EP2066373A1 - Spritzwassergeschütztes injektionsgerät - Google Patents
Spritzwassergeschütztes injektionsgerätInfo
- Publication number
- EP2066373A1 EP2066373A1 EP07720137A EP07720137A EP2066373A1 EP 2066373 A1 EP2066373 A1 EP 2066373A1 EP 07720137 A EP07720137 A EP 07720137A EP 07720137 A EP07720137 A EP 07720137A EP 2066373 A1 EP2066373 A1 EP 2066373A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sleeve
- housing
- relative
- feed
- dose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31536—Blocking means to immobilize a selected dose, e.g. to administer equal doses
- A61M2005/3154—Blocking means to immobilize a selected dose, e.g. to administer equal doses limiting maximum permissible dose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
Definitions
- the present invention relates to a device for administering a fluid product.
- the device may be designed as an injection device for injecting an adjustable dose of the product and in particular in the form of an injection pen, i. of a compact pen-shaped injection device.
- the prior art discloses a large number of injection devices for metered administration of medicaments, such as insulin, growth hormones or osteoporosis preparations, which have to be administered regularly.
- medicaments such as insulin, growth hormones or osteoporosis preparations
- Such devices should reliably and precisely dispense a presettable dose.
- they should be highly user-friendly and user-friendly. This is even more so since they are usually operated by the patient himself.
- the medicament can be accommodated in a replaceable container in the form of a carpule which can be inserted into a carpule holder. This can then be attached to a housing of the injection device, for example by a screw or a bayonet connection.
- a conveyor with a conveying element in the form of a piston rod.
- compact pen-shaped administration devices are known in which the distribution takes place automatically after a first triggering ("power-assisted pens").
- the dose is usually preset in such devices by a rotation on a Dosierknopf.
- the device has a drive, eg a spring drive, which is tensioned when setting the dose.
- the device is triggered by pressing in a triggering device, which may be identical to the dosing button.
- the drive generates a drive movement, for example in the form of a rotational movement, which is converted into a propulsion movement of the piston rod.
- the piston rod is usually formed as a threaded rod on which a drive nut runs.
- DE-A 10 2004 063 644, DE-A 10 2004 063 647, WO-A 2004/002556 and DE-A 102 29 122 disclose injection devices which represent general state of the art for the present invention.
- the piston rod When changing the container, the piston rod may inadvertently come into contact with liquids, be it by accidentally displaced glass with a drink, or by a broken container containing the liquid medication. As a result, liquid can penetrate into the interior of the injection device and impair its function.
- the device according to the invention for administering a fluid product thus comprises a housing and a conveying element for conveying the product from a reservoir.
- the conveyor element extends outwardly from the interior of the housing and is movable relative to the housing.
- the conveying element with respect to the housing or a housing-fixed element is liquid-tight, at least splash-proof, sealed. This effectively prevents ingress of liquids.
- a corresponding seal may be formed directly between the conveyor element and the housing. But it is also conceivable that a first seal between the conveying element and a member which is movable relative to the housing, is formed, and a second seal between the movable member and the housing is formed.
- the movable element can e.g. be arranged so that it is movable only during a change of the reservoir and is immobile during the actual administration to the housing. It may in particular be sleeve-shaped.
- the conveying element has a substantially smooth, cylindrical see, preferably circular cylindrical outer wall area, which is surrounded by at least one annular sealing element.
- the length of the smooth outer wall region corresponds at least to the distance between the distal end position and the proximal starting position, between which the conveying element is movable during the course of administration in order to ensure a seal over this entire region.
- a "substantially smooth" outer wall region is to be understood as meaning an area in which there are no structures such as threads or grooves that could oppose an efficient sealing effect.
- the outer wall area can have very fine structures, in particular in the region below 100 micrometers, preferably below 10 micrometers which are suitable for at least not impairing or even improving the sealing effect, for example a microstructure or nanostructuring. These structures may have a preferred direction to inhibit the flow of liquids.
- the at least one annular sealing element preferably comprises at least one circumferential, flexible sealing lip, which rests on the cylindrical outer wall area and acts as a wiper in the manner of a windshield wiper.
- the contact angle between the sealing lip and the outer wall region is preferably less than 90 degrees. It may, however, be e.g. also be designed as a ring with a round or polygonal cross-section.
- the conveying element is preferably guided rotatably relative to the housing.
- a seal is simplified compared to a conveying element that performs a combined translational and rotational movement.
- the conveying element is preferably driven by a rotary movement, e.g. via a threaded connection with a rotatable element.
- the administering device preferably comprises a drive device for generating the rotational movement relative to the housing, wherein the rotational movement in a suitable manner causes a feed movement of the conveying element along the feed axis.
- the conveying element in a preferred embodiment has an internal thread, whose threaded axis extends along the feed axis. Characterized the thread used for the drive is moved inwards, and it is adapted to the needs of the sealing design of the outside of the conveyor element allows.
