EP3291786B1 - Behälter-entnahmesystem - Google Patents

Behälter-entnahmesystem Download PDF

Info

Publication number
EP3291786B1
EP3291786B1 EP15721575.7A EP15721575A EP3291786B1 EP 3291786 B1 EP3291786 B1 EP 3291786B1 EP 15721575 A EP15721575 A EP 15721575A EP 3291786 B1 EP3291786 B1 EP 3291786B1
Authority
EP
European Patent Office
Prior art keywords
container
removal
disk
blocking element
locking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15721575.7A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3291786A1 (de
Inventor
Michael Spallek
Johannes Geser
Karl Köppel
Alexander Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kocher Plastik Maschinenbau GmbH
Original Assignee
Kocher Plastik Maschinenbau GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kocher Plastik Maschinenbau GmbH filed Critical Kocher Plastik Maschinenbau GmbH
Priority to PL15721575T priority Critical patent/PL3291786T3/pl
Publication of EP3291786A1 publication Critical patent/EP3291786A1/de
Application granted granted Critical
Publication of EP3291786B1 publication Critical patent/EP3291786B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D55/00—Accessories for container closures not otherwise provided for
    • B65D55/02—Locking devices; Means for discouraging or indicating unauthorised opening or removal of closure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends

Definitions

  • the invention relates to a container removal system having the features in the preamble of patent claim 1.
  • Such systems make it possible, via the connecting device, to bring into contact, dissolve or mix desired media which are constituents of a separate container.
  • Such operations are widely practiced in the medical and pharmaceutical arts to produce formulations consisting of at least two initially separate components which must be mixed together prior to use.
  • a particularly widespread field of application relates to the preparation of preparations for parenteral applications for medical or diagnostic purposes.
  • a solvent already present in the infusion bottle such as water, isotonic NaCl solution, a glucose solution, a lactated Ringer's solution or the like, a medicament, for example antibiotic, be supplied in liquid or powder form, which is to be dissolved in the solvent.
  • the various components of the drug can be stored separately from each other when a component needs to be refrigerated, as is often the case with sensitive biotechnological products that must be infused prior to administration, to avoid having to extend the cold chain to the solvent.
  • the removal device as a carrier for a piercing spike, which is formed in the usual way as a cannula with perforation tips located on both sides, a flexible support member in the form of a thin-walled plate, which also forms the locking device of the removal device.
  • the flexible plate has a knob-like peripheral edge, which engages in a latching groove on the inside of the receptacle of the connecting device.
  • the perforable opening portion of the movable container engages the piercing mandrel and on further movement deforms the flexible plate of the withdrawing device to release the lock on the wall of the receptacle.
  • the at the locked Locking axial force is dependent on the perforation resistance at the opening portion of the movable container. The reliability of the locking device therefore leaves something to be desired.
  • the EP 0 843 992 A1 discloses a container removal system having at least one first and at least one second container, which are connectable to each other via a connecting device having a removal device which held by at least one locking device in a locked position prevents media exchange or allows in at least one unlocked position in which the removal device for a removal operation is guided longitudinally movable in a receptacle of the connecting device, wherein the locking device can be moved by moving at least one of the containers in an unlocked position, wherein at the respective movable container additional control means are provided which at least partially this container Include outside circumference and actuate the locking device of the removal device in the sense of unlocking, wherein the connecting device as a receptacle for the removal device and the locking device comprises a housing in the form of a sleeve which is connectable or connected at one end to a container, accessible at the other end for a movable second container and forms a guide for movements of removal device and locking device, wherein the removal device is a disc as
  • the object of the invention is to provide a container removal system which is distinguished by improved functional reliability.
  • the container removal system according to the invention is characterized in that for the latching on the sleeve forming tongue parts second detents are formed on the sleeve, which engage the removal device in an end position at the end of a connection operation.
