EP1973511B1 - Installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires - Google Patents
Installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires Download PDFInfo
- Publication number
- EP1973511B1 EP1973511B1 EP20060829905 EP06829905A EP1973511B1 EP 1973511 B1 EP1973511 B1 EP 1973511B1 EP 20060829905 EP20060829905 EP 20060829905 EP 06829905 A EP06829905 A EP 06829905A EP 1973511 B1 EP1973511 B1 EP 1973511B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- blister
- products
- substrate
- substrates
- mounting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Not-in-force
Links
- 238000004806 packaging method and process Methods 0.000 title abstract description 26
- 230000001502 supplementing effect Effects 0.000 title description 8
- 239000000758 substrate Substances 0.000 claims abstract description 68
- 238000004519 manufacturing process Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims description 13
- 238000004026 adhesive bonding Methods 0.000 claims description 9
- 239000004831 Hot glue Substances 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 239000000969 carrier Substances 0.000 abstract description 2
- 239000013543 active substance Substances 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 238000013461 design Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
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- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000012864 cross contamination Methods 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
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- 230000001105 regulatory effect Effects 0.000 description 3
- 230000000153 supplemental effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 241000239290 Araneae Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
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- 230000000474 nursing effect Effects 0.000 description 1
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- 238000013024 troubleshooting Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
- B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
- B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/30—Compliance analysis for taking medication
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/525—Operation controlled by detector means responsive to work
- Y10T83/536—Movement of work controlled
Definitions
- the invention relates to a system for automatically producing patient-specific packaging for medical and / or pharmaceutical and / or food supplementing products, comprising a transport unit for transporting substrates and the like through the entire system, and at least one device for automatically loading the substrates with medical and / or or pharmaceutical and / or food supplementing products, the device comprising at least one magazine for storing blister strips rolled up on rolls or the like, each magazine having at least one receiving space for the rolls and for each roll in the magazine a feeding device for unwinding the blister belts and feeding the blisters unrolled blister straps is provided to a supply position for the products to be loaded, and a controllable via a controller placement for transporting the products from the provision position to a e delivery position on the substrate.
- the invention relates to a method for the automatic production of patient-specific packaging for medical and / or pharmaceutical and / or food supplementing products, comprising the steps of: transporting substrates and the like by a system for automatically producing patient-specific packaging for medical and / or pharmaceutical and / or supplemental products according to any one of claims 1 to 11, loading the substrates with medical and / or pharmaceutical and / or nutritional supplemental products by transporting the products from a placement controlled by a control head from a ready position to a dispensing position on the substrate.
- Such methods and systems are used in the pharmaceutical and / or packaging industry to put individual packaging units of products together.
- Such packaging for example, adapted to certain courses of therapy. In other words, every package is put together individually.
- placement machines In order to automate a placement process, basically different types of devices for loading, so-called placement machines, are known from the state of the art, but these are usually designed for fitting electronic components for printed circuit boards or the like. In the pharmaceutical and / or packaging industry, however, it is also desired and increasingly necessary in the production of therapy-specific and / or patient-specific packaging that automation can be realized.
- WO 2005/102841 A1 a system for automatic placement of packaging units of drugs known.
- This system is characterized by the fact that the products (capsules, tablets, dragees, etc.) are stored patient-specifically in receiving compartments arranged in rows and columns, wherein in each compartment several products are directly adjacent to each other and each other.
- the WO 2005/102841 A1 maintains the previously described principle of manual loading with a variety of different products in a single shell or nest for each time of administration and enhances the performance of this principle through its automated performance.
- the actual device for loading the compartments comprises an output station for each product. Between rolls on which the products are wound as strip blister and the output stations, a cross conveyor is provided, which ensures the transport of the strip blister in the area of the output station.
- the output stations are associated with ejection units, by means of which the products are pressed out of the strip blisters.
- the products are directly mechanically loaded and conveyed unprotected into the receiving compartments.
- the disadvantage of this system is on the one hand the fact that the risk of cross-contamination is that several identical or different products are pressed into the receiving compartments.
- there are fundamental hygienic problems since the mechanical loads required when expressing the products lead to attrition of the products remaining in the device. This further increases the risk of cross-contamination.
- Another disadvantage is that said plant has a very large footprint, since for each product a squeezing station with associated ejection unit is necessary, which are all arranged in series.
- the device separating means for separating filled with products Blistering sections of the blister strip and the or each placement head for receiving, rotating and dispensing the separated Blisterabroughe with the products sealed therein to the respective placement position on the substrate during transport of the same is formed by the system.
