EP0895546A4 - Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel - Google Patents

Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel

Info

Publication number
EP0895546A4
EP0895546A4 EP98908435A EP98908435A EP0895546A4 EP 0895546 A4 EP0895546 A4 EP 0895546A4 EP 98908435 A EP98908435 A EP 98908435A EP 98908435 A EP98908435 A EP 98908435A EP 0895546 A4 EP0895546 A4 EP 0895546A4
Authority
EP
European Patent Office
Prior art keywords
methods
magnetic particles
target materials
biological target
silica magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98908435A
Other languages
English (en)
French (fr)
Other versions
EP0895546A1 (de
EP0895546B1 (de
Inventor
Craig E Smith
Charles K York
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25134438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0895546(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Promega Corp filed Critical Promega Corp
Priority to DK03014689.8T priority Critical patent/DK1367137T3/da
Priority to EP03014689A priority patent/EP1367137B1/de
Publication of EP0895546A1 publication Critical patent/EP0895546A1/de
Publication of EP0895546A4 publication Critical patent/EP0895546A4/de
Application granted granted Critical
Publication of EP0895546B1 publication Critical patent/EP0895546B1/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/838—Magnetic property of nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/916—Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/96—Of magnetic property

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Compounds Of Iron (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)
EP98908435A 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel Revoked EP0895546B1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK03014689.8T DK1367137T3 (da) 1997-01-21 1998-01-21 Fremgangsmåder til isolering af biologiske målmaterialer ved anvendelse af magnetisk silika-partikler
EP03014689A EP1367137B1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US785097 1997-01-21
US08/785,097 US6027945A (en) 1997-01-21 1997-01-21 Methods of isolating biological target materials using silica magnetic particles
PCT/US1998/001149 WO1998031840A1 (en) 1997-01-21 1998-01-21 Methods of isolating biological target materials using silica magnetic particles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP03014689A Division EP1367137B1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel

Publications (3)

Publication Number Publication Date
EP0895546A1 EP0895546A1 (de) 1999-02-10
EP0895546A4 true EP0895546A4 (de) 2002-03-20
EP0895546B1 EP0895546B1 (de) 2003-08-27

Family

ID=25134438

Family Applications (2)

Application Number Title Priority Date Filing Date
EP03014689A Revoked EP1367137B1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel
EP98908435A Revoked EP0895546B1 (de) 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP03014689A Revoked EP1367137B1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel

Country Status (9)

Country Link
US (5) US6027945A (de)
EP (2) EP1367137B1 (de)
JP (1) JP3253638B2 (de)
AU (1) AU732756B2 (de)
BR (1) BR9805897A (de)
CA (1) CA2249393A1 (de)
DE (3) DE895546T1 (de)
DK (1) DK1367137T3 (de)
WO (1) WO1998031840A1 (de)

