EP3612781B1 - Gefriertrocknungsanlage - Google Patents

Gefriertrocknungsanlage Download PDF

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Publication number
EP3612781B1
EP3612781B1 EP18701750.4A EP18701750A EP3612781B1 EP 3612781 B1 EP3612781 B1 EP 3612781B1 EP 18701750 A EP18701750 A EP 18701750A EP 3612781 B1 EP3612781 B1 EP 3612781B1
Authority
EP
European Patent Office
Prior art keywords
freeze
drying apparatus
lever
product chamber
per
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18701750.4A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3612781A1 (de
Inventor
Kornel ANDRASCHEK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SBM Schoeller Bleckmann Medizintechnik GmbH
Original Assignee
SBM Schoeller Bleckmann Medizintechnik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of EP3612781A1 publication Critical patent/EP3612781A1/de
Application granted granted Critical
Publication of EP3612781B1 publication Critical patent/EP3612781B1/de
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Anticipated expiration legal-status Critical

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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the invention relates to a freeze-drying system with at least one product chamber which comprises at least two adjustable support means arranged within the product chamber.
  • the freeze-drying system comprises at least one adjusting device, which interacts with the support means, for adjusting the distance between the at least two support means.
  • the freeze-drying system additionally comprises at least one drive means for moving the support means, which drive means is arranged outside the product chamber.
  • the invention also relates to a method for adjusting the distance between the at least two support means of the freeze-drying system.
  • the font EP 1 726 901 A1 discloses a freeze-drying system with vertically held shelves arranged within the product chamber as support means for containers.
  • the freeze-drying system comprises two independent lifting cylinders as actuators, which are arranged within the product chamber and via which the support means can be vertically and continuously adjusted.
  • the shelves can be moved up and down via separate drive units that are arranged inside the product chamber. From the U.S. 4,961,273 A another freeze-drying system is known.
  • the object of the invention is to develop a freeze-drying system in which the adjustment plate adjustment is carried out in a simpler and safer manner.
  • the freeze-drying system according to claim 1 comprises a product chamber with at least two adjustable support means arranged within the product chamber.
  • the support means can mean, for example, shelves for storing at least one product to be dried by means of the freeze-drying system, which is filled in small containers, so-called vials.
  • the freeze-drying system comprises at least one adjusting device, which interacts with the support means, for adjusting the distance between the at least two support means.
  • the freeze-drying system according to claim 1 also comprises a drive means for moving the at least two support means. The movement of the support means in the vertical direction is preferably meant here.
  • the drive means is arranged outside the product chamber and preferably represents a hydraulic, pneumatic or motorized linear drive. This can be a hydraulic cylinder, for example.
  • the drive means actuates the adjustment device to adjust the distance between the at least two support means.
  • the adjusting device of the freeze-drying system additionally comprises a pressure plate which is designed to be moved by the at least one drive means.
  • the pressure plate is arranged above the support means and, in freeze-drying systems, also serves to distribute the force that is required to push in the closures of the containers from above evenly over the surface.
  • the adjusting device additionally comprises a lever connected to the pressure plate.
  • the freeze-drying system preferably comprises at least two holding means for holding one of the at least two support means, the at least one lever being connected to the holding means.
  • at least one stop of the adjusting device can preferably be provided, which on the acts at least one lever.
  • a preferably mechanical stop thus offers the advantage that a lever can be operated easily without additional actuators in the product chamber.
  • it can preferably be provided that the at least one lever and the at least one stop are arranged so that they can move relative to one another.
  • the at least one stop is preferably arranged on a side wall of the product chamber. This means that space in the product chamber is not used up unnecessarily and the stops have a stable option for mounting on the side wall of the product chamber. On the other hand, the stops are often easily accessible for maintenance purposes, for example, without being covered by other machine parts.
  • the at least one stop is preferably designed to be movable relative to the product chamber. Thus, different positions can be provided for the stops relative to the product chamber.
  • a pivot point of the lever is preferably arranged on the side of the pressure plate.
  • the pivot point here means the point around which the lever can rotate as a rigid body. This can be a second support, for example. A simple connection between the pressure plate and the lever of the adjusting device can thus be achieved.
  • the at least one lever represents a two-sided lever.
  • the lever is thus designed as a type of rocker with two lever arms, the two lever arms of which can be rotated about a pivot point.
  • a first lever arm of the two-sided lever is designed to hold the at least two holding means.
  • the first lever arm preferably rests on a support connected to the pressure plate and is supported by this.
  • the second lever arm of the two-sided lever interacts with the at least one stop.
  • the adjusting device preferably comprises at least two stops which are arranged within the product chamber. Also preferably includes the adjusting device has at least two bilateral levers connected to the pressure plate, the at least two bilateral levers being connected to the holding means. This would result in a uniform adjustment of the support means. Furthermore, the at least two stops are preferably movably arranged in the product chamber. Thus, different distances between the support means with different positions of the support means would be possible. For example, an inclined position of the support means would thus be made possible.
  • the invention also has a method which is used to adjust a distance between at least two adjustable support means arranged within a product chamber of a freeze-drying system.
  • a first method step at least one drive means arranged outside the product chamber of the freeze-drying system is activated.
  • at least two adjustable support means arranged within the product chamber are moved by means of the drive means.
  • the distance between the at least two support means of the freeze-drying system is adjusted by means of an adjusting device that interacts with the support means.
  • FIG. 1 shows a schematic structure of the freeze-drying system 200 according to the invention.
  • the freeze-drying system 200 here comprises a product chamber 20 within which adjustable shelves are stacked as support means 70a, 70b, 70c, 70d and 70e.
  • An adjusting device is connected to the support means 70a, 70b, 70c, 70d and 70e via holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j, which are connected to the support means 70a, 70b, 70c, 70d and 70e interacts and serves to adjust the distance between the support means 70a, 70b, 70c, 70d, 70e and 70f to one another.
  • the holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j are designed as holding rods which are used to hold the supporting means 70a, 70b, 70c, 70d and 70e.