- This threaded element is preferably fixed relative to the housing along the feed axis and of the drive device in a Rotary movement displaceable about the feed axis to advance the conveyor element along the feed axis.
- the interior of the housing is completely sealed liquid-tight against the outside of the housing, so not only in the area in which the conveying element is guided to the outside, but also in other areas, e.g. in the range of moving dosing or actuating elements.
- the delivery element and / or an e-element sealingly cooperating therewith may be made of a hydrophobic material or may be hydrophobic coated in order to achieve or improve a sealing effect by avoiding capillary creep.
- the device can furthermore have at least one ball bearing, which absorbs forces transmitted between the conveying element and the housing.
- at least one ball bearing By providing a ball bearing, frictional losses caused during administration due to the transfer of forces between the impeller and the housing are substantially minimized.
- a ball bearing is particularly advantageous if the device comprises at least one rotatable element cooperating with the conveying element and a drive device for generating a rotational movement of the rotatable element relative to the housing, wherein the rotational movement of the rotatable element along (preferably linear) advancing movement of the conveying element along a feed axis in a distal direction causes, preferably by a threaded engagement, which is preferably non-blocking.
- the ball bearing is advantageously arranged such that it receives along the feed axis acting (axial) forces, which are transmitted from the (preferably non-rotatable) relative to the housing conveying element on the rotatable element on the housing, ie between the rotatable element and the Housing act.
- axial, in particular transmitting forces acting in the proximal direction between the conveyor element and the housing via a rotatable and axially displaceable connection In the prior art, a sliding connection between the rotatable element and the housing or a housing-fixed element is usually provided for this purpose. In the present invention, however, at least one ball bearing is provided, which is preferably arranged between the rotatable element or an associated element on the one hand and the housing or on the other hand at least during the administration housing-fixed element. As a result, friction losses can be avoided during the rotation of the rotatable element.
- ball bearings which are preferably arranged to provide forces along the feed axis in both the proximal direction and the opposite distal direction, i. the direction in which the feed takes place can record.
- Axial forces in the proximal direction usually arise during administration, while axial forces in the distal direction can arise, in particular, when the delivery element is spring-loaded in the distal direction, as is the case in a preferred embodiment.
- the spring serving for it is preferably so weak that it does not cause expulsion of the product from the reservoir. Rather, it serves to automatically bring the conveying element into its distal end position during a reservoir change, ie to extend it completely when the reservoir is removed from the housing.
- the device can be configured as follows:
- the conveying element is designed sleeve-shaped with a proximal and a distal end and has an internal thread.
- the conveying element is located along the thrust direction rotatably guided relative to the housing. It is (axially) movable between a proximal and a distal end position along the feed direction.
- the rotatable element has an external thread which cooperates with the internal thread of the conveying element.
- such an internal threaded conveying element is surrounded radially at least partially by a guide sleeve having a proximal end and a distal end.
- the length of this guide sleeve preferably corresponds at least to the maximum feed area of the conveying element, i. the distance between the distal and the proximal end position of the conveying element.
- the guide sleeve is rotatably connected at least during administration with the housing or a housing-fixed element.
- the conveyor element is rotatably guided along the feed direction in the guide sleeve.
- the conveying element is at least in the region of its proximal end with the interior of the guide sleeve in a rotationally fixed engagement, but allows an axial displacement.
- an engagement structure projecting radially outwardly from the outer circumferential surface of the conveying element, e.g. in the form of a plurality of longitudinal ribs, formed with a complementary structure, e.g. in the form of a plurality of longitudinal grooves, cooperating on the inner peripheral surface of the guide sleeve.
- the device then preferably further comprises an outer sleeve having a proximal and a distal end which in turn at least partially radially surrounds the guide sleeve.
- this outer sleeve is connected to the rotatable element. Near its distal end, the outer sleeve is guided rotatably and non-displaced relative to the guide sleeve via the at least one ball bearing.
- the conveyor element should be secured against rotation relative to the stationary housing and longitudinally guided.
- the conveying element is preferably substantially smooth on its outer side or on others Way can be configured arbitrarily. This implies that the conveying element is longitudinally guided only in the region of its proximal end in a rotationally fixed to the housing element. However, this in turn requires that this non-rotatable element is at least as long that the guide is ensured over the entire range of the feed of the conveying element.
- a sleeve-like structure of the rotationally fixed member is chosen, which is therefore referred to as a guide sleeve, with a length of this guide sleeve which corresponds at least to the feed region of the conveying element.
- the rotatable element To drive the conveying element, the rotatable element must furthermore be arranged in the interior of the conveying element. In order to ensure a threaded engagement over the entire feed area, the rotatable element must extend at least over a length from proximal to distal in the conveying element, which corresponds to the feed area. The only available access to the rotatable element consists of the proximal end. A drive of the rotatable element must therefore take place via its proximal end.
- the rotatable element must be supported in any way relative to a housing-fixed element.
