh) * 2014-08-11 2019-06-25 广东东阳光药业有限公司 银杏内酯b衍生物及其在药物中的应用
JP6767498B2 (ja) 2015-12-18 2020-10-14 成都百裕金閣莱薬業有限公司 ギンコライドｂ誘導物及びその調製方法並びに応用
KR102277611B1 (ko) * 2019-07-10 2021-07-14 최민우 롤러 마사지 기구
KR102177391B1 (ko) * 2018-11-29 2020-11-11 최민우 롤러 마사지 기구

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418424D0 (en) * 1984-07-19 1984-08-22 Scras Inhibition of platelets aggregation
KR940002795B1 (ko) * 1989-06-16 1994-04-02 주식회사 선경인더스트리 은행잎에서 징코라이드를 분리 및 정제하는 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LIEBIGS ANNALEN DER CHEMIE. no. 1, January 1991, WEINHEIM DE pages 81 - 83 K. WEINGES ET AL. 'Chemie der Ginkgolide, IV. Herstellung von Ginkgolid B aus Ginkgolid C' *

Also Published As

Publication number Publication date
ITMI920807A1 (it) 1993-10-03
AU1470492A (en) 1992-10-15
DK47492D0 (da) 1992-04-08
GB2254612B (en) 1995-05-24
GB9107425D0 (en) 1991-05-22
AU647350B2 (en) 1994-03-17
GB2254612A (en) 1992-10-14
DK171400B1 (da) 1996-10-14
MA22497A1 (fr) 1992-12-31
TW223076B (el) 1994-05-01
FI921523A (fi) 1992-10-10
SE9201125L (sv) 1992-10-10
DZ1569A1 (fr) 2002-02-17
NZ242188A (en) 1993-06-25
DK47492A (da) 1992-10-10
IE69326B1 (en) 1996-09-04
CH684193A5 (fr) 1994-07-29
TNSN92028A1 (fr) 1993-06-08
GB9207131D0 (en) 1992-05-13
IT1255636B (it) 1995-11-09
FR2675145A1 (fr) 1992-10-16
NO921388D0 (no) 1992-04-08
DE4212019A1 (de) 1992-10-15
BE1005089A3 (fr) 1993-04-13
CA2065501C (en) 1997-04-29
ZA922352B (en) 1992-12-30
IE921118A1 (en) 1992-10-21
ATA60992A (de) 1995-10-15
KR920019811A (ko) 1992-11-20
KR100232068B1 (ko) 1999-12-01
PT100363A (pt) 1994-03-31
ES2038560A1 (es) 1993-07-16
CA2065501A1 (en) 1992-10-10
SE9201125D0 (sv) 1992-04-08
NO300215B1 (no) 1997-04-28
FI921523A0 (fi) 1992-04-07
NO921388L (no) 1992-10-12
MY108426A (en) 1996-09-30
AR247568A1 (es) 1995-01-31
LU88094A1 (fr) 1992-10-15
NL9200549A (nl) 1992-11-02
FR2675145B1 (fr) 1995-02-10
OA09695A (fr) 1993-08-30
JP3131494B2 (ja) 2001-01-31
ES2038560B1 (es) 1994-02-16
AT401059B (de) 1996-06-25
JPH05255341A (ja) 1993-10-05
HK48296A (en) 1996-03-29
US5241084A (en) 1993-08-31
ITMI920807A0 (it) 1992-04-03
IN178153B (el) 1997-03-08
DE4212019C2 (de) 2001-04-26

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