EP0648122B1 - PREVENTING TISSUE ADHESION USING $i(IN SITU) MODIFICATION OF ALGINATE - Google Patents

PREVENTING TISSUE ADHESION USING $i(IN SITU) MODIFICATION OF ALGINATE Download PDF

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Publication number
EP0648122B1
EP0648122B1 EP93908588A EP93908588A EP0648122B1 EP 0648122 B1 EP0648122 B1 EP 0648122B1 EP 93908588 A EP93908588 A EP 93908588A EP 93908588 A EP93908588 A EP 93908588A EP 0648122 B1 EP0648122 B1 EP 0648122B1
Authority
EP
European Patent Office
Prior art keywords
alginate
solution
use according
situ
articular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP93908588A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0648122A1 (en
Inventor
Harold M. Aberman
James J. Barry
Paul A. Higham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Howmedica Osteonics Corp
MTG Divestitures LLC
Original Assignee
Howmedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Howmedica Inc filed Critical Howmedica Inc
Publication of EP0648122A1 publication Critical patent/EP0648122A1/en
Application granted granted Critical
Publication of EP0648122B1 publication Critical patent/EP0648122B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP93908588A 1992-06-30 1993-04-02 PREVENTING TISSUE ADHESION USING $i(IN SITU) MODIFICATION OF ALGINATE Expired - Lifetime EP0648122B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/906,953 US5266326A (en) 1992-06-30 1992-06-30 In situ modification of alginate
US906953 1992-06-30
PCT/US1993/002814 WO1994000134A1 (en) 1992-06-30 1993-04-02 Preventing tissue adhesion using in situ modification of alginate

Publications (2)

Publication Number Publication Date
EP0648122A1 EP0648122A1 (en) 1995-04-19
EP0648122B1 true EP0648122B1 (en) 1996-11-20

Family

ID=25423289

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93908588A Expired - Lifetime EP0648122B1 (en) 1992-06-30 1993-04-02 PREVENTING TISSUE ADHESION USING $i(IN SITU) MODIFICATION OF ALGINATE

Country Status (11)

Country Link
US (1) US5266326A (ja)
EP (1) EP0648122B1 (ja)
JP (1) JPH07504682A (ja)
AT (1) ATE145331T1 (ja)
AU (1) AU671114B2 (ja)
CA (1) CA2139311A1 (ja)
DE (1) DE69306114T2 (ja)
DK (1) DK0648122T3 (ja)
ES (1) ES2094537T3 (ja)
GR (1) GR3022093T3 (ja)
WO (1) WO1994000134A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535296B2 (en) 2002-10-28 2013-09-17 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US8998866B2 (en) 2010-07-02 2015-04-07 Smith & Nephew Plc Provision of wound filler
US9044569B2 (en) 2004-04-28 2015-06-02 Smith & Nephew Plc Wound dressing apparatus and method of use