- This bearing must be able to absorb axial forces, as axial forces are transmitted from the conveyor element via the threaded engagement with the rotatable element.
- a storage could be provided directly at the proximal end of the rotatable element. However, this would take up a lot of space in an area that should be available for other tasks if possible. It is therefore desirable to move the location of storage to another location, as close as possible to one of the ends of the housing. This is done here with the help of the outer sleeve, which is firmly connected to the rotatable element and this quasi continues along the outside of the guide sleeve to the distal direction.
- the storage then takes place between the outer sleeve and the guide sleeve, in the region of the distal end of the outer sleeve.
- a very compact unit is created, the radially relatively much space-demanding storage comes to rest in a proximal region, where it only slightly disturbs, and which makes it possible in the radial gap between the outer sleeve and the housing further elements of the Housing injection device.
- outer sleeve (and thus ultimately the rotatable element) is mounted on the guide sleeve and not on the housing itself, that the entire unit of guide sleeve, outer sleeve, bearing, rotatable member and conveyor element relative to the Housing specifically designed to be movable, for example in the context of a container change.
- the reservoir is preferably held in a container holder, which is releasably attachable to the housing. When fastening, it is preferably guided relative to the housing such that it performs a combined rotational movement about an axis of rotation and translational movement along the axis of rotation relative to the housing.
- the device then preferably further comprises a spring element and a latching element. These elements are arranged such that the spring element generates a spring force acting essentially along the axis of rotation on the latching element. The latching element thereby causes in a predetermined holding position of the container holder a releasable latching connection, by which the container holder is fixed relative to the housing.
- the latching connection is preferably designed so that it is by a movement of the container holder relative to the housing, which is opposite to the movement in the fastening, again detachable, i. the locking connection does not need to be unlocked manually.
- connection in the manner of a screw or preferably bayonet connection between the container holder and the housing or between them connected to these elements In customary bayonet connections between two elements, an element with a bayonet pin in a suitably shaped slot or in a corresponding groove is guided in the manner of a slot guide of the other element until the bayonet pin reaches an end position (corresponding to the holding position). In such compounds, the problem is an unintentional To avoid sliding back of the pin out of the end position.
- screw which are fixed by a clamping force and can also solve unintentionally.
- the present embodiment solves this problem by providing an axially spring loaded (and axially movable) detent member.
- Such a locking element ensures a defined fixation of the container holder in the holding position, without the risk of unintentional release exists.
- the connection is only solvable by overcoming a sufficiently large force. This wear, which could lead to a leaching of the connection, avoided.
- the latching element is spring-loaded in the axial direction, a simple and space-saving design of the locking element and the spring element is made possible.
- the container will be a container with a cylindrical wall region and a plug which can be displaced therein, a so-called carpule, which defines a longitudinal direction and is accommodated in a container holder with a correspondingly elongate shape.
- the container holder When mounting on the housing, the container holder is preferably rotated about this longitudinal direction, i. the axis of rotation coincides with the longitudinal axis.
- the stopper is advanced through the conveying element along the longitudinal direction. More generally, thus preferably, the feed direction of the conveying element corresponds to a direction along the axis of rotation about which the container holder is rotated during its attachment.
- the locking element is rotatably relative to the housing and releasably locked in the locking position with an element which is rotationally fixed relative to the container holder.
- the locking element does not follow the rotation of the container holder, but remains in the fastening of the container holder rotationally fixed to the housing.
- the reverse arrangement is conceivable in which the locking element is rotatably relative to the container holder.
- the device comprises a driving element.
- the entrainment element is guided relative to the housing in such a way that it is entrained by the container holder when the container holder is fastened to the housing and when the container holder is detached from the housing, and is set in motion which comprises a rotational movement about the axis of rotation.
- the conveying element is then preferably sealed by a first seal against the driving element, and the driving element is sealed by a second seal relative to the housing.
- the entrainment element can be fixable relative to the housing in at least one predetermined position, for example via a detachable latching connection, as described above.
- the carrier element then holds the container holder.
- the container holder is thus fixed indirectly, via the driving element, relative to the housing in this case.
- the device comprises a relative to the housing rotatably arranged guide element, which may be formed in particular as a guide sleeve.
- This guide member may be rigidly connected to the housing, in particular be made in one piece with this, or it may be axially displaceable relative to the housing.
- the driving element which can also be configured as a sleeve and can then be referred to as a bayonet sleeve, is at least rotatably connected to the guide element.
- the spring element and the latching element are preferably arranged rotationally fixed relative to the guide element, and the latching element is releasably latched in the holding position of the container holder with the driving element.
- the guide element relative to the housing rotatably and axially displaceable and the driving element, although rotatably, but be axially fixed to be connected to the guide element.
- This configuration makes it possible for further parts of the device arranged in the housing, which are connected to the guide element, to be displaced axially when the container holder is attached to the housing.
- the administration device can automatically be used, for example, when the container holder is released. reset and brought back to a ready state when attaching the container holder.
