EP1287804B1 - Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen - Google Patents

Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen Download PDF

Info

Publication number
EP1287804B1
EP1287804B1 EP20020017985 EP02017985A EP1287804B1 EP 1287804 B1 EP1287804 B1 EP 1287804B1 EP 20020017985 EP20020017985 EP 20020017985 EP 02017985 A EP02017985 A EP 02017985A EP 1287804 B1 EP1287804 B1 EP 1287804B1
Authority
EP
European Patent Office
Prior art keywords
hollow body
container
cannula
cannula holder
closure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20020017985
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1287804A2 (de
EP1287804A3 (de
Inventor
Thomas Pfeifer
Dietmar Palm
Michael Becker
Michael Seipp
Rainer Wabnegg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring GmbH
Original Assignee
CSL Behring GmbH Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CSL Behring GmbH Deutschland filed Critical CSL Behring GmbH Deutschland
Publication of EP1287804A2 publication Critical patent/EP1287804A2/de
Publication of EP1287804A3 publication Critical patent/EP1287804A3/de
Application granted granted Critical
Publication of EP1287804B1 publication Critical patent/EP1287804B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means

Definitions

  • the invention relates to a device for combining a liquid component accommodated in a first container and a solid or liquid component received in a second container under sterile conditions.
  • Such a preassemblable device is known from the prior art. It is a device for passing a solvent from a bottle into a second bottle containing a pharmaceutical product to dissolve the product.
  • a transfer system is classified as a disposable medical device.
  • the two glass bottles are preassembled in the transfer device. Sterile packaging ensures that storage of the reconstituted product can take up to 36 hours.
  • a device of the type mentioned is in the EP 0 737 467 A1 described.
  • a secured, directed transfer is achieved by first piercing the closure of the first container containing the liquid component by means of a cannula and then displacing a cannula carrier receiving the cannula by means of this container in the direction of the second container receiving the solid or liquid component so that its closure is pierced by means of the cannula.
  • the cannula carrier takes a single cannula, which is sufficient for the merging of the components, as prevails before the piercing of the second container in this vacuum.
  • the cannula carrier is formed as a plate-shaped, perpendicular to the longitudinal direction of the two containers receiving hollow body oriented body which is connected via retaining webs with the inner wall of the hollow body, wherein the holding webs are rupturable by applying a manual force that is greater than the penetration force of the cannula Piercing the sealing plug of the initially opened container.
  • a disadvantage of this device is that the cannula carrier initially firmly connected to the hollow body is not defined separated from the hollow body.
  • the type of force introduction possibly an asymmetrical introduction of force, first rupture holding webs in an area of the cannula carrier, which involves the risk that the cannula carrier and thus the cannula in a tilted with respect to the longitudinal direction of the two containers position.
  • the result is that in particular the closure of the second container is not exactly pierced and problems arise when passing the liquid, in particular under the aspect of the applied vacuum.
  • the invention proposes according to the claims 1 and 4, two basic designs of the device.
  • a first cylindrical hollow body for receiving the first container in the region of the closure in a receiving opening of this hollow body and a second cylindrical hollow body for receiving the second container in the region of the closure in provided a diametrically arranged receiving opening.
  • the first hollow body and the cannula carrier are thus not separable, they represent a permanent assembly.
  • the cup-shaped design of the assembly ensures that the assembly, especially in the region of the first hollow body, is precisely guided in the second hollow body.
  • the cannula carrier forms the bottom of the pot and the first hollow body, the pot wall, whereby the first hollow body is not extended beyond the cannula carrier out.
