EP1313379A2 - Nouvelle composition & son utilisation - Google Patents

Nouvelle composition & son utilisation

Info

Publication number
EP1313379A2
EP1313379A2 EP01969521A EP01969521A EP1313379A2 EP 1313379 A2 EP1313379 A2 EP 1313379A2 EP 01969521 A EP01969521 A EP 01969521A EP 01969521 A EP01969521 A EP 01969521A EP 1313379 A2 EP1313379 A2 EP 1313379A2
Authority
EP
European Patent Office
Prior art keywords
carbohydrate
composition
weight
glucose
maltodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01969521A
Other languages
German (de)
English (en)
Other versions
EP1313379B1 (fr
Inventor
David Myatt Parker
Andrea Roedig-Penman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to SI200130170T priority Critical patent/SI1313379T1/xx
Publication of EP1313379A2 publication Critical patent/EP1313379A2/fr
Application granted granted Critical
Publication of EP1313379B1 publication Critical patent/EP1313379B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/38—Sucrose-free products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01001—Alpha-amylase (3.2.1.1)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to carbohydrate-containing compositions for oral use, such as beverages and confectionery compositions, and to the use of ⁇ -(l,4)-linked glucose polymers in such compositions to alleviate or prevent the tooth damage associated with the consumption of sugars.
  • Dental caries and dental erosion are caused by the action of acids on the enamel of the tooth surface.
  • Dental erosion is typically associated with the direct consumption of acids such as fruit acids whilst dental caries is associated with the consumption of sugars.
  • the acid which gives rise to dental caries is produced by fermentation of sugars by oral plaque bacteria covering the enamel surface.
  • a particular problem arises with frequent consumption of products containing carbohydrates serving as a source of energy eg. so- called energy or sports drinks.
  • the most common source of carbohydrate in oral products for conferring energy, such as sports drinks are mono-and di-saccharides such as for example glucose (dextrose), sucrose and maltose. Longer chain polymers of glucose such as maltodextrins are also employed in such products as a source of energy.
  • Maltodextrins are carbohydrates which are also known as glucose polymers. They are usually derived from starch, for example corn starch, by hydrolysis. They largely comprise polymers of three or more dextrose units in length but also contain a small percentage, typically up to about 10 % by weight, of monosaccharides or disaccharides. The preparation of maltodextrin from starch results in a range of polymer chain lengths. The degree of depolymerisation of starch is expressed as the dextrose equivalent (D.E.) which is the amount of total reducing sugars present, expressed as dextrose and calculated as a percentage of the total dry matter. Glucose (dextrose) has a D.E. of 100.
  • D.E. dextrose equivalent
  • Glucose syrups generally have a D.E. of 20 or more whereas maltodextrins generally have a D.E. of less than 20.
  • Maltodextrins having D.E. values in the range 1 to 20 are commercially available with low % content of mono- and di-saccharides as detailed below.
  • starch may be- controlled to provide maltodextrins varying in D.E. and with a low percentage content of mono- and di-saccharides.
  • Cerestar Trafford Park, Manchester Ml 7 IPA, UK
  • Staley A.E. Staley Manufacturing Company, 2200 E.Eldorado Street, Decatur, IL 62525 USA
  • D.E. glucose syrups with restricted % content of mono- and di-saccharides are also commercially available.
  • alpha-amylase hydrolyses the ⁇ -(l,4) linkages of non-cariogenic polysaccharides to form cariogenic monosaccharides and disaccharides such as glucose and maltose.
  • the ⁇ -amylase enzyme is able to convert essentially non-cariogenic long chain polymers of glucose into cariogenic substrates that may then be metabolised by plaque bacteria, producing organic acid as a by-product.
  • the cariogenic potential of maltodextrins has been evaluated in a human model by Al-Khatib et al, 1997, Caries Research 31, 316, abstracts 106 & 107. Maltodextrins were found to possess a lower acidogenic potential than sucrose but were found to have demineralising activity in an intra-oral cariogenicity test.
  • EP 0 264 117 addresses the problem of providing a fitness drink which will maintain blood glucose levels in blood during physical exercise, replace lost body fluids and salts and also inhibit damage to the dentition caused by fermentable carbohydrate.
  • EP 0 264 117 describes fitness drink powder compositions comprising 60 to 85 % by weight long chain glucose polymers as the source of carbohydrate with the pH of the composition regulated between pH5.2 and 5.8.
  • the long chain glucose polymer preferably contains less than 10% by weight of monosaccharides and disaccharides.
  • salivary amylase will produce fermentable sugars from such a composition.
  • SE 8904190 discloses a composition intended for oral consumption for use in energy-requiring physical activity comprising maltodextrin as the main energy source and supplemented with xylitol as a caries-preventing substance.