- the release agent provides the ability to "portion" the products in a packaged manner such that they do not need to be unpacked to assemble an individual package. This ensures, on the one hand, that there are no (cross-) contamination hazards.
- the products are also protected during the manufacturing process of the packaging from direct mechanical damage. Also, the production of such packaging in clean room conditions, which have much lower requirements than clean room conditions, be performed, which reduces the production cost and thus the cost.
- two receiving positions of a magazine are arranged one above the other, which means that the device can be made even more compact.
- the stacked receiving spaces of a magazine are offset from one another laterally. As a result, both roles can be used simultaneously, ie without loss of time.
- An expedient embodiment of the invention provides that the magazines are standardized, such that each magazine can be upgraded at any position of the device.
- the magazines can be pre-equipped to ensure a short change cycle.
- Furthermore, can be improved by the possibility of optimized placement of the magazines on the device, the placement times.
- An advantageous embodiment provides that the magazines are modular, such that they are interchangeable according to the so-called plug & play principle. This ensures a quick troubleshooting or a quick replacement of magazines.
- rollers are mounted circumferentially in the magazines or the receiving stations, which ensures a simplified and shortened roll change.
- the placement head has two belt segment drives for pivoting the placement head back and forth in two planes. As a result, very short travel paths of the placement can be realized.
- the device shown in the figures and the system are used for the automatic production of patient-specific packaging containing pharmaceutical and / or medical and / or food supplementing products.
- FIG. 1 is a device 10 for loading of substrates 11, which are supplied to the device 10 in an input region 12, guided in the transport direction T through the device 10 and discharged in an exit region 13 from the device 10 is shown.
- a device 10 comprises at least one magazine 14, but preferably a plurality of juxtaposed magazines 14.
- the device 10 has four such Magazine 14 on. All magazines 14 are preferably arranged on one side of the device 10 with respect to the transport direction T. In other words, all magazines 14 are arranged side by side. Optionally, however, the magazines 14 can also be arranged on both sides in the transport direction T of the substrates 11 through the device 10.
- the magazines 14 are designed for storing or receiving rolls 15, the rolls 15 carrying at least partially rolled-up, preferably single-web blister straps 16.
- Each magazine 14 has at least one receiving station 17, optionally also a plurality of receiving stations 17 for one or more rollers 15. Preferred and in FIG. 1 However, two receiving stations 17 in each magazine 14 are also shown.
- Each receiving station 17 or each roller 15 is assigned a feed device 18.
- the feeders 18, which will be described in more detail later, serve to unroll the blister straps 16 and feed the unrolled blister straps 16 to a ready position 19 for the products to be loaded.
- the device 10 has a placement head 20, which is designed as a pendulum-arm handling device.
- the placement head 20 is designed to pick up the products to be loaded from the provision position 19, to transport them to the respective placement position above the substrate 11 and to deposit them on the substrate 11.
- the movements of the placement head 20 can be controlled and / or regulated by means of a control 21 indicated only schematically.
- the device 10 has a further only schematically indicated control 22 for the magazines 14 or more precisely the feeders 18.
- the controllers 21, 22 can be operatively connected, networked or even designed as a common integral controller.
- the device 10 further comprises separating means 23 for separating product-filled blister sections 24 from the blister strip 16.
- the blister sections 24 may have different lengths.
- a blister portion 24 may have at least a single singulated product.
- such a blister portion 24 is selected such that a single closed nest 25 with a product singulated therein is separated from the blister strip 16.
- packaging for medical and / or pharmaceutical and / or food supplementing products commonly include at least one weekly supply, larger or smaller packaging units are of course possible
- the maximum length of a blister portion 24 to be separated is usually tailored to separate a maximum of seven filled nests 25 from the blister strip 16.
- the lengths of the blister sections 24 and thus the number of products to be separated are freely selectable.
- the placement head 20 is designed for receiving, rotating and discharging the blister sections 24 separated from the blister strip 16 with the products sealed and singulated therein.
- the placement head 20 has a plurality of axes of movement that enable the placement head 20 to reach each point or position on the substrate 11 to be loaded next to each provision position 19 in the apparatus 10 and the blister portions 24 in the plane of the substrate 11 in any orientation. Therefore, the placement head 20 is at least 4-axis movable. In the illustrated embodiments, the placement head 20 has exactly four axes of movement.
- the placement head 20 or a suction bar 39 described below is additionally perpendicular to the Z in the Z direction
- Substrate 11 movable up and down (up and down) and rotatable about the RZ axis (see in particular FIGS. 1 and 3 to 5 ).
- the placement head 20 is formed in the described embodiments of a pendulum arm 30, which consists of two parallel and spaced apart arms 31, 32 or triangular plates, carriers or the like (see in particular FIGS. 4 and 5 ).