  • the adjusting device comprises a pressure plate 100 on which two two-sided levers 40a and 40b are arranged laterally as a rocker.
  • the two-sided lever 40b is mounted rotatably about a pivot point 120a and has a first lever arm 55a and a second lever arm 55b.
  • the pivot point 120a is arranged laterally on the pressure plate.
  • the lever 40a is rotatably mounted about the pivot point 120b and also has a first lever arm 45a and a second lever arm 45b, these being the same length here as the first lever arms 55a and 55b.
  • the pivot point 120b is also arranged laterally on the pressure plate.
  • the first lever arms 45a and 55a are each supported on a support 110a and 110b, so that the second-side levers 40a and 40b are in a horizontal position.
  • the holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j are connected to the bilateral levers 40a and 40b and an equal number of holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j are each assigned to a lever 40a and 40b.
  • One holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j of the associated levers 40a and 40b hold an associated support means 70a, 70b, 70c, 70d and 70e.
  • the holding rods, which thus hold the support means 70a, 70b, 70c, 70d and 70e as pairs, are designed as pairs of the same length. However, different pairs have different rod lengths.
  • the longest support rods as support means 80e and 80j hold the support means 70e located at the bottom in the stack of support means 70a, 70b, 70d and 70e and the shortest support rods as support means 80a and 80f hold the uppermost support means 70a.
  • the longest holding rods as support means 80e and 80j are farthest away from the respective pivot point 120a and 120b and the shortest support rods as support means 80a and 80f are arranged closest to the respective pivot point 120a and 120b.
  • the adjusting device comprises a piston 10 of a hydraulic cylinder, the hydraulic cylinder being arranged as drive means 25 outside the product chamber 20.
  • the hydraulic cylinder as drive means 25 is designed to move the support means 70a, 70b, 70c, 70d and 70e in the vertical direction up and down via its piston and to close the adjustment device for adjusting the distance between the support means 70a, 70b, 70c, 70d and 70e actuate.
  • stops 30a and 30b are arranged, which can act on the bilateral levers 40a and 40b.
  • a table 90 is arranged at the bottom of the product chamber 20, on which the stack of support means 70a, 70b, 70c, 70d and 70e is deposited.
  • Figure 1b shows the freeze dryer 200 from Figure 1a
  • the support means 70a, 70b, 70c, 70d and 70e are held at a maximum distance from one another within the product chamber by means of the holding rods as holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j .
  • the holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j are in turn held by means of the first lever arms 45a and 45b of the bilateral levers 40a and 40b.
  • Hydraulic cylinder as drive means 25 has its piston here in contrast to Figure 1a further retracted and thus the support means 70a, 70b, 70c, 70d and 70e are moved vertically upwards.
  • Containers 190 which contain products which are to be freeze-dried are arranged on the shelves as support means 70a, 70b, 70c, 70d and 70e.
  • the stops 30a and 30b are arranged so that they can move relative to the bilateral levers 40a and 40b and are positioned on them Figure 1b the stop 30a touches the second lever arm 55b of the second-side lever 40b and the stop 30b touches the second lever arm 45b of the second-side lever 40a, but without already transmitting a force to the lever.
  • Figure 1c shows the freeze dryer 200 from Figure 1a and Figure 1b
  • the support means 70a, 70b, 70c, 70d and 70e are held at a reduced distance from one another by means of the rods as holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j.
  • the hydraulic cylinder arranged outside the product chamber 20 as drive means 25 has its piston here in contrast to Figure 1a and 1b retracted even further and thus the support means 70a, 70b, 70c, 70d and 70e are moved further vertically upwards.
  • the stop 30a and the second lever arm 55b cooperate in that the stop 30a transmits a force to the second lever arm 55b of the second-side lever 40b.
  • the stop 30b and the second lever arm 45b work together in the same way, in that the stop 30b transmits an equally large force to the second lever arm 45b of the lever 40a on the other side.
  • the bilateral levers 40a and 40b are thus rotated through a rotation angle 35b.
  • the holding means 80a, 80b, 80c, 80d, 80e, 80f, 80g, 80h, 80i and 80j are connected to the bilateral levers 40a and 40b in such a way that they are also slightly inclined when the bilateral levers 40a and 40b are tilted.
  • FIG. 2 shows the freeze dryer 200 from FIGS Figures 1a , 1b and 1c
  • the two stops 30a and 30b are arranged on the outer wall of the product chamber 20 so that they can move evenly.
  • the stops can be moved down to positions 32a and 32b or up to positions 31a and 31b. This results in a possible travel path 34 for the two stops shown.
  • FIG. 2 shows the freeze dryer 200 from FIGS Figures 1a , 1b , 1c and 1d
  • the two stops 30a and 30b are arranged on the outer wall of the product chamber 20 so as to be movable relative to one another.
  • the one on the Figure 1e shown left stop 30a can be moved down over the travel 35 to the position 33a, while on the Figure 1e shown right stop 30b is not moved.
  • Figure 2 shows a method sequence for adjusting a distance between at least two adjustable support means, which are arranged within a product chamber of a freeze-drying system.
  • the method is carried out here by a freeze-drying system according to the invention.
  • a drive means arranged outside the product chamber of the freeze-drying system is activated.
  • the at least two adjustable support means are moved by means of the drive means.
  • the distance between the at least two support means of the freeze-drying system is adjusted by means of an adjusting device that interacts with the support means.
  • the distance between the support means is adjusted by the drive means actuating the adjustment device.
  • step 330 it is checked whether a first control signal was detected for at least two stops of the adjustment device arranged within the product chamber for a desired inclination of the support means.
  • the stops are moved relative to one another as a function of the detected first control signal for the at least two stops.
  • the at least two stops are moved relative to one another if the first control signal was detected. If the first control signal was not detected, in an optional method step 350 following method step 330, the stops are not moved towards one another and remain in their position.
  • an optional method step 360 following method step 320 it can also be checked whether a second control signal was detected for at least two stops arranged within the product chamber for a desired height adjustment of the support means within the product chamber. Depending on the detected second control signal for the at least two stops, the stops are moved uniformly to one another within the product chamber. Thus, in an optional method step 370 following method step 360, the at least two stops are moved evenly up and down on both sides of the product chamber. If the second control signal was not detected, in an optional method step 380 following method step 330, the stops are not moved and remain in their position.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
EP18701750.4A 2017-03-22 2018-01-25 Gefriertrocknungsanlage Active EP3612781B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017204749.6A DE102017204749A1 (de) 2017-03-22 2017-03-22 Gefriertrocknungsanlage
PCT/EP2018/051792 WO2018171957A1 (de) 2017-03-22 2018-01-25 Gefriertrocknungsanlage

