ES2033871T3 - Un procedimiento para producir una preparacion de insulina para administracion parenteral. - Google Patents

Un procedimiento para producir una preparacion de insulina para administracion parenteral.

Info

Publication number
ES2033871T3
ES2033871T3 ES198787309229T ES87309229T ES2033871T3 ES 2033871 T3 ES2033871 T3 ES 2033871T3 ES 198787309229 T ES198787309229 T ES 198787309229T ES 87309229 T ES87309229 T ES 87309229T ES 2033871 T3 ES2033871 T3 ES 2033871T3
Authority
ES
Spain
Prior art keywords
parenteral administration
procedure
producing
insulin preparation
approximately
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787309229T
Other languages
English (en)
Spanish (es)
Inventor
Klavs Holger Joergensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK503386A external-priority patent/DK503386D0/da
Priority claimed from DK356987A external-priority patent/DK356987D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2033871T3 publication Critical patent/ES2033871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
ES198787309229T 1986-10-20 1987-10-19 Un procedimiento para producir una preparacion de insulina para administracion parenteral. Expired - Lifetime ES2033871T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK503386A DK503386D0 (da) 1986-10-20 1986-10-20 Peptidpraeparater
DK356987A DK356987D0 (https=) 1987-07-10 1987-07-10

Publications (1)

Publication Number Publication Date
ES2033871T3 true ES2033871T3 (es) 1993-04-01

Family

ID=26067111

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787309229T Expired - Lifetime ES2033871T3 (es) 1986-10-20 1987-10-19 Un procedimiento para producir una preparacion de insulina para administracion parenteral.

Country Status (18)

Country Link
US (1) US5070186A (https=)
EP (1) EP0265213B1 (https=)
KR (1) KR880004819A (https=)
CN (1) CN87107049A (https=)
AU (1) AU616381B2 (https=)
CA (1) CA1316819C (https=)
DE (1) DE3778287D1 (https=)
ES (1) ES2033871T3 (https=)
FI (1) FI86254C (https=)
GR (1) GR3004912T3 (https=)
HU (1) HU201475B (https=)
IE (1) IE60264B1 (https=)
IL (1) IL84203A (https=)
NO (1) NO170754C (https=)
NZ (1) NZ222214A (https=)
PH (1) PH23446A (https=)
PT (1) PT85949B (https=)
YU (1) YU46665B (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
WO1999034821A1 (en) * 1998-01-09 1999-07-15 Novo Nordisk A/S Stabilised insulin compositions
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
DE10114178A1 (de) * 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
EP1423079B1 (en) * 2001-08-27 2006-07-19 Novo Nordisk A/S A cartridge and a medical delivery system accommodating such a cartridge
JP2006523609A (ja) * 2002-12-31 2006-10-19 アルタス ファーマシューティカルズ インコーポレイテッド タンパク質結晶およびイオン性ポリマーの複合体
RU2357750C2 (ru) * 2002-12-31 2009-06-10 Элтус Фармасьютикалз Инк. Кристаллы человеческого гормона роста и способы их получения
US20090023629A1 (en) * 2005-12-23 2009-01-22 Altus Pharmaceuticals Inc. Compositions comprising polycation-complexed protein crystals and methods of treatment using them
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
RU2524150C2 (ru) 2006-09-22 2014-07-27 Ново Нордиск А/С Аналоги инсулина, устойчивые к протеазам
JP2010525033A (ja) * 2007-04-30 2010-07-22 ノボ・ノルデイスク・エー／エス 高濃縮のインスリン溶液及び組成物
JP5496082B2 (ja) 2007-04-30 2014-05-21 ノボ・ノルデイスク・エー／エス タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
RS59913B1 (sr) 2008-10-17 2020-03-31 Sanofi Aventis Deutschland Kombinacija insulina i glp-1-agonista
CN102596175A (zh) 2009-07-06 2012-07-18 赛诺菲-安万特德国有限公司 含有甲硫氨酸的水性胰岛素制备物
PT3345593T (pt) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina
MY180661A (en) 2009-11-13 2020-12-04 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
US8637458B2 (en) * 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
US9381247B2 (en) * 2012-04-16 2016-07-05 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9399065B2 (en) 2012-04-16 2016-07-26 Biodel Inc. Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
UA117480C2 (uk) 2013-04-03 2018-08-10 Санофі Лікування цукрового діабету за допомогою складу інсуліну тривалої дії
JP6499184B2 (ja) 2013-10-07 2019-04-10 ノヴォ ノルディスク アー／エス インスリン類似体の新規な誘導体
EP3229828B1 (en) 2014-12-12 2023-04-05 Sanofi-Aventis Deutschland GmbH Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
PE20210857A1 (es) 2016-12-16 2021-05-18 Novo Nordisk As Composiciones farmaceuticas que contienen insulina