- the container holder when releasing the container holder, to move the interior of the device (in particular the drive device and optionally a triggering device connected thereto) in a distal direction so that the triggering device, which can be configured as a pushbutton, can move into the device Housing is retracted and indicates that the device is not ready.
- the triggering device which can be configured as a pushbutton
- the carrier element is preferably guided relative to the housing such that it is entrained by the container holder when the container holder is fastened to the housing and offset relative to the housing in a combined rotational movement about the axis of rotation and translation along the axis of rotation in a proximal direction.
- the driving element between two defined end positions is movable, and the locking element causes in both positions a releasable locking connection, by which the driving element is fixed relative to the housing.
- the driving element assumes its first end position when the container holder assumes its holding position, and it assumes its second end position when the container holder is removed from the housing.
- the latching element is releasably latched in both the first end position and in the second end position directly to the driving element.
- the entrainment element is preferably in at least one guide slot relative to the housing, i. on the actual housing itself or on a housing-fixed element, guided, in particular by one or more corresponding pin.
- the container holder when mounting on the housing in at least one guide slot, guided in the manner of a bayonet connection, relative to the housing.
- the latching element is preferably designed in the form of a ring which extends around the axis of rotation and in particular around the feed element. stretches. On the ring suitable locking lugs may be formed.
- This locking element can be axially spring-loaded by a separate spring element. This may be, for example, a pressure-loaded coil spring or another type of elastic element.
- the spring element preferably has the form of a ring which extends around the axis of rotation and is curved about an axis perpendicular to the axis of rotation, so that the spring force is generated by compressing the spring element along the axis of rotation.
- the locking element is formed integrally with the spring element.
- the locking element may be formed as a projecting in the direction of the axis of rotation projection on the spring element. This is particularly advantageous if the spring element, as described above, has the shape of a curved ring.
- FIG. 1 is an exploded perspective view of an injection device according to a first embodiment
- FIG. 2 shows a longitudinal section through the injection device of FIG. 1;
- FIG. 3 shows an enlarged detail from FIG. 2;
- FIG. 4 shows a longitudinal section through an arrangement of a guide sleeve and a coupling sleeve in the injection device of FIG. 1;
- Fig. 5A is a plan view of a ball bearing ring;
- Fig. 5B is a sectional view of the ball bearing ring in the plane A - A;
- Fig. 6 is a perspective view of a coupling sleeve;
- Fig. 9A is a plan view of a bayonet spring
- Fig. 9C is a perspective view of the bayonet spring of Fig. 9A;
- 11A is a longitudinal section through selected parts of the injection device of Figure 1 with a dose-limiting ring in its end position ..;
- FIG. 12B shows the parts of FIG. 12A in an exploded view
- FIG. 12C shows the coupling shaft of FIG. 12A in a perspective view from another viewing direction
- Fig. 13 is an exploded view of a locking sleeve, a clutch spring and a support ring;
- FIG. 14 is a perspective view of selected parts of the injection device of Fig. 1;
- FIG. 15 is an exploded perspective view of the proximal end of FIG
- FIG. 19 shows the longitudinal section of FIG. 16 after a first triggering and a second metering
- FIG. FIG. 20 shows a longitudinal section through the injection device of FIG. 1 after complete emptying of the carpule
- FIG. Fig. 21 is a longitudinal section through an injection device according to a second
- FIG. 14 the unit of FIG. 10 is shown with yet further components.
- the mechanism holder 150 On the mechanism holder 150, the previously mentioned display drum 70 is now held.
- a stop sleeve 240 can be seen.
- the stop sleeve 240 is immovably connected to the housing sleeve 20 by means of pins which project into the radial holes 242 which can be seen in FIG. 14.
- radial stops 243 are formed. Its proximal end is serrated, i.
- teeth 244 frontally formed for a ratchet connection to be described.
- the display drum 70 has an internal thread, which can be seen in FIG. This runs on the external thread 157 of the mechanism holder, which is particularly well recognizable in Figures 7 and 10. At its proximal end, the display drum 70 tapers to an annular portion 72. On the inside of the annular portion 72 longitudinal grooves are formed. With these longitudinal grooves, the display drum 70 is secured against rotation, but guided displaceably in the longitudinal direction on the longitudinal ribs 212 of the transmission sleeve 210. By combining this longitudinal guide on the transmission sleeve and the thread guide on the mechanism holder, a rotation of the transmission sleeve 210 results in a combined rotation and longitudinal displacement of the indicator drum 70. This movement is limited by radial engagement in both directions.
- the mechanism for setting a dose and triggering the administration of this dose will now be explained with reference to FIGS. 3 and 15.
- the already mentioned metering sleeve 60 is arranged. It is axially 29iebegeschreibt with a spring ring 61 and rotatably fixed to the stop sleeve 240.
