EP0738274A1 - Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique - Google Patents

Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique

Info

Publication number
EP0738274A1
EP0738274A1 EP95905541A EP95905541A EP0738274A1 EP 0738274 A1 EP0738274 A1 EP 0738274A1 EP 95905541 A EP95905541 A EP 95905541A EP 95905541 A EP95905541 A EP 95905541A EP 0738274 A1 EP0738274 A1 EP 0738274A1
Authority
EP
European Patent Office
Prior art keywords
formula
cytidine
residue
thymidine
adenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP95905541A
Other languages
German (de)
English (en)
Inventor
Hans Brachwitz
Peter Langen
Iduna Fichtner
Wolfgang E. Berdel
Matthias Baeseler
Uwe Lachmann
Karin Dressler
Yvonne Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Publication of EP0738274A1 publication Critical patent/EP0738274A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne de nouveaux produits d'addition nucléoside-lipide de formule générale (I), y compris toutes les formes énantiomériques ainsi que tous les sels de ces composés utilisables en pharmacie. Le domaine d'application est l'industrie chimique et l'industrie pharmaceutique. La préparation de ces composés (I) avec un groupement diphosphate ou phosphonophosphate s'effectue par condensation de nucléoside-5'-monoamidophosphates avec les phosphates ou les phosphonates lipidiques correspondants ou par condensation des lipidoamidophosphates ou des lipidoamidophosphonates avec les 5'-nucléosidemonophosphates correspondants. Les composés (I), qui contiennent un groupement triphosphate ou phosphonodiphosphate, sont obtenus par condensation d'un nucléosideamidodiphosphate avec un alkylphosphate ou un alkylphosphonate ou par réaction d'un amidophosphate ou d'un amidophosphonate lipidiques avec un 5'-nucléosidediphosphate ou par condensation d'un phosphate ou d'un phosphonophosphate lipidiques avec un 5'-nucléosidemonoamidophosphate ou par réaction d'un amidodiphosphate ou d'un amidophosphonophosphate lipidiques avec un 5'-nucléosidemonophosphate. Les composés de formule (I) ont une action cytostatique.
EP95905541A 1994-01-07 1995-01-04 Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique Ceased EP0738274A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19944400310 DE4400310A1 (de) 1994-01-07 1994-01-07 Neue Nukleosid-Lipid-Addukte, ihre Herstellung und ihre pharmazeutische Verwendung
DE4400310 1994-01-07
PCT/DE1995/000041 WO1995018816A1 (fr) 1994-01-07 1995-01-04 Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique

Publications (1)

Publication Number Publication Date
EP0738274A1 true EP0738274A1 (fr) 1996-10-23

Family

ID=6507563

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95905541A Ceased EP0738274A1 (fr) 1994-01-07 1995-01-04 Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique

Country Status (3)

Country Link
EP (1) EP0738274A1 (fr)
DE (1) DE4400310A1 (fr)
WO (1) WO1995018816A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090370A1 (fr) * 2004-02-05 2005-09-29 The Regents Of The University Of California Agents pharmacologiquement actifs contenant des phosphonates esterifies, et leurs procedes d'utilisation
WO2020041051A1 (fr) * 2018-08-20 2020-02-27 Cure Biopharma Inc. Promédicaments de gemcitabine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291024A (en) * 1978-04-10 1981-09-22 Turcotte Joseph G Cytotoxic liponucleotide analogs
KR880000093B1 (ko) * 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
EP0355016B1 (fr) * 1988-08-17 1994-02-09 Clarion Pharmaceuticals, Inc. Procédé pour la préparation de cytidine 5'-diphosphate-alkanols et -glycérols
JPH0283393A (ja) * 1988-09-19 1990-03-23 Kyowa Hakko Kogyo Co Ltd ５−フルオロウラシル誘導体
DD279249A1 (de) * 1989-01-01 1990-05-30 Akad Wissenschaften Ddr Verfahren zur herstellung von 2',3'-didesoxythymidin-5'-diphosphat-1,2-di-o-alkylglycerolen und deren salzen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9518816A1 *

Also Published As

Publication number Publication date
WO1995018816A1 (fr) 1995-07-13
DE4400310A1 (de) 1995-07-13

Similar Documents

Publication Publication Date Title
EP0312087B1 (fr) Amides d'acides bis-aldoniques et une méthode pour leur préparation
EP0056265B1 (fr) Pyrimidinenucléosides estérifiés en position 5' ayant une activité antivirale, méthode pour leur préparation et les médicaments les contenant
DD274423A5 (de) Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten
DE3543346A1 (de) Neue nucleosidderivate und verfahren zu ihrer herstellung
DE2848054A1 (de) Verfahren zur herstellung von polynucleotiden mit bestimmter sequenz
DE1918282C3 (de) Verfahren zur Herstellung von Diestern kondensierter Phosphorsäuren
DE2059429C2 (de) Verfahren zur Herstellung von Nucleosiddiphosphatestern
WO1995018816A1 (fr) Nouveaux produits d'addition nucleoside-lipide, preparation et utilisation pharmaceutique
WO1989010370A1 (fr) Nouvelles alkylphosphono- et phosphoserines, procede pour leur preparation, et substances pharmaceutiques les contenant
DE2735455B2 (de) Daunomycinanaloga, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1620258C3 (de) Verfahren zur Herstellung von Thiaminderivaten
EP1521761B1 (fr) Traitement de troubles congenitaux de la glycosilation avec du mannose
EP0432183B1 (fr) Nouveaux alcanols et glycerols de diphosphate de cytidine-5', procede pour leur fabrication, ainsi que leur utilisation
DD140254A1 (de) Verfahren zur herstellung von 4-substituierten pyrimidin-nucleosiden
CH655934A5 (en) 5-Alkylpyrimidine nucleosides
DD279249A1 (de) Verfahren zur herstellung von 2',3'-didesoxythymidin-5'-diphosphat-1,2-di-o-alkylglycerolen und deren salzen
DE19618727C2 (de) Herstellung alkylierter Nucleosid-3'-Phosphate
DD290330A7 (de) P-cytidin-5'-diphosphorsaeurealkylester und verfahren zu ihrer herstellung
DD290197A5 (de) Verfahren zur herstellung von cytidin-5'-diphosphat-1-0-alkylglycerol-derivaten und deren salzen
DE2626792A1 (de) Acylderivate von adenosin-5'-monophosphorsaeure, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DD290331A7 (de) Cytidin-5'-diphosphat-1-0-hexadecyl-1-2-0-(2,2,2-trifluorethyl)glycerol und verfahren zu seiner herstellung
DD279248A1 (de) Verfahren zur herstellung von 2',3'-didesoxythymidin-5'-diamidophosphaten
DE19750508A1 (de) Neue Phospholipid-Addukte des 9-beta-D-Arabinofuranosyl-2-fluoradenins, ihre Herstellung und ihre pharmazeutische Verwendung
DD238979A1 (de) Verfahren zur herstellung von o-alkylglycerophosphoserin-analogen
DD277462A1 (de) Verfahren zur herstellung von cytosinarabinosid-5'-diamidophosphaten

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19960729

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 19980827

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19990419