EP1998752A2 - Nanoparticule de polylactide - Google Patents
Nanoparticule de polylactideInfo
- Publication number
- EP1998752A2 EP1998752A2 EP07711937A EP07711937A EP1998752A2 EP 1998752 A2 EP1998752 A2 EP 1998752A2 EP 07711937 A EP07711937 A EP 07711937A EP 07711937 A EP07711937 A EP 07711937A EP 1998752 A2 EP1998752 A2 EP 1998752A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- agents
- nanoparticles
- lactide
- agent
- primary emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
La présente invention concerne un système d'alimentation ciblée de substances actives pour l'administration d'une substance pharmacologiquement active sur le système nerveux central d'un mammifère au travers de la barrière hémato-encéphalique, le système d'administration ciblée de médicament comprenant une nanoparticule constituée de poly(DL-lactide) et/ou de poly(DL-lactide-co-glycolide) et d'au moins une substance pharmacologiquement active, absorbée dans la nanoparticule, adsorbée à sa surface ou incorporée dans son volume, et soit contenant du TPGS, soit présentant un revêtement du tensioactif Pluronic 188, qui est isolé sur la particule chargée de substance active. L'invention concerne également un procédé de fabrication du système d'administration ciblée de substances actives et l'utilisation du système pour l'administration ciblée de substances actives pour le traitement d'une maladie ou d'un trouble du système nerveux central.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006013531A DE102006013531A1 (de) | 2006-03-24 | 2006-03-24 | Polylactid-Nanopartikel |
PCT/EP2007/002198 WO2007110152A2 (fr) | 2006-03-24 | 2007-03-13 | Nanoparticule de polylactide |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1998752A2 true EP1998752A2 (fr) | 2008-12-10 |
Family
ID=38110479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07711937A Withdrawn EP1998752A2 (fr) | 2006-03-24 | 2007-03-13 | Nanoparticule de polylactide |
Country Status (14)
Country | Link |
---|---|
US (2) | US8003128B2 (fr) |
EP (1) | EP1998752A2 (fr) |
JP (1) | JP2009530325A (fr) |
KR (1) | KR20080111079A (fr) |
CN (1) | CN101410099A (fr) |
AU (1) | AU2007229738A1 (fr) |
BR (1) | BRPI0709352A2 (fr) |
CA (1) | CA2644411A1 (fr) |
DE (1) | DE102006013531A1 (fr) |
IN (1) | IN2008DE08036A (fr) |
MX (1) | MX2008011892A (fr) |
NZ (1) | NZ571354A (fr) |
RU (1) | RU2423104C2 (fr) |
WO (1) | WO2007110152A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111939151A (zh) * | 2020-07-04 | 2020-11-17 | 浙江工业大学 | 一种复合型阿霉素白蛋白纳米粒及其制备方法和应用 |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8946200B2 (en) * | 2006-11-02 | 2015-02-03 | Southwest Research Institute | Pharmaceutically active nanosuspensions |
US8404850B2 (en) * | 2008-03-13 | 2013-03-26 | Southwest Research Institute | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors |
CN102088963A (zh) * | 2008-05-06 | 2011-06-08 | 葛兰素集团有限公司 | 生物活性剂的囊封方法 |
WO2010005725A2 (fr) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Nanoparticules polymères thérapeutiques comprenant des alcaloïdes vinca et procédés de fabrication et d’utilisation associés |
JP2012501965A (ja) * | 2008-06-16 | 2012-01-26 | バインド バイオサイエンシズ インコーポレイテッド | 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法 |
US8613951B2 (en) * | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
EA014044B1 (ru) * | 2008-07-09 | 2010-08-30 | Общество С Ограниченной Ответственностью "Аква-Альянс" | Наносомальная лекарственная форма препарата пролонгированного действия для лечения гепатита с (варианты) |
US8722706B2 (en) * | 2008-08-15 | 2014-05-13 | Southwest Research Institute | Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts |
US8309134B2 (en) * | 2008-10-03 | 2012-11-13 | Southwest Research Institute | Modified calcium phosphate nanoparticle formation |
US8563041B2 (en) * | 2008-12-12 | 2013-10-22 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
WO2010075072A2 (fr) | 2008-12-15 | 2010-07-01 | Bind Biosciences | Longues nanoparticules circulantes pour la libération prolongée d'agents thérapeutiques |
EP2509634B1 (fr) | 2009-12-11 | 2019-03-06 | Pfizer Inc | Formulations stables pour particules thérapeutiques de lyophilisation |
JP5965844B2 (ja) | 2009-12-15 | 2016-08-10 | バインド セラピューティックス インコーポレイテッド | 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物 |
US9028873B2 (en) * | 2010-02-08 | 2015-05-12 | Southwest Research Institute | Nanoparticles for drug delivery to the central nervous system |
US8974691B2 (en) | 2010-09-24 | 2015-03-10 | Fujimi Incorporated | Composition for polishing and composition for rinsing |
JP5687354B2 (ja) * | 2010-11-26 | 2015-03-18 | ユニバーシティ・オブ・ザ・ウィットウォータースランド・ヨハネスブルグUniversity Of The Witwatersrand, Johannesburg | 薬物送達デバイス |
WO2012135010A2 (fr) * | 2011-03-25 | 2012-10-04 | Selecta Biosciences, Inc. | Nanovecteurs synthétiques à libération médiée par voie osmotique |
US10555911B2 (en) | 2012-05-04 | 2020-02-11 | Yale University | Highly penetrative nanocarriers for treatment of CNS disease |
GB201209517D0 (en) * | 2012-05-29 | 2012-07-11 | Univ Birmingham | Nanoparticles |
ES2656091T3 (es) * | 2012-07-27 | 2018-02-23 | Izumi Technology, Llc. | Composiciones de inhibidores de eflujo y métodos de tratamiento que las utilizan |
RS58928B1 (sr) * | 2012-08-29 | 2019-08-30 | Hoffmann La Roche | Transporter za krvno-moždanu barijeru |
ES2732377T3 (es) | 2012-09-17 | 2019-11-22 | Pfizer | Procedimiento de preparación de nanopartículas terapéuticas |
CL2012003209A1 (es) * | 2012-11-16 | 2013-04-19 | Univ Santiago Chile | Metodo de sintesis de nanoparticulas de acido poli (lactico-glicolico) (plga) con pentoxifilina; composicion farmaceutica que comprende nanoparticulas de plga con pentoxifilina; y uso de las nanoparticulas de plga cargada con pentoxifilina en el tratamiento del alivio y prevencion del dolor cronico. |
BR112016021130A2 (pt) | 2014-03-14 | 2017-08-15 | Pfizer | Nanopartículas terapêuticas, composição farmacêutica compreendendo as referidas nanopartículas, processo para a preparação e uso das mesmas |
CN103893769B (zh) * | 2014-04-16 | 2016-03-23 | 江西科技师范大学 | 含聚乙丙交酯靶向高分子药物载体及其制备方法 |
CN109613177B (zh) * | 2014-07-01 | 2021-08-20 | 科蒙森斯公司 | 用于鉴定羊水的诊断组合物 |
US10758520B1 (en) | 2015-05-20 | 2020-09-01 | University Of South Florida | Glutathione-coated nanoparticles for delivery of MKT-077 across the blood-brain barrier |
HRP20220304T1 (hr) | 2015-06-24 | 2022-05-13 | F. Hoffmann - La Roche Ag | Anti-transferinska receptorska protutijela s prilagođenim afinitetom |
RU2595859C1 (ru) * | 2015-07-20 | 2016-08-27 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Полимеросодержащее лекарственное средство на основе противоопухолевого препарата этопозида |
AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
PE20181004A1 (es) | 2015-10-02 | 2018-06-26 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
RU2606839C1 (ru) * | 2015-10-26 | 2017-01-10 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Лекарственный препарат противотуберкулезного действия на основе D-циклосерина в виде лиофилизата и способ получения лекарственного препарата |
RU2649743C1 (ru) * | 2016-10-24 | 2018-04-04 | Станислав Анатольевич Кедик | Жидкая лекарственная форма, содержащая лекарственное вещество, помещенное в биоразлагаемые полимеры |
CN106806352B (zh) * | 2017-01-26 | 2019-01-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种可缓释、靶向应用于神经退行性疾病的纳米药物 |
