EP1065210A1 - Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel - Google Patents

Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel Download PDF

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Publication number
EP1065210A1
EP1065210A1 EP99112553A EP99112553A EP1065210A1 EP 1065210 A1 EP1065210 A1 EP 1065210A1 EP 99112553 A EP99112553 A EP 99112553A EP 99112553 A EP99112553 A EP 99112553A EP 1065210 A1 EP1065210 A1 EP 1065210A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
aryl
nhc
residue
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99112553A
Other languages
English (en)
French (fr)
Inventor
Vichai Dept Chemistry Faculty of Science Reutrakul
Thaiwatchai Santisuk
Gerhard Noessner
Juergen Schmidt
Bernd Nickel
Thomas Klenner
Sebastian Hose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Priority to DE29923419U priority Critical patent/DE29923419U1/de
Priority to EP99112553A priority patent/EP1065210A1/de
Priority to DK00962275T priority patent/DK1200444T3/da
Priority to AU74069/00A priority patent/AU764215B2/en
Priority to AT00962275T priority patent/ATE272641T1/de
Priority to PCT/EP2000/005973 priority patent/WO2001002408A1/en
Priority to BR0012127-4A priority patent/BR0012127A/pt
Priority to MXPA01013340A priority patent/MXPA01013340A/es
Priority to RU2002102495/04A priority patent/RU2220146C2/ru
Priority to JP2001507844A priority patent/JP3848158B2/ja
Priority to SI200030468T priority patent/SI1200444T1/xx
Priority to DE60012750T priority patent/DE60012750T2/de
Priority to UA2002010816A priority patent/UA72260C2/uk
Priority to CNB008096678A priority patent/CN1151156C/zh
Priority to PL00352528A priority patent/PL352528A1/xx
Priority to ES00962275T priority patent/ES2225214T3/es
Priority to HU0201810A priority patent/HUP0201810A3/hu
Priority to IL14703000A priority patent/IL147030A0/xx
Priority to PT00962275T priority patent/PT1200444E/pt
Priority to CA002376681A priority patent/CA2376681A1/en
Priority to EP00962275A priority patent/EP1200444B1/de
Priority to US09/605,650 priority patent/US6403636B1/en
Priority to CO00049358A priority patent/CO5190699A1/es
Priority to ARP000103370A priority patent/AR043089A1/es
Publication of EP1065210A1 publication Critical patent/EP1065210A1/de
Priority to IL147030A priority patent/IL147030A/en
Priority to ZA200110244A priority patent/ZA200110244B/xx
Priority to HK03100586.7A priority patent/HK1048475B/zh
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP99112553A 1999-07-01 1999-07-01 Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel Withdrawn EP1065210A1 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DE29923419U DE29923419U1 (de) 1999-07-01 1999-07-01 Neue Xanthonverbindungen und diese enthaltende Arzneimittel
EP99112553A EP1065210A1 (de) 1999-07-01 1999-07-01 Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel
CNB008096678A CN1151156C (zh) 1999-07-01 2000-06-27 新型呫吨酮化合物、其制备方法和作为药剂的用途
