EP0588028B1 - Ampulle - Google Patents
Ampulle Download PDFInfo
- Publication number
- EP0588028B1 EP0588028B1 EP93111821A EP93111821A EP0588028B1 EP 0588028 B1 EP0588028 B1 EP 0588028B1 EP 93111821 A EP93111821 A EP 93111821A EP 93111821 A EP93111821 A EP 93111821A EP 0588028 B1 EP0588028 B1 EP 0588028B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ampoule
- neck
- longitudinal
- syringe
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
Definitions
- the invention relates to an ampoule made of plastic for a liquid, which the ampoule is removed by means of a syringe body, which on its in the end of the ampoule to be inserted has a shoulder with a one Marking defining the longitudinal central plane and at least one longitudinal channel in the inner wall of the ampoule neck in that intended for the attachment of the approach Area for the intake of air when removing the liquid, the longitudinal channel in the circumferential direction of the ampoule neck compared to the Longitudinal median plane of the ampoule is arranged offset.
- Such ampoules are made in one of two mirror images of the same design Parts of the existing mold are blow molded. After graduation of the molding process, the two parts of the mold become the parting plane in one perpendicular direction separated from each other to the ampoule or if multiple ampoules are molded simultaneously, the ampoule block of the mold to be able to remove.
- the division of the form leads to markings of the Ampoules that define a median longitudinal plane.
- the object of the invention based on developing an ampoule of the type mentioned in such a way that they are particularly good for use with syringes with a so-called Luer approach is suitable.
- each existing longitudinal channel is preferably opposite the median longitudinal plane of the ampoule, because this position of the longitudinal channel in Particularly advantageous with regard to removing the ampoule from the mold is.
- the shape of the outer surface of the ampoule neck then corresponds with the shape of the inner surface.
- Ampoule is the ampoule neck with means, preferably an external thread, for an engagement of the internal thread of a couplable with the ampoule neck Luer lock approach provided a syringe, so that the luer lock approach Do not put the syringe on the neck of the ampoule, but screw it on can.
- One blow molded plastic using one in one Contains dimensionally stable ampoule 101 produced in the longitudinal center plane a pharmaceutical liquid to be injected by means of a syringe 108.
- On the neck of ampoule 101 designated as a whole by 102, closes in usual and not shown a one-piece trained with him Head on, which in turn is integrally formed with a molded gag is.
- the ampoule body is mixed with the liquid for reasons of sterility filled while it is still in the blow mold.
- the neck 102, the head and the gag are made in a known manner following the filling of the Ampoule body shaped, the ampoule 101 being closed at the same time becomes.
- the head Connects to the end of the ampoule body opposite the bottom neck 102, whose diameter is smaller than that of the ampoule body.
- the head can be removed from the head by twisting or tilting it Separate neck 102 along a predetermined breaking point so as to contain the contents of the ampoule body to release.
- the ampoule neck 102 is radially inward projecting annular bead 112, the inner diameter of the Ring bead 112 to the outer diameter of the usually as a Luer approach designated pin or cone 107 of the syringe 108 is adapted.
- the annular bead 112 is outside of the one in the production with the parting plane the shape coinciding longitudinal plane of the ampoule 101, which is defined by a circumferential marking 110, in one opposite this Longitudinal median plane rotated by 90 ° with two diametrically arranged Provide interruptions that each form a longitudinal channel 111.
- the shape and the cross section of the longitudinal channels 111 are taking into account the viscosity the liquid contained in the ampoule selected such that on the one hand the Liquid can be removed at the desired speed and on the other hand, the liquid does not exit through the longitudinal channels 111, either when, as is often the case, the liquid is removed from the ampoule 101 in one position with her neck 102 facing down. It sticks out for you
- the removal process of the cones or cones 107 of the syringe 108 is so far in into the ampoule neck 102 until it lies close to the annular bead 112.
- the ampoule neck is in the exemplary embodiment 102 provided at the level of the annular bead 112 with a circumferential annular groove 113, whose cross-sectional shape corresponds to that of the annular bead 112.
- This annular groove 113 can with one on each of the two longitudinal channels 111 aligned break. It then corresponds to the Shape of the outer surface of the ampoule neck 102 with the inner surface.
- syringes with a Luer lock approach are used the pin or cone 107 also concentrically spaced from one another Surround integrally formed with the syringe 108 socket 114, the inside can be provided with a two-start thread, both of which Threads are designated 114 'and 114' '.
- the ampoule neck 102 then has a corresponding external thread 102 'with which the Engages threads 114 'and 114' '.