Families Citing this family (264)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) * 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
JP2965131B2 (ja) * 1995-07-07 1999-10-18 東洋紡績株式会社 核酸結合用磁性担体およびそれを用いる核酸単離方法
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
DE69810080T2 (de) 1997-01-21 2003-10-09 Grace W R & Co Siliciumdioxidadsorbent auf magnetischem träger
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
WO1998050567A1 (en) * 1997-05-02 1998-11-12 Abbott Laboratories Reagents and methods useful for detecting diseases of the prostate
DE19743518A1 (de) 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US7569342B2 (en) * 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
US20080064108A1 (en) * 1997-12-10 2008-03-13 Tony Baker Urine Preservation System
EP0937497B9 (de) * 1997-12-25 2003-10-29 Tosoh Corporation Magnetischer Träger, seine Herstellung, und Verfahren zum Extrahieren von Nukleinsäuren
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6534262B1 (en) 1998-05-14 2003-03-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
EP0969090A1 (de) * 1998-05-27 2000-01-05 QIAGEN GmbH Schnelles und einfaches Verfahren zur Isolierung von zirkulären Nucleinsäuren
US6368866B1 (en) 1998-08-03 2002-04-09 Reference Diagnostics, Inc. Rapid separation assay for total iron binding capacity
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
DE69929542T2 (de) * 1998-10-27 2006-09-14 Affymetrix, Inc., Santa Clara Komplexitätsmanagement und analyse genomischer dna
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
ES2205914T3 (es) * 1998-11-30 2004-05-01 Roche Diagnostics Gmbh Particulas magneticas para la purificacion de acidos nucleicos.
FI990082A0 (fi) * 1999-01-18 1999-01-18 Labsystems Oy Puhdistusprosessi magneettipartikkeleita käyttäen
US6723237B1 (en) * 1999-01-18 2004-04-20 Precision Systems Science Co., Ltd. Concentration device using magnetic particles and method therefor
JP2002535634A (ja) * 1999-01-20 2002-10-22 レファレンス ダイアグノスティックス インコーポレイテッド 磁気応答性ゲル粒子
AU778486B2 (en) * 1999-05-14 2004-12-09 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6270970B1 (en) * 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
EP1621618B1 (de) 1999-05-14 2011-10-26 Promega Corporation Zell Konzentration und lysat Klärung mittels paramagnetischen Partikeln
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
EP1069131B1 (de) * 1999-07-15 2006-03-15 Qiagen GmbH Verfahren zur Trennung von teilchenförmigen Substraten aus einer Lösung indem man den Teilchenverlust minimiert
DE19937607A1 (de) * 1999-08-09 2001-02-15 Bilatec Ges Zur Entwicklung Bi Reagenzienkit zur Isolierung von Nukleinsäuren
EP1510578A3 (de) * 1999-08-20 2005-03-16 Promega Corporation Simultane Isolierung und Quantifizierung von DNA
CN1370230A (zh) * 1999-08-20 2002-09-18 普罗梅加公司 Dna的同时分离和定量
US6503761B1 (en) * 1999-10-19 2003-01-07 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using articles having magnets
US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
PT1232502E (pt) * 1999-11-17 2006-05-31 Roche Diagnostics Gmbh Particulas de vidro magneticas, metodo para a sua preparacao e suas utilizacoes
US6936414B2 (en) 1999-12-22 2005-08-30 Abbott Laboratories Nucleic acid isolation method and kit
WO2001071732A2 (de) * 2000-03-24 2001-09-27 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
US6672458B2 (en) * 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
DE60137323D1 (de) * 2000-05-19 2009-02-26 Becton Dickinson Co System und verfahren zur behandlung von magnetpartikeln in test-flüssigkeiten zum sammeln von dna und rna
GB0013658D0 (en) * 2000-06-05 2000-07-26 Dynal Asa Nucleic acid isolation
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001272993B2 (en) * 2000-06-21 2005-03-10 Bioarray Solutions, Ltd. Multianalyte molecular analysis
AU2001276830A1 (en) * 2000-06-23 2002-01-08 Irm, Llc Method and apparatus for performing an assay
AU2001288689A1 (en) * 2000-09-06 2002-03-22 Timothy A. Hodge System, method and apparatus for transgenic and targeted mutagenesis screening
US7011943B2 (en) 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US20030082605A1 (en) * 2000-09-06 2003-05-01 Hodge Timothy A. Genomic DNA detection method and system thereof
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
US20030087286A1 (en) * 2000-09-06 2003-05-08 Hodge Timothy A. Isolation of eukaryotic genomic DNA using magnetically responsive solid functionalized particles
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
ATE404688T1 (de) * 2000-09-06 2008-08-15 Timothy A Hodge Verfahren zum screenen von genomischer dns, insbesonderer bei transgener und zielgerichteter mutagenese
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
US20030207289A1 (en) * 2001-09-04 2003-11-06 Hodge Timothy A. Detection of genetic sequences using a bipartite probe
EP1341910B1 (de) * 2000-11-13 2006-10-11 Promega Corporation Lysat-klärung und nukleinsäureisolierung mit silanisierten silicamatrizes
US6607667B2 (en) * 2000-11-28 2003-08-19 W. R. Grace & Co.-Conn. Method for adsorbing substances using silica adsorbent on magnetic substrate
