ES2004451A6 - Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico - Google Patents

Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico

Info

Publication number
ES2004451A6
ES2004451A6 ES8702024A ES8702024A ES2004451A6 ES 2004451 A6 ES2004451 A6 ES 2004451A6 ES 8702024 A ES8702024 A ES 8702024A ES 8702024 A ES8702024 A ES 8702024A ES 2004451 A6 ES2004451 A6 ES 2004451A6
Authority
ES
Spain
Prior art keywords
formula
salts
acid addition
resulting
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8702024A
Other languages
English (en)
Inventor
Janos Fischer
Tamas Fodor
Laszlo Dobay
Bela Stefko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2004451A6 publication Critical patent/ES2004451A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCEDIMIENTO DE PREPARACION DE ACIDO 1-(3-MERCAPTO-(2S)-METILPROPIONIL)-PIRROLIDIN-(2S)-CARBOXILICO DE LA FORMULAO SUS SALES FARMACEUTICAMENTE ACEPTABLES QUE TIENEN UNA VALIOSA ACTIVIDAD ANTIHIPERTENSIVA.DE ACUERDO CON LA INVENCION, UNA OMEGA-HALO-ACILPROLINA DE LA FORMULADONDE X REPRESENTA HALO, O UNA DE SUS SALES, SE HACE REACCIONAR CON TIOUREA EN UN DISOLVENTE APROTICO DIPOLAR ORGANICO PARA DAR UN COMPUESTO DE ISOTIURONIO DE LA FORMULAO UNO DE SUS HIDROHALUROS, QUE, FACULTATIVAMENTE DESPUES DE AISLAMIENTO, SE HIDROLIZA Y, SI SE DESEA, SE TRANSFORMA EL PRODUCTO DE LA FORMULA I EN UNA SAL O SE LIBERA DE UNA SAL.
ES8702024A 1986-06-27 1987-06-26 Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico Expired ES2004451A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862689A HU196959B (en) 1986-06-27 1986-06-27 Process for producing merkapto-acyl-proline derivatives

Publications (1)

Publication Number Publication Date
ES2004451A6 true ES2004451A6 (es) 1989-01-01

Family

ID=10960651

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8702024A Expired ES2004451A6 (es) 1986-06-27 1987-06-26 Procedimiento de preparacion de acido 1-(3-mercapto-(2s)-metilpropionil-pirrolidin-(2s)-carboxilico

Country Status (21)

Country Link
JP (1) JPS6327475A (es)
KR (1) KR900007217B1 (es)
CN (1) CN87104388A (es)
AR (1) AR243159A1 (es)
AT (2) AT395012B (es)
CH (1) CH673279A5 (es)
CS (1) CS276394B6 (es)
DD (1) DD263757A5 (es)
DE (1) DE3721430A1 (es)
DK (1) DK329787A (es)
ES (1) ES2004451A6 (es)
FI (1) FI87770C (es)
GR (1) GR871012B (es)
HU (1) HU196959B (es)
IT (1) IT1206792B (es)
NO (1) NO168941C (es)
PL (1) PL153449B1 (es)
PT (1) PT85190B (es)
SE (1) SE462751B (es)
SU (1) SU1650007A3 (es)
YU (1) YU46319B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE421551B (sv) * 1980-03-26 1982-01-04 Sandvik Ab Borrverktyg for rotations- och/eller slagborrning
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
JPS62125081A (ja) * 1985-11-21 1987-06-06 キングプリンテイング株式会社 捺染方法
PT928191E (pt) * 1996-09-26 2003-01-31 Meditor Pharmaceuticals Ltd Formulacoes farmaceuticas compreendendo derivados de s-alquilisotiouronio
CN103086939A (zh) * 2011-10-28 2013-05-08 华中药业股份有限公司 1-(3-溴-2-d-甲基丙酰基)吡咯烷-2-羧酸的重结晶方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
IE54551B1 (en) * 1982-01-22 1989-11-22 Ici Plc Amide derivatives
KR860001391B1 (ko) * 1984-07-23 1986-09-22 보령제약 주식회사 피롤리딘 유도체의 제조방법

Also Published As

Publication number Publication date
SE8702654D0 (sv) 1987-06-26
HU196959B (en) 1989-02-28
YU118187A (en) 1988-04-30
AT395012B (de) 1992-08-25
NO872690D0 (no) 1987-06-26
SE462751B (sv) 1990-08-27
ATA91186A (de) 1992-01-15
NO872690L (no) 1987-12-28
IT8721085A0 (it) 1987-06-26
DK329787A (da) 1987-12-28
KR880000392A (ko) 1988-03-25
DD263757A5 (de) 1989-01-11
FI87770B (fi) 1992-11-13
DK329787D0 (da) 1987-06-26
YU46319B (sh) 1993-05-28
JPS6327475A (ja) 1988-02-05
NO168941B (no) 1992-01-13
ATA162087A (de) 1988-06-15
GR871012B (en) 1987-11-02
PT85190B (pt) 1990-03-30
PT85190A (en) 1987-07-01
SE8702654L (sv) 1987-12-28
AT387381B (de) 1989-01-10
DE3721430A1 (de) 1988-01-28
KR900007217B1 (ko) 1990-10-05
SU1650007A3 (ru) 1991-05-15
PL266478A1 (en) 1988-06-09
CN87104388A (zh) 1988-03-02
AR243159A1 (es) 1993-07-30
CS479487A3 (en) 1992-01-15
PL153449B1 (en) 1991-04-30
IT1206792B (it) 1989-05-03
NO168941C (no) 1992-04-29
FI872859A (fi) 1987-12-28
CH673279A5 (es) 1990-02-28
FI87770C (fi) 1993-02-25
FI872859A0 (fi) 1987-06-26
HUT44490A (en) 1988-03-28
CS276394B6 (en) 1992-05-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103