EP3595973B1 - System mit alternierender füllung von behältern und verfahren hierzu - Google Patents

System mit alternierender füllung von behältern und verfahren hierzu Download PDF

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Publication number
EP3595973B1
EP3595973B1 EP18712826.9A EP18712826A EP3595973B1 EP 3595973 B1 EP3595973 B1 EP 3595973B1 EP 18712826 A EP18712826 A EP 18712826A EP 3595973 B1 EP3595973 B1 EP 3595973B1
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EP
European Patent Office
Prior art keywords
filling
containers
rows
row
strip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18712826.9A
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German (de)
English (en)
French (fr)
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EP3595973A1 (de
Inventor
Siegfried Strauß
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch and Stroebel Maschinenfabrik Ilshofen GmbH and Co KG
Original Assignee
Bausch and Stroebel Maschinenfabrik Ilshofen GmbH and Co KG
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Publication date
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Publication of EP3595973A1 publication Critical patent/EP3595973A1/de
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Publication of EP3595973B1 publication Critical patent/EP3595973B1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/30—Devices or methods for controlling or determining the quantity or quality or the material fed or filled
    • B65B1/32—Devices or methods for controlling or determining the quantity or quality or the material fed or filled by weighing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/28—Methods or devices for controlling the quantity of the material fed or filled by weighing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/46—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using grippers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/54—Means for supporting containers or receptacles during the filling operation