- the two arms 31, 32 are secured at their upwardly facing free ends to a common pivot plate 33.
- This pivot plate 33 is articulated via corresponding bearing blocks 34, 35 or the like to a frame 36 or the like, which is fixedly connected to the machine frame or is part of the machine frame.
- the arms 31, 32 are connected to each other via a top plate 37 or the like.
- the top plate 37 is pivotally connected to the downwardly directed free ends of the arms 31, 32 via hinge elements 38, such as ball joints or the like.
- a suction bar 39 is arranged on the top plate 37, which will be described in detail below.
- a parallel rod 40 is optionally arranged on the top plate 37.
- the parallel rod 40 is hinged to the top plate 37 via the above-mentioned hinge elements 38 with the free end directed downwards.
- the other upwardly directed free end of the parallel bar 40 is secured to the frame 36 via a ball joint 41 or the like.
- the two arms 31, 32 are fixed on opposite sides of the top plate 37, while the parallel rod 40 is fixed to one side of the top plate 37, which extends transversely to the aforementioned sides.
- the parallel rod 40 is preferably hollow, in particular for the formation or reception of supply lines or the like.
- This unit which essentially comprises the arms 31, 32 or the arms 31, 32 and the parallel rod 40, can also be referred to as compensating linkage 42.
- an intermediate shaft 43 or the like is arranged.
- the intermediate shaft 43 is fixedly secured with an upward end to a lifting slide 44 or the like, wherein the lifting slide 44 is disposed above the pivot plate 33 and associated with the machine frame.
- the lifting slide 44 is movable up and down along suitable guides 45 vertically to the substrate 11 to be loaded in the Z direction.
- the frame 36 could also be designed to be movable upwards and downwards and guided in such a way that they could be moved up and down To allow vertical movement of the suction bar 39 in the Z direction.
- the intermediate shaft 43 is mounted in the region of the top plate 37.
- a bearing 46 can serve as a combined rotary and linear bearings, for example.
- the intermediate shaft 43 via the bearing 46 or within the bearing 46 with a shaft 47 in operative connection or directly connected thereto.
- the shaft 47 in turn is connected to the previously mentioned suction bar 39 and secured thereto.
- the shaft 47 may also be an extension of the intermediate shaft 43.
- the suction bar 39 itself has several, preferably seven nozzles or suction cups 48 or the like.
- the intermediate shaft 43 is formed in the embodiment shown of three segments, namely a fastening segment 49, a balancing segment 50 and a retaining segment 51.
- the fastening segment 49 is preferably attached directly to the lifting slide 44 and thus serves to transmit the vertical movement in the Z direction on the suction bar
- the balancing segment 50 serves to compensate for the oscillating or pivoting movement described by the pendulum arm 30.
- the holding element 51 establishes the connection to the actual suction bar 39 and ensures that the suction bar 39 is aligned with its surface 53 facing the substrate 11 permanently and independently of the pivoting movement in the XZ plane and the YZ plane parallel to the substrate 11. In other words, the suction cups 48 are always aligned vertically to the substrate 11.
- the three segments 49 to 51 are preferably connected to each other via cardan joints 52 or the like. Alternatively, rubber joints or the like may be provided.
- the placement head 20 or more precisely the suction bar 39 is connected to a not explicitly shown vacuum system of conventional type.
- the suction bar 39 is connected to at least one, but preferably a plurality of vacuum lines.
- four preferably individually controllable suction lines are provided, which are introduced in the region of the lifting slide 44 via a suitable (multiple) rotary inlet 54 or the like in the intermediate shaft 43.
- This targeted activation for sucking the Blisterabête 24 of different lengths is possible.
- individual suction cups 48 or groups of suction cups 48 can be activated.
- the intermediate shaft 43 is for receiving and guiding the vacuum lines in all segments 49 to 51 preferably tubular, so hollow. Alternatively, the intermediate shaft 43 may be provided with vacuum holes or the like.
- the segments 49 to 51 may also be formed differently with respect to the vacuum lines.
- the cardan joints 52 are formed as universal joints with a hollow spider. In the event that rubber joints are used, they have correspondingly vacuum holes.
- the intermediate shaft 43 is further associated directly with the drive 29, which acts as a rotary motor for rotating the intermediate shaft 43 about the RZ axis and is drivable in both directions of rotation.
- the vertical movement of the suction bar 39 in the Z-direction is realized by the drive 28 which is fixed to the machine frame (see in particular FIGS. 6 and 7 ).
- the belt segment drive 27 for swinging back and forth in the YZ plane is also associated with the machine frame.