Publications (2)

Publication Number Publication Date
EP3612781A1 EP3612781A1 (de) 2020-02-26
EP3612781B1 true EP3612781B1 (de) 2021-09-08

Family

ID=61054407

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18701750.4A Active EP3612781B1 (de) 2017-03-22 2018-01-25 Gefriertrocknungsanlage

Country Status (5)

Country Link
EP (1) EP3612781B1 (zh)
CN (1) CN110494708B (zh)
DE (1) DE102017204749A1 (zh)
ES (1) ES2900224T3 (zh)
WO (1) WO2018171957A1 (zh)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4961273A (en) * 1987-03-30 1990-10-09 Hull Corporation Method and means for assuring freeze dryer chamber sterility
US4993171B1 (en) * 1989-11-22 1996-07-02 Boc Group Inc Covering for a hydraulic ram of a freeze dryer
FR2695329B1 (fr) * 1992-09-10 1994-11-10 Usifroid Dispositif de nettoyage des étagères d'une cuve de lyophilisation.
DE29709647U1 (de) * 1997-06-03 1997-08-07 Hof, Hans-Georg, 35075 Gladenbach Gefriertrocknungsanlage
DE102005024539B4 (de) 2005-05-28 2008-10-02 Hans-Georg Hof Gefriertrocknungsanlage
GB0613082D0 (en) * 2006-07-03 2006-08-09 Boc Group Plc Freeze dryer
CN201233158Y (zh) * 2008-03-11 2009-05-06 北京天利联合科技有限公司 板层倍增装置
CN203758170U (zh) * 2013-10-24 2014-08-06 上海凛马机械科技有限公司 一种新型冻干机隔板吊挂机构
CN204535359U (zh) * 2014-12-30 2015-08-05 楚天科技股份有限公司 一种驱动装置及冻干机
CN204730626U (zh) * 2015-06-12 2015-10-28 山东新华医疗器械股份有限公司 一种冻干机用板层升降装置
CN204881129U (zh) * 2015-07-09 2015-12-16 楚天科技股份有限公司 冻干板层间距可调的冻干机
CN105258459B (zh) * 2015-11-04 2017-06-16 楚天科技股份有限公司 一种板层可升降可倾斜的冻干机

Also Published As

Publication number Publication date
EP3612781A1 (de) 2020-02-26
DE102017204749A1 (de) 2018-09-27
CN110494708A (zh) 2019-11-22
WO2018171957A1 (de) 2018-09-27
CN110494708B (zh) 2021-08-03
ES2900224T3 (es) 2022-03-16

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