Definitions

  • the present invention relates to a system for filling containers, in particular syringes, in particular in the medical and / or pharmacological field, and an associated method. Similar systems and methods are, for example, from the document EP2832648 A1 known.
  • the amount in the container corresponds as precisely as possible to the amount specified on the container, both in terms of the amount of liquid and the amount of active ingredient.
  • filling systems have been developed in which several filling needles are arranged in a row, these can fill several containers arranged in a row and then a closing station with closing actuators arranged in a row Containers sealed sterile.
  • the row of containers is weighed individually before and after the filling process in order to check the filling quantity. This can also be done as a whole row on a corresponding row of scales or the containers can be removed individually from the row and placed on a single scale.
  • the object of the present invention is therefore to solve the problems occurring in the prior art, in particular to provide a system for filling containers, in particular syringes, in which each container is weighed in the process, i.e. before, during and / or after filling in particular that a tare and gross weighing of each container is carried out in order to guarantee that all containers are correctly filled.
  • a corresponding system must work with sufficient speed and not at high costs.
  • containers are to be understood as meaning all types of containers, but especially those such as are used in the medical and / or pharmacological field, for example for liquids.
  • containers can also be, for example, vials, smaller bottles, test tubes and / or similar containers, in particular of the type used in the medical and / or pharmacological field.
  • Multi-lane denotes here that, viewed along the transport direction, a plurality of containers are always arranged next to one another. These are in general also essentially in line with containers in a previous or subsequent row along the transport direction.
  • multi-lane does not necessarily mean that there are correspondingly several physical lanes, rails or the like running along the transport direction. However, this is also not excluded.
  • the transport takes place in the form of rows of containers, so that when the system is started a first row of containers is arranged first, this is moved accordingly along the transport direction and then a second row of containers is arranged in the same position as before and then also is moved along the transport direction by the transport device.
  • the multi-lane nature of the at least one filling station refers to the fact that it can simultaneously fill several containers arranged next to one another transversely to the transport direction.
  • the filling station is designed in such a way that it can fill as many containers arranged in a row at the same time as there are in the rows of the transport device.
  • Placing the containers on a weighing device means that the containers are positioned with respect to the weighing device in such a way that the weighing device can measure its current weight.
  • the system according to the invention achieves a sufficiently large output with simultaneous gross and tare weighing of each individual container. Namely, by means of the provision of at least two weighing devices and a design of the control system, the rows of containers only at stop one weighing device and at the same time move it past the other weighing device. With each stop for filling, in which time-consuming weighing of the containers is generally necessary, two rows of containers are weighed simultaneously or just one after the other as part of the filling process by the weighing device provided.
  • the at least one filling station is along the transport direction from a first filling position for a filling process of at one of the at least two weighing devices positioned row of containers can be moved to a further filling position for a filling process of a further row of containers positioned in a further row of the at least two weighing devices.
  • At least two or more multi-lane filling stations arranged one behind the other along the transport direction can also be provided, but which are not movable along the transport direction.
  • Two or more corresponding movable filling stations can also be provided, each serving two or more filling positions or rows of containers arranged above a weighing device.
  • Movable / immovable here refers to movements of the filling station along the transport direction. Regardless of this, the filling station can e.g. have moving parts with regard to the filling process, e.g. Filling needles, or be movable as a whole.
  • the transport device is preferably designed as at least one bar per row of containers. These strips accordingly extend transversely to the transport direction and are transported, for example, via a common drive. There are holes in each of the strips into which the containers are inserted for transport, whereby the number of holes determines the number of lanes in the system.
  • Such a bar is preferably designed with two arms with one arm on each side of the holes and is also preferably designed to be hinged. In this way, when the bar is in the closed position, the containers are held by the bar. And when the bar is opened, the containers can be released and their weight can thus be measured by the corresponding weighing device, because otherwise their weight will be on the bar.
  • the holes are of course preferably designed in such a way that they hold the corresponding containers purely by their shape. In the case of syringes, for example, this can be achieved by a conical tapering of the hole from the top of the bar to the bottom of the bar.
  • the course can also be step-shaped and in the case of other containers, for example test tubes with an edge protruding beyond the other wall at the upper end, the hole can also have a completely constant diameter.
