EP2247737A4 - Milieux de fermentation et procédés associés - Google Patents

Milieux de fermentation et procédés associés

Info

Publication number
EP2247737A4
EP2247737A4 EP09719471A EP09719471A EP2247737A4 EP 2247737 A4 EP2247737 A4 EP 2247737A4 EP 09719471 A EP09719471 A EP 09719471A EP 09719471 A EP09719471 A EP 09719471A EP 2247737 A4 EP2247737 A4 EP 2247737A4
Authority
EP
European Patent Office
Prior art keywords
processes
medias
fermentation
fermentation medias
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09719471A
Other languages
German (de)
English (en)
Other versions
EP2247737A2 (fr
EP2247737B1 (fr
Inventor
Sanjay Tiwari
Mukesh Babuappa Patale
Saurabh Garg
Mayank Kumar Garg
Sulekha Joshi
Chittnalli Ramegowda Naveen Kumar
Bimal Kumar
Anuj Goel
Harish Iyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocon Ltd
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Priority to EP12008006.4A priority Critical patent/EP2565272A3/fr
Publication of EP2247737A2 publication Critical patent/EP2247737A2/fr
Publication of EP2247737A4 publication Critical patent/EP2247737A4/fr
Application granted granted Critical
Publication of EP2247737B1 publication Critical patent/EP2247737B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
EP09719471.6A 2008-02-06 2009-02-05 Milieux de fermentation et procédés associés Not-in-force EP2247737B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12008006.4A EP2565272A3 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés correspondants

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN310CH2008 2008-02-06
IN86CH2009 2009-01-12
PCT/IN2009/000078 WO2009113099A2 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés associés

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP12008006.4A Division-Into EP2565272A3 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés correspondants

Publications (3)

Publication Number Publication Date
EP2247737A2 EP2247737A2 (fr) 2010-11-10
EP2247737A4 true EP2247737A4 (fr) 2012-03-14
EP2247737B1 EP2247737B1 (fr) 2018-06-20

Family

ID=41065638

Family Applications (2)

Application Number Title Priority Date Filing Date
EP12008006.4A Withdrawn EP2565272A3 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés correspondants
EP09719471.6A Not-in-force EP2247737B1 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés associés

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP12008006.4A Withdrawn EP2565272A3 (fr) 2008-02-06 2009-02-05 Milieux de fermentation et procédés correspondants

Country Status (12)

Country Link
US (2) US8927256B2 (fr)
EP (2) EP2565272A3 (fr)
JP (1) JP5587795B2 (fr)
KR (2) KR101283734B1 (fr)
CN (2) CN103642843B (fr)
BR (1) BRPI0905853B1 (fr)
IL (2) IL207402A (fr)
MX (2) MX349413B (fr)
MY (1) MY161108A (fr)
RU (3) RU2491345C2 (fr)
SG (1) SG188126A1 (fr)
WO (1) WO2009113099A2 (fr)

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RU2491345C2 (ru) 2008-02-06 2013-08-27 Байокон Лимитид Ферментационная среда и способ для получения рекомбинантных белков
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
AU2013360721A1 (en) 2012-12-21 2015-07-09 Sanofi Exendin-4 Derivatives as dual GLP1/GIP or trigonal GLP1/GIP/Glucagon Agonists
CN103911298B (zh) * 2012-12-31 2016-08-10 中粮营养健康研究院有限公司 培养基组合物和培养基及对菌株进行活菌计数的方法
WO2015086728A1 (fr) 2013-12-13 2015-06-18 Sanofi Analogues peptidiques de l'exendine 4 en tant qu'agonistes mixtes des récepteurs glp-1/gip
TW201609796A (zh) 2013-12-13 2016-03-16 賽諾菲公司 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／升糖素受體促效劑
EP3080154B1 (fr) 2013-12-13 2018-02-07 Sanofi Agonistes doubles du récepteur glp-1/gip
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
DE102014216863B4 (de) 2014-08-25 2019-08-01 Hansgrohe Se Kopfbrause
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
AU2016340880A1 (en) 2015-10-20 2018-05-10 Buckman Laboratories International, Inc. Method to enhance yeast growth for fermentative bioproduct production, and nutrient composition for same
CN108474773A (zh) * 2016-01-23 2018-08-31 拜康有限公司 胰岛素类似物的生物分析方法
CN107022591B (zh) * 2017-05-11 2018-06-12 宜昌东阳光长江药业股份有限公司 一种提高胰岛素及其类似物前体表达的毕赤酵母发酵方法
WO2018216978A1 (fr) * 2017-05-22 2018-11-29 Cj Healthcare Corporation Procédé de culture cellulaire à basse température applicable à la production en masse de protéine
CN107988292B (zh) * 2018-01-18 2023-12-26 江苏江山聚源生物技术有限公司 提高重组人源胶原蛋白稳定性的发酵工艺
CN111411049B (zh) * 2020-04-15 2022-11-22 北京惠之衡生物科技有限公司 一种提高胰岛素前体表达的毕赤酵母的发酵培养基及发酵方法
CN111996136A (zh) * 2020-07-24 2020-11-27 北大方正集团有限公司 一种荧光假单孢杆菌发酵培养基、培养方法与应用
CN114507609B (zh) * 2020-12-22 2023-04-18 益海嘉里(连云港)生物科技有限公司 一种提高磷脂酶c蛋白产量的方法