  • a significant feature of the invention is that additional control means are provided on the respective movable container, which comprise this container at least partially on the outer peripheral side and actuate the locking device of the removal device in the sense of unlocking.
  • the unlocking process is carried out in a controlled manner, which leads to increased security against incorrect operation.
  • the additional control means are provided on the outside or front side of a cap part which surrounds a movable perforated hollow mandrel of the removal device opening area on the movable container.
  • the control means may be formed by the special cap shape itself or be integral with the container in question.
  • the arrangement can be made such that the locking device has a blocking element which prevents the opening movement of the hollow hollow mandrel of the removal device in the locked state and can be transferred by mechanical contact with the control means of the movable container in the unlocked state enabling the movement.
  • the locking device can be actuated by special control means
  • the invention opens up the particularly advantageous possibility of forming an encryption excluding a maloperation between the movable container and the connecting device.
  • a physical coding key element is provided and that as a lock of the system on the body of the locking element, an opening with an internally provided physical coding is provided such that, with appropriate coding, the control means of the container are insertable into the opening of the locking element to convert it into the unlocked state.
  • the coding of the key element may be formed on the cap portion of the movable container by circumferentially provided recesses or projections, in correspondence to the coding of the blocking element provided by at the wall of its opening, with matching coding to the recesses and / or projections of the movable container complementary recesses and / or projections is formed.
  • connection device can have a housing in the form of a cylindrical sleeve as a receptacle for the removal device and the locking device.
  • Guide parts for guiding the disc during movement movements in the sleeve can be provided on the circumference of the disc.
  • the arrangement may be such that at the periphery of the disc second locking members are provided, which hold the locking element in its normal locking position in the locked state and are controllable from the locked position by contact with the introduced into the locking element control means of the movable container in an unlocked position in which they convert the blocking element into the unlocked state.
  • the respective tab for the second latch member having a engaging in the opening of the locking member control member which moves by contact with the introduced into the opening control means of the movable tab, the respective second latch member from the locking position and unlocks the locking element.
  • this unlocking process can only take place when the control means of the movable bottle are sufficiently insertable with the appropriate coding in the opening of the blocking element.
  • the blocking element Upon reaching the unlocked state, the blocking element is movable through the movable container to the disc of the removal device, wherein the tabs are guided in control channels of the blocking element, in that the tongue parts forming the latching on the sleeve are deflected in the control channels so that the removal device is free for the opening movement and can be taken along by the movement of the blocking element for its opening movement.
  • inwardly projecting locking lugs may be provided on the circumference of the removal device, which at the end position of the removal device form a snap connection with a peripheral edge of the key element having cap portion of the movable container.
  • a first container in the form of an infusion container 1 in the form of a plastic container which is produced for example by the known blow-fill-seal method, described by way of example in FIG EP 2 269 558 A1 and the experts also known under the name bottelpack® system.
  • Such containers usually have at least one connection 3 for an infusion set. If the contents of the infusion container 1, which contains, for example, a volume of a solvent, for the preparation of a special infusion liquid, a liquid or powdered further media component is to be supplied, special safety criteria must be observed.
  • the connecting device comprises a removal device with a perforated hollow mandrel in the form of a permeable between perforation cannula and is normally locked in an inoperative position, in which both perforation tips of the puncture mandrel spaced from a perforable opening portion of the infusion bottle 1 and a perforable perforation region of the intended for the removal vial are located.