WO2002044414A2 (en) * 2000-11-28 2002-06-06 Promega Corporation Purification of dna sequencing reactions using silica magnetic particles
US6794141B2 (en) * 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
CA2446478C (en) * 2001-01-19 2008-02-26 Drm, Dr. Muller Ag Method for treating biomass for producing cell lysate containing plasmid dna
US6855499B1 (en) 2001-02-16 2005-02-15 Cortex Biochem, Inc. Magnetic isolation and purification of nucleic acids
EP2090655B1 (de) 2001-02-16 2013-05-08 Promega Corporation Magnetische Isolierung und Reinigung von Nukleinsäuren
US20030022203A1 (en) * 2001-04-23 2003-01-30 Rajan Kumar Cellular Arrays
US6849186B2 (en) * 2001-05-02 2005-02-01 Phillips Plastic Corporation Composite particles
US6656587B2 (en) 2001-05-02 2003-12-02 Phillips Plastics Corporation Composite particles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003033740A2 (en) * 2001-07-10 2003-04-24 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
US20040137449A1 (en) * 2001-10-05 2004-07-15 Nargessi R D Magnetic isolation and purification of nucleic acids
CA2741049C (en) 2001-10-15 2019-02-05 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
EP1442045B1 (de) 2001-11-06 2009-01-07 Cortex Biochem Inc. Isolierung und aufreinigung von nukleinsäuren
US8110351B2 (en) 2002-01-16 2012-02-07 Invitrogen Dynal As Method for isolating nucleic acids and protein from a single sample
WO2003068788A1 (en) * 2002-02-13 2003-08-21 Medimolecular Pty. Ltd. Method of isolating nucleic acids from stool samples
EP1485503A4 (de) * 2002-03-15 2005-12-28 Arcturus Bioscience Inc Verbesserte nukleinsäureamplifikation
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
GB0207975D0 (en) * 2002-04-05 2002-05-15 Genovision As Isolating nucleic acid
GB0210766D0 (en) * 2002-05-10 2002-06-19 Genovision As Isolating nucleic acid
US20040126902A1 (en) * 2002-06-27 2004-07-01 Toyo Boseki Kabushiki Kaisha Magnetic carrier for biological substance, production method thereof and isolation method of biological substance using same
GB0215185D0 (en) 2002-07-01 2002-08-07 Genovision As Binding a target substance
WO2004005553A1 (en) * 2002-07-10 2004-01-15 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
AU2003258542A1 (en) * 2002-07-29 2004-02-23 Axxima Pharmaceuticals Ag Method for isolating atp binding proteins by means of immobolized protein inhibitors
US7183104B1 (en) 2002-08-23 2007-02-27 Duane Morris Llp Separator and particle detection system
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
US7601491B2 (en) 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
JP2004000922A (ja) * 2003-03-26 2004-01-08 Toyobo Co Ltd 核酸またはタンパク質抽出用シリカ粒子組成物
CA2526409A1 (en) * 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
JP4612789B2 (ja) * 2003-05-29 2011-01-12 キヤノン株式会社 Ｄｎａハイブリッド及びｄｎａハイブリッドを用いた環境浄化システム
EP1633869A1 (de) * 2003-06-04 2006-03-15 Qiagen AS Verfahren zur sequenziellen isolierung von dns und rns aus derselben nukleinsäure-enthaltenden probe
US20050042660A1 (en) * 2003-07-31 2005-02-24 Hall Gerald Edward Devices and methods for isolating RNA
GB0319671D0 (en) * 2003-08-21 2003-09-24 Secr Defence Apparatus for processing a fluid sample
EP1510577A1 (de) 2003-08-29 2005-03-02 Qiagen GmbH Verfahren zur Magnetische Kügelchem Isolierung von Nukleinsäuren
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
AU2004276761B2 (en) * 2003-09-22 2009-12-24 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
JP2007521017A (ja) * 2003-10-28 2007-08-02 バイオアレイ ソリューションズ リミテッド 固定化捕捉プローブを用いる遺伝子発現分析法の最適化
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US20050106577A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Cleavable solid phases for isolating nucleic acids
US20050106589A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Compositions and methods for releasing nucleic acids from solid phase binding materials
US20050136477A1 (en) * 2003-11-17 2005-06-23 Hashem Akhavan-Tafti Methods for isolating nucleic acids from biological and cellular materials
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106602A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Simplified methods for isolating nucleic acids from cellular materials
DE10358137A1 (de) * 2003-12-12 2005-07-07 Merck Patent Gmbh Verfahren und Kit zur Isolierung von RNA
WO2005068662A1 (en) * 2003-12-30 2005-07-28 Sigma-Aldrich Co. Rapid preparation of nucleic acids by enzymatic digestion
EP2277987A3 (de) * 2004-02-18 2011-10-12 Life Technologies Corporation Polyelektrolytbeschichtete Ionenaustauscheteilchen
US8426126B2 (en) 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US20050236299A1 (en) * 2004-04-27 2005-10-27 Mark Weber Folded material containment packages and related methods of packaging folded material products
NL1026271C2 (nl) * 2004-05-26 2005-11-30 Keygene Nv Werkwijze en inrichting voor het isoleren van nucleïnezuur uit nucleïnezuur bevattend materiaal.
WO2006004611A2 (en) * 2004-06-25 2006-01-12 Invitrogen Corporation Separation of nucleic acid
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
WO2006015326A2 (en) 2004-07-30 2006-02-09 Agencourt Bioscience Corporation Methods of isolating nucleic acids using multifunctional group-coated solid phase carriers
