EP1559480B1 - Pipette avec mécanisme de déplacement fixé de façon détachable au mécanisme d'actionnement - Google Patents

Pipette avec mécanisme de déplacement fixé de façon détachable au mécanisme d'actionnement Download PDF

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Publication number
EP1559480B1
EP1559480B1 EP05000211.2A EP05000211A EP1559480B1 EP 1559480 B1 EP1559480 B1 EP 1559480B1 EP 05000211 A EP05000211 A EP 05000211A EP 1559480 B1 EP1559480 B1 EP 1559480B1
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EP
European Patent Office
Prior art keywords
drive
displacement
pipetting
displaceable
pipetting device
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EP05000211.2A
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German (de)
English (en)
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EP1559480A1 (fr
Inventor
Herbert Belgardt
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Eppendorf SE
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Eppendorf SE
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other

Definitions

  • the invention relates to a pipetting device with a displacement device and a drive device detachably connected thereto.
  • Pipetting devices are used in particular in the laboratory for dosing liquids. These are picked up in pipette tips through a tip opening and dispensed.
  • a displacement device for a gas is integrated in the pipetting device and connected in a communicating manner with the pipette tip through the approach.
  • the displacement device is usually a cylinder with a piston displaceable therein.
  • the pipette tips are releasably connected to the neck so that they can be replaced with a fresh pipette tip after use. As a result, contamination can be avoided at subsequent dosages.
  • Single-use pipette tips are available inexpensively from plastic.
  • the approach for attaching pipette tips is often a cylindrical or conical projection with respect to a base body or a housing, on which a pipette tip with a mating Aufsteckö réelle or recording is clamped. This can be done without touching the pipette tip by pressing the projection into the plug-in opening of the pipette tip provided in a holder.
  • pipetting devices In order to avoid contamination of the users, pipetting devices have a discharge device with a drive device and an ejector. By Actuating the drive means, the ejector is displaced so that it releases the pipette tip of the approach, without having to be handled by the user.
  • the drive device has a mechanism which must be manually operated by means of an actuating button to release the pipette tip from the neck.
  • drive devices with an electric motor drive. The release of the pipette tip from the neck can require considerable effort, especially with pipette tips firmly clamped onto the neck.
  • Air bubble pipettes can lead to contamination of the displacement device.
  • the reason for this can be, for example, the penetration of liquid due to improper handling or the rising of vapors or fine liquid droplets of the liquid to be pipetted into the displacement device.
  • Pipetting devices are already known in which the displacement device with the attachment for attaching the pipette tip can be separated from a drive device for driving the displacement device.
  • a pipetting device in which the displacement device can be screwed by means of a union nut to a shaft of the drive device.
  • the attachment is cumbersome in use, time consuming and prone to failure.
  • a pipetting device with a displacement device and a drive device has become known.
  • the displacement device is equipped with a cylinder and a piston.
  • the drive device can be connected via a bayonet connection with the cylinder of the displacement device.
  • connection can be formed by a connector assembly with a flanged connector.
  • the object of the invention is to provide a pipetting device in which the displacement device and the drive device can be connected and disconnected more easily and more quickly, and in which the connection is less prone to failure.
  • the displacement device and the drive device of the pipetting device can be connected to one another in a simple manner by plugging along a longitudinal axis of the bayonet connection and rotating about the longitudinal axis of the bayonet connection or can be separated from one another in the reverse manner.
  • the operative connection between the drive member and displaceable boundary is at the same time produced, without requiring special further actions for this purpose.
  • the active compound is released without any special further actions.
  • the invention enables a particularly simple, fast and secure connection and disconnection of the displacement device and the drive device, for example, during assembly, before autoclaving or other cleaning of the lower part, before replacing the lower part for purposes of changing the work area, repair uää ..
  • the bayonet connection is particularly susceptible to interference.
  • the drive device can be designed in various ways. It has technical means to shift the drive member so that this shifts the movable limit of the displacement device.
  • the drive organ eg a linear movement.
  • the drive device has a linear drive.
  • a lifting rod which can be manually actuated directly by a key operation or a lifting rod which can be displaced linearly via an electric drive motor and a transmission.