  • the connecting device has a cylindrical, sleeve-shaped receptacle into which the vial 5 provided for the removal process can be inserted, wherein the sleeve-shaped receptacle forms a guide for a movement of the vial 5, in which the perforable opening region of the vial 5 approaches the piercing spike, the Detaching locking of the removal device and moves it to an end position in which the perforated mandrel perforated the opening areas of the vial 5 and infusion bottle 1 and establishes the media connection.
  • the container removal system according to the invention is based on the same principle of operation.
  • the fundamental difference of the invention is that an unlocking of the removal device designated in the figures 27 and thus the production of a media-carrying connection only when using a specially designed for the respective removal operation, movable container, ie the vial 5, is possible.
  • 5 special control means are provided on the movable vial through which the locking device of the removal device can be unlocked.
  • FIGS. 2 and 3 showing a movable vial 5 separately, it will be seen that on the neck portion 11 of the vial 5, where the perforable opening portion 48 is located, for example in the form of an elastomeric plug, not shown in detail, a cap member 13 is attached, in the present example consists of a one-piece injection-molded plastic part.
  • the FIGS. 2 and 3 show the cap member 13 in the initial state before use, which is at the top of the cap member 13 is a molded cover 15 as a truism mark, which is easily removable for use of the vial 5, for example, by bending, prying or twisting and without the necessary auxiliary tools. Instead of the cover 15, a removable film could be provided.
  • a central opening 17 is exposed on the cap portion 13, which is aligned with the perforable opening portion 48 on the neck portion 11 of the vial 5.
  • a radiation-permeable film is provided instead of the cover 15, a corresponding foil with high-energy radiation, for. B. irradiate UV or beta radiation, to kill possibly on the elastomer surface (perforation surface) existing germs.
  • the preferably formed from a polymer cap member 13 may, as Fig. 2 shows, at the edge 19 of the neck portion 11 of the vial 5 form, force or materially connected.
  • the coding of the cap portion 13 could be integral with the vial 5.
  • caps 13 according to the invention with coding can also be part of per se known multi-piece plastic closures, as they are for example in WO 2011/032798 A1 .
  • the outline of the cap part 13 has the shape of a Reuleaux triangle with rounded corners.
  • the cap part 13 forms with the outer circumference of the Reuleaux triangle a physically coded key element, wherein the coding on the cap part 13 is formed by recesses 21.
  • the recesses 21 are in the form of circumferentially recessed grooves, the circumferential length of which are bounded by walls 23 defining radial planes with respect to the central opening 17, and of which only in Fig. 7 some walls 23 are numbered.
  • the axial depth of the recesses 21 is less than the thickness of the cap member 13, so that the recesses 21 on the in Fig. 7 visible face is open and the main part of the vial 5 facing side of the cap member 13 which in Fig. 8 is visible, is free of recesses 21.
  • a ring body 25 As encodable lock for the key-lock system is a ring body 25 (see in particular FIGS. 6 and 8 ), which forms a blocking element as part of the locking device of the removal device 27, in Fig. 5 is shown separately.
  • the annular body 25 has for insertion of the key element formed by the cap member 13 on an opening 29 which is adapted to the circumference of the cap member 13, that has the shape of a Reuleaux triangle.
  • the opening 29 is provided with a coding in the form of projections 31, which, with appropriate coding, to the recesses 21 of the key part on the cap part 13 are complementary.
  • the projections 31 do not extend to the in Fig.
  • the Fig. 4 shows the initial state before the beginning of a removal operation, wherein the annular body 25 is located at the upper end of a sleeve-shaped receptacle 9 of the connecting device 7.
  • Fig. 6 most clearly shows, the annular element forming the blocking element 25 on the outside circumferentially axially continuous grooves 33, with which the annular body 25 (not shown) on axial guide rails of the sleeve-shaped receptacle 9 is guided.
  • removal device 27 is guided axially movable below the ring body 25 in the sleeve-shaped receptacle 9 for their opening movement.
  • Fig. 6 shows the annular element forming the blocking element 25 on the outside circumferentially axially continuous grooves 33, with which the annular body 25 (not shown) on axial guide rails of the sleeve-shaped receptacle 9 is guided.
  • removal device 27 is guided axially movable below the ring body 25 in the sleeve