WO2018237004A1 (fr) * | 2017-06-20 | 2018-12-27 | University Of Maryland, Baltimore | Nanoparticules sélectives chargées de ligand de rary pour la manipulation de la croissance osseuse cible |
RU2675810C1 (ru) * | 2017-12-19 | 2018-12-25 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Полимерный комплекс для молекулярно-прицельной терапии и способ его получения |
US10842755B2 (en) | 2018-03-23 | 2020-11-24 | University Of South Carolina | Nanoparticles for brain targeted drug delivery |
CN108395543B (zh) * | 2018-05-31 | 2020-09-22 | 华南理工大学 | 一种改性聚轮烷、基于聚轮烷的载药胶束及其制备方法与应用 |
US20220175687A1 (en) * | 2019-04-11 | 2022-06-09 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
EP3750524A1 (fr) * | 2019-06-13 | 2020-12-16 | CAPNOMED GmbH | Administration retardée et modifiée de médicaments anti-cancer |
EP3750523A1 (fr) * | 2019-06-13 | 2020-12-16 | CAPNOMED GmbH | Système de distribution de substances actives |
RU2734710C1 (ru) * | 2019-06-14 | 2020-10-22 | Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБТМ ФМБА России) | Наночастицы на основе биодеградирующих полимеров с инкапсулированными в них противоопухолевыми препаратами |
CN116018401A (zh) * | 2020-07-29 | 2023-04-25 | 加利福尼亚大学董事会 | 驱动生肌性干细胞扩增的化学物混合物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
WO1995022963A1 (fr) * | 1994-02-28 | 1995-08-31 | Medinova Medical Consulting Gmbh | Systeme de ciblage d'un medicament, procede de preparation et utilisation de ce medicament |
WO1998056361A1 (fr) | 1997-06-13 | 1998-12-17 | Medinova Medical Consulting Gmbh | Systeme de ciblage de medicament, procede permettant de le preparer et son utilisation |
US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US20060024248A1 (en) * | 2003-03-23 | 2006-02-02 | Combe Incorporated | Composition and method employing membrane structured solid nanoparticles for enhanced delivery of oral care actives |
WO2004084871A1 (fr) | 2003-03-26 | 2004-10-07 | Ltt Bio-Pharma Co., Ltd. | Nanoparticules intraveineuses pour cibler une administration de medicaments et pour une liberation de medicaments prolongee |
WO2005003180A2 (fr) * | 2003-04-10 | 2005-01-13 | Pr Pharmaceuticals | Procede de production de microparticules a base d'emulsion |
JP2006528700A (ja) * | 2003-05-20 | 2006-12-21 | エリモス・ファーマスーティカルズ・エルエルシー | 肥満の治療のためのカテコールブタンの投与のための方法と組成物 |
US7728036B2 (en) * | 2003-05-20 | 2010-06-01 | Erimos Pharmaceuticals, Llc | Methods for delivery of catecholic butanes for treatment of tumors |
US20050084456A1 (en) * | 2003-10-21 | 2005-04-21 | Liping Tang | Functionalized particles |
KR101123520B1 (ko) * | 2003-12-04 | 2012-03-13 | 디에스엠 아이피 어셋츠 비.브이. | 자외선 필터 활성을 갖는 미세캡슐 및 그의 제조방법 |
US20070128289A1 (en) * | 2005-12-07 | 2007-06-07 | Zhao Jonathon Z | Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases |
-
2006
- 2006-03-24 DE DE102006013531A patent/DE102006013531A1/de not_active Withdrawn
-
2007
- 2007-03-13 CA CA002644411A patent/CA2644411A1/fr not_active Abandoned
- 2007-03-13 NZ NZ571354A patent/NZ571354A/en not_active IP Right Cessation
- 2007-03-13 MX MX2008011892A patent/MX2008011892A/es not_active Application Discontinuation
- 2007-03-13 AU AU2007229738A patent/AU2007229738A1/en not_active Abandoned
- 2007-03-13 WO PCT/EP2007/002198 patent/WO2007110152A2/fr active Application Filing
- 2007-03-13 RU RU2008140367/15A patent/RU2423104C2/ru active IP Right Revival
- 2007-03-13 CN CNA2007800106413A patent/CN101410099A/zh active Pending
- 2007-03-13 JP JP2009500737A patent/JP2009530325A/ja active Pending
- 2007-03-13 KR KR1020087025603A patent/KR20080111079A/ko not_active Application Discontinuation
- 2007-03-13 US US12/225,555 patent/US8003128B2/en not_active Expired - Fee Related
