EP1171240B1 - Pointe de pipette, dispositif a pipetter et combinaison de pointe de pipette et de dispositif de pipette - Google Patents

Pointe de pipette, dispositif a pipetter et combinaison de pointe de pipette et de dispositif de pipette Download PDF

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Publication number
EP1171240B1
EP1171240B1 EP00926950A EP00926950A EP1171240B1 EP 1171240 B1 EP1171240 B1 EP 1171240B1 EP 00926950 A EP00926950 A EP 00926950A EP 00926950 A EP00926950 A EP 00926950A EP 1171240 B1 EP1171240 B1 EP 1171240B1
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EP
European Patent Office
Prior art keywords
pipette tip
pipette
coupling
axial
unit according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00926950A
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German (de)
English (en)
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EP1171240B2 (fr
EP1171240A1 (fr
Inventor
Armin Panzer
Johann L. Camenisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hamilton Bonaduz AG
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Hamilton Bonaduz AG
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Application filed by Hamilton Bonaduz AG filed Critical Hamilton Bonaduz AG
Publication of EP1171240A1 publication Critical patent/EP1171240A1/fr
Application granted granted Critical
Publication of EP1171240B1 publication Critical patent/EP1171240B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means

Definitions

  • the invention is concerned with the attachment of a pipette tip to a Pipetting.
  • Pipetting devices are used, for example, in the field of molecular biology or medical analysis for fluid transfer. Special pipette tips are often used, which on the Pipetting device can be attached and intended for single use are. Such disposable tips are also known as "tip" known.
  • the pipetting device can be a manual one Actuate pipetting device that only a single pipetting unit having.
  • pipetting machines or So-called pipetting robots are used, which are a variety of in a row or have pipetting units arranged in a matrix. With such Automatic pipetting machines can simultaneously use a variety of tubes Samples are sucked in and released again at another point.
  • a pipetting unit described in EP 0 760 255 A1 has one adjustable pretensioning element in the form of an inflatable rubber sleeve, whose edge facing the pipette tip on a radial Axial stop surface of the pipette tip is in contact. Because the edge of the Rubber sleeve is more or less elastic, but can not be spoken of a precisely maintained coupling position in the event of an attack become. If the pipette tip does not touch the Edge of the rubber sleeve is pushed on, but its Stop surface a more or less large clear distance to Has rubber collar, this distance remains when inflating the Rubber sleeve more or less obtained what the positioning accuracy drastically frittered away.
  • a defined position of the pipette tip is relative to the coupling attachment however, particularly in the case of automatic pipetting machines which have a large number of pipetting units have essential.
  • Different Positioning of the pipette tips in pipetting machines with several For example, ten or even several hundred pipetting units can be used of liquid aspiration cause some pipette tips properly in the vessels or recesses assigned to them immerse a microtiter plate while other pipette tips are over the Liquid levels remain in the vessels or depressions.
  • individual pipette tips at the bottom of the vessels or Initiate depressions and thereby at least their mouth opening is partially blocked. The consequence can be insufficient dosing accuracy in both fluid intake and fluid delivery his.
  • the object of the invention is therefore to show a way, in particular in automatic pipetting devices with a variety of Pipetting units improve the dosing accuracy during liquid transfer can be.
  • the present invention provides a solution to the stated problem a pipetting unit according to claim 1.
  • the pipette tip for attachment to a pipetting device
  • the pipette tip has a jacket and one enclosed by the jacket Through opening, the through opening along a longitudinal axis between one to be pipetted for immersion Medium determined end of the pipette tip and one in Axial direction opposite to the tip of the pipette extends and wherein the pipette tip near the plug end Coupling area for coupling with a coupling attachment of the pipetting device having.
  • the jacket in the coupling area Axial positioning means which cooperates with complementary counter-axial positioning means of the coupling approach are determined and together with the counter-axial positioning means an axial coupling position of the pipette tip on the pipetting device define.