  • SE 8904190 addresses the problem of providing a slowly absorbed drink product based on low molecular weight carbohydrate sources such as dextrose and sucrose and of caries formation due to use of these sources of carbohydrate as a substrate for the bacterial flora in the mouth.
  • the maltodextrin composition of SE 8904190 is defined in terms of its mono-, di- and oligosaccharide content up to 10 glucose units in length with the remainder (55 to 70% by weight) being oligosaccharides of over 10 glucose units in length.
  • the range for monosaccharide and disaccharide content is from 2.1 to 4.0 % by weight.
  • the preferred monosaccharide and disaccharide content of the maltodextrin composition is 3.0% by weight.
  • the pH of the compositions of SE 8904190 is not defined.
  • SE 8904190 states that the carbohydrate source should not be a good substrate for caries-producing bacteria, it is notable that the only example in the specification, a sports drink composition, contains 51.8% by weight maltodextrin and 38% by weight of the cariogenic monosaccharide fructose. Due to the action of ⁇ -amylase and of oral bacteria, the compositions disclosed in SE 8904190 will inevitably have the potential for plaque acid production and tooth demineralisation.
  • the present invention provides non-cariogenic, carbohydrate-containing compositions for oral administration comprising ⁇ -(l,4)-linked polymers of glucose such as maltodextrin as the primary source of carbohydrate.
  • ⁇ -(l,4)-linked polymers of glucose such as maltodextrin as the primary source of carbohydrate.
  • Use of such compositions according to the present invention will overcome the problem of the potential damage to the teeth caused by plaque acid produced in the mouth by oral bacteria.
  • reference herein to ⁇ -(l,4)-linked polymers of glucose includes polymers having ⁇ -(l,6) linkages as well as ⁇ -( 1,4) linkages.
  • compositions formulated at low pH with ⁇ -(l,4)-linked polymers of glucose such as maltodextrin as the primary carbohydrate source Whilst not being bound by theory, it is postulated that at a reduced pH, the ⁇ -amylase enzyme is not able to hydrolyse the ⁇ -(l,4) linkage and convert the glucose polymer into the readily fermentable mono- and disaccharides. Therefore compositions may be formulated to contain energy-producing carbohydrate with minimal damage to teeth from plaque acid production.
  • a carbohydrate-containing composition having an effective pH of 4.5 or less and comprising at least 1.0% by weight of an ⁇ -amylase digestible, ⁇ -(l,4)-linked polymer of glucose as a source of carbohydrate, in which composition the concentration of mono- and di-saccharides is no greater than 2.0% by weight, in the manufacture of an orally administrable composition for the reduction or prevention of tooth damage by plaque acid production.
  • effective pH is defined as the pH of a composition that will confer a transient intra-oral pH of 4.5 or less during administration of the composition whilst it is in contact with saliva in the mouth.
  • Compositions formulated to confer a pH below pH 4.5 have been found effective and for greatest benefit the effective pH should be below 4.0.
  • compositions according to the invention will have an effective pH no less than 2.0.
  • the carbohydrate source for use in the present invention will suitably be a maltodextrin having a low DE, typically 15 or less, such that the concentration of mono- and di- saccharides is minimised.
  • concentration of carbohydrate to be applied to the composition other than that dictated by the practicalities of preparation and other organoleptic considerations, provided that the concentration of mono- and disaccharides in the composition is minimised.
  • the concentration of mono- and di-saccharides in the composition will preferably be no greater than 1.5% by weight and more advantageously no greater than 1.0% or even 0.5% by weight.
  • the invention is applicable to a wide range of carbohydrate-containing products for oral consumption or use, in particular to beverages and confectionary products.
  • Compositions may be in the form of liquids, solids or semi-solids.
  • beverage encompasses ready to drink liquid compositions as well as concentrates and powder formulations for dilution or dissolution.
  • the invention may be applied in a variety of beverages such as concentrates, still or carbonated drinks with or without fruit juices or fruit extracts, and in particular to drinks such as sport and energy drinks or vitamin added beverages.
  • Compositions may be unsweetened or sweetened with intense sweeteners such as saccharine, aspartyl phenyl alanyl methyl ester, or other non-sugar sweeteners known in the art.
  • Compositions may also contain other conventional additives such as sodium benzoate, sorbic acid, sodium metabisulfite, ascorbic acid, flavourings, colourings, stabilizers, eg. food hydrocolloids and carbon dioxide.