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WO2009061225A1 (fr) * 2007-11-05 2009-05-14 Skotan Spolka Akcyjna Nouvelle souche de yarrowia lipolytica et son utilisation dans la réutilisation industrielle de fractions de glycérol obtenues au cours de la production de biodiesel

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WO2000056903A2 (fr) * 1999-03-22 2000-09-28 Zymogenetics, Inc. Methodes ameliorees de production de proteines dans la pichia transformee
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EP1323831A1 (fr) * 2001-12-28 2003-07-02 CJ Corporation Corynebacteria surproductant acide 5'-xanthylique
WO2008026883A1 (fr) * 2006-08-29 2008-03-06 Chung Choung Buk Do Procédé de production en série d'acide mycophénolique avec utilisation d'urée comme source d'azote
WO2009061225A1 (fr) * 2007-11-05 2009-05-14 Skotan Spolka Akcyjna Nouvelle souche de yarrowia lipolytica et son utilisation dans la réutilisation industrielle de fractions de glycérol obtenues au cours de la production de biodiesel

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Title
DALY R ET AL: "EXPRESSION OF HETEROLOGOUS PROTEINS IN PICHIA PASTORIS: A USEFUL EXPERIMENTAL TOOL IN PROTEIN ENGINEERING AND PRODUCTION", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 18, no. 2, 1 March 2005 (2005-03-01), pages 119 - 138, XP009059265, ISSN: 0952-3499, DOI: 10.1002/JMR.687 *
HERMAN SURYADI ET AL: "Polyol production by culture of methanol-utilizing yeast", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 89, no. 3, 1 January 2000 (2000-01-01), pages 236 - 240, XP055018120, ISSN: 1389-1723, DOI: 10.1016/S1389-1723(00)88825-8 *
PESSOA-JNIOR ET AL: "Evaluation of sugar cane hemicellulose hydrolyzate for cultivation of yeasts and filamentous fungi.", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, vol. 18, no. 6, 1 June 1997 (1997-06-01), pages 360 - 363, XP055018140, ISSN: 1367-5435 *
See also references of WO2009113099A2 *
XIUPING HE ET AL: "Ergosterol production from molasses by genetically modified Saccharomyces cerevisiae", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, vol. 75, no. 1, 16 January 2007 (2007-01-16), pages 55 - 60, XP019513637, ISSN: 1432-0614, DOI: 10.1007/S00253-006-0807-6 *

Also Published As

Publication number Publication date
IL207402A (en) 2013-07-31
US8927256B2 (en) 2015-01-06
CN101983242A (zh) 2011-03-02
RU2556120C2 (ru) 2015-07-10
JP5587795B2 (ja) 2014-09-10
IL207402A0 (en) 2010-12-30
RU2491345C2 (ru) 2013-08-27
EP2565272A2 (fr) 2013-03-06
BRPI0905853A2 (pt) 2015-06-30
US20100317056A1 (en) 2010-12-16
KR101492011B1 (ko) 2015-02-10
RU2012145969A (ru) 2014-05-10
JP2011510677A (ja) 2011-04-07
KR20100118592A (ko) 2010-11-05
RU2595380C2 (ru) 2016-08-27
CN101983242B (zh) 2015-12-16
WO2009113099A2 (fr) 2009-09-17
SG188126A1 (en) 2013-03-28
RU2011153811A (ru) 2013-07-10
CN103642843A (zh) 2014-03-19
MX2010008654A (es) 2010-10-06
MX349413B (es) 2017-07-19
RU2010137009A (ru) 2012-03-20
US20140141467A1 (en) 2014-05-22
KR101283734B1 (ko) 2013-07-08
BRPI0905853A8 (pt) 2019-01-29
WO2009113099A3 (fr) 2009-11-05
IL221379A (en) 2013-08-29
US9255285B2 (en) 2016-02-09
BRPI0905853B1 (pt) 2019-03-26
EP2565272A3 (fr) 2013-07-03
KR20120066068A (ko) 2012-06-21
IL221379A0 (en) 2012-10-31
EP2247737A2 (fr) 2010-11-10
EP2247737B1 (fr) 2018-06-20
MY161108A (en) 2017-04-14
CN103642843B (zh) 2017-03-01

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