JP4798971B2 (ja) * 2004-07-30 2011-10-19 キヤノン株式会社 磁性粒子集合体およびそれを用いた標的核酸の抽出装置および抽出方法
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
AU2005271687A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
WO2006015374A2 (en) 2004-08-03 2006-02-09 Novartis Vaccines And Diagnostics Inc. Compositions and methods for preparation of nucleic acids from microbial samples
CA2575446C (en) * 2004-08-03 2014-03-25 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
US20060099605A1 (en) * 2004-11-11 2006-05-11 Hall Gerald E Jr Devices and methods for isolating RNA
US7320891B2 (en) * 2004-09-10 2008-01-22 Promega Corporation Methods and kits for isolating sperm cells
US7166680B2 (en) * 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
EP1650297B1 (de) * 2004-10-19 2011-04-13 Samsung Electronics Co., Ltd. Verfahren und Apparatur zur schnellen Zerstörung von Zellen und Viren durch die Verwendung von mikro magnet Kügelchen und Laser
DE102005002343A1 (de) 2005-01-18 2006-07-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur spezifischen oder unspezifischen Separation von Zellen und/oder Viren aus flüssigen Medien und dessen Verwendung
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
EP1690938A1 (de) * 2005-02-11 2006-08-16 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren, wobei die Nukleinsäuren bei erhöhter Temperatur an einer Matrix immobilisiert werden
US7914982B2 (en) * 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
ITRM20050067A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
WO2006122002A2 (en) * 2005-05-09 2006-11-16 Panomics, Inc. Multiplex capture of nucleic acids
US8632970B2 (en) 2005-05-09 2014-01-21 Affymetrix, Inc. Multiplex capture of nucleic acids
DE602006020715D1 (de) * 2005-05-12 2011-04-28 Affymetrix Inc Multiplex-assays für verzweigtkettige dna
US20060269929A1 (en) * 2005-05-26 2006-11-30 Hall Gerald E Jr Methods and kits for DNA purification on polymeric membranes at low ionic strength
US20060270843A1 (en) * 2005-05-26 2006-11-30 Hall Gerald E Jr Methods for isolation of nucleic acids
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007001986A2 (en) * 2005-06-20 2007-01-04 Yuling Luo Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
EP1907585A4 (de) * 2005-07-01 2010-04-07 Promega Corp Netzwerk aus auftriebspartikeln für die biomolekülreinigung und verwendung von auftriebspartikeln oder dem netzwerk aus auftriebspartikeln zur biomolekülreinigung
US20070072195A1 (en) * 2005-09-29 2007-03-29 Constantine Haralambopoulos Bio-commemorative article incorporating amplified genetic material
US7927798B2 (en) * 2005-10-05 2011-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US20070092403A1 (en) * 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
EP1963526A4 (de) 2005-12-09 2009-11-18 Promega Corp Nukleinsäurereinigung mittels bindungsmatrix
CN101384715A (zh) * 2006-02-15 2009-03-11 东曹株式会社 从生物材料中提取核酸的方法
US20070254284A1 (en) * 2006-05-01 2007-11-01 Biwei Zhao A nucleic acid detection method
WO2008002882A2 (en) * 2006-06-26 2008-01-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20100143878A1 (en) * 2006-10-06 2010-06-10 Promega Corporation Methods and kits for isolating cells
EP1911844A1 (de) 2006-10-10 2008-04-16 Qiagen GmbH Verfahren und Zusammenstellung zur Isolierung von Nukleinsäure
EP3604553A3 (de) 2006-11-03 2020-04-29 Siemens Healthcare Diagnostics Inc. System für wahlfreien zugriff zum testen mit polymerasekettenreaktion
EP2126074B1 (de) * 2006-12-13 2010-12-01 Roche Diagnostics GmbH Verwendung von acetalen zur isolation von nukleinsäuren
EP2094846B8 (de) * 2006-12-13 2013-10-16 Roche Diagnostics GmbH Verwendung von tde zur isolation von nukleinsäuren
US20100207051A1 (en) * 2006-12-21 2010-08-19 Invitrogen Dynal As Particles and their use in a method for isolating nucleic acid or a method for isolating phosphoproteins
US8993292B2 (en) * 2007-01-16 2015-03-31 Applied Biosystems Llc Methods and systems for differential extraction
US7960180B2 (en) * 2007-02-20 2011-06-14 University Of Notre Dame Du Lac Methods and apparatus to capture and release microbe particles using amino-functionalized silica
WO2008134470A2 (en) * 2007-04-25 2008-11-06 3M Innovative Properties Company Methods for nucleic acid amplification
ES2665280T3 (es) * 2007-06-29 2018-04-25 Becton, Dickinson And Company Métodos para la extracción y purificación de componentes de muestras biológicas
US7868145B2 (en) * 2007-07-11 2011-01-11 Industrial Technology Research Institute Magnetic particles containing a copolymer core, magnetic layer and silicon layer
US8969044B2 (en) 2007-07-23 2015-03-03 Life Technologies Corporation Method for recovering sperm nucleic acid from a forensic sample
PL2612926T3 (pl) * 2007-08-22 2018-07-31 Trovagene, Inc. Metody wykorzystania mirna do wykrywania śmierci komórkowej in vivo
CN101363045B (zh) * 2007-09-10 2012-10-17 厦门致善生物科技有限公司 一种用超微磁颗粒分离纯化生物靶物质的方法
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
EP2214822A1 (de) * 2007-11-26 2010-08-11 Atonomics A/S Integrierte trenn- und nachweiskartusche unter verwendung magnetischer partikel mit bimodaler grössenverteilung