  • the present invention is particularly suitable for use in sport drinks formulated with about 6% carbohydrate, for example in the range 4.0 to 8.0% carbohydrate, and in energy providing products made with higher levels of carbohydrate, eg. about 15 to 25% carbohydrate. If a fruit juice or similar substance containing fermentable, mono- or di- saccharide carbohydrate sources is a component of the composition then this will contribute to the concentration of mono- and disaccharides in the composition and appropriate allowance will be required .
  • High energy compositions formulated in accordance with the present invention containing ⁇ -(l ,4)-linked polymers of glucose as the primary source of carbohydrate energy for example compositions having more than about 15% by weight carbohydrate, in particular more than 20% by weight carbohydrate, are believed to be novel and as such form part of the present invention.
  • WO 92/05711 discloses a method for preventing the erosion of tooth enamel by consuming an acid beverage (having a pH of less than 5.5) comprising from 0.02% to 0.15% of calcium in the form of a calcium citrate malate complex having a molar ratio of citrate to malate of 1:0.5 to 1:4.5.
  • WO 97/30601 and WO 99/08550 disclose compositions having reduced tooth erosion properties containing a calcium compound and an acidulant characterised in that calcium is present in the range of 0.3 to 0.8 mol per mol of acidulant and the pH of the composition is from 3.5 to 4.5.
  • WO 00/13531 discloses the use of viscosity modifying polymer materials, commonly used as thickening agents, stabilisers and emulsifyers, in acidic compositions for oral use to alleviate or inhibit the tooth damage associated with the consumption of acid.
  • the present invention is particularly suitable for application to acidic, carbohydrate-containing products for oral consumption such as acidic sports and energy beverages, acidic beverages made with fruit juices and also to other acidic products to be taken orally.
  • acidic, carbohydrate-containing products for oral consumption such as acidic sports and energy beverages, acidic beverages made with fruit juices and also to other acidic products to be taken orally.
  • Acid compositions may contain organic and/or inorganic acids and may be supplemented with vitamins such as for example B vitamins and ascorbic acid. Acid solutions may also contain sodium ions, particularly in the formulation of sport drinks. Preferred acidulants include potable acids such as citric, malic, lactic, phosphoric, acetic and tartaric acids. The invention is advantageously applied to drink products containing natural or added citric acid. The acidulant concentration in a composition will be determined by the type of product, the desired effective pH, the desired organoleptic properties and the acidity of the chosen acid source.
  • the acidity of a composition may be expressed in terms of titratable acidity which is a measure of the percentage weight of acid present in a solution as calculated from the volume of sodium hydroxide required to neutralise the acidic species present.
  • titratable acidity is measured potentiometrically with standardised sodium hydroxide solution of a known concentration at a temperature of 20 degrees
  • a typical beverage will have a titratable acidity in the range 0.01 to 4%w/w and a typical fruit-flavour ready to drink beverage will have a titratable acidity in the range 0.1 to 2%w/w.
  • the acid concentration in compositions of the invention for example the acid concentration in a fruit-flavour product would be in the range 0.01% w/w to 4% w/w, suitably in the range 0.1 % w/w to 2.5% w/w.
  • a typical ready to drink fruit- flavoured beverage based on citric and/or malic acid as the acidulant will have an acid concentration in the range 0.01 to as great as 2% w.w, preferably 0.01 to 1.0 %w/w of the beverage composition.
  • typical citric/malic acid concentration will be in the range 0.1 to 4%w/w of the composition.
  • Mixtures of potable acids may be used, for example mixtures of acids selected from citric, malic, phosphoric and lactic acids and other suitable food grade excipients known in the art.
  • the effective pH of compositions according to the invention will vary according to type of product, acid content and desired organoleptic properties.
  • a typical effective pH range of compositions is from pH 2.4 to pH 4.0, and more preferably from pH 2.7 to pH 4.0, especially for beverages containing fruit acids. It will be appreciated that for liquid compositions such as beverages, the effective pH will be very close to the actual pH of the composition.
  • compositions according to the invention may be prepared by mixing the ingredients according to conventional methods. Solid ingredients may be dissolved in water or in hot water if required prior to mixing with other components. Typically beverage compositions are pasteurised prior to filling in bottles or cans or other packs or are "in-pack pasteurised” after filling.
  • Results are described as the % of a carbohydrate species as part of the total carbohydrate. Time: 0 minutes
  • DP degree of polymerisation
  • DPI represents monosaccharide