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2076082A (en) * 1935-04-08 1937-04-06 Nordisk Insulinlab Therapeutic product and process
US2179384A (en) * 1937-04-05 1939-11-07 Univ Alberta Therapeutic composition and process of making it
US2190134A (en) * 1939-06-09 1940-02-13 Norton Co Grinding machine
US2538018A (en) * 1944-04-04 1951-01-16 Nordisk Insulinlab Crystalline product of insulin and alkaline protein and process of making it
US2474729A (en) * 1945-01-03 1949-06-28 Rhone Poulenc Sa Insulin preparations
US2801953A (en) * 1952-02-28 1957-08-06 Hoechst Ag Process of preparing crystallized insulin preparations
US3102077A (en) * 1953-08-19 1963-08-27 Christensen Henry Marinus Preparation of insulin containing 2.75 to 8 percent zinc content
DK98342C (da) * 1959-06-16 1964-03-31 Henry Marinus Dr Christensen Fremgangsmåde til fremstilling af et insulinpræparat til peroral applikation.
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product
GB1426061A (en) * 1972-12-28 1976-02-25 Ici Ltd Polypeptides
US3856771A (en) * 1973-07-16 1974-12-24 Lilly Co Eli Process for manufacturing alkali metal or ammonium insulin
US4196196A (en) * 1978-06-19 1980-04-01 Tiholiz Ivan C Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states
AU550068B2 (en) * 1981-03-10 1986-02-27 Novo Nordisk A/S Zinc insulin stabilized with calcium or magnesium salts
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production

Also Published As

Publication number Publication date
KR880004819A (ko) 1988-06-27
CA1316819C (en) 1993-04-27
IE60264B1 (en) 1994-06-29
NO874347L (no) 1988-04-21
NZ222214A (en) 1989-11-28
AU7990787A (en) 1988-04-21
EP0265213A2 (en) 1988-04-27
YU191887A (en) 1989-04-30
FI874596A0 (fi) 1987-10-19
EP0265213B1 (en) 1992-04-15
NO170754C (no) 1992-12-02
IL84203A (en) 1993-04-04
CN87107049A (zh) 1988-07-06
DE3778287D1 (de) 1992-05-21
US5070186A (en) 1991-12-03
EP0265213A3 (en) 1988-11-09
FI874596L (fi) 1988-04-21
HUT46232A (en) 1988-10-28
NO874347D0 (no) 1987-10-19
PT85949A (en) 1987-11-01
FI86254B (fi) 1992-04-30
FI86254C (fi) 1992-08-10
AU616381B2 (en) 1991-10-31
PT85949B (pt) 1990-07-31
GR3004912T3 (https=) 1993-04-28
PH23446A (en) 1989-08-07
NO170754B (no) 1992-08-24
HU201475B (en) 1990-11-28
IE872799L (en) 1988-04-20
YU46665B (sh) 1994-01-20

Similar Documents

Publication Publication Date Title
ES2033871T3 (es) Un procedimiento para producir una preparacion de insulina para administracion parenteral.
DK179286D0 (da) Insulinpraeparat
DE3768536D1 (de) Infusionsnadel.
SE8402560L (sv) Farmaceutisk komposition
FI931274A0 (fi) Menetelmä puhdistettujen glykolipidien valmistamiseksi käyttäen membraanierotusmenetelmää
ATE64526T1 (de) Zubereitung von pregnanolol in einer stabilen oel- in-wasser-emulsion.
NL960005I1 (nl) Optisch zuivere verbinding, en werkwijze voor de bereiding daarvan.
IE45415L (en) Long acting preparation of cefalexin
ATE183385T1 (de) Lyopilisierte, wirkstoffhaltige emulsion
EP1283044A3 (en) Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
KR840001279A (ko) 항종양 물질의 제조방법
EP0132359A3 (en) Natural human interleukin-2 and production thereof
DE69031569D1 (de) Podophyllotoxinzubereitung enthaltend triglyceride
DK499583D0 (da) Fremgangsmade til fremstilling af en isoquinolinforbindelse
ES2059479T3 (es) Procedimiento para preparar pregneno-oxazolinas.
ES8601694A1 (es) Procedimiento para preparar un compuesto de inclusion a base de n,n-dimetil-2-cloro-5(3-metil-2-(fenilimino)-4-tiazolin-4-il)-fenilsulfonamida y b-ciclodextrina
JPS5339491A (en) Complex connector housing
JPS52148699A (en) Preparation of low salt soy
JPS5417182A (en) Preparation of choline-oxidase
JPS5352687A (en) Preparation of choline-oxidase
ES2043896T3 (es) Procedimiento para la preparacion de derivados de tetrahidropiridina.
IT1209617B (it) Procedimento per la preparazione di alchilarileteri.
JPS5241210A (en) Method of making insulin preparations for rectal administration
JPS5423194A (en) Preparation of inosine-5'-monophosphate
JPS5294484A (en) Production of glucose isomerase

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 265213

Country of ref document: ES