- 2007-03-13 BR BRPI0709352-7A patent/BRPI0709352A2/pt not_active IP Right Cessation
- 2007-03-13 EP EP07711937A patent/EP1998752A2/fr not_active Withdrawn
-
2008
- 2008-09-24 IN IN8036DE2008 patent/IN2008DE08036A/en unknown
-
2011
- 2011-07-20 US US13/136,015 patent/US20110293730A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO2007110152A2 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111939151A (zh) * | 2020-07-04 | 2020-11-17 | 浙江工业大学 | 一种复合型阿霉素白蛋白纳米粒及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
US20110293730A1 (en) | 2011-12-01 |
WO2007110152A8 (fr) | 2007-12-13 |
US8003128B2 (en) | 2011-08-23 |
IN2008DE08036A (fr) | 2009-03-20 |
RU2423104C2 (ru) | 2011-07-10 |
DE102006013531A1 (de) | 2007-09-27 |
US20090263491A1 (en) | 2009-10-22 |
AU2007229738A1 (en) | 2007-10-04 |
KR20080111079A (ko) | 2008-12-22 |
MX2008011892A (es) | 2008-11-14 |
WO2007110152A3 (fr) | 2008-02-21 |
BRPI0709352A2 (pt) | 2011-07-12 |
CA2644411A1 (fr) | 2007-10-04 |
CN101410099A (zh) | 2009-04-15 |
RU2008140367A (ru) | 2010-04-20 |
JP2009530325A (ja) | 2009-08-27 |
NZ571354A (en) | 2011-02-25 |
WO2007110152A2 (fr) | 2007-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1998752A2 (fr) | Nanoparticule de polylactide | |
DE60311801T2 (de) | Zusammensetzungen aus östradiol-metaboliten mit kontrollierter freisetzung | |
EP1817035B1 (fr) | Formulations solides d'agents liquides biologiquement actifs | |
EP2819659B1 (fr) | Procédé de fabrication de nanoparticules chargées d'une substance active | |
G Nava-Arzaluz et al. | Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles | |
DE60220519T2 (de) | Mizellares arzneistoffverabreichungssystem für hydrophobe arzneistoffe | |
CZ377296A3 (en) | Stabilized and sterilizably filterable nano particles, process of their preparation and pharmaceutical composition containing thereof | |
EP2029119A2 (fr) | Nanoparticules polymères solides fonctionnalisées pour applications diagnostiques et thérapeutiques | |
WO2009074274A1 (fr) | Nanoparticules polymères solides fonctionnalisées contenant des épothilones | |
EP2408438A2 (fr) | Matériaux composites chargés en produits thérapeutiques et de diagnostics comprenant des nanoparticules polymères et des fibres polymères | |
CH710313B1 (de) | Anti-Tumor-Medikament mit aktivem Targeting und dessen Herstellungsmethode. | |
CN102099016A (zh) | 载药的聚合物纳米微粒及其制备和使用方法 | |
CN101495148A (zh) | 包括至少一种抗癌药和至少一种聚合物的药物组合物 | |
JP5425890B2 (ja) | 難溶性薬物を含む均一なサイズの高分子ナノ粒子製造方法 | |
CN109381447B (zh) | 一种载虾青素磷脂纳米粒及其制备方法与应用 | |
US10172867B2 (en) | Afobazole nanoparticles formulation for enhanced therapeutics | |
US20210106536A1 (en) | Drug delivery agents for prevention or treatment of pulmonary disease | |
WO2012089220A1 (fr) | Procédé de préparation d'une forme médicamenteuse soluble dans l'eau d'antibiotique issu du groupe des rifamycines et composition obtenue par ce procédé | |
Domb et al. | Lipospheres for controlled delivery of substances | |
US20230270681A1 (en) | Drug delivery agents for prevention or treatment of pulmonary disease | |
EP2355794B1 (fr) | Solutions de substances lipophiles, en particulier solutions de médicament | |
WO2019048424A1 (fr) | Invention concernant des nanparticules contenant des taxanes destinées à une application par inhalation | |
KR20170114245A (ko) | 저분자 메틸셀룰로오스 기반의 비경구 생리활성물질 전달용 조성물 | |
WO2009059989A1 (fr) | Émulsions aqueuses contenant un principe actif hydrophobe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20080908 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
17Q | First examination report despatched |
Effective date: 20090323 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20111222 |