- the drive movement of the belt segment drive 27 can be transferred via suitable and customary means to a circular segment-shaped section 65, which in turn is firmly connected to the pivot plate 33.
- the belt segment drive 26 for swinging back and forth in the XZ plane however, in particular arranged to achieve a compact design on the pivot plate 33.
- the drive movement of the belt segment drive 26 can be transferred via suitable and customary means to a circular segment-shaped section 66, which is formed from an extension of an arm, here the arm 32.
- a circular segment-shaped section 66 which is formed from an extension of an arm, here the arm 32.
- the arm 32 is connected to the arm 31 via the pivot plate 33, the pivotal movement in the XZ plane is transmitted to the arm 31.
- the frame 36 which may be formed in addition to the rectangular, provided with a passage 67 shape as a U-beam or the like, designed or provided with sufficient clearance to the pivot plate 33 that free pivoting is ensured in both mentioned levels .
- the drives, in particular the belt segment drives 26, 27, are in operative connection with the suction bar 39 via the compensating linkage 42 and the intermediate shaft 43 such that the suction bar 39 with its suction cups 48 is always the same regardless of the pivot position of the belt segment drives 26, 27 in the direction of the substrate 11 is aligned.
- the drives 28, 29 via the intermediate shaft 43 with the suction bar 39 in direct operative connection.
- the compensating linkage 42 may also be replaced by suitable known solutions, such as a linear actuator or a delta robot or the like.
- each magazine 14 preferably comprises two receiving locations 17. This means that two rollers 15 are then arranged in a magazine 14.
- the receiving places 17 are arranged one above the other, in such a way that the receiving places 17 or more precisely the rollers 15 arranged therein are aligned in alignment.
- the blister strips 16 unrolled from the rollers 15 are arranged above or below each other.
- FIG. 12 can be seen in which the stacked receiving seats 17 are laterally offset from each other. In other words, the blister straps 16 unrolled by the rollers 15 are then juxtaposed in the ready position 19.
- the size of the lateral offset may vary, but is preferably at least the width of the blister straps 16 to be processed.
- Each receiving station 17 is associated with a feed device 18, which is essentially formed by a feed motor 55 and a measuring means for controlling the advance of the blister strip 16.
- the measuring means may comprise a plurality of measuring elements, for example a sensor 56 for advancing the blister strip 16 and / or a sensor 57 for the end of the blister strip 16.
- the feed device 18 may additionally have a roll-off motor 58, which in particular helps to roll heavy rolls 15 can be.
- a blister loop 59 may be formed.
- a further sensor 60 may be arranged, the information for a not explicitly shown control unit for Blisterschlairfe 59 receives and passes.
- Each magazine 14 is a release agent 23rd
- the separating means 23 may be formed from one or more separating elements, for example separating knives 61.
- each magazine 14 is assigned a common for both recording slots 17 separating knife 61.
- the guillotine-type separating knife 61 is preferably arranged above the blister strips 16 to be separated.
- Below the blister straps 16, the separating blade 61 is assigned a corresponding counter-layer 62.
- each feed device 18 may be associated with separate separating blades 61. This means that each blister strip 16 is then separated from its own separating knife 61. This can be helpful, in particular, for the case in which the blister straps 16 of a magazine 14 lie side by side in the ready position 19.
- the or each separating knife 61 is controlled and actuated by pneumatic, hydraulic or otherwise conventional manner.
- the rollers 15 within the magazines 14 and 17 in the receiving stations are stored for easy change.
- a peripheral bearing of the rollers 15, e.g. on suitable bearing pin 63 is preferred.
- Other types of storage, such as journal on which the rollers 15 are mounted centrally, can also be used.
- Each roller 15 may be stored in each magazine 14. This means that a freely selectable assignment of the rollers 15 to the magazines 14 can take place.
- the magazines 14 are standardized, so that each magazine 14 can be upgraded at any position on the device 10.
- these are also modular. Thereby, in a simple manner, e.g. a change of magazines 14 are made by means of the plug and play principle.
- the sequence of steps for the separation of individual Blisterabroughe 24 from a blister strip 16 is based on the FIGS. 13 to 15 briefly explained:
- a code which is eg directly on the roller 15.
- the blister strip 16 is then removed from the roll 15 donated.
- the positioning of the blister strip 16 likewise preferably takes place by means of markings on the blister strip 16 which are suitable for the optical recognition. As markings, pictorial representations, centering marks, holes, notches or the like can be used.
- the blister strip 16 may be pre-dispensed by a variable length or number of products.