  • the removal device 27 has a the inner diameter of the sleeve-shaped receptacle 9 adapted disc 35 as a carrier for a centrally located piercing spike 37, which is formed in a conventional manner as a multi-channel cannula and protrudes on both sides of the disc 35 to To perforate the opening operation, both the opening portion 50 of the infusion bottle 1 and the opening portion 48 of the vial 5.
  • the disc 35 At the periphery of the disc 35 are high-level functional elements. Of these, three guide plates are designated 39, with which the disc 35 is guided during driving movements on the inner wall of the sleeve-shaped receptacle 9. Between two successive guide plates 397 are two tabs, each with three mutually contiguous tongue parts 41, 43 and 45.
  • located above the surface of the disc 35 inwardly projecting lugs 47 to form a snap connection, which will be discussed below.
  • Fig. 4 shows, which is the blocking element of the locking device forming annular body 25 at the upper edge of the sleeve of the receptacle 9.
  • the annular body 35 is in the locked, ie axially non-movable state.
  • the removal device 27 located under the ring body 25 is in turn locked against an axial movement, because the disc 35 is latched with the detents 49 on the tongue parts 41 which are slightly spread outwards in a latching groove 51 of the sleeve.
  • the annular body 25 serving as a blocking element is also in the locked position because the tongue parts 45 of the raised lugs of the disc 35 prevent the movement of the annular body 25.
  • This condition is in Fig. 9 shown.
  • the cap member 13 of the vial 5 and the annular body 25 introduces.
  • the mandrel 37 perforates the opening portion 48 of the vial 5 and the cap portion 13 comes into contact with a driving nose 53 at the tongue portions 43.
  • the tongue parts 43, 45 are deflected for the unlocking process.
  • the annular body 25 is movable toward the disk 35 of the removal device 27, the tongue parts 41, 43, 45 of the straps being guided in guide channels 55 of the annular body 25 in such a manner that the detents 49 on the tongue parts 41 are received in the locking groove 51 of the sleeve 9 to be dug.
  • the achievement of this condition is in Fig. 13 shown.
  • Fig. 14 shows the vial 5 are further retracted with the cap member 13, wherein the ring body 25 is entrained, which in turn abuts the disc 35 of the removal device 27 and entrains them for the opening movement, see Fig. 4
  • the piercing spike 37 also perforates the opening area 50 of the infusion container 1.
  • the piercing hollow mandrel 37 has for a removal operation via two parallel to the respective injection direction withdrawal channels.
  • a further locking groove 57 for forming a catch for the removal device 27 in the end position at the conclusion of the connection process, as shown in FIGS. 15 and 16 is shown.
  • the noses 47 which, like Fig. 5 shows, above the disc 35 protrude inwardly, a snap connection with the cap member 13 by overlapping its free from the recesses 21 edge 59, see Fig. 16 , As a result, the vial 5 is secured in a form-fitting manner to the connecting device 7 when the end position of the removal process is reached.
  • FIGS. 17 to 25 illustrate in the manner of function sketches envisaged in the embodiment shown encryption system.
  • Fig. 17 shows that on the circumference of the cap part 13, which has the shape of a Reuleaux triangle with rounded corners, a coding region is provided on each triangle side, each coding region having two groups 61 and 63 with coding positions and the groups 61, 63 by a code-free one Intermediate area 65 are spatially offset from each other. Since the same code groups 61, 63 are provided on each side of the triangle with codepositions equally selected for the formation of a relevant key, the key element can be inserted in three positions (orientations) into a lock coded in the same way.
  • the coding of code positions of one of the groups 61, 63 characterizes the filling volume of the respective vial 5, while the other group 61 or 63 represents the type of an ingredient of a container.
  • the coding on the cap part 13 is formed in each case by recesses 21 provided within the groups 61, 63.
  • the sketchy representation of Fig. 17 is the raw state shown without coding by recesses 21.
  • the coding in the respective group 61 denotes the type of a container substance, for example the type of a container in the infusion bottle 1 located solvent
  • the coding of the group 63 denotes a volume, for example, the volume of a solvent to which a substance contained in the vial 5 is added or may be added.
  • the annular body 25 forming the lock correspondingly identifies the projections 31 for the respective coding groups 61, 63 the volume of the infusion bottle 1 or the type of container contents, for example of the special solvent present in the infusion bottle 1.
  • Fig. 18 shows an example in which the cap member 13 signals through a recess 21 in a first coding position of the group 61 that the vial 5 is intended for supply to an ingredient A of the bottle 1, while the group 63 contains no recess 21, which in turn signals that the bottle 1 contains a certain volume of solvent.
