ES2018967A6 - Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro. - Google Patents

Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro.

Info

Publication number
ES2018967A6
ES2018967A6 ES8903974A ES8903974A ES2018967A6 ES 2018967 A6 ES2018967 A6 ES 2018967A6 ES 8903974 A ES8903974 A ES 8903974A ES 8903974 A ES8903974 A ES 8903974A ES 2018967 A6 ES2018967 A6 ES 2018967A6
Authority
ES
Spain
Prior art keywords
preparation
piperazine
ethoxyacetic acid
alkali metal
phenylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903974A
Other languages
English (en)
Spanish (es)
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of ES2018967A6 publication Critical patent/ES2018967A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES8903974A 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro. Expired - Lifetime ES2018967A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
ES2018967A6 true ES2018967A6 (es) 1991-05-16

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903974A Expired - Lifetime ES2018967A6 (es) 1988-11-23 1989-11-22 Procedimiento de preparacion del acido 2-(2-(4-n(4-clorofenil)fenilmeti-piperazinil etoxin-acetico y de su dihidrocloruro.

Country Status (17)

Country Link
KR (1) KR970009727B1 (no)
AT (1) AT398970B (no)
CA (1) CA1320732C (no)
CY (1) CY1696A (no)
DK (1) DK174289B1 (no)
ES (1) ES2018967A6 (no)
FI (1) FI91861C (no)
GB (2) GB8827390D0 (no)
GR (1) GR1000576B (no)
HK (1) HK45493A (no)
HU (1) HU208002B (no)
NO (1) NO172287C (no)
PH (1) PH26334A (no)
PL (1) PL161374B1 (no)
PT (1) PT92363B (no)
RU (1) RU1838306C (no)
SG (1) SG12793G (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08501561A (ja) * 1992-09-24 1996-02-20 セプラコア，インコーポレイテッド （−）セチリジンを用いたアレルギー疾患の治療のための組成物
DK0661975T3 (da) * 1992-09-24 1999-09-27 Sepracor Inc Transdermal behandling af nældefeber ved anvendelse af optisk rent (+)-cetirizin
BE1010094A3 (fr) 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003238883A1 (en) * 2002-06-05 2003-12-22 Dr.Reddy's Laboratories Ltd. A novel amorphous form of (2-(4-((4-chlorophenyl)-phenyl methyl)-1- piperazinyl) ethoxy) acetic acid dihydrochloride (cetirizine dihydrochloride)
WO2004065360A2 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
AU2003228011A1 (en) * 2003-05-21 2004-12-13 Wockhardt Limited 2-(2-(4-((4-chlorophenyl) phenylmethyl)-1-piperazinyl)ethoxy)acetic acid monohydrochloride as anti-allergenic compound and process for its production
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.

Also Published As

Publication number Publication date
GB2225320B (en) 1992-09-02
GB8926242D0 (en) 1990-01-10
FI91861C (fi) 1994-08-25
GB2225320A (en) 1990-05-30
KR970009727B1 (ko) 1997-06-17
NO894650L (no) 1990-05-25
PT92363A (pt) 1990-05-31
PH26334A (en) 1992-04-29
HUT53626A (en) 1990-11-28
DK174289B1 (da) 2002-11-18
NO172287C (no) 1993-06-30
DK586589D0 (da) 1989-11-22
KR900007824A (ko) 1990-06-02
GB8827390D0 (en) 1988-12-29
SG12793G (en) 1993-04-16
FI91861B (fi) 1994-05-13
CY1696A (en) 1994-01-14
GR890100771A (en) 1990-12-31
DK586589A (da) 1990-05-24
NO894650D0 (no) 1989-11-22
PT92363B (pt) 1995-07-18
CA1320732C (en) 1993-07-27
HU208002B (en) 1993-07-28
ATA266489A (de) 1994-07-15
GR1000576B (el) 1992-08-26
AT398970B (de) 1995-02-27
FI895563A0 (fi) 1989-11-22
PL161374B1 (pl) 1993-06-30
HK45493A (en) 1993-05-21
HU896130D0 (en) 1990-02-28
RU1838306C (ru) 1993-08-30
NO172287B (no) 1993-03-22

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-11-22

FD1A Patent lapsed

Effective date: 20100803