- the blister strip 16 is pre-dispensed exactly the length of a product. If it is desired to load a blister section 24 with a plurality of singulated and packaged products, the blister strip 16 is pre-dispensed by the desired number of products. In the example of FIGS. 13 to 15 the blister strip 16 is pre-dispensed in a length bearing seven products. As soon as the blister section 24 to be separated is in the ready position 19, the blister section 24 to be separated is fixed by the descending suction bar 39. Preferably, in parallel, the separation process is initiated. This means that the severing blade 61 separates the blister section 24 from the blister strip 16 while the blister section 24 awaiting placement is fixed.
- the time of separation can vary and in particular also take place after fixation.
- the separation takes place between the nests 25, which are also called tablet yards.
- the separating cuts optionally run along provided perforations or the like or without perforation across the blister strip 16.
- the separated blister section 24 is then picked up by the placement head 20, possibly rotated and deposited on the substrate 11. After placing the blister section 24 on the substrate 11, it is visually checked whether the correct blister section 24 has been deposited at the correct position of the substrate 11.
- the composition of the individual components of the system 70 can of course vary, in particular also in the number and sequence of the components.
- One of the central components is the apparatus 10 for loading the substrates 11.
- Other essential components are a transport unit 71 and a gluing station 72.
- the transport unit 71 By means of the transport unit 71, the substrates 11 can be transported in the transport direction T through the apparatus 10 and through upstream and downstream components ,
- the transport unit 71 can in the usual way as a belt conveyor or be formed. However, a design as an endless circulating vacuum chain is preferred.
- the gluing station 72 is arranged in the transport direction T in front of the apparatus 10 for loading and serves to apply adhesive melt or the like to the substrates 11 at the positions at which blister sections 24 are positioned.
- the gluing station 72 could under certain circumstances also be dispensed with if the blister sections 24 are fixed by the packaging itself, for example by clamping the blister sections 24 between the substrate 11 and a cover element or the like assigned to the substrate 11.
- the transport unit 71 may be assigned on the input side a feed 73 for the ordered and singulated feeding of the substrates 11.
- the feeder 73 is designed for the automatic feeding of different substrates 11, that is, for example, so-called wallets with two panels low or high, additional panels or the like.
- the wallets or the like are pre-perforated in the area of the nests 25 with a standardized perforation.
- Several substrates 11 can be composed of different wallets, panels or the like and are preferably already pre-printed.
- the feeder 73 can be arranged in alignment with the transport unit 71 or, as shown, as a cross conveyor.
- an inspection unit (not explicitly shown) by means of which the position and orientation of the substrates 11 on the transport unit 71 are controlled.
- the devices 10 may also be equipped with optical inspection units.
- at least one further gluing station 74 is arranged. This gluing station 74 can be used to join hot glue or the like for connecting the assembled substrate 11 to the cover element or the like already mentioned above.
- the cover elements or the like can be supplied via a further feeder 75, such as a magazine or the like of the transport unit 71.
- the cover elements can be printed on a patient-specific basis, in particular by printing information on the drug, date of taking, time of taking, type of intake, company logo, etc.
- the holes or recesses for the nests 25 in the cover elements are provided by suitable means which can be assigned to the feeder 75 punched a fixed grid, with different punching patterns can be realized.
- the holes can also be pre-cut.
- the feeder 75 may also serve to discharge the loaded substrates 11 from the plant 70.
- the feed 75 is preferably arranged transversely to the transport unit 71. In the transport direction T behind the gluing station 74, a further processing unit 76 is arranged.
- the processing unit 76 may comprise means for connecting the assembled substrates 11 with additional panels, for folding the substrates 11 or the units formed from substrate 11 and additional panel, for printing, punching or the like of variable data and for optical control.
- the processing unit 76 may comprise means for connecting the assembled substrates 11 with additional panels, for folding the substrates 11 or the units formed from substrate 11 and additional panel, for printing, punching or the like of variable data and for optical control.
- suitable codings on the blister sections 24, the substrates 11, the cover elements, etc. the patient-specific assembly can be 100% controlled.
- all variable data can be controlled o-line by means of cameras or the like.
- additional components such as, for example, a further gluing station in the region of the processing unit 76, can of course be assigned to the system 70.
- Each component may also be associated with a means for discharging the products (e.g., empty substrates 11, glued substrates 11, assembled substrates 11 1, etc.). This can be done in any process section in case of faulty or otherwise undesirable products a discharge from the process.
- a control unit for the system which may be formed as a single parent unit. However, there is also the possibility that the individual components have separate units, which are in operative connection via a common control.
- the placement head 20 is formed with its suction bar 39 such that the blister sections 24 can be picked up from the stationary supply position 19 and supplied to the substrate 11.