  • the axial positioning means make it possible for everyone Always attach the pipette tip to the pipetting device predetermined defined axial position of the pipette tip relative to the Obtain pipetting device. This enables a positionally accurate and Equipped in the same position for all pipetting units of an automatic pipetting machine with pipette tips.
  • the tip of the pipette is on with its push-on end the coupling attachment can be plugged on, which is why the axial positioning means expediently at least in part on the inner circumference of the jacket in axial distance from the push-on end of the pipette tip will be.
  • the inner circumference of the jacket can be at least in the coupling area an envelope formed essentially by cylindrical sections have.
  • the axial positioning means can have at least one on the jacket arranged axial stop, which cooperate with a complementary counterstop of the coupling approach is determined.
  • the Axial stop in engagement with the counter stop of the coupling attachment, which results in a defined axial position of the pipette tip.
  • the coupling attachment also carries an elastically deformable O-ring that due to axial crushing and the resulting radial expansion in has come into frictional engagement with a sealing surface of the pipette tip a particularly simple, yet highly accurate attachment option for given the pipette tip on the pipetting device.
  • the axial stop can be easily manufactured from an axial Step heel of the inner circumference of the jacket be formed, which one Sliding closer first cylindrical inner circumferential section larger diameter with one further away from the push-on end second cylindrical inner circumferential section of smaller diameter combines.
  • the following dimensions are recommended:
  • the by the Graduated step caused diameter reduction from the first to the second inner circumferential section can be between 0.8 and 1.2 mm, preferably between 0.9 and 1.1 mm, most preferably about 1.0 mm be.
  • the diameter of the first inner circumferential section can between 6.5 and 7.1 mm, preferably between 6.7 and 6.9 mm, most preferably about 6.8 mm.
  • the diameter of the As far as the second inner circumferential section is concerned this can be between 5.5 and 6.1 mm, preferably between 5.7 and 5.9 mm, most preferably about 5.8 mm. It is recommended to use a standard coupling interface between the pipette tip and the pipetting device to define, so that pipette tips with different recording volumes for liquids to be pipetted, but with standardized coupling areas, can be combined with one and the same pipetting device.
  • the sealing element of an O-ring are formed and according to US-A-5,063,790 by a Squeeze device of the pipetting device to be axially compressible. It can then be provided that the attack surface designed and attached to the jacket is localized in the coupling position of the pipette tip the sealing element in an axially uncompressed state in essentially except for pre-tensioning engagement with the surface of the attack stands and in the course of an axial compression in prestressing force generators Engages with the attack surface.
  • the attack surface can be, for example, in the inner circumference of the jacket incorporated circumferential groove into which the sealing element of the Coupling approach can "snap".
  • the circumferential groove can be curved in a circular arc be, their radius of curvature between 0.3 and 0.9 mm, preferably between 0.4 and 0.8 mm, most preferably between 0.5 and 0.7 mm can be.
  • the contact surface is preferably axially between the Axial stop and the second end of the pipette tip arranged.
  • a pipetting device with at least one pipetting unit which has a pipetting channel running along a channel axis and a coupling approach for coupling a pipette tip in particular of the type described above, has the Coupling approach for interaction with axial positioning means of Pipette tip certain complementary counter-axial positioning means which, together with the axial positioning means, has an axial Define the coupling position of the pipette tip on the pipetting unit.
  • the coupling attachment can be plugged into the Pipette tip can be inserted, it then being expedient recommends that the counter-axial positioning means be at least partially on the Outer periphery of the coupling approach at an axial distance from the push-on end to arrange.
  • the inner circumference of the pipette tip can be the outer circumference of the Coupling approach at least in the in the coupling position in the Pipette tip protruding area of the coupling attachment in essentially have envelopes formed by cylindrical sections.
  • the counter-axial positioning means can be at least one for Determine interaction with an axial stop of the pipette tip complement complementary counterstop on the coupling approach.
  • This Counterstop can be from a step heel on the outer circumference of the Coupling approach be formed.