  • the pot wall should have at least one guide section which cooperates with at least one guide section of the second hollow body. Due to the precise guidance of the assembly due to its cup-shaped design in the second hollow body ensures that the assembly and thus the cannula support does not tilt.
  • the cannula In a displacement movement of the cannula carrier, the cannula is defined in the longitudinal direction of the two hollow body moves by moving the first container in the direction of the second container and pierces the shutter.
  • the cannula holder takes the cannula firmly, so that it is not displaceable in the longitudinal direction.
  • only one cannula is received by the cannula carrier, wherein there is a vacuum in the second container.
  • the liquid component located in the first container passes into the second container due to the vacuum mixes with the solid or liquid component located there under sterile conditions.
  • the terms "cannula carrier” and “cannula” are to be understood comprehensively.
  • the cannula carrier and the cannula can form two separate components, wherein the cannula carrier is made in particular of plastic and the cannula in particular of metal. But it is quite conceivable to make the cannula carrier and the cannula in one piece, wherein the cannula is designed in the manner of a mandrel or spikes. Preferably, this assembly is made of plastic.
  • the spike / spike has one or two passages according to the circumstances. If there is vacuum in the second bottle, one passage is sufficient.
  • the two hollow bodies are inserted into each other and form the first hollow body and a cup-shaped cannula carrier with at least one of this cannula received separate components, wherein the first hollow body and the cannula carrier inserted into each other and in Guided longitudinal direction of the two hollow bodies are displaceable relative to each other.
  • the first hollow body and the cannula carrier do not form a structural unit. Instead, the cannula carrier, in order to ensure the precise guidance during its displacement, cup-shaped.
  • the first hollow body serves to receive the first container, while the cannula carrier serves to mount the cannula and its precise guidance in the longitudinal direction of the two hollow bodies.
  • the function of the storage of the first hollow body and the storage of the cannula is thus shifted in this design to two basic components, in contrast to the first solution.
  • the cannula carrier may well accommodate more than one cannula, depending on the application.
  • the pot wall should have at least one guide section which cooperates with at least one guide section of the first hollow body.
  • the first hollow body is mounted immovably in inserted in this first container in the second hollow body. If the first container is inserted into the first hollow body, only the advancement of the cup-shaped cannula carrier takes place when advancing the first container.
  • the first hollow body or the cup-shaped cannula carrier forming a structural unit with the cannula carrier has latching means for locking in different positions of the cannula carrier in complementary latching means of the second hollow body. These locking means ensure a defined displacement of the cannula holder and thus the cannula safely. If the closure of the first container is to be pierced before the cannula carrier is advanced and before it comes into contact with the closure of the second container, the detent of the cannula holder in this position must be dimensioned so that it is in contact of the closure of the first container the cannula does not move.
  • the puncture resistance of the closure of the second container is greater than that of the closure of the first container, so that the closure of the second container brings about the resistance with respect to the cannula which, when the first container is advanced, causes the latter Lock is punctured. In this case, the aforementioned detent would not be required.
  • the second detent serves to fix the cannula carrier or a component connected thereto in the maximally advanced position. It ensures that when removing the second container from the second hollow body of the cannula carrier is not tightened and therefore the cannula is pulled out of the closure of the second container.
  • Essential aspects of the device according to the invention are thus in handling safety and robustness in the application by a new design of the cannula holder, which is no longer firmly connected to a cylindrical hollow body and is no longer designed as a disc.