  • a pneumatically or hydraulically operated pressure medium cylinder as a drive for the lifting rod, which is actuated by a pneumatic or hydraulic control and a pressure medium reservoir. If the drive member does not perform a linear movement, but a spatial feed movement, the drive means has a corresponding drive.
  • the drive device has a housing in which drive and drive member are arranged.
  • the drive member is a displaceable parallel to the longitudinal axis of the bayonet connection lifting rod of the drive device and has the displacement means connected to the boundary, directed transversely to the lifting rod contact surface, which is pressed by a lifting spring against the end of the lifting rod.
  • the operative connection between the drive member and displaceable boundary is automatically produced when producing the bayonet connection and automatically released when dissolving the bayonet connection.
  • the contact surface is formed on a connected via a rod with the movable boundary pressure member and the lifting spring is designed as a helical spring which is supported at one end on the pressure piece and the other end to the displacement chamber.
  • the drive device has a cylindrical receptacle having at one end an opening through which the cylindrical receptacle is accessible in the axial direction from the outside, which has at least one axially directed longitudinal groove which is connected to an annular groove directed in the circumferential direction of the cylindrical receptacle, and the displacement device has on a cylindrical portion at least one outwardly projecting projection, wherein the cylindrical portion in the axial direction of the cylindrical receptacle through the opening in the receptacle and with the projection in the longitudinal groove is inserted and screwed with the projection in the annular groove.
  • the drive means is the female and the displacement means the male part.
  • the annular groove at a distance from the longitudinal groove on a in the axial direction of the receptacle extending boundary wall, to which the projection is rotatable. Reaching the limit indicates to the user that the bayonet connection is made.
  • the annular groove is connected at a distance from the longitudinal groove with a parallel thereto extending L jossnutabexcellent, which ends at a distance from the opening.
  • the annular groove has a ramp-like boundary wall whose distance from the opening increases with increasing distance from the longitudinal groove.
  • the ramp-like course of the boundary wall facilitates the finding of the connection position and the separation of the displacement device from the drive device.
  • the longitudinal groove, the annular groove and optionally the L jossnutabêt is formed in a cylindrical coupling piece which forms the receptacle of the drive means and is fixed in this. This facilitates manufacture, assembly and disassembly.
  • the drive device has a spring which presses against the displacement device connected to the drive device via the bayonet connection. This will secure the bayonet connection.
  • the spring is arranged on a further opening of the receptacle, which is opposite to the opening for the axial insertion of the displacement device. Through the opening displacement and spring act on each other.
  • the spring is a helical spring, which is supported on an inner end face of the coupling piece.
  • the longitudinal groove and / or annular groove and / or the L jossnutabites open to the other opening.
  • the displacement device is a piston-cylinder device with a cylinder and a piston displaceable therein and the piston has the displaceable boundary.
  • Other displacement means are also included in the invention, for example a displacement chamber with a displaceable boundary forming elastic wall.
  • a piston-cylinder device is actuated, for example, by a linear drive device.
  • a corresponding actuation is possible with a displacement chamber with an elastic wall.
  • the latter can also be controlled via a drive device with a spatial drive movement. So it is possible, for example, the to control elastic wall by the action of a hydraulic or pneumatic pressure medium from the outside.
  • the approach is aligned coaxially to the longitudinal axis of the bayonet connection. According to a further embodiment, the approach is firmly connected to the displacement device.
  • the pipetting device has a discharge device for ejecting a pipette tip from the attachment, which has a discharge drive arranged on the drive device, an ejector arranged on the displacement device and a directed in the direction of the longitudinal axis of the bayonet connection, detachable axial clamping connection between discharge drive and ejector.
  • the clamping connection can be produced simultaneously with the production of the bayonet connection with the phase of the axial collapse of the displacement device and the drive device and can be released in the reverse direction.
  • the ejector drive a projecting from the drive device parallel to the bayonet release rod and the ejector to a neck parallel, axial bore, with which the discharge rod is press-connected.
  • the ejector is guided on the displacement device.
  • the ejector is a sleeve guided on the displacement device.
  • the pipetting device is a hand-held device and / or a stationary device and / or an electrically driven device and / or a (semi-) automaton.
  • the pipetting device of Hand guided to the location of sample and sample dispensing and the recording and dispensing of liquid and the operation of the ejection device is controlled by hand.