  • a recess 21 is formed over a plurality of coding positions, which signals a different volume of solvent, while a depression in the groups 61 at one opposite Fig. 18 deviating coding position another solvent, such as a solvent B signals, for example, 50 ml, corresponding to the recess in the group 63rd
  • FIGS. 20 to 22 show examples in which the vial 5 signals by longer recesses 21 in the groups 61 that it is intended for both the media supply to a solvent A and to a solvent B in the bottle 1.
  • a recess 21 in the groups 63 is signaled at the same time that the addition is intended only for a certain volume of solvent in the bottle 1, for example, 250 ml.
  • the example of Fig. 21 in that the vial 5 can be combined with a bottle 1 containing the solvent A with 250 ml.
  • Fig. 22 shows, however, the combination is not possible with a bottle 1 containing the solvent B with a different volume, for example 50 ml.
  • FIGS. 20 to 22 clarify the FIGS. 23 to 25 Examples in which the vial 5 signals through a recess 21 in only one coding position of the group 61, that the vial 5 is intended only for a solvent A in the bottle 1, but that is signaled by a recess 21 via two coding of the group 63 in that the combination is allowed over a larger volume range, for example for 100 to 250 ml of the solvent.
  • Fig. 24 shows, the vial 5 to an infusion bottle with the solvent A at 250 ml volume fits.
  • Fig. 25 shows that the combination is excluded both for another solvent B and for another solvent volume.
  • FIGS. 26 to 28 clarifies in sketchy representation further possibilities of shaping the outline of the uncoded key element, wherein Fig. 26 which shows in the embodiment described so far selected triangular shape, while Fig. 27 a different, non-circular outline shape in the form of a kind of ellipse 69 shows.
  • Fig. 28 shows, in a circular outline, shape irregularities, such as a pattern of protrusions and depressions, of which in the Fig. 28 only a projection 71 is shown, may be provided, which in turn may be provided in mutually remote groups.
  • the key-lock connection is possible only in a unique, relative insertion position (orientation), while in the in Fig.
  • the Fig. 29 illustrates in highly simplified schematic representation of an embodiment in which the piercing hollow mandrel 37 carrying body 73 of the removal device itself forms a kind of pot, which forms with its inner wall 75, the lock element into which the cap member 13 of the vial 5 with suitable coding is used so that the cap member 13 when applied to the body 73 moves this for the perforation. Since the body 73 is guided during the movement with its circumferential rib 75 in a threaded track 77 of the sleeve of the receptacle 9, the perforation process is advantageously carried out under a rotational movement of the piercing spigot 37th
  • the Fig. 30 illustrates in a highly schematically simplified representation of another embodiment of the key lock design.
  • the sleeve body forming the receptacle 9 of the connection device and the body 73 of the removal device carrying the piercing spike 37 are already preassembled on the vial 5, although its opening region 48 has not yet been pierced.
  • the coding of the key-lock system provides a pin 79 or more pins on the body, which are retractable into corresponding holes 61 which are formed as a lock on the neck portion 8 of the bottle 1 in a coded arrangement.
  • FIGS. 31 and 32 sees as a key on the cap portion 13 of the vial 5, a pattern of axial bores 83 and a corresponding pattern of pins 85 on the carrier 73 of the piercing mandrel 37 before.
  • the cap member 13 can be applied to latch members 87 to release the locking of the body 73 on the receptacle 9 so that it can be moved by inserting the vial 5 for the connection process.
  • FIGS. 33 and 34 sees for unlocking the mandrel 37 carrying body 73 in Fig. 34 separately shown ring 89 of elastically interconnected pressure bodies 91 before. These can be opened up by the cap part 13 of the vial 5, which can be inserted with the appropriate coding, in such a way that the one formed on the bottle neck 1 Enclosure 93 of the body 73 is expanded, as indicated by arrows 95, so that the body 73 is released from a step 97 of the enclosure 93 for the movement and opening movement.
  • all types of media-carrying and media-containing containers which also include tube systems in the broadest sense, can be coupled to one another in a sterile and fluid-tight manner for media exchange.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Branching, Merging, And Special Transfer Between Conveyors (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Apparatus For Making Beverages (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP15721575.7A 2015-05-06 2015-05-06 Behälter-entnahmesystem Active EP3291786B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL15721575T PL3291786T3 (pl) 2015-05-06 2015-05-06 System pobierania z pojemników