  • the strip can be designed as a hollow strip, the transport device further comprising strip inserts that can be pushed into and along a longitudinal direction of the hollow strips, the strip inserts each comprising one hole per hole in the hollow strip.
  • the strip inserts can be guided / positioned, for example, by means of rails or grooves in the interior of the hollow strips.
  • the diameter and shape of the passage from the top to the bottom of the strip can then be varied, so that, depending on the position, containers are either retained or released.
  • the shape of the strip inserts and / or the interior of the hollow strip is preferably such that direct or indirect engagement with the container is possible in a holding position of the strip insert.
  • the shape of the holes in the strip inserts does not match the shape of the holes in the hollow strip.
  • the shape of the holes of the strip inserts and / or the hollow strip preferably comprises a circular or elliptical section and one of the Circular or elliptical deviating section.
  • a shape of half to three quarters of a circle and a triangle in the remainder of the section which is no longer circular is preferred.
  • the shape of a hole here means in particular the edge contour of the hole when viewed from bottom to top or top to bottom in relation to the bar / bar insert.
  • the system preferably comprises a centering insert, the shape of which can be passed through the holes in the strips, the centering insert having one end designed to be suitable for coupling with the weighing devices and a clamping device for clamping and / or centering one at a further end Has container.
  • the filling quantity / filling weight can also be reliably determined.
  • the strips are permanently coupled to a drive device, so that all strips are accordingly always moved simultaneously.
  • the strips are individually driven or can be moved relative to one another in some other way, so that the distance between strips following one another in the transport direction can be reduced and increased during transport.
  • the closing station which for example has to close two rows of containers during a filling process, does not itself have to be designed with elements that can move along the transport direction. This is because the two bars at the closing station and the bars following in the transport direction are simply moved further so that two rows of containers come into the position suitable for the closing process during the filling process.
  • the system preferably further comprises at least one tong device per filling station, which is designed to raise and / or lower at least one container or a device holding the container. This allows, especially in combination with the hinges of the bars or the other mechanisms mentioned for holding the containers directly or indirectly on the strips, the containers can be easily and quickly placed on the respective weighing device.
  • the tong device in combination with the design of the transport device in the form of strips is designed so that the at least one container or a device holding it can be raised from a hole in the strip and / or lowered onto a weight sensor of the weighing device.
  • the forceps device is designed to grip all containers / devices simultaneously during or shortly before the bar is opened.
  • tong devices can also be provided for gripping all containers / devices in a row or in a bar.
  • the strips can also be designed to be individually movable in the vertical direction in relation to the transport direction.
  • the bar can thus directly implement the function of lowering or lifting containers or devices accordingly.
  • the corresponding devices under or over the strips can also be designed to move up to the containers / devices, e.g. in that the weighing devices or corresponding parts thereof are vertically movable.
  • the features and designs with regard to the distance between two consecutive bars then based on a standard distance between consecutive bars, for example the distance that results when all bars are arranged at the same distance along the transport direction, or the technically usual distance in the entrance or exit area of the Transport device.
  • a standard distance between consecutive bars for example the distance that results when all bars are arranged at the same distance along the transport direction, or the technically usual distance in the entrance or exit area of the Transport device.
  • distance for variants with strips that can be moved relative to one another is to be read and understood as such a standard distance, since in the case of individual mobility, the distance between two specific adjacent strips can also vary, e.g. during use a single, immovable sealing station and individually movable strips in the area of the sealing station.
  • the distance between two successive weighing devices in the transport direction is preferably such that when a row of containers is positioned at and / or above each of the successive weighing devices, there is either no more space between any row of containers or a number of rows of containers equal to the total number corresponds to the filling station or a multiple thereof.
  • control can be designed in such a way that it controls the transport device only in two alternating steps, namely once to advance a number of rows of containers equal to the number of weighing devices and then stand still for the duration of the filling process and possibly the Weighing processes.
  • Such a control could even be implemented mechanically or electromechanically, so that programming errors with regard to the control are excluded.
  • each row of containers is only once at a filling stop at a weighing device and is not at a weighing device at all other filling stops.
  • the filling stations are preferably also designed according to the features mentioned above with regard to the weighing devices or the system is designed accordingly. For example, that the distance between two filling stations is appropriate or that the control is designed such that a row of containers is only present once at a filling station during a filling process.