- the dosing sleeve 60 is rotatable about the longitudinal axis of the housing sleeve 20 via a slip clutch in the form of a ratchet connection in both a clockwise and counterclockwise direction, wherein it can assume a plurality of predefined detent positions. This mechanism will be explained below.
- an inner ring 250 is arranged and rigidly connected to the dosing sleeve 60.
- the inner ring 250 has a plurality of longitudinal grooves in its radial inner surface.
- a ratchet ring 260 is held axially displaceably, but secured against rotation, in the dosing sleeve 60.
- the ratchet ring 260 is formed jagged on its distal end side, complementary to the teeth 244 of the serration.
- the ratchet ring 260 is axially displaceable between the distal end surface of the inner ring 250 and the serrated proximal end face of the stop sleeve 240 by a certain amount. The amount by which an axial displacement is possible is at least so great that the serrated end faces of the ratchet ring 260 and the stop sleeve 240 can disengage.
- the ratchet ring 260 is resiliently urged against the stop sleeve 240 by a spring force.
- a plurality of axial bores 251 in the form of blind holes are provided in the inner ring 250.
- pressure-loaded coil springs 252 are used. The coil springs 252 press the ratchet ring elastically against the stop sleeve.
- a latching connection which can be released resiliently by turning with a sufficient torque is produced in a plurality of predefined angular positions of the metering sleeve 60 relative to the housing sleeve 20.
- This mechanism can also be referred to as a double-slip clutch.
- a plurality of spring coils which rotate around the longitudinal axis and are arranged radially to the longitudinal axis one above the other.
- the inner end of the spiral the 310 is fastened to a spring holding region 311 of the coupling shaft 230, which is particularly clearly visible in FIG. 12C.
- the outer end of the coil spring 310 is attached to a spring sleeve 320, which is rotatably held in the stop sleeve 240.
- the metering sleeve 60 has an axial passage opening, in which the push button 80 is arranged axially displaceable.
- the push button 80 is with a plurality of radially resilient arms 81 rotatably and non-displaced clicked on the proximal end 233 of the coupling shaft 230. He pushes with its distal end against a proximal end face of the clutch disc 270.
- a coil spring 82 Inside the push button 80 is a coil spring 82, which abuts with its proximal end to the inner end face of the push button and presses with its distal end against a support ring 83.
- the support ring 83 has on its outer peripheral surface longitudinal ribs which are guided in corresponding longitudinal grooves in the inner Mantelfambae the push button 80.
- the support ring 83 in the push button 80 rotatably and axially displaceable.
- At its distal end face of the support ring 83 is formed flat jagged.
- the proximal end face of the clutch disc 270 is designed to be jagged in a complementary manner, so that the support ring 83 is axially toothed with the clutch disc 270.
- the clutch disc 270 rotates relative to the support ring 83.
- the serrated surfaces slide on each other, so that the teeth alternately into and out of engagement. This produces a distinctive click sound that indicates to the user that a takes place.
- the toothing of the support ring 83 and the clutch disc 270 is preferably designed such that each click corresponds to just one unit (or a predetermined multiple of a unit) of the administered medicament.
- the other two seals are located at the proximal end of the injection device.
- the seal D3 comprises a sealing ring which bears sealingly between the dosing sleeve 60 and the stop sleeve 240.
- the stop sleeve 240 is immovable and tightly mounted in the housing sleeve 20, while the dosing sleeve 60 against the stop sleeve 240 is rotatable.
- the seal D4 comprises a further sealing ring, which rests sealingly between the dosing sleeve 60 and the push button 80.
- a transparent te window cover 22 attached liquid-tight.
- the seal to the feed sleeve out is preferably designed such that it acts as a scraper, similar to a windscreen wiper in the car.
- at least to the distal side preferably a smallest possible contact angle between the surfaces of the sealing element and the feed sleeve. This can be below 90 degrees.
- the parts to be sealed against one another can have a hydrophobic surface, in particular be formed from or coated with a hydrophobic material.
- a hydrophobic surface prevents the parts from being wetted.
- water droplets emit water and creep of liquids through gaps between the parts to be sealed due to capillary effect is effectively prevented.
- the provided with a hydrophobic surface, against each other to be sealed parts can therefore be arranged at a certain distance (gap) to each other without the sealing effect is lost ("virtual seal").
- FIG. 16 in which the injection device is shown in its initial position before the first use.
- the above-explained mechanism for setting and dispensing a dose has three clutches K1, K2, and K3 for the transmission of torques. Each of these couplings can be brought into and out of engagement with each other by an axial movement of two components.
- the coupling K1 is formed by the longitudinal grooves on the inner surface of the axial flange 235 of the coupling shaft 230 as a coupling input member in cooperation with the longitudinal ribs 122 on the outside of the coupling sleeve 120 (see Fig. 5) as a coupling output member. In the position of FIG. 16, this coupling is disengaged, ie the teeth formed by the longitudinal grooves and longitudinal ribs is disengaged.
- the coupling K1 can be coupled by an axial displacement of the coupling shaft 230 in the distal direction.