  • the drive devices for the displacement device and / or the ejector are designed mechanically and / or electromechanically. The latter also applies to the execution of the pipetting as a stationary device.
  • the pipetting device When the pipetting device is designed as a (semi) automaton, all functions or part of the functions of the pipetting devices (picking up and dispensing liquid, moving the pipetting devices into positions for picking up and dispensing liquid or pipette tips, picking up and dispensing pipette tips) are automatically carried out ,
  • the pipetting device has a series of parallel lugs for receiving pipette tips. It is a multi-channel pipetting system. Each approach of the pipetting device is associated with a separate displacement means or a common, which is connected via a bayonet connection with the drive means. It may be a common drive device for all displacement devices.
  • top refers to the orientation of the pipetting device according to the drawing. This is an orientation of the pipetting device, with the pipette tip with its tip opening at the bottom, to receive liquid from a vessel located below the pipetting device or to deliver it into such a vessel.
  • the pipetting device according to Fig. 1 and 2 has an elongated, shaped as a handle housing 1 with an upper housing part 2 and a lower housing part 3.
  • the upper housing part 2 with all the parts contained forms a drive means and the lower housing part 3 with all parts contained a displacement device.
  • the upper housing part 2 has at the top a screw cap 4. From this stands upwards an adjusting sleeve 5.
  • the adjusting sleeve 5 is mounted axially non-displaceably and rotatably in the upper housing part 2.
  • a push button 6 is arranged, which protrudes further upwards.
  • the push button 6 is connected to a lifting rod 7, which is passed through a spindle 8 in the upper housing part 2.
  • the spindle 8 is screwed into an internal thread 9 of a bearing body 10 fixed in the housing upper part 2.
  • the spindle 8 has a rotatably connected to her driver 11 above.
  • the driver 11 has on the circumference two diametrically opposed radial projections 12.
  • the radial projections 12 engage in - not shown - axially extending grooves of the adjusting sleeve 5 a.
  • the spindle 8 has an end stop 13 in the form of radially outwardly projecting ribs. In the position shown, the end stop 13 is located a short distance below a shoulder 14 of the bearing body 10, with which it cooperates.
  • the lifting rod 7 has a flange 15 which rests in the position shown at the bottom of the spindle 8.
  • a spring plate 16 is arranged, which engages with a collar 17 in the bearing body 10.
  • the spring plate 16 has an axially projecting, sleeve-shaped bearing portion 18 below, through which the lifting rod 7 is passed.
  • the pipetting device on a spring, not shown, which pushes the lifting rod 7 upwards, so that the flange 15 rests against the underside of the spindle 8.
  • a coil spring between flange 15 and spring plate 16 is arranged.
  • a coupling piece 19 is fixed in the housing. This has inside several pockets 20. These have an axially over the entire length of the coupling piece 19 extended longitudinal groove 21. Furthermore, they have at the upper end of the coupling piece 19 over a small part of the circumference of the coupling piece 19 extended annular groove 22. This has at a distance from upper end of the coupling piece 19 below a ramp-like boundary wall, which is increasingly approximated starting from the longitudinal groove 21 to the upper end of the coupling piece 19. Finally, the pockets 20 at the other end of the annular groove 22 have a short axial L jossnutabexcellent 23 which terminates at a distance from the upper end of the coupling piece 19 in the coupling piece 19.
  • a spring 24 is arranged under bias, which is designed as a helical spring.
  • the adjusting sleeve 5 has on the circumference a sprocket 25 which cooperates with a gear 26 which drives a counter 27 with a plurality of superimposed on an axis 28 Zählwerkssonn 29.
  • the Zählwerksson 29 each have numerals from 0 to 9. the lower Zählwerksrad 29 is driven by the gear 26.
  • the overlying Zählwerksson 29 are further rotated in each case by one digit when the underlying Zählwerksrad 29 passes from 9 to 0.
  • the lower housing part 3 can be detachably connected to the upper housing part 2.
  • the lower housing part 3 on the mantle of an upper, cylindrical portion 30 a plurality of outwardly projecting projections or ribs 31, which extend in the axial direction of the cylindrical portion 30.
  • the lower housing part 3 has below the cylindrical portion 30 a plurality of conical sections 31 to 33 of different length and conicity, which emerge from the drawing.