WO2009117167A1 (en) * 2008-01-02 2009-09-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US20110165565A1 (en) 2008-01-03 2011-07-07 The Johns Hopkins University Compositions and methods for polynucleotide extraction and methylation detection
KR101053023B1 (ko) * 2008-02-14 2011-08-01 (주)바이오니아 구형 실리카 자성입자 및 이의 제조방법
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
AU2009223122B2 (en) 2008-03-12 2014-12-11 University Of Virginia Patent Foundation Detection of polymeric analytes
US20120149587A1 (en) * 2008-03-12 2012-06-14 University Of Virginia Patent Foundation Method for detecting nucleated cells
DE102008029356A1 (de) * 2008-06-20 2009-12-24 Siemens Healthcare Diagnostics Gmbh Verfahren zur Aufreinigung von Nukleinsäuren, insbesondere aus fixiertem Gewebe
EP2147981A1 (de) * 2008-07-25 2010-01-27 Biotype AG Kit und Verfahren zur Auswertung der Detektionseigenschaften bei Verstärkungsreaktionen
US20100062518A1 (en) * 2008-09-09 2010-03-11 Sukanta Banerjee Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample
US8632671B2 (en) * 2008-10-03 2014-01-21 Board Of Regents, University Of Texas System Method for measuring carbon nanotubes taken-up by a plurality of living cells
EP2362907A4 (de) * 2008-11-04 2012-08-08 Blood Cell Storage Inc Nukleinsäureextraktion auf gewölbten glasoberflächen
US8846878B1 (en) 2009-01-23 2014-09-30 Cubrc Corporation Method and device for isolating a protein sample
WO2010088517A1 (en) * 2009-01-30 2010-08-05 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Methods and systems for purifying transferring and/or manipulating nucleic acids
DE102009001864A1 (de) * 2009-03-25 2010-09-30 Qiagen Gmbh Überschichtung zur Partikelabtrennung
DE102009022512A1 (de) * 2009-05-25 2010-12-02 Qiagen Gmbh Verfahren zur Reaktivierung von Silikaoberflächen zur Isolierung von Nukleinsäuren
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
US11096345B2 (en) 2009-09-01 2021-08-24 Basf Se Method for treating post-emergent rice
TW201113377A (en) 2009-09-01 2011-04-16 Basf Agrochemical Products Bv Herbicide-tolerant plants
TWI407994B (zh) 2009-10-22 2013-09-11 Ind Tech Res Inst 分離核酸的方法、試劑及套組
BR112012015266A2 (pt) * 2009-12-23 2017-10-10 Koninl Philips Electronics Nv dispositivo configurado para receber uma amostra e método para determinar a presença de um analito em uma amostra
EP2345719A1 (de) 2010-01-18 2011-07-20 Qiagen GmbH Verfahren zur Isolierung kleiner RNA
CA2977845C (en) 2010-02-23 2020-08-04 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US20110223588A1 (en) * 2010-03-09 2011-09-15 Biosample Llc Solid Phase Nucleic Acid Extraction From Small Sample Volumes, and Release of Controlled Quantities
EP2407540A1 (de) 2010-07-15 2012-01-18 Qiagen GmbH Verfahren zur Reinigung von Nukleinsäure
DE102010036111B4 (de) 2010-09-01 2013-08-29 Bundesrepublik Deutschland (Bundesamt für Ausrüstung, Informationstechnik und Nutzung der Bundeswehr) Vorbehandlungsverfahren zur Isolierung und Aufkonzentrierung von Nukleinsäuren aus einer Umweltprobe
EP3034625B1 (de) 2010-10-21 2017-10-04 Advanced Cell Diagnostics, Inc. Hochsensitives verfahren für den in-situ-nachweis von nukleinsäuren
WO2012075133A1 (en) 2010-11-30 2012-06-07 Life Technologies Corporation Alkylene glycols and polymers and copolymers thereof for direct isolation of nucleic acid from embedded samples
CN103261424B (zh) 2010-12-16 2017-12-12 巴斯夫农业公司 对除草剂具有增强的耐受性的植物
EP2465934A1 (de) 2010-12-20 2012-06-20 Steffen Mergemeier Extraktion von Nukleinsäuren
US9051563B2 (en) 2011-01-14 2015-06-09 Zymo Research Corporation Nucleic acid purification
WO2012151473A2 (en) 2011-05-04 2012-11-08 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2012159063A2 (en) 2011-05-19 2012-11-22 Blood Cell Strorage, Inc. Gravity flow fluidic device for nucleic acid extraction
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
DE102011054474B4 (de) 2011-07-20 2014-02-13 Stratec Biomedical Ag System zur Stabilisierung, Aufbewahrung und Lagerung einer Nukleinsäure
DK2742152T3 (en) 2011-08-12 2017-07-31 Qiagen Gmbh PROCEDURE FOR ISOLATING NUCLEIC ACIDS
US9315853B2 (en) 2012-01-30 2016-04-19 Exact Sciences Corporation Modification of DNA on magnetic beads
EP2634254A1 (de) 2012-02-29 2013-09-04 QIAGEN GmbH Verfahren zur Isolierung von Nukleinsäuren aus Nahrungsmittelproben
US10041087B2 (en) 2012-06-19 2018-08-07 BASF Agro B.V. Plants having increased tolerance to herbicides
AR091489A1 (es) 2012-06-19 2015-02-11 Basf Se Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo)
US9278353B2 (en) 2012-06-25 2016-03-08 The General Hospital Corporation Sorting particles using high gradient magnetic fields
EP2770056B1 (de) 2012-07-18 2017-05-31 Zymo Research Corporation Nukleinsäurereinigung
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
US10233508B2 (en) 2012-08-21 2019-03-19 Qiagen Gmbh Virus particle stabilisation and method for isolating viral nucleic acids
WO2014029791A1 (en) 2012-08-21 2014-02-27 Qiagen Gmbh Method for isolating nucleic acids from a formaldehyde releaser stabilized sample
JP6440616B2 (ja) 2012-09-03 2018-12-19 キアゲン ゲーエムベーハー 高収量で小型ｒｎａを含むｒｎａを単離するための方法