  • the design as a "pot” allows a much stronger guided movement when activated according to the principle "piston in the cylinder".
  • the activation of the device takes place in a vertically oriented position by pressure on the first container located above.
  • the first and / or second hollow body is formed segment-shaped in the region of its container-side end.
  • the segments form in particular spreading tabs, which can embrace a crimp cap of the respective container.
  • the device is used in particular in connection with containers which are designed as vials. It is preferably glass vials with a filling volume of 1 to 10 ml.
  • the device has a visual endpoint display, in which by viewing window reaching the end position of the cannula holder and thus the puncturing of the closure of the second container can be traced by means of the cannula.
  • the second hollow body is provided for this purpose laterally with the or the viewing windows.
  • the device For immediate use, the device, that is, with the two pre-assembled in the hollow containers in a package, especially a soft plastic packaging, sealed. It thus exists during the reconstitution procedure There is no risk of microbiological contamination since the transfer process can take place within the sterile outer packaging and also allows storage of the reconstituted product under sterile conditions.
  • the device according to the invention also prevents the handling of cannulas with freely accessible needle tips. There is no risk of injury during removal of the product bottle after reconstitution because the cannula carrier is retained in the device.
  • the device is immediately available because of the pre-assembly of the relevant components. Within a short time, the liquid can be transferred from the first to the second container. This requires a considerable time savings during the preparation process.
  • the reconstitution can either be prepared beforehand by a single person or take place directly in the sterile area of an operating room.
  • FIGS. 1 and 2 illustrate the device according to the invention, also referred to as the transfer system 1, in a three-part embodiment.
  • a first hollow body 2 serves for the displaceable reception of a cup-shaped cannula carrier 3 and can be inserted into the second hollow body 4.
  • the hollow body 2 serves as a holder for a solvent bottle and is provided for this purpose with various parallel to the longitudinal axis of the cylindrical hollow body 2 arranged flexible segments 5. These carry inwardly directed beads 6.
  • the opening 7 of the hollow body 2, which is the top of the transfer system when using the transfer, serves to accommodate the solvent bottle.
  • In the region of the lower opening 8 of the hollow body 2 is provided with an inner guide portion 9 for the cannula carrier 3 received by this, which has an outer complementary guide surface 10, so that the cannula carrier 3 is guided in the hollow body 2 with little play.
  • the cup-shaped cannula support 3 receives in the region of its bottom portion 11 fixed to a central, axially directed transfer cannula 12, which is provided with pointed ends.
  • the length of the transfer cannula 12 is dimensioned so that their respective projections, with respect to the bottom portion 1 of the cannula support 3, sufficient to pierce the closures of the containers cooperating with the device.
  • the second hollow body 4 serves to receive the first hollow body 2 and the cannula carrier 3 in its advanced position.
  • the relative to the position of use of the device lower end of the hollow body 4 is provided according to the design of the hollow body 2 with flexible segments 13, which in turn have inwardly directed beads 14.
  • the second container which receives the solid or liquid component, inserted into the hollow body 4.
  • the hollow body 4 is widened so that, when the hollow body 2 is inserted in it, its flexible segments have sufficient space to be spread outwards.
  • the hollow body 2 is held in the hollow body 4 in the region of its lower, outer guide section 17, which is provided with a circumferential one Locking groove 18 is provided, in which in the region of the complementary inner guide portion 19 a local circumferential locking projection 20 engages. In the inserted position of the hollow body 2, this is thus fixed relative to the hollow body 4.
