EP1085867A1 - Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty - Google Patents

Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty

Info

Publication number
EP1085867A1
EP1085867A1 EP99914723A EP99914723A EP1085867A1 EP 1085867 A1 EP1085867 A1 EP 1085867A1 EP 99914723 A EP99914723 A EP 99914723A EP 99914723 A EP99914723 A EP 99914723A EP 1085867 A1 EP1085867 A1 EP 1085867A1
Authority
EP
European Patent Office
Prior art keywords
compound
oxo
ethyl
pyridin
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99914723A
Other languages
German (de)
English (en)
French (fr)
Inventor
Hua Zhu Ke
Mei Li
Lydia Codetta Pan
David Duane Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of EP1085867A1 publication Critical patent/EP1085867A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP99914723A 1998-06-16 1999-05-03 Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty Withdrawn EP1085867A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8942498P 1998-06-16 1998-06-16
US89424P 1998-06-16
PCT/IB1999/000796 WO1999065488A1 (en) 1998-06-16 1999-05-03 Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty

Publications (1)

Publication Number Publication Date
EP1085867A1 true EP1085867A1 (en) 2001-03-28

Family

ID=22217565

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99914723A Withdrawn EP1085867A1 (en) 1998-06-16 1999-05-03 Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty

Country Status (29)

Country Link
EP (1) EP1085867A1 (zh)
JP (1) JP2002518328A (zh)
KR (1) KR20010052817A (zh)
CN (1) CN1305378A (zh)
AP (1) AP9901581A0 (zh)
AR (1) AR018868A1 (zh)
AU (1) AU3342099A (zh)
BG (1) BG105128A (zh)
BR (1) BR9911357A (zh)
CA (1) CA2335112A1 (zh)
CO (1) CO5070586A1 (zh)
EA (1) EA200001189A1 (zh)
GT (1) GT199900083A (zh)
HR (1) HRP20000857A2 (zh)
HU (1) HUP0102395A2 (zh)
ID (1) ID26726A (zh)
IL (1) IL139587A0 (zh)
IS (1) IS5727A (zh)
MA (1) MA26648A1 (zh)
NO (1) NO20006381L (zh)
OA (1) OA11569A (zh)
PA (1) PA8472101A1 (zh)
PE (1) PE20000633A1 (zh)
PL (1) PL345064A1 (zh)
SK (1) SK18902000A3 (zh)
TN (1) TNSN99118A1 (zh)
UY (1) UY25557A1 (zh)
WO (1) WO1999065488A1 (zh)
ZA (1) ZA993973B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004306A3 (en) * 1998-08-06 2000-06-07 Pfizer Products Inc. Estrogen agonists/antagonists
JP2004507502A (ja) 2000-08-30 2004-03-11 ファイザー・プロダクツ・インク 成長ホルモン分泌促進物質のための徐放性製剤
IL145106A0 (en) * 2000-08-30 2002-06-30 Pfizer Prod Inc Intermittent administration of a geowth hormone secretagogue
US7524866B2 (en) 2001-11-29 2009-04-28 Gtx, Inc. Prevention and treatment of androgen—deprivation induced osteoporosis
EP1666033B1 (en) * 2001-11-29 2008-12-31 GTX, Inc. Prevention and treatment of androgen-deprivation induced osteoporosis
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
JP2010518090A (ja) 2007-02-09 2010-05-27 トランザイム・ファーマ，インコーポレイテッド 大環状グレリン受容体修飾因子およびその使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA51676C2 (uk) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція
TW432073B (en) * 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
HN1996000101A (es) * 1996-02-28 1997-06-26 Inc Pfizer Terapia combinada para la osteoporosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9965488A1 *

Also Published As

Publication number Publication date
ID26726A (id) 2001-02-01
PL345064A1 (en) 2001-11-19
TNSN99118A1 (fr) 2005-11-10
IL139587A0 (en) 2002-02-10
NO20006381D0 (no) 2000-12-14
GT199900083A (es) 2000-12-05
AU3342099A (en) 2000-01-05
WO1999065488A1 (en) 1999-12-23
SK18902000A3 (sk) 2001-12-03
CA2335112A1 (en) 1999-12-23
BG105128A (en) 2001-11-30
HUP0102395A2 (hu) 2001-11-28
EA200001189A1 (ru) 2001-06-25
MA26648A1 (fr) 2004-12-20
JP2002518328A (ja) 2002-06-25
AR018868A1 (es) 2001-12-12
KR20010052817A (ko) 2001-06-25
ZA993973B (en) 2000-12-15
CO5070586A1 (es) 2001-08-28
OA11569A (en) 2004-07-01
CN1305378A (zh) 2001-07-25
BR9911357A (pt) 2001-03-13
HRP20000857A2 (en) 2001-10-31
AP9901581A0 (en) 1999-06-30
IS5727A (is) 2000-11-24
PE20000633A1 (es) 2000-07-26
UY25557A1 (es) 2001-01-31
PA8472101A1 (es) 2000-09-29
NO20006381L (no) 2000-12-14

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