- the advantage is that the bridge-type dispensing stations known from the above-mentioned WO publication can be avoided, as a result of which the throughput time of a substrate 11 through the device 10 or the system 70 can be shortened and a shortened system 70 can be realized overall.
- a system 70 for the automatic production of patient-specific packaging for medical and / or pharmaceutical and / or food supplementing products comprising at least one magazine 14 for storing blister belts 16 rolled up on rolls 15 or the like , wherein each magazine 14 has at least one receiving space 17 for the rollers 15 and for each roller 15 in the magazine 14, a feeder 18 for unrolling the blister straps 16 and feeding the unrolled blister straps 16 is provided to a supply position 19 for the products to be loaded, and a via a controller 21 controllable placement head 20 for transporting the products from the supply position 19 to a dispensing position on the substrate 11, which is characterized in that the device 10 separating means 23 for separating blistered portions filled with products 24 of the blister strip 16 and the placement head 20 is adapted to receive, rotate and deliver the separated blister sections 24 with the products sealed therein, the following features are suitable for further
- a further embodiment is characterized in that the device 10 has a plurality of juxtaposed magazines 14.
- a further embodiment is characterized in that two receiving places 17 of a magazine 14 are arranged one above the other.
- a further embodiment is characterized in that the two receiving places 17 are arranged one above the other in alignment.
- a further embodiment is characterized in that the stacked receiving spaces 17 of a magazine 14 are laterally offset from each other, at least by the width of the blister belts 16 to be processed.
- each receiving space 17 and thus each blister strip 16 is assigned a separate separating element.
- a further embodiment is characterized in that the magazines 14 are standardized, such that each magazine 14 can be upgraded at any position of the device 10.
- a further embodiment is characterized in that the magazines 14 are of modular design, such that they are exchangeable according to the so-called plug & play principle.
- Another embodiment is characterized in that all the magazines 14 are arranged on one side of the device 10.
- a further embodiment is characterized in that the belt segment drives 26, 27 are assigned a common compensating linkage 42.
- a further embodiment is characterized in that the compensating linkage 42 is associated with an intermediate shaft 43.
- the intermediate shaft 43 is formed of three segments 49, 50, 51, wherein the segments 49 to 51 are connected to each other by means of universal joints 52 or the like.
- a further embodiment is characterized in that the intermediate shaft 43 is designed for connection to a vacuum unit.
- a further embodiment is characterized in that the placement head 20 on the one hand and the feed device 18 on the other hand have separate controls 21, 22.
- Another embodiment is characterized in that the controls 21, 22 are in operative connection with each other or are networked with each other.
- a further embodiment is characterized in that the transport unit 71 in the input area, a supply 73 for automatically feeding substrates 11, such as wallets, is assigned to the transport unit 71.
- a further embodiment is characterized in that the transport unit 71 in the region of each processing station are assigned means for discharging the substrates 11.
- a further embodiment is characterized in that it has a higher-level control unit for controlling and / or regulating all components of the system 70.
- a further embodiment is characterized in that the transport unit 71 comprises a vacuum chain.
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mechanical Engineering (AREA)
- Medical Informatics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Auxiliary Devices For And Details Of Packaging Control (AREA)
- Packages (AREA)
- Basic Packing Technique (AREA)
- Container Filling Or Packaging Operations (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (14)
- Installation (70) pour la fabrication automatique d'emballages individuels pour chaque patient, pour des produits médicaux et/ou pharmaceutiques et/ou compléments alimentaires, comprenant une unité de transport (71), destinée à transporter des substrats (11) et analogues à travers la totalité de l'installation (70), ainsi qu'au moins un dispositif (10), pour garnir automatiquement les substrats (11) de produits médicaux et/ou pharmaceutiques et/ou compléments alimentaires, le dispositif (10) comprenant au moins un magasin (14), destiné au stockage de bandes alvéolées (17), enroulées sur des rouleaux (15) ou analogues, chaque magasin (14) comprenant au moins un logement (17) pour les rouleaux (15), un dispositif d'amenée (18), destiné à dérouler les bandes alvéolées (16) et à amener les bandes alvéolées déroulées (16) en position de mise à disposition (19) pour les produits à charger étant prévu pour chaque rouleau (15) dans le magasin (14), ainsi qu'une tête de chargement (20), pouvant être commandée par un organe de commande (21), destinée au transport des produits, d'une position de mise à disposition (19) en position de décharge sur le substrat (11), caractérisée en ce que le dispositif (10) comprend des moyens de séparation (23) destinés à séparer de la bande alvéolée (16) des plaquettes alvéolées (24) remplies de produits, et en ce que la tête de chargement (20), ou chaque tête de chargement (20) est configurée de façon à loger, faire pivoter et décharger les plaquettes alvéolées séparées (24), avec les produits qui y sont enfermés selon chaque position de chargement respective sur le substrat (11) pendant son transport à travers l'installation (70).