  • the cannula support 3 has in the region of its outer guide portion 10 has a circumferential latching projection 21, which cooperates in the largely remote from the bottom opening 11 position with an extension 22 in the hollow body 4. If the cannula carrier 3 is acted upon by applying a force directed in the direction of the opening 15, the cannula carrier 3 is advanced until the latching projection 21 rests with a latching groove 23 of the hollow body 4 located further in the front in the hollow body 4. In this position, the cannula carrier 3 rests with its bottom portion 11 against a circumferential annular projection 24 of the hollow body 4.
  • FIG. 1 illustrates the mounting state of the transfer system 1 when inserted into the hollow body 4 hollow body 2, before advancing the cannula holder 3 in the direction of the opening 15 in the hollow body 4th
  • FIG. 3 shows the different steps in the assembly and in the activation of the transfer system 1.
  • step a is the Einzelteilildwolf according to FIG. 2 illustrates, further provided for insertion into the hollow body 2 glass bottle 25 which receives the solvent.
  • the bottle 25 is provided with an elastic, pierceable closure 26 and has a crimp cap 27 in the region of the closure.
  • the other, the fixed or designed liquid component receiving glass bottle 28 which can be inserted from below into the hollow body 4.
  • orientation shown - glass bottle top 25 and glass bottle bottom 28 - is, starting from the mounting state of the transfer system 1 according to FIG. 1 or mounting condition b. in FIG. 3 , the glass bottle 25 inserted into the hollow body 2 and the glass bottle 28 in the hollow body 4.
  • FIG. 3 illustrates the beads 6 of the segments 5 and the beads 14 of the segments 13, the bottles 25 and 28, wherein the bottle 28 abuts the annular projection 24 of the hollow body 4. If the two bottles 25 and 28 are now pressed towards one another or the glass bottle 25 is pressed further into the hollow body 2, the cannula 12 of the cannula holder 3 remaining in its position pierces the closure 26 of the bottle 25, the bottle having a greater diameter during advancement of the bottle Bottle body, the segments 5 of the hollow body 1 are spread outwards. This condition is too d. in FIG. 3 illustrated.
  • FIGS. 4 and 5 is different from the one after the FIGS. 1 and 2 in that instead of the two components - hollow body 2 and cannula carrier 3 - a component 29 is provided, which unites the function of these two components in itself.
  • Matching components are in the FIGS. 4 and 5 as well as the functional representation after FIG. 6 for the sake of simplicity designated by the same reference numerals.
  • the assembly 29 is pot-shaped and is formed by the cylindrical hollow body 2 and the cannula carrier 3.
  • the assembly 29 is provided with an outer circumferential locking projection 30, whose function is that of the locking projection 21 on the cannula carrier 3 in the embodiment according to the FIGS. 1 and 2 equivalent.
  • the outer guide portion 31 of the assembly 29 cooperates with the inner guide portion 32 of the hollow body 4, which is provided in the two functional positions of the cannula holder 3 of the assembly 29 with inner locking grooves 33 and 34, in their function of the extension 22 and the locking groove 23 correspond to the hollow body 2 in the embodiment described above.
  • the bottles 25 and 28 inserted into this, wherein the upper bottle 25 engages with its crimp cap 27 in a circumferential recess 35 of the flexible segments 5 of the assembly 29.
  • the segments 5 are spread over the bottle body to the outside and the crimp cap 27 of the bottle 25 against the cannula support 3, in particular in the region of the projection 36 which carries the cannula 12 moves.
  • the assembly 29 is moved out with its locking projection 30 from the locking groove 33 of the hollow body 4.
  • the lower end position of the cannula holder 3 is to e. in FIG.
  • FIGS. 7A to 7D illustrate a sealed in a blister foil transfer system 1 with the bottles inserted therein 25 and 28, in a state as in the Figures 3 and 6 to the stage c. is illustrated.
  • the Blister sheet 37 is welded to a sealing paper 38, which is preferably continuous for a sterilizing agent.
  • FIG. 7A shows the arrangement in a plan view
  • FIG. 7B this in a side view
  • the Figures 7C and 7D make cuts according to the lines AA and BB in FIG. 7A represents.
EP20020017985 2001-08-31 2002-08-10 Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen Expired - Lifetime EP1287804B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142450 2001-08-31
DE2001142450 DE10142450C1 (de) 2001-08-31 2001-08-31 Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen

Publications (3)

Publication Number Publication Date
EP1287804A2 EP1287804A2 (de) 2003-03-05
EP1287804A3 EP1287804A3 (de) 2003-10-29
EP1287804B1 true EP1287804B1 (de) 2012-02-01

Family

ID=7697074

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020017985 Expired - Lifetime EP1287804B1 (de) 2001-08-31 2002-08-10 Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen

Country Status (11)

Country Link
US (1) US8172824B2 (es)
EP (1) EP1287804B1 (es)
JP (1) JP4359030B2 (es)
KR (1) KR100895418B1 (es)
AT (1) ATE543482T1 (es)
AU (1) AU2002300778B2 (es)
CA (1) CA2399826C (es)
DE (1) DE10142450C1 (es)
DK (1) DK1287804T3 (es)
ES (1) ES2380655T3 (es)
MX (1) MXPA02007786A (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9707410B2 (en) 2010-11-01 2017-07-18 General Electric Company Pierce and fill device
US11505776B2 (en) 2019-12-17 2022-11-22 Oribiotech Ltd Connector

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048724B2 (en) * 2002-12-17 2006-05-23 Denver Biomedicals, Inc. Device for withdrawing body fluids
EP1829518A4 (en) * 2004-12-16 2009-08-19 Zhongshan Botai Pharmaceutic I MEDICAL USE MIXER FOR DRUG DELIVERY
US7597680B2 (en) * 2005-02-09 2009-10-06 Kaken Pharmaceutical Co., Ltd. Syringe device and method of preparing medicine using the device
US20060184103A1 (en) * 2005-02-17 2006-08-17 West Pharmaceutical Services, Inc. Syringe safety device
AT503142B1 (de) 2006-01-18 2009-05-15 Friedrich Ing Pipelka Behälter zur einbringung zumindest eines unsterilen gefässes in einen sterilen bereich
ATE447923T1 (de) * 2006-02-16 2009-11-15 Hoffmann La Roche System und vorrichtung zum entnehmen von pharmazeutika
ES2608284T3 (es) 2006-05-25 2017-04-07 Bayer Healthcare Llc Dispositivo de reconstitución
DE102006031712B3 (de) * 2006-07-08 2007-12-06 Haindl, Hans, Dr.med. Dipl.-Ing. Transfervorrichtung zur Überleitung einer Flüssigkeit aus einer ersten Flasche in eine zweite Flasche
DE102007031799B3 (de) * 2007-07-07 2008-10-16 Haindl, Hans, Dr. med. Kanülenvorrichtung zur Entnahme von Rückenmarksflüssigkeiten (Liquor)
JP5333850B2 (ja) 2009-07-15 2013-11-06 ニプロ株式会社 連結器具
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
US8424713B2 (en) * 2009-12-17 2013-04-23 Michael J. Bolland Multiple container retaining device and method for using same
US8753325B2 (en) 2010-02-24 2014-06-17 Medimop Medical Projects, Ltd. Liquid drug transfer device with vented vial adapter
US8684994B2 (en) 2010-02-24 2014-04-01 Medimop Medical Projects Ltd. Fluid transfer assembly with venting arrangement
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
JP5888606B2 (ja) * 2012-06-18 2016-03-22 ニプロ株式会社 薬剤調製器具
ES2836824T3 (es) * 2012-06-27 2021-06-28 Carmel Pharma Ab Dispositivo de conexión médica
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
JP5868555B2 (ja) 2012-09-13 2016-02-24 メディモップ・メディカル・プロジェクツ・リミテッド 入れ子式雌薬瓶アダプタ
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd A ready-to-use medicine vial device including a medicine vial closure, and a medicine vial closure for it
JP6199483B2 (ja) 2013-05-10 2017-09-20 メディモップ・メディカル・プロジェクツ・リミテッド インライン乾燥薬剤モジュールを有するバイアルアダプタを備える医療用デバイス
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
CN205626622U (zh) 2013-08-07 2016-10-12 麦迪麦珀医疗工程有限公司 与输液容器一起使用的液体转移装置
JP6191378B2 (ja) * 2013-10-16 2017-09-06 ニプロ株式会社 医療用容器および移注具
WO2015085110A1 (en) * 2013-12-04 2015-06-11 Wayne State University Fluid sample transfer adaptor and related methods and devices
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
CA159103S (en) * 2014-04-29 2015-06-01 Bayer Animal Health Gmbh Transfer device
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
AU2015360746B2 (en) 2014-12-08 2020-10-01 Genentech, Inc. Versatile syringe platform
DE102015107312A1 (de) * 2014-12-30 2016-06-30 Sfm Medical Devices Gmbh Misch- und oder Transfervorrichtung
EP3217944B1 (en) 2015-01-05 2019-04-10 West Pharma. Services IL, Ltd Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage
EP3291786B1 (de) * 2015-05-06 2019-07-10 Kocher-Plastik Maschinenbau GmbH Behälter-entnahmesystem
US10357429B2 (en) 2015-07-16 2019-07-23 West Pharma. Services IL, Ltd. Liquid drug transfer devices for secure telescopic snap fit on injection vials
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
BR112018010435B1 (pt) 2015-11-25 2022-06-28 West Pharma. Services IL, Ltd. Conjunto adaptador de ampola dupla para uso com uma seringa sem agulha com um conector macho, uma ampola de fármaco e uma ampola de líquido