- All three clutches K1, K2 and K3 can be engaged or disengaged by the push button 80 is moved far enough axially. Thereby a certain order is kept.
- the clutch disc 270 and the coupling shaft 230 fixedly connected to it are displaced in the distal direction.
- the clutch K1 comes into engagement, ie the clutch shaft is coupled to the coupling sleeve 120 for torque transmission.
- the coupling shaft 230 advances the transmission sleeve 210 in the distal direction. This takes the locking sleeve 280 in the distal direction, whereby the clutch spring 290 is compressed.
- the clutch spring 290 pushes the locking sleeve 280, the transmission sleeve 210, the clutch shaft 230, the clutch disc 270 and the push button 80 back into the distal starting position.
- a second unit is formed by the metering sleeve 60, the inner ring 250 and the ratcheting ring 260. It can be functionally understood as a rotatable metering device. This metering device is via the ratchet connection solvable on the housing, but held torque-resistant up to a certain value.
- a third unit is formed by the clutch disc 270, the clutch shaft 230 and the transmission sleeve 210, which are all rigidly connected to each other, and by the associated coil spring 310, which acts as the actual drive element.
- This unit can be understood as a drive device.
- the rotational movement of the drive device is limited by two limiting elements, both of which are guided on the transmission device.
- the first limiting element is formed by the display drum 70, which limits the range of movement of the drive device in both directions, a metering direction and a correction and Aus presentides.
- the second limiting element is formed by the dose-limiting ring 220, which limits the range of movement of the drive device at least in one direction, the metering direction, independently of the first limiting element.
- the drive device can be releasably coupled by means of the clutch K2 in a rotationally fixed manner to the metering device, which makes it possible to tension the drive element in the form of the spiral spring 310.
- a fourth unit comprises the coupling sleeve 120 and the threaded rod 180, which form a rigid unit, the elements on which these parts are mounted, namely the guide sleeve 110, the bearing holder 130 and the ball bearing rings 140, and the feed sleeve 90.
- This unit provides a Conveyor, which converts a rotational movement of an input member in the form of the coupling sleeve 120 in a feed of the conveying element in the form of the feed sleeve 90.
- Your input member is releasably rotatably coupled by the clutch K1 with the drive device.
- it is releasably rotatably coupled to the holding device (i.e., the housing) via the clutch K3.
- a triggering device which primarily comprises the push button 80 and serves to operate the clutches K1 to K3. functionality
- the injection device is operated as follows. Starting from the starting position of FIG. 16, a dose to be administered is initially set. For this purpose, the dosing sleeve 60 is rotated clockwise. The dosing sleeve takes over the clutch K2 the clutch disc 270 and the clutch shaft 230 with. As a result, the coil spring 310 is wound up. The resulting torque is maintained by the ratchet connection between the co-rotating ratchet ring 260 and the stationary stop sleeve 240. By the rotation of the coupling shaft 230 and the transmission sleeve 210 and the display drum 70 guided thereon are also rotated.
- the display drum 70 is also displaced axially in the proximal direction because of their thread guide on the mechanism holder 150, thus performs a total of a screw movement in the proximal direction. As a result, marks on the surface of the display drum 70 pass under the window 21 and indicate the currently set dose. Furthermore, due to its threaded engagement with the interior of the transmission sleeve 210 and due to its rotationally secured arrangement on the coupling sleeve 120, the dose limiting ring 220 is displaced in the proximal direction.
- Fig. 17 shows the injection device after half the maximum single dose has been set.
- the display drum has moved halfway between its distal and proximal end positions to the rear.
- the dose limiting ring 220 has moved in the proximal direction by an amount proportional to the set single dose.
- the rotation of the metering sleeve 60 in the clockwise direction is limited on the one hand by the maximum range of movement of the display drum 70, on the other hand by the maximum range of movement of the dose limiting ring 220.
- the display drum 70 abuts after a predetermined number of revolutions of the metering sleeve 60 with its proximal radial stop against the stop sleeve 240, unless the rotation of the metering sleeve 60 has not previously by the Dose limiting ring 220 has been limited, as described in more detail below. As a result, further rotation of the dosing sleeve 60 is no longer possible. This position corresponds to the maximum adjustable single dose. This situation is shown in FIG.
- the dosing sleeve 60 can be turned counterclockwise against the force of the ratchet connection. Since the ratchet in this direction also has to absorb the torque of the coil spring 310, the ratchet connection is designed asymmetrically: The frontal toothing has on the side which is loaded by a torque acting counterclockwise on the dosing, a larger pitch angle on than on the side which is loaded at a torque in a clockwise direction (see the configuration of the teeth 244 in Fig. 14).
- the absolute angle of the angle between the respective flank of a tooth on the end face of the ratchet ring 260 or on the end face of the stop sleeve 240 and a cross-sectional area through the injector is understood as the pitch angle.
- the distribution of the dose thus set takes place by pressing the push button 80.
