ES2000616A6 - Procedimiento para la preparacion de 6-metil-3,4-dihidro-1,2,3-oxatiazin-4-on-2,2-dioxido asi como su purificacion - Google Patents
Procedimiento para la preparacion de 6-metil-3,4-dihidro-1,2,3-oxatiazin-4-on-2,2-dioxido asi como su purificacionInfo
- Publication number
- ES2000616A6 ES2000616A6 ES8601535A ES8601535A ES2000616A6 ES 2000616 A6 ES2000616 A6 ES 2000616A6 ES 8601535 A ES8601535 A ES 8601535A ES 8601535 A ES8601535 A ES 8601535A ES 2000616 A6 ES2000616 A6 ES 2000616A6
- Authority
- ES
- Spain
- Prior art keywords
- dihydro
- dioxide
- methyl
- oxatiazin
- sulfuric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XLXCHZCQTCBUOX-UHFFFAOYSA-N 1-prop-2-enylimidazole Chemical compound C=CCN1C=CN=C1 XLXCHZCQTCBUOX-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 8
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/06—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE PREPARA 6-METIL-3,4-DIHIDRO-1,2,3-OXATIAZIN-4-ON-2,2-DIOXIDO MEDIANTE CIERRE DE ANILLO DE ACETOACETAMIDO-N-ACIDO SULFONICO O DE SUS SALES CON UNA CANTIDAD POR LO MENOS CASI EQUIMOLAR DE SO3 EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE. PARA EL TRATAMIENTO, EN EL CASO DE EMPLEARSE UNA CANTIDAD EQUIMOLAR DE SO3, DESPUES DE HABERSE TERMINADO LA REACCION DE CIERRE DE ANILLO SE AÑADE ACIDO SULFURICO ACUOSO; EN EL CASO DE EMPLEARSE UNA CANTIDAD DE SO3 MAYOR QUE LA EQUIMOLAR SE HIDROLIZA POR ADICION DE AGUA O DE HIELO EL 6-METIL-3,4-DIHIDRO-1,2,3-OXATIAZIN-4-ON-2,2-DIOXIDO RESULTANTE COMO ADUCTO CON SO3, RESULTANDO ACIDO SULFURICO A PARTIR DEL SO3 FIJADO EN EL ADUCTO CON SO3. A PARTIR DE LA RESULTANTE MEZCLA DE VARIAS FASES SE SEPARA ENTONCES POR DESTILACION EL DISOLVENTE ORGANICO INERTE Y A PARTIR DE LA FASE ACUOSA EN ACIDO SULFURICO, REMANENTE, SE OBTIENE EN FORMA PURA POR CRISTALIZACION EL 6-METIL-3,4-DIHIDRO-1,2,3-OXATIAZIN-4-ON-2,2-DIOXIDO. ADEMAS DE ELLO, DE MANERA ENTERAMENTE GENERAL, SE PURIFICA A PARTIR DE ACIDO SULFURICO ACUOSO, POR RECRISTALIZACION, 6-METIL-3,4-DIHIDRO-1,2,3-OXATIAZIN-4-ON-2,2-DIOXIDO PURO. LAS SALES NO TOXICAS DEL 6-METIL-3,4-DIHIDRO-1,2,3-OXATIAZIWN-4-ON-2,2-DIOXIDO ESPECIALMENTE LA SAL POTASICA SON SUSTANCIAS EDULCORANTES SINTETICAS VALIOSAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853531359 DE3531359A1 (de) | 1985-09-03 | 1985-09-03 | Verfahren zur herstellung von 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid sowie zu dessen reinigung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2000616A6 true ES2000616A6 (es) | 1988-03-01 |
Family
ID=6279976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8601535A Expired ES2000616A6 (es) | 1985-09-03 | 1986-09-01 | Procedimiento para la preparacion de 6-metil-3,4-dihidro-1,2,3-oxatiazin-4-on-2,2-dioxido asi como su purificacion |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4806639A (es) |
| EP (1) | EP0215347B1 (es) |
| JP (1) | JPH0625189B2 (es) |
| KR (1) | KR940008750B1 (es) |
| CN (1) | CN1008094B (es) |
| AR (1) | AR245117A1 (es) |
| AT (1) | ATE49757T1 (es) |