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd A device with two vial adapters includes two identical vial adapters
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Devices with two vial adapters include an aerated drug vial adapter and an aerated liquid vial adapter
IL246073A0 (en) 2016-06-06 2016-08-31 West Pharma Services Il Ltd A fluid transport device for use with a slide-driven piston medicine pump cartridge
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Injector assembly
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
EP3542772B1 (en) * 2016-11-21 2023-08-16 Terumo Kabushiki Kaisha Drug solution filling unit, drug solution filling set, and filling adapter
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd A device for transporting fluids for use with an infusion fluid container and a hand tool similar to a plunger to release a vial from it
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd Liquid drug delivery devices are user-operated for use in pre-prepared liquid drug delivery assemblies (rtu)
US11275096B2 (en) * 2017-09-28 2022-03-15 Bioceryx Technologies Inc. Blood transfer devices and methods thereof
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd A device with two vial adapters includes two identical perforated vial adapters
CN108433816B (zh) * 2018-04-17 2020-08-11 陕西省人民医院 一种用于医疗器械的可调整型放置架
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1630477S (es) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (es) 2019-01-17 2019-12-16
ES2946032T3 (es) 2019-01-31 2023-07-12 West Pharma Services Il Ltd Dispositivo de transferencia de líquido
JP7001838B2 (ja) 2019-04-30 2022-01-20 ウェスト ファーマ サービシーズ イスラエル リミテッド デュアルルーメンｉｖスパイク付き液体移送装置
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
WO2022076908A2 (en) 2020-10-09 2022-04-14 Icu Medical, Inc. Fluid transfer device and method of use for same
US20220125681A1 (en) * 2020-10-26 2022-04-28 Chad Jensen Medicament compounding devices, systems, and methods
EP4112035A1 (en) * 2021-06-29 2023-01-04 Kairish Innotech Private Ltd. Tray for positioning a medical vial together with a vial adapter in a fixed positional relationship relative to each other and packaging unit comprising the same
HUE065035T2 (hu) * 2021-07-26 2024-04-28 Kairish Innotech Private Ltd Fluidumtranszferáló kanüllel ellátott komponens-összekeverõ készülék és rendszer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022339A (en) * 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180070A (en) * 1977-08-29 1979-12-25 Abbott Laboratories Disposable double vial syringe
US4898209A (en) * 1988-09-27 1990-02-06 Baxter International Inc. Sliding reconstitution device with seal
JPH06239352A (ja) * 1993-02-05 1994-08-30 Nissho Corp 溶解液注入セット
JPH0871121A (ja) * 1994-09-02 1996-03-19 Terumo Corp 薬剤収納容器
DE19513666C1 (de) * 1995-04-11 1996-11-28 Behringwerke Ag Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
FR2738550B1 (fr) * 1995-09-11 1997-11-07 Biodome Dispositif d'obturation d'un recipient lui-meme ferme, ensemble pour dispenser un produit comprenant un tel recipient et un tel dispositif d'obturation
DE19604113C2 (de) * 1996-02-06 2000-10-26 Schott Glas Einkammer-Transfersystem für Wirksubstanzen, und der daraus fertig montierte Transferbehälter
EP0904763B1 (en) * 1997-09-25 2005-12-14 Becton Dickinson France S.A. A locking ring connector assembly for a vial
US6090093A (en) * 1997-09-25 2000-07-18 Becton Dickinson And Company Connector assembly for a vial having a flexible collar
US6019750A (en) * 1997-12-04 2000-02-01 Baxter International Inc. Sliding reconstitution device with seal
US6209738B1 (en) * 1998-04-20 2001-04-03 Becton, Dickinson And Company Transfer set for vials and medical containers
FR2783808B1 (fr) * 1998-09-24 2000-12-08 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
US6558365B2 (en) * 2001-01-03 2003-05-06 Medimop Medical Projects, Ltd. Fluid transfer device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022339A (en) * 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9707410B2 (en) 2010-11-01 2017-07-18 General Electric Company Pierce and fill device
US10625095B2 (en) 2010-11-01 2020-04-21 Ge Healthcare Limited Pierce and fill device
US11505776B2 (en) 2019-12-17 2022-11-22 Oribiotech Ltd Connector