  • 'Other' means other carbohydrate species calculated by difference.
  • a reduction in pH to 4.5 inhibits the hydrolysis of the ⁇ -(l,4) linkages. Above pH 4.5, there is a reduction in higher sugar polymers (DP>5) and increase in mono-, di- and tri saccharides (DP 1-3). Considerable hydrolysis of the maltodextrin was observed at pH7.0
  • composition of the carbohydrate species in the maltodextrin / enzyme incubations was subsequently established by HPLC.
  • HPLC details as per example 1.
  • Results are described as the % of a carbohydrate species as part of the total carbohydrate.
  • DP degree of polymerisation
  • DPI represents monosaccharide
  • 'Other' means other carbohydrate species calculated by difference.
  • Example 3 Sport Drink Composition
  • Sport drinks compositions were prepared according to the formula detailed below. Four different maltodextrins each having a D.E. ranging from 6-14 were added to give a carbohydrate concentration of 6.4% by weight. The total volume of each test composition was 1 litre and the pH was 3.8. The sodium concentration was about 55mg per lOOmls.
  • composition of the four maltodextrins used was established by HPLC (see below).
  • DP means degree of polymerisation; DPI represents monosaccharide, DP2 disaccharide etc. 'Other' means other carbohydrate species calculated by difference.
  • the maltodextrin-containing sport drinks were evaluated by means of a plaque pH study to assess the utility of the invention with respect to the ability of plaque bacteria to produce acid from the formulations.
  • a sample of plaque was taken from the buccal surfaces of four sites of the subjects' teeth using a sterile stainless steel straight probe. This formed the baseline plaque sample (time 0).
  • the sample was mixed with 20 microlitres of distilled water and the pH measured with a micro electrode. Subjects then rinsed their mouths thoroughly with 15ml of the sports drinks or of the controls for 1 minute.
  • the following table shows that the pH of the four different maltodextrin-containing compositions never dropped below 6.15 whereas the pH of the sucrose control composition dropped to 5.42.
  • the criteria of "toothfriendliness" is that the pH does not drop below a pH of 5.5, below which enamel may begin to be dissolved.
  • the maltodextrin formulations did not cause a reduction in plaque pH to a level for enamel damage to occur.
  • the sport drink formulation without carbohydrate and the sorbitol control composition reduced plaque pH less than the test solutions. Analysis of the data showed that there was a statistically significant difference between the pH drop from sucrose and the pH drop of the four maltodextrin-containing compositions. There was no difference between the four maltodextrin-containing compositions.
  • the results demonstrate that a beverage can be formulated containing appreciable quantities of low D.E. maltodextrin that has no significant cariogenic potential.
  • Energy/sport drink compositions were prepared according to the formula detailed below. Three different 5 D.E. maltodextrin solutions were prepared using from 6-24% carbohydrate. The test compositions had a product acidity of 0.3% w/w citric acid monohydrate and a product pH was 3.2.
  • Maltodextrin (Staley Star-Dri 5 D.E.) is 95% carbohydrate.
  • composition of the three maltodextrin solutions used was established by HPLC (see below).
  • DP means degree of polymerisation; DPI represents monosaccharide, DP2 disaccharide.
  • the maltodextrin-containing energy/sport drinks were evaluated by means of a plaque pH study to assess the utility of the invention with respect to the ability of plaque bacteria to produce acid from the formulations. This was conducted in a similar manner to that described in Example 3. This involved 9 volunteers in a five leg study that also included acidified sucrose and acidified sorbitol positive and negative control legs (10% solutions dissolved in the same base composition as the test maltodextrin solutions). On each test day, a sample of plaque was taken from the buccal surfaces of the subjects' teeth using a sterile stainless steel straight probe. This formed the baseline plaque sample (time 0). The sample was mixed with 30 microlitres of distilled water and the pH measured with a micro electrode.
  • the following table shows that the pH of the three maltodextrin-containing compositions never dropped below 5.5 whereas the pH of the sucrose control composition dropped to 5.28.
  • the criteria of "toothfriendliness" is that the pH does not drop below a pH of 5.5, below which enamel may begin to be dissolved.
  • the maltodextrin formulations did not cause a reduction in plaque pH to a level for enamel damage to occur.
  • the sorbitol control composition reduced plaque pH less than the test solutions.
  • a powdered sport drink formulation was made according to the following list of ingredients that are dry blended typically using a ribbon blender until an homogeneous mixture is obtained. The product is then filled into appropriate packaging such as sachets, jars or drums.