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2015/000921 WO2016177383A1 (de) 2015-05-06 2015-05-06 Behälter-entnahmesystem

Publications (2)

Publication Number Publication Date
EP3291786A1 EP3291786A1 (de) 2018-03-14
EP3291786B1 true EP3291786B1 (de) 2019-07-10

Family

ID=53174971

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15721575.7A Active EP3291786B1 (de) 2015-05-06 2015-05-06 Behälter-entnahmesystem

Country Status (14)

Country Link
US (1) US10932990B2 (ko)
EP (1) EP3291786B1 (ko)
JP (1) JP6595620B2 (ko)
KR (1) KR102444990B1 (ko)
CN (1) CN107567325B (ko)
AU (1) AU2015393961B2 (ko)
BR (1) BR112017022694B1 (ko)
CA (1) CA2984968A1 (ko)
ES (1) ES2749427T3 (ko)
MX (1) MX2017013994A (ko)
PL (1) PL3291786T3 (ko)
RU (1) RU2696486C2 (ko)
SG (1) SG11201708573UA (ko)
WO (1) WO2016177383A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2702333C2 (ru) * 2015-05-06 2019-10-08 Кохер-Пластик Машиненбау Гмбх Система перемещения содержимого контейнеров
CN109297893B (zh) * 2018-10-26 2021-03-12 竹田（无锡）汽配制造有限公司 一种用于汽车零部件检验的加速热老化试验装置
EP3747421A1 (de) * 2019-06-06 2020-12-09 Fresenius Kabi Deutschland GmbH Als infusionsbeutel ausgebildete medizinische verpackung sowie verfahren zum überführen der flüssigkeit aus einem vial in einen infusionsbeutel

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114411A (en) * 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
JPH04329956A (ja) * 1991-04-30 1992-11-18 Takeda Chem Ind Ltd 個別密封容器に収容した薬剤の無菌保持混合装置
JP2605345Y2 (ja) * 1992-05-01 2000-07-10 株式会社大塚製薬工場 薬剤容器
CN2149899Y (zh) * 1993-06-19 1993-12-22 张振桥 一次性多种药液快速汲送混合器
JP3493198B2 (ja) * 1993-06-28 2004-02-03 味の素ファルマ株式会社 医療用容器
JPH08126683A (ja) * 1994-10-31 1996-05-21 Fujisawa Pharmaceut Co Ltd 輸液用容器
GB9611562D0 (en) * 1996-06-03 1996-08-07 Applied Research Systems Device
FR2753624B1 (fr) * 1996-09-25 1999-04-16 Biodome Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue
DE10142450C1 (de) * 2001-08-31 2003-06-18 Aventis Behring Gmbh Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen
CN2745587Y (zh) * 2004-06-24 2005-12-14 霍平安 内压式粉针剂自动预混加药注射器
US20060235364A1 (en) * 2005-04-13 2006-10-19 Wizard Med, Llc Needle-less fluid delivery assembly and error prevention system
MX344382B (es) * 2009-10-23 2016-12-14 Amgen Inc * Adaptador de vial y sistema.
WO2012085017A2 (en) * 2010-12-22 2012-06-28 Sanofi-Aventis Deutschland Gmbh Dedicated cartridge
WO2012128115A1 (ja) * 2011-03-18 2012-09-27 テルモ株式会社 穿刺針一体型アダプタ
CN102283774B (zh) * 2011-09-14 2013-05-08 重庆莱美药业股份有限公司 带双针加药器的软瓶
US20140005629A1 (en) * 2012-06-29 2014-01-02 Hospira, Inc. Medicament admixing system
FR3001953B1 (fr) * 2013-02-14 2016-01-01 Transformation Des Elastomeres A Usages Medicaux Et Ind Soc D Dispositif de fixation pour obturer un reservoir de produit fluide.
WO2015075221A1 (en) 2013-11-25 2015-05-28 Xellia Pharmaceuticals Aps Container system for intravenous therapy
RU2702333C2 (ru) * 2015-05-06 2019-10-08 Кохер-Пластик Машиненбау Гмбх Система перемещения содержимого контейнеров