- the socket 114 of the Luer lock approach the syringe 108 is therefore not attached to the neck of the ampoule, but screwed on.
- the external thread 102 ' others can also Means can be provided for thread-like engagement of the threads Allow 114 'and 114' '.
- the axial length of the bush 114 is less than that of the pin or Cone 107.
- the outer diameter of the neck 102 is the entire length of the neck 102 is chosen only slightly smaller than the inside diameter of the Syringe 108 socket 114.
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packaging Frangible Articles (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Coating Apparatus (AREA)
- Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4230645 | 1992-09-12 | ||
DE4230645A DE4230645C2 (de) | 1992-09-12 | 1992-09-12 | Ampulle |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0588028A2 EP0588028A2 (de) | 1994-03-23 |
EP0588028A3 EP0588028A3 (es) | 1994-08-03 |
EP0588028B1 true EP0588028B1 (de) | 1999-02-24 |
Family
ID=6467873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93111821A Expired - Lifetime EP0588028B1 (de) | 1992-09-12 | 1993-07-23 | Ampulle |
Country Status (11)
Country | Link |
---|---|
US (1) | US5897008A (es) |
EP (1) | EP0588028B1 (es) |
JP (1) | JP2622347B2 (es) |
AU (1) | AU664302B2 (es) |
CA (1) | CA2104363C (es) |
DE (1) | DE4230645C2 (es) |
DK (1) | DK0588028T3 (es) |
ES (1) | ES2127770T3 (es) |
FI (1) | FI105451B (es) |
MX (1) | MX9305493A (es) |
NO (1) | NO307167B1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996000556A1 (fr) * | 1994-06-28 | 1996-01-11 | Daniel Vuille | Ampoule medicale avec cone luer femelle incorpore |
DE29502782U1 (de) * | 1995-02-20 | 1996-06-20 | Thera Ges Fuer Patente | Behälter, insbesondere für Dentalpräparate |
US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
FR2804940B1 (fr) * | 2000-02-10 | 2002-08-30 | Au Liegeur Ets J Pontneau Deni | Bouchon pour bouteilles a vins effervescents et procede de fabrication d'un tel bouchon |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US7100600B2 (en) * | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US6764463B1 (en) * | 2000-06-27 | 2004-07-20 | Barry Farris | Method and needleless apparatus for the storage of a first substance followed by subsequent mixing with a second substance and transfer without ambient air incursion |
CA2472644C (en) | 2002-01-07 | 2013-11-05 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
WO2003059424A1 (en) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Methods and systems for operating an aerosol generator |
ES2572770T3 (es) | 2002-05-20 | 2016-06-02 | Novartis Ag | Aparato para proporcionar pulverización para tratamiento médico y métodos |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
CA2607747C (en) | 2005-05-25 | 2015-12-01 | Aerogen, Inc. | Vibration systems and methods |
CN101663206B (zh) * | 2007-04-27 | 2011-05-11 | 大和制罐株式会社 | 聚酯树脂制带有待破裂部的容器及其制造方法 |
CN102014845B (zh) | 2008-04-25 | 2014-11-05 | 日本脏器制药株式会社 | 塑料安瓿 |
AU2009256148B2 (en) | 2008-06-04 | 2014-11-27 | Butamax(Tm) Advanced Biofuels Llc | A method for producing butanol using two-phase extractive fermentation |
BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
WO2011041426A1 (en) | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
MX2012007712A (es) | 2009-12-29 | 2012-08-15 | Butamax Tm Advanced Biofuels | Expresion de hexosa cinasa en celulas huesped recombinantes. |
EP2582823A1 (en) | 2010-06-18 | 2013-04-24 | Butamax(tm) Advanced Biofuels LLC | Supplementation of fatty acids for improving alcohol productivity |
BR112012032172A2 (pt) | 2010-06-18 | 2015-11-24 | Butamax Tm Advanced Biofuels | método para produzir um álcool e composição |
WO2014035935A1 (en) * | 2012-08-27 | 2014-03-06 | Ultradent Products, Inc. | Ampoule dispenser |