RU2015114330A (ru) 2012-09-17 2016-11-10 У.Р. Грейс Энд Ко.-Конн. Хроматографические среды и устройства
GB201217405D0 (en) 2012-09-28 2012-11-14 Fermentas Uab Protein removal agent
US10745686B2 (en) 2013-02-08 2020-08-18 Qiagen Gmbh Method for separating DNA by size
WO2014132201A1 (en) 2013-03-01 2014-09-04 Spinomix Sa A magnetic particles based separation and assaying method
CA2905425A1 (en) * 2013-03-13 2014-10-02 Abbott Molecular Inc. Methods of isolating nucleic acid using a lysis buffer containing ethanol
US9670479B2 (en) 2013-03-15 2017-06-06 F Cubed, LLC Sample preparation device and methods of use
JP5802237B2 (ja) * 2013-04-18 2015-10-28 三洋化成工業株式会社 磁性粒子及びその製造方法
UA123757C2 (uk) 2013-08-12 2021-06-02 Басф Агро Б. В. Мутована протопорфіриногеноксидаза, що надає рослинам стійкості до ппо-інгібуючого гербіциду
EA201690382A1 (ru) 2013-08-12 2016-07-29 Басф Агро Б.В. Растения с повышенной устойчивостью к гербицидам (ппо )
DE202014002379U1 (de) 2014-03-15 2014-08-19 Ruprecht-Karls-Universität Heidelberg DNA Stabilisierungssystem
WO2015150465A2 (en) 2014-04-03 2015-10-08 Basf Se Plants having increased tolerance to herbicides
EP3137209B1 (de) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Funktionalisiertes trägermaterial und verfahren zur herstellung und verwendung eines funktionalisierten trägermaterials
KR102344395B1 (ko) * 2014-06-24 2021-12-29 (주)바이오니아 자성 입자를 이용한 핵산 분리 방법
US10000750B2 (en) 2014-10-09 2018-06-19 Promega Corporation Method of isolating nucleic acid
EP3210216A1 (de) 2014-10-23 2017-08-30 Corning Incorporated Polymerverkapselte magnetische nanopartikel
JP6773402B2 (ja) * 2014-11-04 2020-10-21 三洋化成工業株式会社 磁性シリカ粒子を用いた対象物質の分離方法
EP3059312A1 (de) 2015-02-20 2016-08-24 QIAGEN GmbH Nukleinsäureextraktionsverfahren
US9422596B1 (en) 2015-04-27 2016-08-23 Norgen Biotek Corp. Methods and columns for nucleic acid purification
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
WO2016193282A1 (en) 2015-06-01 2016-12-08 Qiagen Gmbh Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach
US10794859B2 (en) 2015-06-01 2020-10-06 Qiagen Gmbh Electrophoresis assisted method and device for purifying a charged target molecule from a sample
PL3302784T3 (pl) 2015-06-05 2022-01-17 W.R. Grace & Co.-Conn. Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania
EP3303630B1 (de) 2015-06-05 2022-01-05 Qiagen GmbH Verfahren zum trennen von dns anhand der grösse
EP3347490A1 (de) * 2015-09-11 2018-07-18 Corning Incorporated Zusammensetzungen und verfahren zur nukleinsäurereinigung aus blutproben
CN108368543B (zh) 2015-10-12 2023-06-13 领先细胞医疗诊断有限公司 高噪声样品中原位检测核苷酸变体及相关的组合物和方法
AR106931A1 (es) 2015-10-22 2018-03-07 Basf Se Plantas que tienen una mayor tolerancia a herbicidas
EP4166660A1 (de) 2016-04-29 2023-04-19 BASF Plant Science Company GmbH Verbesserte verfahren zur modifizierung von zielnukleinsäuren
TR201606310A2 (tr) 2016-05-12 2017-11-21 Akdeniz Ueniversitesi Genomik dna izolasyon yöntemi ve kiti.
EA201892517A1 (ru) 2016-05-20 2019-05-31 Басф Агро Б.В. Двойные транзитные пептиды для нацеливания полипептидов
EP3480320A4 (de) 2016-06-30 2020-03-11 Biois Co., Ltd. Signalsonde einer doppelsträngigen nukleinsäure und verfahren zum nachweis von zielmolekülen unter verwendung davon
US11149030B2 (en) 2016-07-27 2021-10-19 BASF Agro B.V. Plants having increased tolerance to herbicides
US10077465B2 (en) * 2016-09-13 2018-09-18 The United States Of America, As Represented By The Secretary Of The Navy Sorbents for extraction and stabilization of nucleic acids
EP3519093B1 (de) 2016-09-30 2021-03-10 Koninklijke Philips N.V. System zum aufbringen eines reagens auf eine probe
KR102476709B1 (ko) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
US11879132B2 (en) 2016-12-20 2024-01-23 BASF Agro B.V. Plants having increased tolerance to herbicides
US11891599B2 (en) * 2017-05-22 2024-02-06 Qiagen Healthcare Biotechnologies Systems Gmbh Recovery of nucleic acids from solid supports
US11725200B2 (en) 2017-09-27 2023-08-15 Qiagen Gmbh Method for isolating RNA with high yield
AU2019271028A1 (en) 2018-05-14 2020-12-03 Bruker Spatial Biology, Inc. Chemical compositions and methods of using same
JP7428657B2 (ja) * 2018-10-26 2024-02-06 テルモ株式会社 標的物質の分離方法および定量方法
EP3968029A4 (de) * 2019-05-08 2023-01-18 Hitachi High-Tech Corporation Vorbehandlungsverfahren einer automatischen analysevorrichtung
US11807909B1 (en) 2019-09-12 2023-11-07 Zymo Research Corporation Methods for species-level resolution of microorganisms
JPWO2021100801A1 (de) * 2019-11-20 2021-05-27
EP4163397A4 (de) 2020-06-05 2024-08-28 Seegene Inc Probentransportkit zum nachweis von atemwegspathogenen und verfahren zum nachweis von atemwegspathogenen damit
KR20220075978A (ko) 2020-11-30 2022-06-08 (주)바이오니아 중저 비유전율을 가진 화합물을 포함한 핵산 결합 완충액을 이용한 핵산 분리방법
KR20240090267A (ko) 2021-10-29 2024-06-21 주식회사 씨젠 검체 채취 스왑 도구 및 호흡기 병원체의 검출 방법
WO2024126113A1 (en) 2022-12-12 2024-06-20 BASF Agricultural Solutions Seed US LLC Plants having increased tolerance to herbicides
WO2024124348A1 (en) * 2022-12-15 2024-06-20 Stemcell Technologies Canada Inc. Methods for nucleic acid extraction