- the clutch K1 is engaged.
- the clutch K2 disengages.
- the rotationally fixed connection between the metering sleeve 60 on the one hand and the coupling shaft 230 with the coupling sleeve 120 now coupled and threaded rod 180 on the other hand is canceled. This causes the ratchet connection no longer absorbs the torque of the coil spring 310.
- the system is still rotatably held on the clutch K3 in the mechanism holder 150 and thus in the housing sleeve 20.
- the clutch K3 also disengages.
- the torque of the coil spring 310 is free and acts on the threaded rod 190 via the coupling shaft 230 and the coupling sleeve 120.
- these parts are rotated in a counterclockwise direction.
- the feed sleeve 90 undergoes an axial displacement in the distal direction.
- the feed sleeve pushes the plug 41 in the carpule 40 before. In this way, the drug is released.
- the display drum 70 is again entrained counterclockwise by the rotation of the transfer sleeve 210, and is thereby again distally moved because of its threaded engagement with the stationary mechanism holder 150 until it resumes its distal home position. In this position, it is prevented by a radial stop on further rotation, whereby the distribution is terminated. After the end of the distribution, the display drum again displays the dose "zero".
- the payout can be interrupted at any time by the push button 80 is released. As a result, the clutches K3 and K2 engage again, and the clutch K1 disengages again.
- the display drum 70 indicates the remaining remaining dose that is still being dispensed when the push button is pressed again, thereby continuing the dispensing.
- the dose-limiting ring 220 maintains its axial position during dispensing, as the transmission sleeve 210 and the coupling sleeve 120, between which the dose-limiting ring 220 is located, rotate synchronously. After the end of the distribution, the injection device is ready for the next injection process. Compared to FIG. 16, however, two components have changed their position: on the one hand, the feed sleeve 90 has migrated in the distal direction in accordance with the distributed dose. On the other hand, the dose-limiting ring 220 has also migrated by a proportional amount in the proximal direction. Apart from this, the state after the end of the injection corresponds to the initial state of FIG. 16.
- the advancement sleeve 90 moves further in the distal direction, while the dose-limiting ring 220 moves in the proximal direction.
- FIG. 19 depicts the injection device after initially administering a first dose which corresponds to half the maximum single dose, and then again setting a dose with the dosing sleeve which in turn corresponds to half the maximum individual dose.
- the display drum now shows again, as in FIG. 15, half the maximum single dose, while the dose-limiting ring 220 now occupies a position in the transmission sleeve 210, which corresponds to the sum of the previously set doses, in this case twice the maximum single dose.
- the cartridge sleeve 30 is released against the elastic resistance of the bayonet spring 170 from the mechanism holder 150 and out through the corresponding guide slot 156 in the mechanism holder out.
- the bayonet sleeve 160 is forcibly also twisted along its own, parallel guide slot 155 and simultaneously displaced in the distal direction.
- the guide sleeve 110 is pulled in the distal direction.
- the feed sleeve 90 was not yet maximally extended before the cartridge change, so had not yet their reached distal end position.
- the coil spring 190 now presses the guide needle 200, the feed flange 100 and the feed sleeve 90 in the distal direction.
- the threaded rod 180 is rotated via its screw connection with the interior of the feed sleeve 90 in rotation.
- the threaded rod 180 takes in particular the coupling sleeve 120 and the dose-limiting ring 220.
- the dose limiting ring 220 is displaced in this rotation by its threaded engagement with the transmission sleeve 210 in its proximal end position. Once the dose limiting ring 220 has reached this starting position, it prevents further rotation of the coupling sleeve 120 and the threaded rod 180, so that no further extension of the feed sleeve 90 is possible. The feed sleeve 90 has now reached its distal end position. This situation is shown in FIG. Overall, so now is the display drum 70 in the neutral position, the dose limiting ring 220 in the proximal end position and the feed sleeve 90 in its distal end position.
- a new carpule 40 is inserted into the cartridge case 30, and the cartridge case 30 with the carpule 40 received therein is axially guided in the proximal direction against the housing sleeve 20.
- the plug 41 of the carpule presses the feed flange 100 and the feed sleeve 90 against the force of the coil spring 190 in the proximal direction.
- the threaded rod 180 is rotated.
- the threaded rod again takes the coupling sleeve 120 and the dose limiting ring 220 with.
- the dose limiting ring is moved in the distal direction, ie in the direction of its initial position due to its threaded engagement with the transmission sleeve 210.
- the amount by which it is displaced in this direction corresponds to the dose present in the carpule 40.
- the dose-limiting ring 220 migrates to its distal starting position.
- the cartridge sleeve 30 is then inserted into the mechanism holder 150, with the radial pins 36 of the cartridge sleeve 30 again engaging in the guide slots 156 in the mechanism holder 150 (compare FIGS. 1 and 3). Due to the positive guidance of the cartridge case 30 when inserting into the mechanism holder 150, in turn, the bayonet sleeve 160 is forced to follow the movement of the cartridge case 30 in the corresponding guide slots.