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Abstract

L'invention porte sur des compositions contenant des glucides destinées à un usage oral et visant à réduire ou prévenir les dégradations des dents imputables à la production de l'acide des plaques dont le pH effectif est égal ou inférieur à 4,5 et comprenant au moins 1,0 % en poids d'une α-amylase digestible, un polymère réticulé α-(1,4) de glucose comme source glucidique, la concentration de cette composition en mono- et disaccharides étant inférieure ou égale à 2,0 % en poids.
EP01969521A 2000-08-01 2001-07-26 Nouvelle composition & son utilisation Expired - Lifetime EP1313379B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SI200130170T SI1313379T1 (en) 2000-08-01 2001-07-26 Alpha-(1,4)linked glucose polymers containing oral compositions to alleviate or prevent tooth damage

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0018849.0A GB0018849D0 (en) 2000-08-01 2000-08-01 Novel composition and use
GB0018849 2000-08-01
PCT/EP2001/008638 WO2002009537A2 (fr) 2000-08-01 2001-07-26 Nouvelle composition & son utilisation

Publications (2)

Publication Number Publication Date
EP1313379A2 true EP1313379A2 (fr) 2003-05-28
EP1313379B1 EP1313379B1 (fr) 2004-06-30

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EP01969521A Expired - Lifetime EP1313379B1 (fr) 2000-08-01 2001-07-26 Nouvelle composition & son utilisation

Country Status (27)

Country Link
US (1) US20030175215A1 (fr)
EP (1) EP1313379B1 (fr)
JP (1) JP2004505027A (fr)
KR (1) KR100804928B1 (fr)
CN (1) CN1240322C (fr)
AR (1) AR033550A1 (fr)
AT (1) ATE270052T1 (fr)
AU (2) AU2001289757B2 (fr)
BR (1) BR0112900A (fr)
CA (1) CA2416927C (fr)
CZ (1) CZ301463B6 (fr)
DE (1) DE60104128T2 (fr)
DK (1) DK1313379T3 (fr)
ES (1) ES2223005T3 (fr)
GB (1) GB0018849D0 (fr)
HK (1) HK1057848A1 (fr)
HU (1) HUP0303936A3 (fr)
MX (1) MXPA03000987A (fr)
MY (1) MY139947A (fr)
NZ (1) NZ523736A (fr)
PL (1) PL201806B1 (fr)
PT (1) PT1313379E (fr)
SI (1) SI1313379T1 (fr)
TR (1) TR200401819T4 (fr)
TW (1) TWI243024B (fr)
WO (1) WO2002009537A2 (fr)
ZA (1) ZA200300652B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0018849D0 (en) * 2000-08-01 2000-09-20 Smithkline Beecham Plc Novel composition and use
WO2005009147A1 (fr) * 2003-07-31 2005-02-03 Shannon Minerals Ltd. Preparation prete a la consommation contenant un principe actif
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AU8975701A (en) 2002-02-13
US20030175215A1 (en) 2003-09-18
CZ2003298A3 (cs) 2003-06-18
HK1057848A1 (en) 2004-04-23
HUP0303936A3 (en) 2004-12-28
AR033550A1 (es) 2003-12-26
DE60104128T2 (de) 2005-08-25
PL201806B1 (pl) 2009-05-29
JP2004505027A (ja) 2004-02-19
ES2223005T3 (es) 2005-02-16
DE60104128D1 (de) 2004-08-05
EP1313379B1 (fr) 2004-06-30
TR200401819T4 (tr) 2004-09-21
TWI243024B (en) 2005-11-11
HUP0303936A2 (hu) 2004-05-28
MXPA03000987A (es) 2003-06-09
MY139947A (en) 2009-11-30
KR20030029802A (ko) 2003-04-16
DK1313379T3 (da) 2004-10-18
SI1313379T1 (en) 2004-12-31
AU2001289757B2 (en) 2005-08-25
ATE270052T1 (de) 2004-07-15
CA2416927C (fr) 2009-10-06
KR100804928B1 (ko) 2008-02-20
BR0112900A (pt) 2003-07-01
ZA200300652B (en) 2004-04-23
PT1313379E (pt) 2004-10-29
CA2416927A1 (fr) 2002-02-07
CN1240322C (zh) 2006-02-08
NZ523736A (en) 2004-07-30
PL365184A1 (en) 2004-12-27
WO2002009537A3 (fr) 2003-03-06
CN1446054A (zh) 2003-10-01
CZ301463B6 (cs) 2010-03-10
WO2002009537A2 (fr) 2002-02-07
GB0018849D0 (en) 2000-09-20

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