  • the duration of a filling process it can be advantageous to provide more than one closing station in succession in the transport direction. It is particularly preferred to provide a closing station for every two filling stations and / or two weighing devices.
  • the system preferably comprises a nest removal device at the beginning of the transport device in order to remove containers from a nest and to bring them into the transport device.
  • the system also preferably comprises a nest loading device at one end of the transport device in order to remove containers from the transport device and insert them into a nest. Both can be designed similarly to the pliers devices described above.
  • Steps b), c), d) are preferably applied to different containers and rows at the same time, apart from the filling after substeps d1) and d2), which is preferably applied alternately or simultaneously to different rows of containers.
  • the containers arranged in rows are thus moved along a transport direction, with several filling points being provided along the transport direction and each row of containers being filled only at a respective filling point and passing the other filling points without filling.
  • a part of rows of containers is filled at the first filling point and another part is filled at the further filling point or points.
  • the duration of the filling process or, in particular, a weighing process required is no longer the critical time component, which limits the overall performance.
  • each row of containers only stands still at exactly the desired filling point for a filling process and is moved past the other filling points.
  • the same result can also be achieved in that successive rows are not always at the same distance, but rather the distance between successive rows changes in a regular manner according to the distance between the filling points.
  • the feed alternating with the standstill can then take place similarly to steps c1) and c2), but the feed then usually corresponds to the length after which the different distances between the rows are repeated again.
  • the filling level and / or the absolute filling quantity are measured, especially during filling.
  • the containers can also be weighed immediately before filling and immediately after filling is complete.
  • the time for weighing is also no longer critical and accordingly a high throughput can be achieved, while at the same time a high level of product safety is ensured through tare weighing and gross weighing of each individual container.
  • FIG Figure 1 An exemplary embodiment of the system 10 according to the invention for filling containers 100, which are embodied here as syringes by way of example, comprises as in FIG Figure 1 a transport device formed by means of strips 40, two filling stations 20, two weighing devices 30 and a closing station 14 can be seen.
  • a single strip 40 comprises five holes 42, the strip 40 being formed from arms 40a and 40b which are coupled via a hinge 44.
  • the arms 40a and 40b can thus be folded apart, wherein in other embodiments the hinge or a correspondingly different mechanism can be designed so that the arms 40a and 40b can only be folded apart by a few degrees. An opening angle that is just large enough to release the containers 100 held in the holes is sufficient.
  • the holes 42 are as in cross-section through a hole in FIG Figure 2c can be seen tapering from top to bottom, so that as in Figure 1 shown, the thinner head region of the syringe 100 can protrude downwards, while the wider upper region cannot pass through the hole and is thus held.
  • the strips 40 are fed empty from the left and syringes 100 are inserted into the holes 42 of the strips 40.
  • control is designed in such a way that the transport device or the strips 40 are moved forwards by two strip distances and then stand still for a filling process.
  • the syringes 100 located at the filling stations 20 will be filled as much as the hatched area for the syringes further to the right indicates.
  • the bars 40 that hold the syringes 100 that have just been filled are opened, whereupon the syringes 100 additionally held with the pliers devices 24 are lowered onto the weight sensors 32 of the weighing devices 30 in order to determine the gross weight of each syringe. Since the tare weight was previously determined in a similar way, the exact filling level or the exact filling amount is known for each syringe.
  • the syringes 100 can also remain on the weight sensors 32 during the filling process, so that the weight is measured continuously and the difference between the initial weight and the current or final weight is used to monitor the filling quantity.
  • the closing actuators 16 of the closing station 14 are also the in Figure 1 have provided syringes 100 currently located directly below the closure actuator 16 with a stopper or closure 18, as is already the case with the syringes 100 on the far right.
  • one or more immovable closing stations 14 can alternatively also be used.
  • two closing stations 14 are provided one behind the other along the transport direction and / or in that the strips 40 can move relative to one another.
  • the strips 40 in the vicinity of the closing station 14 would be moved in such a way that two rows of syringes 100 are positioned one after the other for closing at the closing station 14.
  • the distance between the strips 40 and / or between the rear filling position would have to be suitably selected so that there is sufficient play for the individual movement of the strips 40.
  • the pliers devices 24 lift the syringes again so that the associated strips 40 can be closed and then the pliers devices 24 are released from the syringes 100 so that the pliers devices 24 do not impede the subsequent forward movement of the strips 40 to the right.
  • the control is designed in such a way that it moves the bars 40 forward by the distance from two adjacent bars and then lets the bars stand still for the period required for weighing and filling and then moves them forward again by two bar distances.
  • the syringes 100 on the far left will come to a standstill immediately below the filling needles 22 of the first filling station 20.