| AU (1) | AU587493B2 (es) |
| BR (1) | BR8604202A (es) |
| CA (1) | CA1283912C (es) |
| CS (1) | CS262440B2 (es) |
| DD (1) | DD253820A5 (es) |
| DE (2) | DE3531359A1 (es) |
| DK (1) | DK168044B1 (es) |
| ES (1) | ES2000616A6 (es) |
| FI (1) | FI81792C (es) |
| HU (1) | HU201035B (es) |
| IE (1) | IE59131B1 (es) |
| IL (1) | IL79895A (es) |
| MX (1) | MX173525B (es) |
| NO (1) | NO163774C (es) |
| SU (1) | SU1535380A3 (es) |
| ZA (1) | ZA866648B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3429039A1 (de) * | 1984-08-07 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid und dessen nichttoxischen salzen |
| DE3527070A1 (de) * | 1985-07-29 | 1987-01-29 | Hoechst Ag | Verfahren zur herstellung von 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid |
| DE3531358A1 (de) * | 1985-09-03 | 1987-03-12 | Hoechst Ag | Verfahren zur herstellung der nicht-toxischen salze des 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxids |
| JP2005263779A (ja) * | 2004-02-17 | 2005-09-29 | Daicel Chem Ind Ltd | ３，４−ジヒドロ−１，２，３−オキサチアジン−４−オン−２，２−ジオキサイド化合物又はその塩の製造法 |
| JP2008037777A (ja) * | 2006-08-03 | 2008-02-21 | Daicel Chem Ind Ltd | ３，４−ジヒドロ−１，２，３−オキサチアジン−４−オン−２，２−ジオキサイド化合物のカリウム塩の製造方法 |
| JP2008037778A (ja) | 2006-08-03 | 2008-02-21 | Daicel Chem Ind Ltd | ３，４−ジヒドロ−１，２，３−オキサチアジン−４−オン−２，２−ジオキサイド化合物又はその塩の製造法 |
| JP5678449B2 (ja) * | 2010-03-25 | 2015-03-04 | Jsr株式会社 | 感放射線性組成物 |
| US9024016B2 (en) * | 2012-06-08 | 2015-05-05 | Nutrinova Nutrition Specialists & Food Ingredients GmbH | Process for producing acesulfame potassium |
| CN104292181B (zh) * | 2014-09-27 | 2016-10-26 | 安徽金禾实业股份有限公司 | 一种mvr系统浓缩安赛蜜母液的方法 |
| CN119192099A (zh) | 2016-09-21 | 2024-12-27 | 国际人造丝公司 | 乙酰舒泛钾组合物和用于生产其的方法 |
| JP6912582B2 (ja) | 2016-09-21 | 2021-08-04 | セラニーズ・インターナショナル・コーポレーション | アセスルファムカリウム組成物及びその製造方法 |
| EP3623363A1 (en) | 2016-09-21 | 2020-03-18 | Celanese International Corporation | Acesulfame potassium compositions and processes for producing same |
| CN107835807A (zh) * | 2016-09-21 | 2018-03-23 | 国际人造丝公司 | 乙酰舒泛钾组合物和其生产方法 |
| CN107820491A (zh) * | 2016-09-21 | 2018-03-20 | 国际人造丝公司 | 乙酰舒泛钾组合物和用于生产其的方法 |
| SI3319949T1 (sl) * | 2016-09-21 | 2020-11-30 | Celanese International Corporation, | Sestavki kalijevega acesulfama in postopki za njihovo izdelavo |
| CN107820490A (zh) * | 2016-09-21 | 2018-03-20 | 国际人造丝公司 | 乙酰舒泛钾组合物和用于生产其的方法 |
| CN112424176A (zh) * | 2020-09-21 | 2021-02-26 | 安徽金禾实业股份有限公司 | 安赛蜜的精制方法 |
| CN113454072B (zh) * | 2021-05-28 | 2022-11-25 | 安徽金禾实业股份有限公司 | 乙酰磺胺酸钾的制备方法 |
| EP4335841A4 (en) * | 2021-05-28 | 2024-07-24 | Anhui Jinhe Industrial Co., Ltd. | PROCESS FOR PREPARING ACESULFAM POTASSIUM |
| WO2022246862A1 (zh) * | 2021-05-28 | 2022-12-01 | 安徽金禾实业股份有限公司 | 乙酰磺胺酸钾组合物 |
| WO2022246865A1 (zh) * | 2021-05-28 | 2022-12-01 | 安徽金禾实业股份有限公司 | 乙酰磺胺酸钾的制备方法 |
| WO2022246868A1 (zh) * | 2021-05-28 | 2022-12-01 | 安徽金禾实业股份有限公司 | 乙酰磺胺酸钾的制备方法 |