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
RU2017139786A (ru) 2019-06-06
JP2018521709A (ja) 2018-08-09
BR112017022694A2 (pt) 2018-07-17
KR102444990B1 (ko) 2022-09-20
EP3291786A1 (de) 2018-03-14
JP6595620B2 (ja) 2019-10-23
KR20180030779A (ko) 2018-03-26
RU2017139786A3 (ko) 2019-06-06
CN107567325B (zh) 2020-09-22
BR112017022694B1 (pt) 2021-12-14
CA2984968A1 (en) 2016-11-10
US10932990B2 (en) 2021-03-02
CN107567325A (zh) 2018-01-09
AU2015393961B2 (en) 2020-04-09
US20180153772A1 (en) 2018-06-07
ES2749427T3 (es) 2020-03-20
PL3291786T3 (pl) 2019-12-31
AU2015393961A1 (en) 2017-12-07
MX2017013994A (es) 2018-03-14
SG11201708573UA (en) 2017-11-29
WO2016177383A1 (de) 2016-11-10
RU2696486C2 (ru) 2019-08-02

Similar Documents

Publication Publication Date Title
DE69724537T2 (de) Verbesserte Phiolenverbindung für einen Arzneimittelbehälter
EP2678054B1 (de) Injektionsspritzenkopf, auspresseinheit sowie daraus gebildete injektionsspritze
DE68909906T2 (de) Einwegspritze.
DE60019446T2 (de) Flüssigkeitstransferset für phiolen und andere medizinische behälter
DE69502357T2 (de) Injektionsmodul für eine spritze
EP2531164B1 (de) Vorrichtung zum entnehmen eines fluids aus einem behälter
DE69513920T2 (de) Spritze mit zurückziehbarer Nadel
DE60011386T2 (de) Injektionsspritze zur einmaligen Verwendung
DE69626413T2 (de) Medizinisches ventil mit ringartiger dichtung
DE69922147T2 (de) Gleitende wiederherstellungsvorrichtung für einen verdünnungsmittelbehälter
DE69324115T2 (de) Sicherheitsspritze
DE60315006T2 (de) Vorrichtung zum mischen von medizinischen flüssigkeiten
DE69812542T2 (de) Sicherheitseinwegspritze
EP2688603B1 (de) Behälter, haltevorrichtung, haltesystem und injektionshilfe
WO2009112489A1 (de) Mischvorrichtung
EP2556013B1 (de) Vorrichtung zum öffnen einer ampulle
EP2826457B1 (de) Ampulle für eine medizinische Flüssigkeit und Verfahren zum Herstellen einer Ampulle
WO2006042579A1 (de) Verschlusskappe für mit medizinischen flüssigkeiten befüllte behältnisse
EP3240520B1 (de) Misch- und/oder transfervorrichtung
EP1973590A1 (de) Behälter zur einbringung zumindest eines unsterilen gefässes in einen sterilen bereich
DE602004013125T2 (de) Sicherheits-nadelschutz für spritzen
EP3291786B1 (de) Behälter-entnahmesystem
WO2016177384A1 (de) Behälter-entnahmesystem
EP4203889A1 (de) Kopplungsvorrichtung für einen adapter für ein vial, adapter für ein vial, set umfassend einen derartigen adapter und system umfassend einen derartigen adapter
EP2744468B1 (de) Adapter für eine transfervorrichtung für ein fluid sowie transfervorrichtung

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170925

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20190104

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 1152771

Country of ref document: AT

Kind code of ref document: T

Effective date: 20190715

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502015009598

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191010

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191111

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191010

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191110

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191011

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2749427

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20200320

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200224

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502015009598

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG2D Information on lapse in contracting state deleted

Ref country code: IS

26N No opposition filed

Effective date: 20200603

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200531

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200531

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20200531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200506

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200506

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20210318

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200531

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20210304

Year of fee payment: 7

Ref country code: GB

Payment date: 20210304

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20210531

Year of fee payment: 7

Ref country code: IT

Payment date: 20210507

Year of fee payment: 7

Ref country code: NL

Payment date: 20210517

Year of fee payment: 7

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20210520

Year of fee payment: 7

Ref country code: ES

Payment date: 20210603

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190710

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 502015009598

Country of ref document: DE

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20220601

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 1152771

Country of ref document: AT

Kind code of ref document: T

Effective date: 20220506

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20220506

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220506

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220506

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20221201

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20230626

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220506

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220507

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220506