  • the coupling attachment can be a seal between the pipette tip and the coupling element serving sealing element, in particular an O-ring, wear from elastically deformable material, the pipetting unit Assigned squeezing device for axially compressing the sealing element can be.
  • the sealing element can not only perform a sealing function, but also take on a pretension function if the Pipette tip an appropriately designed and localized target for the sealing element, which has a radial surface component and loaded with an axial force component from the sealing element can be.
  • FIG. 1 You can also see one there as a tip designated pipette tip 1 with a rotationally symmetrical about a longitudinal axis 3 Jacket 5, the one axially passing through the pipette tip 1 Encloses through opening 7.
  • the pipette tip 1 has a coupling area 11, that for coupling to a pipetting device not shown in FIG. 1 serves.
  • the pipette tip has the plug-on end 9 opposite 1 has a mouth end 13 which is to be pipetted for immersion in Medium is determined.
  • the jacket 5 of the pipette tip 1 has an outer circumference 15 and one Inner circumference 17.
  • the inner circumference 17 has in the coupling region 11 a cylindrical inner peripheral portion 19 which is substantially from the push-on end 9 extends to an annular step heel 21, to the another cylindrical inner circumferential section 23 connects.
  • the Step heel 21 forms an axially directed stop surface.
  • In the area of Inner peripheral portion 19 is an annular groove extending in the circumferential direction 25 incorporated into the jacket 5.
  • This axially between the push-on end 9 and the step groove 21 arranged annular groove 25 has in the sectional view 1 is a groove contour that follows an arc.
  • the jacket 5 has a first conical wall section 27 and a second conical wall section 29, whose taper is weaker than that of the wall section 27.
  • the area of the wall sections 27 and 29 is the jacket 5 with a smaller one Wall thickness than in the coupling area 11.
  • the bigger wall thickness in the coupling area 11 increases the stability and rigidity of the Pipette tip 1. This allows a safe and leak-free coupling of the Pipette tip 1 to a pipetting device.
  • Inner diameter of the jacket 5 in the area of the inner peripheral portion 19 are approximately 6.8 mm and in the area of the inner circumferential section 23 about 5.8 mm.
  • the step heel 21 can be at an axial distance be arranged from the front end 9 of about 5 mm.
  • the radius of curvature the circular contour of the annular groove 25 can be approximately 0.6 mm.
  • the maximum radial depth of the annular groove 25 can be approximately 0.2 mm.
  • the axial distance between the step 21 and the axial center of the annular groove 25, that is, its lowest point, can be approximately 2.1 mm.
  • a section of a pipetting unit can be seen in the upper part of FIG. 2 201, which is part of a manually or automatically operated pipetting device is and has a coupling approach 203, which for coupling with the Pipette tip 101 is determined.
  • the mentioned pipetting device can train a variety of such pipetting units when trained as a pipetting robot 201 wear, for example up to a few hundred.
  • the pipetting unit 201 has a pipetting tube 205, which has a pipetting channel 207 contains, which runs along a channel axis 209 and in the coupling state the pipette tip 101 on the pipetting unit 201 from the Through opening 107 of the pipette tip 101 is continued.
  • the Coupling attachment 203 comprises one fixed to the lower end of the pipetting tube 205 attached to this, for example pressed or screwed Coupling sleeve 211.
  • An O-ring 213 made of elastically deformable and if desired, electrically conductive material is on the pipetting tube 205 pushed on and lies on the pipette tip 101 axially facing away Front side of the coupling sleeve 211.
  • a ferrule 215 is on the Pipette tube 205 pushed on. This ferrule 215 is axially relative to the pipetting tube 205 slidably and serves for the axial crushing of the O-sealing rings 213.
  • the crimp sleeve 215 is by means of not shown Actuating means can be actuated. These actuators can be manual or allow automatic actuation of the ferrule 215.
  • the crimp sleeve 215 can be actuated hydraulically. It is also conceivable to use a screw drive for adjusting the crimp sleeve Provide 215, which can be operated by hand, but also can be actuated by means of an electric motor.
  • step heels 121, 219 By working together of these two step heels 121, 219 is in the final assembly state the axial position of the pipette tip 101 relative to the pipetting unit 201 exactly defined.