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ATE198418T1 (de) * 1993-10-04 2001-01-15 Maurizio Dr Tonetti Pharmazeutische zusammensetzung zur förderung der gewebeheilung und -regenerierung und darreichungssatz
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US6150581A (en) * 1995-06-07 2000-11-21 United States Surgical Corporation Chitosan/alginate anti-adhesion barrier
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US20050074495A1 (en) * 1997-06-17 2005-04-07 Fziomed, Inc. Compositions of polyacids and methods for their use in reducing adhesions
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US20040096422A1 (en) * 1997-06-17 2004-05-20 Schwartz Herbert E. Compositions of polyacids and polyethers and methods for their use in reducing pain
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6302848B1 (en) 1999-07-01 2001-10-16 Sonotech, Inc. In vivo biocompatible acoustic coupling media
KR20010010151A (ko) * 1999-07-16 2001-02-05 김윤 수용성 알긴산염과 카르복시메틸 셀룰로오스를 주성분으로 하는 유착방지제 및 그의 제조방법
ES2491866T3 (es) 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH
EP1233751A1 (en) * 1999-11-29 2002-08-28 ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, Inc. Sustained percutaneous delivery of a biologically active substance
ATE243049T1 (de) * 1999-12-09 2003-07-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6638917B1 (en) 2000-02-25 2003-10-28 Scimed Life Systems, Inc. Reducing adhesion
GB0005743D0 (en) * 2000-03-10 2000-05-03 Reckitt & Colmann Prod Ltd Pharmaceutical compositions including alginates
JP2003531682A (ja) * 2000-04-28 2003-10-28 フジオメッド インコーポレイテッド ポリ酸及びポリアルキレンオキシドの止血性組成物、並びにその使用方法
KR20010107067A (ko) * 2000-05-25 2001-12-07 김정식 유착방지제
DK1294414T3 (da) 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
US6989373B2 (en) * 2000-11-15 2006-01-24 Bio Syntech Canada Inc. Method for restoring a fat-pad
US20040091540A1 (en) * 2000-11-15 2004-05-13 Desrosiers Eric Andre Method for restoring a damaged or degenerated intervertebral disc
CA2493083C (en) * 2002-07-16 2012-11-06 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
US7846141B2 (en) 2002-09-03 2010-12-07 Bluesky Medical Group Incorporated Reduced pressure treatment system
US20050008660A1 (en) * 2003-03-10 2005-01-13 The Regents Of The University Of Michigan Compositions and methods for use of alginate dural sealants
AU2004243513A1 (en) * 2003-05-30 2004-12-09 Arc Pharmaceuticals, Inc. Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents
US20050118206A1 (en) * 2003-11-14 2005-06-02 Luk Andrew S. Surfactant-based gel as an injectable, sustained drug delivery vehicle
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
AU2005295927B2 (en) * 2004-10-12 2012-02-02 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
WO2007051311A1 (en) * 2005-11-04 2007-05-10 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
DE102006029500A1 (de) * 2006-06-27 2008-01-03 Schulz, Hans H. Verwendung einer antimikrobiellen härtenden Alginatmasse zur topischen Behandlung von Wunden und Entzündungen in der Human-, Zahn- und Veterinärmedizin
CA2677532A1 (en) * 2007-02-06 2008-08-14 Incept, Llc Polymerization with precipitation of proteins for elution in physiological solution
KR101440170B1 (ko) 2007-02-21 2014-09-12 모찌다 세이야쿠 가부시끼가이샤 연골 질환 치료용 조성물
KR20100063744A (ko) * 2007-08-28 2010-06-11 에프엠씨 코포레이션 지연된 자가-겔화 알기네이트 시스템 및 이의 용도
KR20100094982A (ko) * 2007-11-13 2010-08-27 바이오-테크널러지 제너럴 (이스라엘) 리미티드 점탄성 바이오폴리머의 희석식 여과 멸균 방법
US20090149746A1 (en) * 2007-11-19 2009-06-11 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
EP2987510B1 (en) 2007-11-21 2020-10-28 T.J. Smith & Nephew Limited Suction device and dressing
CN101868203B (zh) 2007-11-21 2014-10-22 史密夫及内修公开有限公司 伤口包敷物
GB0722820D0 (en) 2007-11-21 2008-01-02 Smith & Nephew Vacuum assisted wound dressing
GB0723875D0 (en) 2007-12-06 2008-01-16 Smith & Nephew Wound management
US11253399B2 (en) 2007-12-06 2022-02-22 Smith & Nephew Plc Wound filling apparatuses and methods
ITRM20080037A1 (it) * 2008-01-23 2009-07-24 Uni Degli Studi Perugia Procedimento per la ultrapurificazione di alginati.
US8668863B2 (en) 2008-02-26 2014-03-11 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
GB0803564D0 (en) 2008-02-27 2008-04-02 Smith & Nephew Fluid collection
EP2095832A1 (de) 2008-02-28 2009-09-02 Bayer MaterialScience AG Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile.
DE102008022086A1 (de) * 2008-05-05 2009-11-12 Schulz, Hans H. Zweikomponenten-Alginat
US8367637B2 (en) * 2008-08-19 2013-02-05 Mochida Pharmaceutical Co., Ltd. Composition for treating arthritic disorder
EP2396070A4 (en) * 2009-02-12 2012-09-19 Incept Llc ACTIVE COMPOSITION WITH HYDROGEL PLUGS
US8252317B2 (en) * 2009-02-26 2012-08-28 General Electric Company Metal alginate hydrogel and articles thereof
WO2010117266A1 (en) 2009-04-06 2010-10-14 Broockeville Corporation N.V. In situ gelling alginate systems
US9061095B2 (en) 2010-04-27 2015-06-23 Smith & Nephew Plc Wound dressing and method of use
US9095558B2 (en) 2010-10-08 2015-08-04 Board Of Regents, The University Of Texas System Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications
WO2012048283A1 (en) 2010-10-08 2012-04-12 Board Of Regents, The University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
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RU2463986C2 (ru) * 2010-12-13 2012-10-20 Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНЦ "ВТО" им. акад. Г.А. Илизарова" Минздравсоцразвития России) Способ стимуляции репаративных процессов при лечении внутрисуставных переломов
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US20160120706A1 (en) 2013-03-15 2016-05-05 Smith & Nephew Plc Wound dressing sealant and use thereof
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535296B2 (en) 2002-10-28 2013-09-17 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US8834451B2 (en) 2002-10-28 2014-09-16 Smith & Nephew Plc In-situ wound cleansing apparatus
US9205001B2 (en) 2002-10-28 2015-12-08 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9387126B2 (en) 2002-10-28 2016-07-12 Smith & Nephew Plc Apparatus for aspirating, irrigating and cleansing wounds
US9044569B2 (en) 2004-04-28 2015-06-02 Smith & Nephew Plc Wound dressing apparatus and method of use
US8998866B2 (en) 2010-07-02 2015-04-07 Smith & Nephew Plc Provision of wound filler
US9801761B2 (en) 2010-07-02 2017-10-31 Smith & Nephew Plc Provision of wound filler

Also Published As

Publication number Publication date
CA2139311A1 (en) 1994-01-06
JPH07504682A (ja) 1995-05-25
WO1994000134A1 (en) 1994-01-06
AU3935693A (en) 1994-01-24
DK0648122T3 (da) 1996-12-09
GR3022093T3 (en) 1997-03-31
DE69306114D1 (de) 1997-01-02
DE69306114T2 (de) 1997-03-13
EP0648122A1 (en) 1995-04-19
US5266326A (en) 1993-11-30
ATE145331T1 (de) 1996-12-15
AU671114B2 (en) 1996-08-15
ES2094537T3 (es) 1997-01-16

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