ES00962275T ES2225214T3 (es) 1999-07-01 2000-06-27 Nuevos compuestos de xantona, su preparacion y uso como medicamento.
AT00962275T ATE272641T1 (de) 1999-07-01 2000-06-27 Neue xanthon derivate, deren herstellung und verwendung als arzneimittel
PCT/EP2000/005973 WO2001002408A1 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicament
BR0012127-4A BR0012127A (pt) 1999-07-01 2000-06-27 Compostos de xantona, sua preparação e uso como medicamento
MXPA01013340A MXPA01013340A (es) 1999-07-01 2000-06-27 Nuevos compuestos de xantona, su preparacion y uso como medicamento.
RU2002102495/04A RU2220146C2 (ru) 1999-07-01 2000-06-27 Новые производные ксантона, их получение и применение в качестве лекарственного средства
JP2001507844A JP3848158B2 (ja) 1999-07-01 2000-06-27 新規のキサントン化合物、その製造および医薬としての使用
SI200030468T SI1200444T1 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicament
DE60012750T DE60012750T2 (de) 1999-07-01 2000-06-27 Neue xanthon derivate, deren herstellung und verwendung als arzneimittel
UA2002010816A UA72260C2 (uk) 1999-07-01 2000-06-27 Похідні ксантону, їх одержання та використання як лікарських засобів
DK00962275T DK1200444T3 (da) 1999-07-01 2000-06-27 Nye xanthon-forbindelser, deres fremstilling og anvendelse som lægemiddel
PL00352528A PL352528A1 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicament
AU74069/00A AU764215B2 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicament
HU0201810A HUP0201810A3 (en) 1999-07-01 2000-06-27 Sootepenseone and its derivatives, their preparation and use as medicament
IL14703000A IL147030A0 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicaments
PT00962275T PT1200444E (pt) 1999-07-01 2000-06-27 Novos compostos xantona, sua preparacao e sua utilizacao como medicamento
CA002376681A CA2376681A1 (en) 1999-07-01 2000-06-27 Novel xanthone compounds, their preparation and use as medicament
EP00962275A EP1200444B1 (de) 1999-07-01 2000-06-27 Neue xanthon derivate, deren herstellung und verwendung als arzneimittel
US09/605,650 US6403636B1 (en) 1999-07-01 2000-06-28 Xanthone compounds, their preparation and use as medicament
CO00049358A CO5190699A1 (es) 1999-07-01 2000-06-30 Nuevos compuestos de xantona, su procedimiento de preparacion y preparaciones farmaceuticas que los contienen
ARP000103370A AR043089A1 (es) 1999-07-01 2000-06-30 Compuestos de xantona, su preparacion y uso como medicamento
IL147030A IL147030A (en) 1999-07-01 2001-12-11 Xanthone compounds, their preparations and pharmaceutical preparations containing them
ZA200110244A ZA200110244B (en) 1999-07-01 2001-12-13 Novel xanthone compounds, their preparation and use as medicament.
HK03100586.7A HK1048475B (zh) 1999-07-01 2003-01-23 新型呫吨酮化合物、其製備方法和作為藥劑的用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99112553A EP1065210A1 (de) 1999-07-01 1999-07-01 Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
EP1065210A1 true EP1065210A1 (de) 2001-01-03