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4307262A1 (de) * 1993-03-02 1994-09-08 Christian Bergemann Magnetisches polymeres Siliciumdioxid
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
WO1996041811A1 (de) * 1995-06-08 1996-12-27 Boehringer Mannheim Gmbh Magnetisches pigment
EP0757106A2 (de) * 1995-07-07 1997-02-05 Toyo Boseki Kabushiki Kaisha Nukleinsäuren magnetischer Binder und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233169A (en) * 1979-04-13 1980-11-11 Corning Glass Works Porous magnetic glass structure
US4395271A (en) * 1979-04-13 1983-07-26 Corning Glass Works Method for making porous magnetic glass and crystal-containing structures
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
DE3211309A1 (de) 1982-03-26 1983-09-29 Metin Dipl.-Ing. 6100 Darmstadt Colpan Chromatographisches verfahren zur isolierung von makromolekuelen
US5482834A (en) 1982-05-17 1996-01-09 Hahnemann University Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US6027750A (en) * 1986-09-04 2000-02-22 Gautsch; James Systems and methods for the rapid isolation of nucleic acids
DE3639949A1 (de) 1986-11-22 1988-06-09 Diagen Inst Molekularbio Verfahren zur trennung von langkettigen nukleinsaeuren
US4767670A (en) 1987-01-21 1988-08-30 E. I. Du Pont De Nemours And Company Chromatographic supports for separation of oligonucleotides
ES2066851T3 (es) * 1988-05-24 1995-03-16 Anagen Uk Ltd Particulas atraibles magneticamente y metodo de preparacion.
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5075430A (en) * 1988-12-12 1991-12-24 Bio-Rad Laboratories, Inc. Process for the purification of DNA on diatomaceous earth
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
US5243037A (en) * 1990-09-21 1993-09-07 E. I. Du Pont De Nemours And Company Poly(fluoroalkyl) sugar reagents for surface modification of supports
AU654323B2 (en) 1991-01-04 1994-11-03 Perseptive Biosystems, Inc. Sulfonamide bonded hydrophilic coating
US5155018A (en) * 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5734020A (en) 1991-11-20 1998-03-31 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5610274A (en) * 1991-11-20 1997-03-11 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
EP0555798B1 (de) 1992-02-13 1999-05-06 Becton, Dickinson and Company Celithydrat und Reinigung von DNS
AU687352B2 (en) * 1992-06-08 1998-02-26 Gen-Probe Incorporated Preparation of nucleic acid from mononuclear cells
US5316680A (en) 1992-10-21 1994-05-31 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
WO1994018156A1 (en) 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
EP0723549B1 (de) * 1993-08-30 2003-12-17 Promega Corporation Zusammensetzungen und verfahren zur reinigung von nukleinsäuren
JP4113580B2 (ja) 1994-02-07 2008-07-09 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング エンドトキシンを減量又は除去する方法
US5990301A (en) 1994-02-07 1999-11-23 Qiagen Gmbh Process for the separation and purification of nucleic acids from biological sources
DE4420732A1 (de) * 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
DE59508069D1 (de) * 1994-07-27 2000-04-27 Herbert Pilgrimm Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
US5660984A (en) * 1994-12-09 1997-08-26 Davis; Thomas E. DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof
US5783686A (en) * 1995-09-15 1998-07-21 Beckman Instruments, Inc. Method for purifying nucleic acids from heterogenous mixtures
SE9600590D0 (sv) 1996-02-19 1996-02-19 Pharmacia Biotech Ab Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris
US5904848A (en) 1996-02-21 1999-05-18 Cpg, Inc. Controlled pore glass-synthetic resin membrane
WO1997034015A1 (en) * 1996-03-15 1997-09-18 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
JP3940935B2 (ja) * 1996-06-11 2007-07-04 東洋紡績株式会社 プラスミドｄｎａの抽出精製方法
JPH09327291A (ja) * 1996-06-11 1997-12-22 Toyobo Co Ltd Ｒｎａの抽出精製方法
DE69810080T2 (de) 1997-01-21 2003-10-09 Grace W R & Co Siliciumdioxidadsorbent auf magnetischem träger
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
JP4196227B2 (ja) 1997-05-20 2008-12-17 東洋紡績株式会社 核酸またはタンパク質抽出用シリカ粒子組成物
US6410725B1 (en) * 1999-02-26 2002-06-25 Myriad Genetics Inc. Method for extracting DNA from dried specimens