  • Fig. 3 shows the state when the pipette tip 101 is attached and the O-ring 213 is still not crimped. It can be seen that the axial Distance of the step shoulder 219 of the coupling sleeve 211 from the axial End face of the coupling sleeve 211, on which the O-ring 213 rests, such is dimensioned that in the plug-on position shown in Fig. 3, the 0-seal 213 is axially offset somewhat from the annular groove 125. More accurate said is the axial center of the annular groove 125 with respect to the axial Center of the uncompressed O-ring 213 slightly towards the pipette tip 101 offset.
  • FIGS. 4 and 4a show the state in which the pinch of the O-ring 213 is completed and the final assembly position of the pipette tip 101 on the Pipetting unit 201 is manufactured, and of which Fig. 4a one shows enlarged section in the area of the O-ring 213.
  • the ferrule 215 is on a leading tip 225 at its end facing the O-ring 213 which, when the ferrule 215 approaches the o-ring 213 penetrates between this and the pipetting tube 205, so that the O-ring 213 is not only compressed axially, but by the tip 225 is also pressed radially somewhat towards the annular groove 125.
  • the O-ring 213 is enlarged as a result of being crushed of its outside diameter. Its radially pushed out parts can be in escape the space saved by the annular groove 125, which is shown in Fig. 4a is indicated by dashed lines.
  • the parts of the O-rings 213 try to relax in the ring groove 125 and expand, where they come to rest on the bottom of the annular groove 125 and push against it.
  • the axial offset of the Ring groove 125 opposite the O-ring 123 causes the O-ring 213 primarily against the axially upper region of FIG. 4a Bottom of the ring groove 125 presses.
  • the bottom of the Ring groove 125 an engagement surface 127 for the O-ring 213.
  • This Attack surface 127 has a radial component due to its curvature, so that when the O-ring 213 against the attack surface 127 presses a force on the pipette tip 101 with an axial Component is exercised.
  • the crimp sleeve 215 is removed from it in Fig. 4 pinched position axially raised, whereby the O-ring 213 relaxed again and withdrawn from the ring groove 125.
  • the 4 to the step heels 121, 219
  • the pre-tensioning force is released. It finally turns out again the state shown in FIG. 3.
  • the O-ring is expediently 213 not completely out of contact in this state according to FIG. 3 with the inner circumference 117 of the pipette tip 101, but in such Engagement with the inner circumference 117 of the pipette tip 101 that the Pipette tip 101 does not fall off the pipetting unit 201 on its own.
  • the O-ring can, for example, in this situation 213 at the transition edge designated by 129 between the Annular groove 125 and the cylindrical inner peripheral portion 119 of the Trigger pipette tip 101.
  • this transition edge 129 moves past the O-ring 213 be what only under a simultaneous slight radial compression of the O-ring 213 is possible.
  • This radial compression of the O-ring 213, however, increases friction, which in itself Demand for a smooth wiping of the pipette tip 101 from would run counter to the pipetting unit 201.
  • the cylindrical inner peripheral portion located above the annular groove 125 119 of the pipette tip 101 is preferably staggered, as is the case with this can be seen in particular in FIG. 4a.
  • the ejector 217 is provided to be accomplished manually. This can be operated in a variety of ways. For example hydraulic or electromotive actuation of the ejector 217 conceivable. Alternatively, a not shown on the ejector 217 Attack biasing spring, which when placing the pipette tip 101 on the Pipetting unit 201 is clamped when the pipette tip 101 with its End 109 of the ejector tube forming the ejector 217 upwards suppressed. If the pinch of the O-ring 213 is then removed, this ejector spring can relax again.
  • the Ejector pretensioning spring will be dimensioned so that it in the tensioned state on the ejector tube 217 not the force axial holding force of the O-ring 213 exceeds. At the same time it will be like this be measured in such a way that the force exerted on the Pipette tip 101 is applied, sufficient to the edge 129 on the O-ring 213 moving past.
  • Fig. 5 shows the release state in which the ejector 217 is down is moved and the pipette tip 101 completely on the O-sealing ring 213 has passed.
  • Suction means can, for example, axially in the pipetting tube 205 comprise movably arranged pistons which are operated by means of electrical hydraulic or pneumatic actuating means is axially adjustable.
  • the pipette tip 101 is preferably made of a plastic material manufactured, for example by injection molding.
  • This plastic material can be electrically conductive to conduct conductivity measurements in a manner known per se to be able to perform on the liquid to be pipetted.
  • the coupling sleeve 211 and the pipetting tube can 205 consist of conductive materials.
  • Plastic materials for the coupling sleeve 211 and the pipetting tube 205 are not excluded.
  • the capacity of as a disposable item trained pipette tip 101 can for example between 0.1 and 1300 ⁇ l.