  • the conical section 33 is connected at the bottom with a long, slightly conical projection 34 for attaching a pipette tip. This in turn has a short, more conical Aufsteckende 35 below.
  • the lower housing part 3 houses a displacement device in the form of a piston-cylinder unit 36. This has a conical portion 32 arranged in the cylinder 37, in which a piston 38 dips.
  • the piston 38 is connected at the top via a piston rod 39 with a pressure piece 40.
  • the piston 38 forms a displaceable boundary of the cylinder 37.
  • the lower housing part 3 has a piston holder 41, which bridges the cylindrical portion 30 above.
  • the piston holder 41 has at the top a central passage 42, through which a lower portion of the piston 7 can be axially guided.
  • a lifting spring 43 is arranged, which is designed as a helical spring. By the lifting spring 43, the piston 38 and the piston rod 39 are passed.
  • the lifting spring 43 is biased and presses the pressure piece 40 against the piston holder 41, so that the piston 38 is pulled out of the cylinder 37 maximum.
  • a connecting channel 44 extends through the lug 34 and connects the cylinder 37 with an orifice in the push-on end 35.
  • the pipetting device has a discharge device 45.
  • the discharge device 45 has in the upper housing part 2 in addition to the adjustment knob 5, an operating button 46.
  • the actuating button 46 is connected to a discharge bar 47 which extends parallel to the lifting rod 7 through the upper housing part 2 therethrough.
  • a transmission 48 is integrated in the discharge rod 47.
  • the gear 48 converts an axial actuating stroke of the actuating knob 46 into a smaller drive stroke with increased force.
  • Suitable transmissions 48 are in the EP 0 992 288 A described generally in the general part of the description and specifically in the description of the figures, which are incorporated by reference into the present application.
  • the discharge rod 47 is supported via a further coil spring 49 in the upper housing part 2, so that the actuating button 46 is pressed into the initial position shown, in which it can be pressed against the action of the other coil spring 49.
  • the lower end of the discharge rod 47 projects into a receptacle 50 at the lower end of the housing upper part 2.
  • the discharge device 45 has on the lower housing part 3 a discharge sleeve 51. This is guided on the cylindrical portion 30, the conical portion 32 and the projection 34. Accordingly, the contour of the discharge sleeve 51 is equalized to the contours of the aforementioned sections of the housing lower part 3. In this case, the discharge sleeve 51 has internal steps 52, 53 which limit the sliding of the discharge sleeve 51 upwards by abutting against conical sections 31, 33 of the housing lower part 3.
  • the discharge sleeve 51 has laterally at the upper edge a projection 54 which has an axial bore 55 for pressing in the lower end of the discharge rod 47.
  • the pipetting device can be used as follows:
  • Upper housing part 2 and lower housing part 3 can be connected by axial insertion and rotation of the lower part 3 in the coupling piece 19.
  • a bayonet connection is made.
  • the ribs 31 are inserted into the longitudinal grooves 21, rotated by the annular grooves 22 and inserted into the short Lssensnutabête 23.
  • the spring 24 presses against the upper edge of the cylindrical portion 30, whereby the lower housing part 3 is fixed in its mounting position, in which the ribs 31 abut against the lower ends of the Lssensnutabroughe 23, which form a stop.
  • the discharge sleeve 51 is pressed with the bore 55 on the lower portion of the discharge rod 47. The dismantling of the upper housing part 2 and lower housing part 3 can be done in the reverse manner.
  • the lifting rod 7 engages through the passage 42 and lies with its lower end against the pressure piece 40.
  • the adjustment sleeve 5 is rotated until the counter 27 indicates the desired volume.
  • the driver 11 is rotated due to the radial projections 12.
  • the spindle 8 rotates in the internal thread 9 and displaces axially in the upper housing part 2 with entrainment of the flange 15 and thus the lifting rod 7.
  • the radial projections 12 displace axially along the grooves on the inside of the adjusting 5. In this way, the stroke of the lifting rod 7 changed, which is executable upon actuation of the push button 6.
  • a pipette tip 56 is clamped on the lower end of the projection 34.
  • the pipette tip 56 has a lower tip opening 57 for receiving and dispensing liquid.