Also Published As

Publication number Publication date
KR20030019186A (ko) 2003-03-06
ES2380655T3 (es) 2012-05-17
DE10142450C1 (de) 2003-06-18
JP4359030B2 (ja) 2009-11-04
DK1287804T3 (da) 2012-05-07
CA2399826C (en) 2011-09-27
US20030069538A1 (en) 2003-04-10
MXPA02007786A (es) 2004-07-16
AU2002300778B2 (en) 2008-01-31
US8172824B2 (en) 2012-05-08
EP1287804A2 (de) 2003-03-05
ATE543482T1 (de) 2012-02-15
EP1287804A3 (de) 2003-10-29
JP2003126221A (ja) 2003-05-07
KR100895418B1 (ko) 2009-05-07
CA2399826A1 (en) 2003-02-28

Similar Documents

Publication Publication Date Title
EP1287804B1 (de) Vorrichtung zum Zusammenführen von Komponenten unter sterilen Bedingungen
EP0509281B1 (de) Behälterverschluss mit durchstossbarem Verschlusskörper
DE60019446T2 (de) Flüssigkeitstransferset für phiolen und andere medizinische behälter
EP2903583B1 (de) Transfervorrichtung zur entnahme oder übergabe eines fluids
EP2667838B1 (de) Verbindungsvorrichtung zum verbinden eines ersten reservoirs mit einem zweiten reservoir
DE19513666C1 (de) Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
EP2531164B1 (de) Vorrichtung zum entnehmen eines fluids aus einem behälter
DE60210735T2 (de) Transfervorrichtung sowie System mit einer Kappenanordnung, einem Behälter und der Transfervorrichtung
DE102007046625B4 (de) Vorrichtung zum getrennten Aufbewahren einer Substanz, vorzugsweise eines medizinischen oder pharmazeutischen Wirkstoffs, und einer Flüssigkeit und zum Mischen derselben vor dem Gebrauch
EP2155140B1 (de) Durchstossvorrichtung und verfahren zum entnehmen einer flüssigkeit aus einem beutel oder zuführen einer substanz in einen beutel
EP1060106B1 (de) Behälter mit einer auslassdüse
DE10247963A1 (de) Membranspritze
EP3250171B1 (de) Vorrichtung zum überführen einer flüssigkeit zwischen einem lagerbehälter und mindestens einem weiteren gebrauchsbehälter
EP2153717B1 (de) Kennzeichnungs- und Probenahmevorrichtung für Tiere
DE2815377C3 (de) Vorrichtung zum Sammeln von Blut
DE102004044288A1 (de) Vorrichtung zur Verbindung eines rohrförmigen Teils, insbesondere einer Kanüle, mit dem Inneren einer Flasche oder dergleichen
EP2393597B1 (de) Testvorrichtung für biologische flüssigkeiten
DE102006035545B4 (de) Vorrichtung zum Zusammenführen vom Komponenten mittels Unterdruck unter sterilen Bedingungen
DE4332087A1 (de) Verschluß- und Entnahmeeinrichtung
WO2016120161A1 (de) Vorrichtung zum überführen einer flüssigkeit zwischen einem lagerbehälter und mindestens einem weiteren gebrauchsbehälter
DE10163719A1 (de) Blutentnahmevorrichtung
WO2007062775A1 (de) Vorrichtung zum überleiten von flüssigkeiten, suspensionen und/oder feststoffen von einem ersten gefäss in ein zweites gefäss
WO2005087649A1 (de) Flaschenverschluss-durchbohrungs-vorrichtung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

17P Request for examination filed

Effective date: 20040429

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: ZLB BEHRING GMBH

17Q First examination report despatched

Effective date: 20041216

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CSL BEHRING GMBH

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 543482

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120215

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 50215367

Country of ref document: DE

Effective date: 20120329

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2380655

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20120517

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20120400991

Country of ref document: GR

Effective date: 20120614

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120601

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120201

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20121105

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 50215367

Country of ref document: DE

Effective date: 20121105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20120501

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 14

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20200814

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20200804

Year of fee payment: 19

Ref country code: GR

Payment date: 20200715

Year of fee payment: 19

Ref country code: FI

Payment date: 20200811

Year of fee payment: 19

Ref country code: DK

Payment date: 20200811

Year of fee payment: 19

Ref country code: TR

Payment date: 20200806

Year of fee payment: 19

Ref country code: ES

Payment date: 20200901

Year of fee payment: 19

Ref country code: IE

Payment date: 20200811

Year of fee payment: 19

Ref country code: GB

Payment date: 20200729

Year of fee payment: 19

Ref country code: FR

Payment date: 20200715

Year of fee payment: 19

Ref country code: LU

Payment date: 20200724

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20200715

Year of fee payment: 19

Ref country code: IT

Payment date: 20200713

Year of fee payment: 19

Ref country code: CH

Payment date: 20200814

Year of fee payment: 19

Ref country code: AT

Payment date: 20200728

Year of fee payment: 19

Ref country code: SE

Payment date: 20200811

Year of fee payment: 19

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 50215367

Country of ref document: DE

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20210831

REG Reference to a national code

Ref country code: FI

Ref legal event code: MAE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20210901

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 543482

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210810

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20210831

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20210810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210811

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220308

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210810

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220301

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210831

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210811