| CN113527226A (zh) * | 2021-07-05 | 2021-10-22 | 南通醋酸化工股份有限公司 | 一种制备乙酰磺胺酸钾过程的酸中ach含量控制方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624104A (en) * | 1969-10-27 | 1971-11-30 | Searle & Co | Aralkanoyl derivatives of dibenzoxazepine-n-carboxylic acid hydrazides |
| FR2133022A5 (es) * | 1971-04-06 | 1972-11-24 | Skm Sa | |
| DE2327804C3 (de) * | 1973-06-01 | 1980-08-14 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von 3,4-Dihydro-l,23-oxathiazin-4-onen |
| US3992375A (en) * | 1974-08-12 | 1976-11-16 | G. D. Searle & Co. | Dibenzoxazepine N-carboxylic acid hydrazines and derivatives |
| DE2453063A1 (de) * | 1974-11-08 | 1976-05-13 | Hoechst Ag | Verfahren zur herstellung von acetoacetamid-n-sulfofluorid |
| DE3410439A1 (de) * | 1984-03-22 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid und dessen nichttoxischen salzen sowie der dabei als zwischenprodukt(e) auftretenden acetoacetamind-n-sulfonsaeure(salze) |
| DE3410440A1 (de) * | 1984-03-22 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxid und dessen nichttoxischen salzen |
| DE3531358A1 (de) * | 1985-09-03 | 1987-03-12 | Hoechst Ag | Verfahren zur herstellung der nicht-toxischen salze des 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-on-2,2-dioxids |
-
1985
- 1985-09-03 DE DE19853531359 patent/DE3531359A1/de not_active Withdrawn
-
1986
- 1986-08-27 AT AT86111840T patent/ATE49757T1/de not_active IP Right Cessation
- 1986-08-27 DE DE8686111840T patent/DE3668455D1/de not_active Expired - Lifetime
- 1986-08-27 EP EP86111840A patent/EP0215347B1/de not_active Expired - Lifetime
- 1986-08-29 CA CA000517244A patent/CA1283912C/en not_active Expired - Fee Related
- 1986-08-29 US US06/902,206 patent/US4806639A/en not_active Expired - Lifetime
- 1986-09-01 DD DD86294056A patent/DD253820A5/de not_active IP Right Cessation
- 1986-09-01 IL IL79895A patent/IL79895A/xx not_active IP Right Cessation
- 1986-09-01 HU HU863765A patent/HU201035B/hu not_active IP Right Cessation
- 1986-09-01 SU SU864028042A patent/SU1535380A3/ru active
- 1986-09-01 ES ES8601535A patent/ES2000616A6/es not_active Expired
- 1986-09-01 CS CS866324A patent/CS262440B2/cs not_active IP Right Cessation
- 1986-09-01 AR AR86305108A patent/AR245117A1/es active
- 1986-09-01 FI FI863522A patent/FI81792C/fi not_active IP Right Cessation
- 1986-09-02 DK DK418086A patent/DK168044B1/da not_active IP Right Cessation
- 1986-09-02 IE IE234386A patent/IE59131B1/en not_active IP Right Cessation
- 1986-09-02 ZA ZA866648A patent/ZA866648B/xx unknown
- 1986-09-02 JP JP61205244A patent/JPH0625189B2/ja not_active Expired - Lifetime
- 1986-09-02 BR BR8604202A patent/BR8604202A/pt not_active IP Right Cessation
- 1986-09-02 AU AU62172/86A patent/AU587493B2/en not_active Ceased
- 1986-09-02 CN CN86105339A patent/CN1008094B/zh not_active Expired
- 1986-09-02 NO NO863503A patent/NO163774C/no not_active IP Right Cessation
- 1986-09-03 KR KR1019860007364A patent/KR940008750B1/ko not_active Expired - Fee Related
- 1986-09-03 MX MX003635A patent/MX173525B/es unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-09-01 |
|
| FD1A | Patent lapsed |
Effective date: 20040902 |