  • the push button 6 For pipetting the push button 6 is pressed down, so that the piston 38 displaces air from the cylinder 37. Then, the pipette tip 56 is immersed with its lower tip opening 57 in the liquid to be pipetted. Thereafter, the push button 6 is released and the lifting rod 7 is returned to its original position under spring action. Similarly, the piston 38 returns under the action of the spring 43 to its original position. In this case, the piston 38 sucks liquid through the lower tip opening 57 into the pipette tip 56.
  • the lower tip opening 57 of the pipetting device is aligned to a delivery location.
  • the liquid contained in the pipette tip 56 is delivered by depressing the push button 6, re-immersing the piston 38 in the cylinder 37 and expressing air through the connecting channel 44. After releasing the operating knob 6, the lifting rod 7 and the piston 38 again by spring force back to the starting position.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Claims (17)

  1. Pipette avec
    • un mécanisme de déplacement (36) comportant une chambre de déplacement (37) avec une limitation décalable (38), un raccord (34) pour la connexion avec une pointe de pipette (56), et un conduit de connexion (44) entre la chambre de déplacement (37) et l'extrémité libre du raccord (34),
    • un mécanisme d'entraînement (6, 7, 8) pour entraîner la limitation décalable (38) du mécanisme de déplacement (36), avec un élément d'entraînement (7) qui a une connexion opérationnelle détachable avec la limitation décalable (38), et
    • une jonction à baïonnette (19, 22, 30, 31) entre le mécanisme d'entraînement (6, 7, 8) et le mécanisme de déplacement (36), qui se laisse faire en produisant la connexion opérationnelle entre l'élément d'entraînement (7) et la limitation décalable (38) et qui est détachable en desserrant la connexion opérationnelle entre l'élément d'entraînement (7) et la limitation décalable (38),
    • l'élément d'entraînement (7) étant une tige de piston du mécanisme d'entraînement (6, 7, 8), décalable en parallèle à l'axe longitudinal de la jonction à baïonnette, et le mécanisme de déplacement (36) ayant une surface de contact, reliée à la limitation (38) et dirigée en travers de la tige de piston (7) et étant pressée contre l'extrémité de la tige de piston (7) par un ressort de levage (43), et
    • le mécanisme d'entraînement (6, 7, 8) ayant un logement cylindrique (19) avec une ouverture dans une extrémité à travers laquelle le logement cylindrique (19) est accessible de l'extérieur en la direction axiale, qui a au moins une rainure longitudinale (21) axialement dirigée qui est reliée à une rainure annulaire (22) dirigée en la direction circonférentielle du logement cylindrique (19), et dans lequel le mécanisme de déplacement (36) a au moins une partie en saillie (31) faisant saillie vers l'extérieur dans une portion cylindrique (30), la portion cylindrique (30) se laissant introduire dans le logement (19) en la direction axiale du logement cylindrique (19) à travers l'ouverture, et dans la rainure longitudinale (21) avec la partie en saillie (31), et se laissant visser dans la rainure annulaire (22) avec la partie en saillie (31).
  2. Pipette selon la revendication 1, dans laquelle la surface de contact est faite sur une pièce de pression (40) qui est reliée à la limitation (38) à travers une tige (39), et est supportée sur la pièce de pression (40) dans l'une extrémité et dans l'autre extrémité sur la chambre de déplacement (37) via un ressort de levage (43) fait comme un ressort cylindrique.
  3. Pipette selon une des revendications 1 ou 2, dans laquelle la rainure annulaire (22) a une paroi de limitation, s'étendant dans la direction axiale du logement (19) en un écart de la rainure longitudinale (21) et jusqu'à laquelle le raccord (31) se laisse tourner.
  4. Pipette selon l'une quelconque des revendications 1 à 3, dans laquelle la rainure annulaire (22) est reliée à une portion de rainure longitudinale (23), située en un écart de la rainure longitudinale (21) et en parallèle à celle-ci et qui finit en un écart de l'ouverture.
  5. Pipette selon l'une quelconque des revendications 1 à 4, dans laquelle la rainure annulaire (22) a une paroi de limitation en forme de rampe, dont la distance de l'ouverture augmente avec distance croissante de la rainure longitudinale (21).
