EP1411976A2 - Impfstoff für veterinäre und humanmedizinische prophylaxe und therapie von dermatophytosen - Google Patents
Impfstoff für veterinäre und humanmedizinische prophylaxe und therapie von dermatophytosenInfo
- Publication number
- EP1411976A2 EP1411976A2 EP02767271A EP02767271A EP1411976A2 EP 1411976 A2 EP1411976 A2 EP 1411976A2 EP 02767271 A EP02767271 A EP 02767271A EP 02767271 A EP02767271 A EP 02767271A EP 1411976 A2 EP1411976 A2 EP 1411976A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- vaccine
- strains
- ccm
- vaccination
- vaccination strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 85
- 239000003814 drug Substances 0.000 title description 11
- 238000002560 therapeutic procedure Methods 0.000 title description 3
- 238000011321 prophylaxis Methods 0.000 title description 2
- 238000002255 vaccination Methods 0.000 claims abstract description 53
- 208000002474 Tinea Diseases 0.000 claims abstract description 13
- 238000011282 treatment Methods 0.000 claims abstract description 5
- 206010012504 Dermatophytosis Diseases 0.000 claims abstract description 4
- 241001460074 Microsporum distortum Species 0.000 claims abstract description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 52
- 241000893966 Trichophyton verrucosum Species 0.000 claims description 22
- 229940055035 trichophyton verrucosum Drugs 0.000 claims description 14
- 235000015097 nutrients Nutrition 0.000 claims description 13
- 239000007795 chemical reaction product Substances 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 9
- 241000223229 Trichophyton rubrum Species 0.000 claims description 9
- 229920001817 Agar Polymers 0.000 claims description 8
- 241001045770 Trichophyton mentagrophytes Species 0.000 claims description 8
- 239000008272 agar Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 239000008098 formaldehyde solution Substances 0.000 claims description 7
- 230000002779 inactivation Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 238000000265 homogenisation Methods 0.000 claims description 5
- 241000282412 Homo Species 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 claims 3
- 239000012467 final product Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 241001480043 Arthrodermataceae Species 0.000 abstract description 6
- 230000037304 dermatophytes Effects 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 11
- 239000002609 medium Substances 0.000 description 9
- 229910019142 PO4 Inorganic materials 0.000 description 7
- 244000309466 calf Species 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 7
- 239000010452 phosphate Substances 0.000 description 7
- 239000002504 physiological saline solution Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 208000003455 anaphylaxis Diseases 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- 241000223238 Trichophyton Species 0.000 description 5
- 150000001720 carbohydrates Chemical class 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 230000002052 anaphylactic effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000036512 infertility Effects 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000003371 toe Anatomy 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- 206010067409 Trichophytosis Diseases 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010002216 Anaphylactoid reaction Diseases 0.000 description 1
- 241000893451 Arthroderma Species 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241001480035 Epidermophyton Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 241001480037 Microsporum Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000995680 Nannizzia Species 0.000 description 1
- 241000105542 Scytalidium cuboideum Species 0.000 description 1
- 241000893962 Trichophyton equinum Species 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000001255 hallux Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000012770 revaccination Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
Definitions
- Embodiments with the ratio a1: a2: a3: a4 of 4: 2: 10: 3 or 10: 1: 30: 2 and the ratios a1: a3: a4 of 1: 3 are very particularly preferred for human use. 1 and a2: a4 of 1: 2 or the sole use of a4 (Trichophyton rubrum CCM 8291).
- the mixture of the strains a1: a2: a3: a4 corresponds to the ratio of 0 or 2-10: 0 or 1-5: 0 or 5-30: 0 or 2-10 in the end product, the abovementioned Mixing ratios and individual strains are particularly preferred.