- Installation selon la revendication 1, caractérisée en ce que l'installation (70) comprend au moins deux dispositifs (10).
- Installation selon la revendication 1 ou 2, caractérisée en ce que l'installation (70) comprend au moins une station d'encollage (72) destinée à appliquer sur les substrats (11) une colle fusible auto-adhésive ou analogues.
- Installation selon l'une des revendications 1 à 3, caractérisée en ce que la tête de chargement (20) est mobile sur au moins 4 axes.
- Installation selon la revendication 4, caractérisée en ce que la tête de chargement (20) comprend deux organes d'entraînement à courroie (26, 27), destinés à faire pivoter dans un sens et dans l'autre la tête de chargement (20) dans deux plans (plan XZ, plan YZ).
- Installation selon la revendication 5, caractérisée en ce que, outre les organes d'entraînement à courroie (26, 27), on a prévu un organe d'entraînement (28) destiné à déplacer vers le haut et vers le bas la tête de chargement (20) perpendiculairement (direction Z) au substrat (11), ainsi qu'un organe d'entraînement (29) destiné à faire pivoter (axe RZ) la tête de chargement (20).
- Installation selon l'une des revendications 1 à 6, caractérisée en ce qu'à la tête de chargement (20) est affectée une rampe d'aspiration (39), destinée à reprendre une plaquette alvéolée (24) de longueur variable.
- Installation selon la revendication 7, caractérisée en ce que la rampe d'aspiration (39) est reliée, par une liaison active, à la tringlerie de compensation (42) et à l'arbre intermédiaire (43), de telle sorte que la rampe d'aspiration (39), avec sa surface (53) dirigée vers le substrat (11), soit toujours orientée parallèlement au substrat (11), indépendamment de la position de pivotement des organes d'entraînement à courroie (26, 27).
- Installation selon l'une des revendications 3 à 8, caractérisée en ce qu'un moyen destiné au contrôle de la position des substrats (11) sur l'unité de transport (71) est disposé dans la direction de transport T des substrats (11), en avant de la station d'encollage (72).
- Installation selon l'une des revendications 1 à 9, caractérisée en ce qu'un moyen destiné au contrôle du chargement en termes de position et/ou de contenu est disposé dans la direction du transport T immédiatement derrière le ou chaque dispositif (10) destiné au chargement.
- Installation selon l'une des revendications 1 à 10, caractérisée en ce qu'à l'unité de transport (71) sont affectés des moyens destinés découper et/ou détacher et/ou enfoncer et/ou plier les substrats chargés (11).
- Procédé de fabrication automatique d'emballages individuels pour chaque patient, pour des produits médicaux et/ou pharmaceutiques et/ou compléments alimentaires, comportant les étapes suivantes :- transport de substrats (11) et analogues à travers une installation (70) destinée à la fabrication automatique d'emballages individuels pour un patient pour des produits médicaux et/ou pharmaceutiques et/ou compléments alimentaires selon l'une des revendications 1 à 11,- chargement des substrats (11) en produits médicaux et/ou pharmaceutiques et/ou compléments alimentaires,- les produits étant transportés, par une tête de chargement (20) commandée par un organe de commande (21), d'une position de mise à disposition (19) en position de décharge sur le substrat (11),caractérisé en ce qu'on sépare des bandes alvéolées (16) mises à disposition les plaquettes alvéolées (24) remplies de produits et en ce que ces plaquettes alvéolées séparées (24) sont reprises par la tête de chargement (20), pivotées, et amenées en position de chargement respective sur le substrat (11) pendant son transport à travers l'installation (70).
- Procédé selon la revendication 12, caractérisé en ce que le chargement des substrats (11) est effectué par plusieurs dispositifs (10), disposés les uns derrière les autres et pourvus d'une tête de chargement (20).