  6. Pipette selon l'une quelconque des revendications 1 à 5, dans laquelle la rainure longitudinale (21), la rainure annulaire (22) et au choix la portion de rainure longitudinale (23) sont faites avec une pièce d'accouplement cylindrique (19) qui forme le logement du mécanisme d'entraînement (6, 7, 8) et est fixée dans celui-ci.
  7. Pipette selon l'une quelconque des revendications 1 à 6, dans laquelle le mécanisme d'entraînement (6, 7, 8) comporte un ressort (24) qui pousse contre le mécanisme de déplacement (36) qui est relié au mécanisme d'entraînement (6, 7, 8) à travers la jonction à baïonnette (19, 22, 30, 31).
  8. Pipette selon la revendication 7, dans laquelle le ressort (24) est disposé dans une autre ouverture du logement (19) qui est située en face de l'ouverture pour l'introduction axiale du mécanisme de déplacement (36).
  9. Pipette selon la revendication 7 ou 8, dans laquelle le ressort (24) est un ressort cylindrique qui est supporté sur un côte de front dans l'intérieur de la pièce d'accouplement (19).
  10. Pipette selon l'une quelconque des revendications 8 à 9, dans laquelle la rainure longitudinale (21) et/ou la rainure annulaire (22) et/ou la portion de rainure longitudinale (23) sont ouvertes vers l'autre ouverture.
  11. Pipette selon l'une quelconque des revendications 1 à 10, dans laquelle le mécanisme de déplacement (36) est un mécanisme piston cylindre avec un cylindre (37) et un piston (38) déplaçable dans ceci, et le piston (38) comporte la limitation décalable.
  12. Pipette selon l'une quelconque des revendications 1 à 11, dans laquelle le raccord (34) est aligné de façon coaxiale à l'axe longitudinal de la jonction à baïonnette (19, 22, 30, 31).
  13. Pipette selon l'une quelconque des revendications 1 à 12, dans laquelle le raccord (34) est fixement relié à la chambre de déplacement (37).
  14. Pipette selon l'une quelconque des revendications 1 à 13, avec un mécanisme d'éjection (45) pour détacher la pointe de pipette (56) du raccord (34), comportant un entraînement d'éjection (46, 47, 48) disposé sur le mécanisme d'entraînement (6, 7, 8), un éjecteur (51) disposé sur le mécanisme de déplacement (36) et une jonction de serrage axiale détachable (47, 55) entre l'entraînement d'éjection (45) et éjecteur (51), dirigée en la direction de l'axe longitudinal de la jonction à baïonnette (19, 22, 30, 31).
  15. Pipette selon la revendication 14, dans laquelle l'entraînement d'éjection (46, 47, 48) comporte une tige d'éjection (47), en saillie du mécanisme d'entraînement de façon parallèle la jonction à baïonnette (19, 22, 30, 31), et l'éjecteur (51) comporte un alésage axial (55) parallèle au raccord (34) et relié à la tige d'éjection (47) par pression.
  16. Pipette selon la revendication 15, dans laquelle l'éjecteur (51) est guidé sur le mécanisme de déplacement (36).
  17. Pipette selon l'une quelconque des revendications 4 à 16, dans laquelle l'éjecteur (51) est un manchon guidé sur le mécanisme de déplacement (36).
EP05000211.2A 2004-01-21 2005-01-07 Pipette avec mécanisme de déplacement fixé de façon détachable au mécanisme d'actionnement Active EP1559480B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004003434 2004-01-21
DE102004003434A DE102004003434B4 (de) 2004-01-21 2004-01-21 Pipettiervorrichtung mit einer Verdrängungseinrichtung und einer damit lösbar verbundenen Antriebseinrichtung

Publications (2)

Publication Number Publication Date
EP1559480A1 EP1559480A1 (fr) 2005-08-03
EP1559480B1 true EP1559480B1 (fr) 2013-05-01

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US (1) US7320260B2 (fr)
EP (1) EP1559480B1 (fr)
DE (1) DE102004003434B4 (fr)

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US10610406B2 (en) * 2004-07-21 2020-04-07 Vanderbilt University Drug delivery device and applications of same
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US7320260B2 (en) 2008-01-22
EP1559480A1 (fr) 2005-08-03
US20050155438A1 (en) 2005-07-21
DE102004003434A1 (de) 2005-08-25

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