- the bayonet sleeve 160 is thereby returned to its proximal end position, in which it is releasably locked by the bayonet disc 170 (see Figures 8 to 10).
- the injection device is now back in the starting position of Fig. 16 and is available after screwing a new needle holder 31 for a new sequence of administrations available.
- FIG. 21 shows as a variant a second embodiment of the injection device according to the invention.
- the operation is substantially the same as in the first embodiment.
- Like-acting parts are therefore designated by the same reference numerals as in the first embodiment. In the following, only the essential differences will be discussed.
- stop sleeve 240 omitted. Their function is taken over by the correspondingly elongated housing sleeve 20.
- the drive device which is formed in the first embodiment, apart from the coil spring 310, from the clutch disc 270, clutch shaft 230 and transmission sleeve 210 is here formed by other parts, namely by a connecting shaft 400 (with thereon integrally formed clutch disc 401) , a first transmission sleeve 410 closed at the proximal end and a second transmission sleeve 420 adjoining thereto distally. These three parts are in turn rigidly connected to one another.
- the display drum served not only to indicate the set dose, but also to limit the maximum adjustable single dose in the dosing direction and to limit the movement in the dispensing direction, the latter function is used in the second embodiment.
- This is rotatably, but axially displaceably guided in the housing sleeve 20. With an internal thread, it runs on a corresponding external thread of the first transmission sleeve 410. Its axial movement is limited by two radial stops between a distal starting position, which corresponds to the zero position, and a proximal end position, which corresponds to the maximum adjustable dose. In this way, it takes over the stop functions of the display drum according to the first embodiment.
- the display drum 70 is guided in the second embodiment via a rigidly connected to it driving sleeve 440 axially and rotatably on the second transmission sleeve 420. Their operation is otherwise the same as in the first embodiment.
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Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH14752006 | 2006-09-15 | ||
PCT/CH2007/000240 WO2008031236A1 (de) | 2006-09-15 | 2007-05-11 | Spritzwassergeschütztes injektionsgerät |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2066373A1 true EP2066373A1 (de) | 2009-06-10 |
Family
ID=38320161
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22188664.1A Pending EP4159257A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP07720137A Withdrawn EP2066373A1 (de) | 2006-09-15 | 2007-05-11 | Spritzwassergeschütztes injektionsgerät |
EP19202165.7A Active EP3626289B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP20177292.8A Active EP3738626B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP07720138.2A Active EP2077878B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP07720140.8A Active EP2076303B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit mehreren kupplungen |
EP07720136A Withdrawn EP2073872A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verlustarmem antrieb |
EP07720139A Withdrawn EP2076302A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit automatisch rückstellbarer dosisbegrenzungseinrichtung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP22188664.1A Pending EP4159257A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19202165.7A Active EP3626289B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP20177292.8A Active EP3738626B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP07720138.2A Active EP2077878B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verbessertem förderelement |
EP07720140.8A Active EP2076303B1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit mehreren kupplungen |
EP07720136A Withdrawn EP2073872A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit verlustarmem antrieb |
EP07720139A Withdrawn EP2076302A1 (de) | 2006-09-15 | 2007-05-11 | Injektionsgerät mit automatisch rückstellbarer dosisbegrenzungseinrichtung |
Country Status (9)
Country | Link |
---|---|
US (10) | US8048037B2 (de) |
EP (8) | EP4159257A1 (de) |
JP (5) | JP2010503432A (de) |
CN (5) | CN101594897A (de) |
DE (1) | DE102007022791A1 (de) |
DK (2) | DK3626289T3 (de) |
HU (2) | HUE060243T2 (de) |
PL (2) | PL3626289T3 (de) |
WO (5) | WO2008031236A1 (de) |
Families Citing this family (174)
Publication number | Priority date | Publication date | Assignee | Title |
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US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
BR0307589A (pt) | 2002-02-11 | 2005-02-01 | Antares Pharma Inc | Dispositivo de injeção intradérmica |
DE602005016952D1 (de) | 2004-10-21 | 2009-11-12 | Novo Nordisk As | Wählmechanismus für einen drehstift |
KR20070117543A (ko) | 2005-01-24 | 2007-12-12 | 앤태어스 파머, 인코퍼레이티드 | 프리필 니들 조력 제트 주사기 |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
WO2007134954A1 (en) | 2006-05-18 | 2007-11-29 | Novo Nordisk A/S | An injection device with mode locking means |
CN101594897A (zh) | 2006-09-15 | 2009-12-02 | 特克法马许可公司 | 带有可自动复位的剂量限定组件的注射仪器 |
AU2008250037B2 (en) * | 2007-05-14 | 2010-11-04 | Shl Medical Ag | Delivery device |
DE102008011885A1 (de) | 2008-02-29 | 2009-09-10 | Tecpharma Licensing Ag | Doppelfunktionsfeder |
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