ES2019010A6 - Un procedimiento de resolucion optica de dropropizina racemica. - Google Patents

Un procedimiento de resolucion optica de dropropizina racemica.

Info

Publication number
ES2019010A6
ES2019010A6 ES8904429A ES8904429A ES2019010A6 ES 2019010 A6 ES2019010 A6 ES 2019010A6 ES 8904429 A ES8904429 A ES 8904429A ES 8904429 A ES8904429 A ES 8904429A ES 2019010 A6 ES2019010 A6 ES 2019010A6
Authority
ES
Spain
Prior art keywords
optical resolution
dropropizine
carried out
aqueous medium
tartaric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8904429A
Other languages
English (en)
Inventor
Roberto Giani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe Farmaceutici SpA
Original Assignee
Dompe Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farmaceutici SpA filed Critical Dompe Farmaceutici SpA
Publication of ES2019010A6 publication Critical patent/ES2019010A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Prostheses (AREA)
  • Semiconductor Lasers (AREA)
  • Glass Compositions (AREA)

Abstract

UN PROCEDIMIENTO DE RESOLUCION OPTICA DE DROPOPIZINA RACEMICA. SE DESCRIBE UN PROCEDIMIENTO DE RESOLUCION OPTICA DE DROPROPIZINA RACEMICA, QUE SE EFECTUA UTILIZANDO ACIDO L(+)TARTARICO COMO AGENTE DE RESOLUCION OPTICA, EN MEDIO ACUOSO.
ES8904429A 1989-07-20 1989-12-29 Un procedimiento de resolucion optica de dropropizina racemica. Expired - Fee Related ES2019010A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921244A IT1231158B (it) 1989-07-20 1989-07-20 Procedimento per la risoluzione ottica della dropropizina.

Publications (1)

Publication Number Publication Date
ES2019010A6 true ES2019010A6 (es) 1991-05-16

Family

ID=11178946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8904429A Expired - Fee Related ES2019010A6 (es) 1989-07-20 1989-12-29 Un procedimiento de resolucion optica de dropropizina racemica.

Country Status (12)

Country Link
US (1) US5087698A (es)
EP (1) EP0409044B1 (es)
JP (1) JP2977237B2 (es)
KR (1) KR0146047B1 (es)
AT (1) ATE116975T1 (es)
CA (1) CA2007385C (es)
DE (2) DE69015907T2 (es)
ES (1) ES2019010A6 (es)
GR (2) GR910300062T1 (es)
HK (1) HK1006309A1 (es)
IT (1) IT1231158B (es)
PT (1) PT92767B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) * 1992-06-24 1995-10-11 Procedimento per la preparazione degli enantiomeri della dropropizina
IN187238B (es) * 1995-06-30 2002-03-09 Astra Ab
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE601394A (es) *
NL275711A (es) * 1962-03-15
US4255426A (en) * 1979-07-09 1981-03-10 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted-piperazines and piperidines
US4312877A (en) * 1979-07-09 1982-01-26 Pfizer Inc. 1-(2-Hydroxy-3-n-alkoxypropyl)-4-substituted piperidines, pharmaceutical compositions, thereof and use thereof
IT1210639B (it) * 1981-02-25 1989-09-14 Menarini Sas Prodotto: 3(4-fenil1piperazinio-1-il)-1,2-propandiolo 3(teofillin-7-il)-1propansolfonato,utilizzabile in terapia,e relativo procedimento di fabbricazione
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono
NL8801622A (nl) * 1988-06-25 1990-01-16 Stamicarbon Bereiding van enantiomeren van dropropizine.
IT1217950B (it) * 1988-06-28 1990-03-30 Dott Formenti Ind Chimica E Fa Sali di (r,s) 3 (4 fenil 1 piperazinil) 1,2 propandtolo
IT1226570B (it) * 1988-08-01 1991-01-24 Bidachem Spa Procedimento di preparazione della levo- e destro-dropropizina

Also Published As

Publication number Publication date
ATE116975T1 (de) 1995-01-15
DE69015907T2 (de) 1995-05-24
EP0409044A2 (en) 1991-01-23
EP0409044B1 (en) 1995-01-11
KR910002745A (ko) 1991-02-26
EP0409044A3 (en) 1991-05-29
KR0146047B1 (ko) 1998-08-17
JP2977237B2 (ja) 1999-11-15
DE69015907D1 (de) 1995-02-23
JPH0381270A (ja) 1991-04-05
IT8921244A0 (it) 1989-07-20
CA2007385C (en) 1997-12-30
GR910300062T1 (en) 1991-11-15
GR3014936T3 (en) 1995-05-31
HK1006309A1 (en) 1999-02-19
DE409044T1 (de) 1991-07-25
PT92767B (pt) 1995-11-30
IT1231158B (it) 1991-11-19
US5087698A (en) 1992-02-11
CA2007385A1 (en) 1991-01-20
PT92767A (pt) 1991-03-20

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-12-29

FD1A Patent lapsed

Effective date: 20101018