- Example 8 Preparation of a human medical vaccine and application
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20012732 | 2001-07-27 | ||
| CZ20012732A CZ20012732A3 (cs) | 2001-07-27 | 2001-07-27 | Vakcína proti dermatofytózám a způsob její výroby |
| PCT/EP2002/008435 WO2003011329A2 (de) | 2001-07-27 | 2002-07-29 | Impfstoff für veterinäre und humanmedizinische prophylaxe und therapie von dermatophytosen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1411976A2 true EP1411976A2 (de) | 2004-04-28 |
Family
ID=5473491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02767271A Withdrawn EP1411976A2 (de) | 2001-07-27 | 2002-07-29 | Impfstoff für veterinäre und humanmedizinische prophylaxe und therapie von dermatophytosen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040151726A1 (pl) |
| EP (1) | EP1411976A2 (pl) |
| JP (1) | JP2004536146A (pl) |
| CN (1) | CN1545417A (pl) |
| CA (1) | CA2453831A1 (pl) |
| CZ (1) | CZ20012732A3 (pl) |
| PL (1) | PL365029A1 (pl) |
| RU (1) | RU2253467C1 (pl) |
| WO (1) | WO2003011329A2 (pl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2560572C2 (ru) * | 2013-08-20 | 2015-08-20 | Федеральное государственное унитарное предприятие "Ставропольская биофабрика" | Способ производства вакцины для профилактики и терапии трихофитоза крупного рогатого скота |
| CN112877217B (zh) * | 2020-12-10 | 2022-04-15 | 贵州大学 | 一种黄褐奈尼兹皮真菌菌株及其降解鸡毛中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO153458C (no) * | 1978-06-07 | 1986-03-26 | Inst Experimentalnoi Veterinar | Fremgangsm¨te for fremstilling av vaksine for profylakse o g behandling av ringorm hos pelsdyr og kaniner for¨rsaket av trichophyton mentagrophytes. |
| CA2011896C (en) * | 1989-04-21 | 2001-05-08 | Mark Werner | Ringworm vaccine |
| RU2020959C1 (ru) * | 1991-10-21 | 1994-10-15 | Игорь Дмитриевич Поляков | Вакцина поливак-тм для профилактики и лечения дерматофитозов животных |
| WO2001015725A1 (en) * | 1998-09-24 | 2001-03-08 | Alpharma As | Vaccine for the protection of a vertebrate animal against fungal skin infection |
-
2001
- 2001-07-27 CZ CZ20012732A patent/CZ20012732A3/cs not_active IP Right Cessation
-
2002
- 2002-07-29 JP JP2003516559A patent/JP2004536146A/ja not_active Withdrawn
- 2002-07-29 RU RU2003137591/15A patent/RU2253467C1/ru not_active IP Right Cessation
- 2002-07-29 CN CNA028149149A patent/CN1545417A/zh active Pending
- 2002-07-29 EP EP02767271A patent/EP1411976A2/de not_active Withdrawn
- 2002-07-29 WO PCT/EP2002/008435 patent/WO2003011329A2/de not_active Ceased
- 2002-07-29 CA CA002453831A patent/CA2453831A1/en not_active Abandoned
- 2002-07-29 PL PL02365029A patent/PL365029A1/pl not_active Application Discontinuation
- 2002-07-29 US US10/480,406 patent/US20040151726A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| None * |
| See also references of WO03011329A3 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003011329A3 (de) | 2003-07-17 |
| WO2003011329A2 (de) | 2003-02-13 |
| PL365029A1 (pl) | 2004-12-27 |
| US20040151726A1 (en) | 2004-08-05 |
| CA2453831A1 (en) | 2003-02-13 |
| JP2004536146A (ja) | 2004-12-02 |
| CN1545417A (zh) | 2004-11-10 |
| RU2253467C1 (ru) | 2005-06-10 |
| RU2003137591A (ru) | 2005-03-27 |
| CZ290509B6 (cs) | 2002-08-14 |
| CZ20012732A3 (cs) | 2002-08-14 |
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Legal Events
| Date | Code | Title | Description |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20040202 |
|
| AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR |
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| AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
| 17Q | First examination report despatched |
Effective date: 20070115 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20070726 |