DE102012021525A1 (de) | 2012-10-31 | 2014-04-30 | Kocher-Plastik Maschinenbau Gmbh | Dichtungsanordnung sowie einer solchen zugeordneter Behälter |
AU2013202778A1 (en) | 2013-03-14 | 2014-10-02 | Gen-Probe Incorporated | Systems, methods, and apparatuses for performing automated reagent-based assays |
AU2013202805B2 (en) | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
CA2923696C (en) * | 2013-09-12 | 2021-10-26 | Fresenius Kabi Deutschland Gmbh | Ampoule for medical liquid and method for producing an ampoule |
DE102017007443A1 (de) | 2017-08-05 | 2019-02-07 | Kocher-Plastik Maschinenbau Gmbh | Blasform-, Füll- und Schließverfahren sowie danach hergestelltes Behältererzeugnis, insbesondere Ampullenerzeugnis |
EP3769745B1 (en) * | 2018-03-23 | 2024-05-01 | TERUMO Kabushiki Kaisha | Drug-filled synthetic resin ampule, and synthetic resin ampule body used therein |
DE102018007993A1 (de) | 2018-10-08 | 2020-04-09 | Kocher-Plastik Maschinenbau Gmbh | Dichtungsanordnung mit zugeordnetem Behälter und einem Dichtstoff |
JP2021020739A (ja) * | 2019-07-29 | 2021-02-18 | ウェイラー エンジニアリング インコーポレイテッド | 熱可塑性材料の気密封止容器 |
JP2021070503A (ja) * | 2019-10-31 | 2021-05-06 | 小林製薬株式会社 | スクイズ容器 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2236528A1 (de) * | 1972-07-21 | 1974-01-31 | Dichter Hans Joachim | Glasbehaelter mit verschlusstopfen |
US4046145A (en) * | 1976-06-29 | 1977-09-06 | American Hospital Supply Corporation | Syringe connector |
US4172457A (en) * | 1977-10-06 | 1979-10-30 | American Hospital Supply Corporation | Plural component mixing system and method |
US4192429A (en) * | 1978-03-02 | 1980-03-11 | Becton, Dickinson And Company | Vented vacuum tube and stopper |
US4641663A (en) * | 1985-05-17 | 1987-02-10 | Juhn Steven K | Apparatus for collecting specimens |
IT207944Z2 (it) * | 1986-07-25 | 1988-03-14 | Erba Farmitalia | Dispositivo di bloccaggio di una siringa su di un corpo al quale la siringa deve essere accoppiata. |
GB8800448D0 (en) * | 1988-01-09 | 1988-02-10 | Smiths Industries Plc | Liquid containers |
GB8801655D0 (en) * | 1988-01-26 | 1988-02-24 | Waverley Pharma Ltd | Ampoules |
GB8802349D0 (en) * | 1988-02-03 | 1988-03-02 | Waverley Pharma Ltd | Ampoule with luer |
DE3916840A1 (de) * | 1988-09-21 | 1990-03-29 | Bernd Hansen | Ampulle |
-
1992
- 1992-09-12 DE DE4230645A patent/DE4230645C2/de not_active Expired - Lifetime
-
1993
- 1993-07-23 EP EP93111821A patent/EP0588028B1/de not_active Expired - Lifetime
- 1993-07-23 DK DK93111821T patent/DK0588028T3/da active
- 1993-07-23 ES ES93111821T patent/ES2127770T3/es not_active Expired - Lifetime
- 1993-08-18 CA CA002104363A patent/CA2104363C/en not_active Expired - Lifetime
- 1993-08-20 AU AU44792/93A patent/AU664302B2/en not_active Expired
- 1993-08-24 US US08/110,958 patent/US5897008A/en not_active Expired - Lifetime
- 1993-09-08 MX MX9305493A patent/MX9305493A/es unknown
- 1993-09-08 FI FI933933A patent/FI105451B/fi not_active IP Right Cessation
- 1993-09-09 JP JP5224532A patent/JP2622347B2/ja not_active Expired - Lifetime
- 1993-09-10 NO NO933244A patent/NO307167B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH06218025A (ja) | 1994-08-09 |
CA2104363C (en) | 1998-06-16 |
EP0588028A2 (de) | 1994-03-23 |
AU664302B2 (en) | 1995-11-09 |
CA2104363A1 (en) | 1994-03-13 |
NO933244L (no) | 1994-03-14 |
FI105451B (fi) | 2000-08-31 |
ES2127770T3 (es) | 1999-05-01 |
FI933933A0 (fi) | 1993-09-08 |
DK0588028T3 (da) | 1999-09-27 |
JP2622347B2 (ja) | 1997-06-18 |
DE4230645C2 (de) | 1996-03-07 |
DE4230645A1 (de) | 1994-03-17 |
FI933933A (fi) | 1994-03-13 |
AU4479293A (en) | 1994-03-17 |
US5897008A (en) | 1999-04-27 |
MX9305493A (es) | 1994-03-31 |
EP0588028A3 (es) | 1994-08-03 |
NO933244D0 (no) | 1993-09-10 |
NO307167B1 (no) | 2000-02-21 |
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