Claims (13)

  1. Unité formant pipette (201) pourvue d'une pointe de pipette destinée à un dispositif à pipetter, l'unité formant pipette (201) présentant une pièce rapportée d'accouplement (203), sur laquelle la pointe de pipette est susceptible d'être enfoncée, dans une direction d'enfoncement, pour être accouplée, la pièce rapportée d'accouplement (203) présentant un organe de précontrainte (213) déplaçable, susceptible de passer d'un état de précontrainte à un état libéré grâce à la présence d'un dispositif d'actionnement (215) prévu dans la pièce rapportée d'accouplement,
       caractérisée en ce que
       la pointe de pipette (101) présente une butée axiale (121) qui coopère, dans une position axiale d'accouplement de la pointe de pipette (101), avec une butée complémentaire (219) de la pièce rapportée d'accouplement (203), en ce que l'organe de précontrainte (213), dans son état de précontrainte, s'applique sur une surface d'application (127) de la pointe de pipette (101) enfoncée, par des composantes de surface de la pointe de pipette (101) qui sont orientées à l'opposé de la direction d'enfoncement, s'étendant radialement vers l'intérieur, de telle sorte qu'il repose de façon étanche contre la surface d'application et précontraigne la pointe de pipette (201) dans la direction axiale d'accouplement, et en ce que l'organe de précontrainte (213), dans son état libéré, laisse sensiblement à découvert la surface d'application (127) de la pointe de pipette (101).
  2. Unité formant pipette (201) selon la revendication 1, caractérisée en ce que la surface d'application (127) est constituée par une rainure annulaire (125).
  3. Unité formant pipette selon la revendication 1 ou 2, caractérisée en ce que la butée axiale (121) est située, au moins partiellement, sur une circonférence interne (117) d'une enveloppe (105) de la pointe de pipette, à distance axiale de l'extrémité (109) à laquelle la pointe de pipette (101) est enfoncée.
  4. Unité formant pipette selon la revendication 3, caractérisée en ce que la circonférence interne (117) de l'enveloppe possède, au moins dans la zone d'accouplement (111), une extrémité formant gaine constituée sensiblement par des tronçons cylindriques (119, 123).
  5. Unité formant pipette selon l'une des revendications précédentes, caractérisée en ce que la butée axiale (121) est constituée par un épaulement de la circonférence Interne (117) de l'enveloppe qui relie un premier tronçon cylindrique de circonférence interne d'enveloppe (119), de plus gros diamètre, proche de l'extrémité (109) à laquelle la pointe de pipette est enfoncée, avec un deuxième tronçon cylindrique de circonférence interne d'enveloppe (123), de plus petit diamètre, éloigné de l'extrémité (109) à laquelle la pointe de pipette est enfoncée.
  6. Unité formant pipette selon la revendication 5, caractérisée en ce que la diminution de diamètre, entre le premier (119) et le deuxième (123) tronçon de circonférence interne d'enveloppe, due à la présence de l'épaulement (121), est comprise entre 0,8 et 1,2 mm.
  7. Unité formant pipette selon la revendication 5 ou 6, caractérisée en ce que le diamètre du premier tronçon de circonférence interne d'enveloppe (119) est compris entre 6,5 et 7,1 mm.
  8. Unité formant pipette selon l'une des revendications 5 à 7, caractérisée en ce que le diamètre du deuxième tronçon de circonférence interne d'enveloppe (123) est compris entre 5,5 et 6,1 mm.
  9. Unité formant pipette selon l'une des revendications précédentes, caractérisée en ce que la section transversale de la rainure annulaire (125) est délimitée par un arc de cercle et possède un rayon de courbure compris entre 0,3 et 0,9 mm.
  10. Unité formant pipette selon l'une des revendications précédentes, caractérisée en ce que la surface d'application (127) est située, axialement, entre la butée axiale (121) et l'extrémité (109) à laquelle la pointe de pipette (101) est enfoncée.
  11. Unité formant pipette selon l'une des revendications précédentes, caractérisée en ce que la butée complémentaire (219) est constituée par un épaulement présent sur la circonférence externe de la pièce rapportée d'accouplement (203),
  12. Unité formant pipette selon l'une des revendications précédentes, caractérisée en ce que la pièce rapportée d'accouplement (203) porte un élément d'étanchéité (213) servant à assurer l'étanchéité entre la pointe de pipette (101) et la pièce rapportée d'accouplement (203), constitué en matériau élastiquement déformable et, si cela est souhaité, en matériau conduisant l'électricité, et en ce qu'est associé, à l'unité formant pipette (201), un dispositif d'écrasement (215) destiné à comprimer axialement l'élément d'étanchéité (213).
  13. Unité formant pipette selon la revendication 12, caractérisée en ce que l'élément d'étanchéité (213) est un joint annulaire.
EP00926950A 1999-04-16 2000-04-14 Pointe de pipette, dispositif a pipetter et combinaison de pointe de pipette et de dispositif de pipette Expired - Lifetime EP1171240B2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19917375 1999-04-16
DE19917375A DE19917375C2 (de) 1999-04-16 1999-04-16 Pipettiereinheit
PCT/EP2000/003423 WO2000062933A1 (fr) 1999-04-16 2000-04-14 Pointe de pipette, dispositif a pipetter et combinaison de pointe de pipette et de dispositif de pipette

