ES2137986T3 - Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos. - Google Patents

Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos.

Info

Publication number
ES2137986T3
ES2137986T3 ES93905015T ES93905015T ES2137986T3 ES 2137986 T3 ES2137986 T3 ES 2137986T3 ES 93905015 T ES93905015 T ES 93905015T ES 93905015 T ES93905015 T ES 93905015T ES 2137986 T3 ES2137986 T3 ES 2137986T3
Authority
ES
Spain
Prior art keywords
image
pct
biciclicos
aza
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93905015T
Other languages
English (en)
Inventor
Frank J Urban
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2137986T3 publication Critical patent/ES2137986T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

INTERMEDIARIOS OPTICAMENTE PUROS DE LA FORMULA (1) EN LA QUE EL SUSTITUYENTE B ES BIEN CIS O BIEN TRANS AL ENLACE C9AC1 Y ESTA SELECCIONADO DEL GRUPO QUE CONSISTE EN -CH2OH, -CHO, -CH2OSO2R, CH2CN, -CH(OH)CH2NO2, -CH=CH-NO2, (2) Y (39, C ESTA SELECCIONADO DEL GRUPO QUE CONSISTE EN -H, (4), (5), Y UN GRUPO PROTECTOR DE NITROGENO QUE SE PUEDE RETIRAR POR HIDROGENIZACION O TRATAMIENTO ACIDO; Y EN LA QUE R ES ALQUILO (C1-C8), FENIL O ALQUILO SUSTITUIDO FENIL; X ES N O CH; Y ES O O S Y Z ES H O CL; PARA LA SINTESIS DE AGENTES ANXIOLICOS OCTAHIDRO-1H-PIRIDOL(1,2-A)PIRACINIL ETIL CARBOXAMIDA.
ES93905015T 1992-06-16 1993-02-16 Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos. Expired - Lifetime ES2137986T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89956092A 1992-06-16 1992-06-16

Publications (1)

Publication Number Publication Date
ES2137986T3 true ES2137986T3 (es) 2000-01-01

Family

ID=25411215

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93905015T Expired - Lifetime ES2137986T3 (es) 1992-06-16 1993-02-16 Procedimiento y productos intermedios para agentes ansioliticos bis-aza-biciclicos.

Country Status (11)

Country Link
US (1) US5719286A (es)
EP (1) EP0646116B1 (es)
JP (2) JP2753146B2 (es)
AT (1) ATE185565T1 (es)
CA (1) CA2138018C (es)
DE (1) DE69326767T2 (es)
DK (1) DK0646116T3 (es)
ES (1) ES2137986T3 (es)
FI (2) FI102898B1 (es)
GR (1) GR3032285T3 (es)
WO (1) WO1993025552A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
ATE209648T1 (de) * 1994-09-30 2001-12-15 Pfizer 2,7,-substituierte octahydro-1h-pyrido(1,2- a)pyrazin derivate
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
MXPA05009660A (es) * 2003-03-12 2005-10-20 Pfizer Prod Inc Derivados azabiciclicos de piridiloximetilo y bencisoxazol.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
CA2099563C (en) * 1991-01-31 1998-09-29 Charles W. Murtiashaw Preparation of (7s, trans)-2-(2-pyrimidinyl)-7-(hydroxymethyl) octahydro-2h-pyrido[1,2-a]pyrazine
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines

Also Published As

Publication number Publication date
CA2138018C (en) 1998-01-27
US5719286A (en) 1998-02-17
FI102898B (fi) 1999-03-15
WO1993025552A1 (en) 1993-12-23
FI932744A (fi) 1993-12-17
FI982486A0 (fi) 1998-11-17
FI932744A0 (fi) 1993-06-15
DE69326767T2 (de) 2000-03-02
DK0646116T3 (da) 1999-12-27
JPH07504678A (ja) 1995-05-25
EP0646116B1 (en) 1999-10-13
DE69326767D1 (de) 1999-11-18
EP0646116A1 (en) 1995-04-05
JP2744224B2 (ja) 1998-04-28
CA2138018A1 (en) 1993-12-23
JP2753146B2 (ja) 1998-05-18
GR3032285T3 (en) 2000-04-27
ATE185565T1 (de) 1999-10-15
FI102898B1 (fi) 1999-03-15
JPH09176166A (ja) 1997-07-08

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