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
DE4307262A1 (de) * 1993-03-02 1994-09-08 Christian Bergemann Magnetisches polymeres Siliciumdioxid
WO1996041811A1 (de) * 1995-06-08 1996-12-27 Boehringer Mannheim Gmbh Magnetisches pigment
EP0757106A2 (de) * 1995-07-07 1997-02-05 Toyo Boseki Kabushiki Kaisha Nukleinsäuren magnetischer Binder und Verfahren für die Nukleinsäureisolierung unter dessen Verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9831840A1 *

Also Published As

Publication number Publication date
DE895546T1 (de) 2002-10-17
EP0895546A1 (de) 1999-02-10
WO1998031840A1 (en) 1998-07-23
DE69817484T2 (de) 2004-06-17
AU6647598A (en) 1998-08-07
CA2249393A1 (en) 1998-07-23
US20020086326A1 (en) 2002-07-04
BR9805897A (pt) 1999-08-24
EP1367137A1 (de) 2003-12-03
US6027945A (en) 2000-02-22
DE69817484D1 (de) 2003-10-02
US20040086930A1 (en) 2004-05-06
US6368800B1 (en) 2002-04-09
JPH11509742A (ja) 1999-08-31
DK1367137T3 (da) 2010-07-12
EP0895546B1 (de) 2003-08-27
US6673631B1 (en) 2004-01-06
DE69841555D1 (de) 2010-04-22
EP1367137B1 (de) 2010-03-10
JP3253638B2 (ja) 2002-02-04
AU732756B2 (en) 2001-04-26

Similar Documents

Publication Publication Date Title
EP0895546A4 (de) Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel
AU8951191A (en) Isolation of biological materials using magnetic particles
AU6544598A (en) Compositions and methods for analysis of nucleic acids
EP1027145A4 (de) Vorrichtung und verfahren zur isolierung von nukleinsäure
EP1027450A4 (de) Verfahren zum dna-shuffling
AU3374797A (en) Methods for detection of rearranged dna
AU1408899A (en) Method and apparatus for isolation and purification of biomolecules
HUP0001272A3 (en) Direct expression of peptides into culture media
GB9726824D0 (en) Method of manufacturing particles
ID25722A (id) Penganalisa partikel-partikel padat terlarut
AU8370298A (en) Process for preparation of soft magnetic composites and the composites prepared
EP1005479A4 (de) Rns-isolationsreagenz und verfahren
AU7816198A (en) Process for separation and preconcentration of radium from water
AU6387000A (en) Serial analysis of genetic alterations
AU4397797A (en) Method of gene introduction
AU7831498A (en) Low density silica particles and method for their preparation
AU3972899A (en) Analysis of gene family expression
AU8898198A (en) Methods of identifying biological agent compositions
GB9410345D0 (en) Method of genetic testing
AU2411501A (en) Methods and means of carrying off contaminated materials
AU1742300A (en) Apparatus and methods for transport of charged biological materials
PL336487A1 (en) Mammalian glucuronil c5-epimerase encoding dna sequence and method of obtaining same
AU3083400A (en) Method of magnetically separating particulate materials
GB9724270D0 (en) Methods and means for mutagenesis of dna
AU7035598A (en) Method of measuring particle sizes

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE DK FR GB IT LI NL SE

17P Request for examination filed

Effective date: 19981221

D17D Deferred search report published (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20020206

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE CH DE DK FR GB IT LI NL SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 12Q 1/68 A, 7C 12N 15/10 B

DET De: translation of patent claims
17Q First examination report despatched

Effective date: 20020925

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Designated state(s): BE CH DE DK FR GB IT LI NL SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030827

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 69817484

Country of ref document: DE

Date of ref document: 20031002

Kind code of ref document: P

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031127

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

ET Fr: translation filed
PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

26 Opposition filed

Opponent name: JOSEF HOEDL

Effective date: 20040527

NLR1 Nl: opposition has been filed with the epo

Opponent name: JOSEF HOEDL

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

RDAF Communication despatched that patent is revoked

Free format text: ORIGINAL CODE: EPIDOSNREV1

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

APBP Date of receipt of notice of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA2O

APBQ Date of receipt of statement of grounds of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA3O

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

APBU Appeal procedure closed

Free format text: ORIGINAL CODE: EPIDOSNNOA9O

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20100125

Year of fee payment: 13

RDAG Patent revoked

Free format text: ORIGINAL CODE: 0009271

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT REVOKED

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20100127

Year of fee payment: 13

Ref country code: FR

Payment date: 20100205

Year of fee payment: 13

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

27W Patent revoked

Effective date: 20100426

GBPR Gb: patent revoked under art. 102 of the ep convention designating the uk as contracting state

Effective date: 20100426

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20100125

Year of fee payment: 13

REG Reference to a national code

Ref country code: SE

Ref legal event code: ECNC

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20100124

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF THE APPLICANT RENOUNCES

Effective date: 20030827

Ref country code: CH

Free format text: LAPSE BECAUSE OF THE APPLICANT RENOUNCES

Effective date: 20030827

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20100127

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20110127

Year of fee payment: 14

REG Reference to a national code

Ref country code: DE

Ref legal event code: R107

Ref document number: 69817484

Country of ref document: DE

Effective date: 20110922