Publications (3)

Publication Number Publication Date
EP1171240A1 EP1171240A1 (fr) 2002-01-16
EP1171240B1 true EP1171240B1 (fr) 2003-07-02
EP1171240B2 EP1171240B2 (fr) 2006-06-14

Family

ID=7904895

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00926950A Expired - Lifetime EP1171240B2 (fr) 1999-04-16 2000-04-14 Pointe de pipette, dispositif a pipetter et combinaison de pointe de pipette et de dispositif de pipette

Country Status (7)

Country Link
US (2) US7033543B1 (fr)
EP (1) EP1171240B2 (fr)
JP (1) JP3977597B2 (fr)
AT (1) ATE244070T1 (fr)
DE (2) DE19917375C2 (fr)
ES (1) ES2197094T5 (fr)
WO (1) WO2000062933A1 (fr)

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DE19917375A1 (de) 2000-11-02
EP1171240B2 (fr) 2006-06-14
ATE244070T1 (de) 2003-07-15
US7033543B1 (en) 2006-04-25
DE50002736D1 (de) 2003-08-07
JP2002542017A (ja) 2002-12-10
US20060233669A1 (en) 2006-10-19
EP1171240A1 (fr) 2002-01-16
US9415388B2 (en) 2016-08-16
JP3977597B2 (ja) 2007-09-19
WO2000062933A1 (fr) 2000-10-26
ES2197094T3 (es) 2004-01-01
DE19917375C2 (de) 2001-09-27
ES2197094T5 (es) 2006-11-16

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