Family

ID=8238476

Family Applications (2)

Application Number Title Priority Date Filing Date
EP99112553A Withdrawn EP1065210A1 (de) 1999-07-01 1999-07-01 Neue Xanthon-Derivate, deren Herstellung und Verwendung als Arzneimittel
EP00962275A Expired - Lifetime EP1200444B1 (de) 1999-07-01 2000-06-27 Neue xanthon derivate, deren herstellung und verwendung als arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP00962275A Expired - Lifetime EP1200444B1 (de) 1999-07-01 2000-06-27 Neue xanthon derivate, deren herstellung und verwendung als arzneimittel

Country Status (24)

Country Link
US (1) US6403636B1 (de)
EP (2) EP1065210A1 (de)
JP (1) JP3848158B2 (de)
CN (1) CN1151156C (de)
AR (1) AR043089A1 (de)
AT (1) ATE272641T1 (de)
AU (1) AU764215B2 (de)
BR (1) BR0012127A (de)
CA (1) CA2376681A1 (de)
CO (1) CO5190699A1 (de)
DE (2) DE29923419U1 (de)
DK (1) DK1200444T3 (de)
ES (1) ES2225214T3 (de)
HK (1) HK1048475B (de)
HU (1) HUP0201810A3 (de)
IL (2) IL147030A0 (de)
MX (1) MXPA01013340A (de)
PL (1) PL352528A1 (de)
PT (1) PT1200444E (de)
RU (1) RU2220146C2 (de)
SI (1) SI1200444T1 (de)
UA (1) UA72260C2 (de)
WO (1) WO2001002408A1 (de)
ZA (1) ZA200110244B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100344616C (zh) * 2001-06-12 2007-10-24 维尔斯达医疗公司 用于治疗代谢失调的化合物
US6927234B2 (en) * 2003-09-26 2005-08-09 Kuboyama Bio Ken Inc. Xanthone derivatives, method of production thereof, and pharmaceutical composition containing the same
JP2006261107A (ja) * 2005-02-18 2006-09-28 Kuraray Co Ltd 照明装置及びそれを用いた表示装置
CN102101864B (zh) * 2009-12-18 2012-09-05 中国科学院昆明植物研究所 三宝木内酯a-d,其药物组合物,制备方法和应用
US8618125B2 (en) 2011-01-14 2013-12-31 Heptiva LLC Composition comprising hepatic therapeutic active for treating liver diseases, certain cancers and liver health maintenance
CN102558193B (zh) * 2012-01-18 2014-12-17 上海交通大学医学院附属第九人民医院 藤黄精酸衍生物及其制备方法和应用
JP6830401B2 (ja) * 2017-04-27 2021-02-17 株式会社てまひま堂 にんにく卵黄の製造方法とこの方法により製造されたにんにく卵黄
JP2019030278A (ja) * 2017-08-09 2019-02-28 株式会社てまひま堂 乾燥にんにく粉末の製造方法とこの方法により製造された乾燥にんにく粉末
CN108272790A (zh) * 2018-01-17 2018-07-13 上海中医药大学 一种占吨酮类化合物a的药物用途

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ASANO ET AL.: "Cytotoxic Xanthones from Garcinia hanburyi", PHYTOCHEMISTRY, vol. 41, no. 3, 1996, pages 815 - 820, XP002116431 *
CAO S -G ET AL: "Novel Cytotoxic Polyprenylated Xanthonoids from Garcinia gaudichaudii (Guttiferae)", TETRAHEDRON, vol. 54, no. 36, 3 September 1998 (1998-09-03), pages 10915-10924, XP004130029, ISSN: 0040-4020 *
CHEMICAL ABSTRACTS, vol. 119, no. 12, 20 September 1993, Columbus, Ohio, US; abstract no. 124959, LIN ET AL.: "Isogambonic acid and isomorellinol from Garcinia hanburyi" XP002116433 *
CHEMICAL ABSTRACTS, vol. 129, no. 26, 28 December 1998, Columbus, Ohio, US; abstract no. 341671, SINZ ET AL.: "Novel acetogenins from the leavesof Dasymaschalon sootepense" XP002116434 *
SULTANBAWA: "Xanthonoids of tropical plants", TETRAHEDRON, vol. 36, 1980, pages 1465 - 1506, XP002116432 *

Also Published As

Publication number Publication date
RU2220146C2 (ru) 2003-12-27
CN1368973A (zh) 2002-09-11
JP3848158B2 (ja) 2006-11-22
BR0012127A (pt) 2002-03-26
DE60012750T2 (de) 2005-09-01
AU764215B2 (en) 2003-08-14
WO2001002408A1 (en) 2001-01-11
ES2225214T3 (es) 2005-03-16
PL352528A1 (en) 2003-08-25
DE60012750D1 (de) 2004-09-09
HUP0201810A2 (en) 2002-09-28
HK1048475A1 (en) 2003-04-04
AU7406900A (en) 2001-01-22
HK1048475B (zh) 2004-12-17
US6403636B1 (en) 2002-06-11
UA72260C2 (uk) 2005-02-15
IL147030A0 (en) 2002-08-14
CN1151156C (zh) 2004-05-26
SI1200444T1 (en) 2004-10-31
DK1200444T3 (da) 2004-11-22
EP1200444B1 (de) 2004-08-04
PT1200444E (pt) 2004-11-30
MXPA01013340A (es) 2002-11-04
JP2003503503A (ja) 2003-01-28
HUP0201810A3 (en) 2004-12-28
EP1200444A1 (de) 2002-05-02
ATE272641T1 (de) 2004-08-15
ZA200110244B (en) 2002-06-28
CO5190699A1 (es) 2002-08-29
CA2376681A1 (en) 2001-01-11
DE29923419U1 (de) 2001-02-08
IL147030A (en) 2006-07-05
AR043089A1 (es) 2005-07-20

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