- Procédé selon la revendication 12 ou 13, caractérisé en ce que, avant chargement des plaquettes alvéolées (24) on applique une colle auto-adhésive fusible ou analogues sur le substrat (11).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20060829905 EP1973511B9 (fr) | 2005-12-21 | 2006-12-21 | Installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires |
PL06829905T PL1973511T3 (pl) | 2005-12-21 | 2006-12-21 | Instalacja do automatycznego wytwarzania opakowań dla produktów medycznych i/lub farmaceutycznych i/lub uzupełniających dietę |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20050090355 EP1800645A1 (fr) | 2005-12-21 | 2005-12-21 | Emballage pour produits médicaux et autres |
EP20060829905 EP1973511B9 (fr) | 2005-12-21 | 2006-12-21 | Installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires |
PCT/EP2006/012642 WO2007077032A1 (fr) | 2005-12-21 | 2006-12-21 | Dispositif permettant de garnir automatiquement des substrats avec des produits medicaux et/ou pharmaceutiques et/ou des complements alimentaires ; et installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1973511A1 EP1973511A1 (fr) | 2008-10-01 |
EP1973511B1 true EP1973511B1 (fr) | 2011-11-16 |
EP1973511B9 EP1973511B9 (fr) | 2012-05-09 |
Family
ID=36215478
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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EP20050090355 Withdrawn EP1800645A1 (fr) | 2005-12-21 | 2005-12-21 | Emballage pour produits médicaux et autres |
EP20060841238 Not-in-force EP1978912B1 (fr) | 2005-12-21 | 2006-12-21 | Emballage de produits medicaux et equivalent |
EP20060829905 Not-in-force EP1973511B9 (fr) | 2005-12-21 | 2006-12-21 | Installation de production automatique d'emballages de produits medicaux et/ou pharmaceutiques et/ou de complements alimentaires |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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EP20050090355 Withdrawn EP1800645A1 (fr) | 2005-12-21 | 2005-12-21 | Emballage pour produits médicaux et autres |
EP20060841238 Not-in-force EP1978912B1 (fr) | 2005-12-21 | 2006-12-21 | Emballage de produits medicaux et equivalent |
Country Status (12)
Country | Link |
---|---|
US (2) | US8020702B2 (fr) |
EP (3) | EP1800645A1 (fr) |
JP (2) | JP2009520651A (fr) |
AT (2) | ATE536163T1 (fr) |
AU (2) | AU2006332071B2 (fr) |
CA (2) | CA2634518C (fr) |
DK (2) | DK1978912T3 (fr) |
ES (2) | ES2376744T3 (fr) |
PL (2) | PL1973511T3 (fr) |
PT (2) | PT1978912E (fr) |
RU (2) | RU2008129699A (fr) |
WO (2) | WO2007077032A1 (fr) |
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-
2005
- 2005-12-21 EP EP20050090355 patent/EP1800645A1/fr not_active Withdrawn
-
2006
- 2006-12-21 US US12/158,581 patent/US8020702B2/en not_active Expired - Fee Related
- 2006-12-21 RU RU2008129699/14A patent/RU2008129699A/ru not_active Application Discontinuation
- 2006-12-21 EP EP20060841238 patent/EP1978912B1/fr not_active Not-in-force
- 2006-12-21 RU RU2008129701/14A patent/RU2008129701A/ru not_active Application Discontinuation
- 2006-12-21 WO PCT/EP2006/012642 patent/WO2007077032A1/fr active Application Filing
- 2006-12-21 US US12/158,532 patent/US7934355B2/en active Active
- 2006-12-21 AU AU2006332071A patent/AU2006332071B2/en not_active Ceased
- 2006-12-21 PL PL06829905T patent/PL1973511T3/pl unknown
- 2006-12-21 JP JP2008546293A patent/JP2009520651A/ja active Pending
- 2006-12-21 PL PL06841238T patent/PL1978912T3/pl unknown
- 2006-12-21 JP JP2008546294A patent/JP5081835B2/ja not_active Expired - Fee Related
- 2006-12-21 PT PT06841238T patent/PT1978912E/pt unknown
- 2006-12-21 AT AT06841238T patent/ATE536163T1/de active
- 2006-12-21 EP EP20060829905 patent/EP1973511B9/fr not_active Not-in-force
- 2006-12-21 CA CA 2634518 patent/CA2634518C/fr not_active Expired - Fee Related
- 2006-12-21 ES ES06829905T patent/ES2376744T3/es active Active
- 2006-12-21 CA CA2634524A patent/CA2634524C/fr not_active Expired - Fee Related
- 2006-12-21 DK DK06841238T patent/DK1978912T3/da active
- 2006-12-21 AT AT06829905T patent/ATE533458T1/de active
- 2006-12-21 AU AU2006332069A patent/AU2006332069B2/en not_active Ceased
- 2006-12-21 ES ES06841238T patent/ES2377347T3/es active Active
- 2006-12-21 DK DK06829905T patent/DK1973511T3/da active
- 2006-12-21 WO PCT/EP2006/012644 patent/WO2007077034A1/fr active Application Filing
- 2006-12-21 PT PT06829905T patent/PT1973511E/pt unknown
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