  • the second syringes 100 from the left will come to a stop at the first position behind the first filling station 20.
  • the syringes 100 just filled by the first filling station 20 will come to a standstill as fully filled syringes one position in front of the second filling station 20 and the previously empty syringes 100 that were in the first position behind the first filling station 20 will be under the second filling station 20 come to a standstill.
  • the filled syringes 100, which were previously one position in front of the second filling station 20, will now come to a standstill one position behind the filling station 20.
  • the system thus realizes a multi-lane and alternating two-row filling, with a complete determination of the filling weight, for example via a tare and gross weighing of the objects to be filled, for example syringes, vials or cartridges, with full machine performance.
  • filling stations 20 can either also fill adjacent rows and be positioned accordingly (again with the problem that many filling systems are too are voluminous) or the filling stations 20 must be spaced apart from in Figure 1 to be ordered.
  • the number of bars between two bars under adjacent filling stations 20 or weighing devices 30 is equal to the number of filling stations 20 or Weighing devices 30 is a total. Then, with a feed by the number of bars equal to the number of filling stations 20 or weighing devices 30, each bar will only be once under a filling station 20 or above a weighing device 30 during the standstill and otherwise always at the intervals between during the standstill two adjacent filling stations 20 or weighing devices 30.
  • FIG Figure 4 Such an embodiment with a movable filling station 20 and two weighing devices 30 is shown in FIG Figure 4 shown.
  • the holes 42c, 42d of the hollow strip 40c include a circular section 42c and a triangular section 42d.
  • the holes 48 of the strip inserts 46, however, are elliptical.
  • system 10 or the transport device comprises centering inserts 50 such as the one in FIG Figures 5c and 5d shown with a lower end 52 suitable for coupling positioning on a weight sensor 32; the shape of this end 52 thus depends on the shape of the weight sensors 32 and vice versa.
  • the centering insert 50 has at an upper end a clamping device 54, 56 comprising a clamping holder 54 and a clamping block 56, which is elastically movably mounted in a guide recess 58, between which container ends of containers 100 can be clamped or centered.
  • the shape of the centering inserts 50 between the two ends essentially corresponds to a circle, with a triangular projection 60 being provided at a suitable height, so that the shape as a whole is suitable for passage through the holes 42c, 42d of the hollow strip 40c.
  • the centering insert 50 can thus be released or retained in the downward direction.
  • the bar insert 46 can be lifted slightly if necessary by slightly lifting the centering inserts 50 by means of e.g. the pliers 24 are moved again so that the centering insert 50 is again held by the hollow strip 40c.
  • the weighing process can be implemented in a technically simple manner and, on the other hand, containers 100 with different diameters can be clamped by the centering insert 50 and thus held by the hollow strips 40c.
  • holes 42c, 42d, holes 48 and centering inserts 50 can also realize a corresponding connection, since it is sufficient for this if part of the cross-section of the holes 42c, 42d is blocked in one position of the strip insert 46 and none in another position Area is blocked.
  • the centering insert 50 can also comprise movable components in addition to the projection 60, which for example protrude above the strip 40 or hollow strip 40c and are moved accordingly to release.
  • both exemplary embodiments shown can also be designed without pliers or pliers device 24. Since these essentially serve the function of placing / lifting the container 100 from the weight sensors 32, the strips 40 and / or the weight sensors 32 can alternatively and / or additionally also be designed to be vertically movable individually or together.
  • the bar 40 is suitably lowered and / or the corresponding weight sensors 32 are suitably raised so that the weight of the containers 100 then immediately load on the weight sensors 32.
  • bars 40 or weight sensors 32 can be shifted slightly again in order to produce an optimal relative positioning between containers 100 or centering inserts 50 or bars 40 and / or bar inserts 46 for the purpose of engagement.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Quality & Reliability (AREA)
  • Basic Packing Technique (AREA)
EP18712826.9A 2017-03-13 2018-03-13 System mit alternierender füllung von behältern und verfahren hierzu Active EP3595973B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102017204092 2017-03-13
DE102017207307.1A DE102017207307A1 (de) 2017-03-13 2017-05-02 System mit alternierender Füllung von Behältern und Verfahren hierzu
PCT/EP2018/056226 WO2018167054A1 (de) 2017-03-13 2018-03-13 System mit alternierender füllung von behältern und verfahren hierzu

Publications (2)

Publication Number Publication Date
EP3595973A1 EP3595973A1 (de) 2020-01-22
EP3595973B1 true EP3595973B1 (de) 2021-01-27

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EP18712826.9A Active EP3595973B1 (de) 2017-03-13 2018-03-13 System mit alternierender füllung von behältern und verfahren hierzu

Country Status (6)

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US (1) US11498707B2 (zh)
EP (1) EP3595973B1 (zh)
CN (1) CN109311542B (zh)
DE (1) DE102017207307A1 (zh)
ES (1) ES2861249T3 (zh)
WO (1) WO2018167054A1 (zh)

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CN111846308B (zh) * 2020-08-05 2022-02-22 楚天科技股份有限公司 药液灌装方法
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Publication number Publication date
ES2861249T3 (es) 2021-10-06
EP3595973A1 (de) 2020-01-22
WO2018167054A1 (de) 2018-09-20
DE102017207307A1 (de) 2018-09-13
CN109311542B (zh) 2021-09-17
US11498707B2 (en) 2022-11-15
CN109311542A (zh) 2019-02-05
US20210221541A1 (en) 2021-07-22

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