EP0436334A2 - 3-Aminopiperidinderivate und verwandte Nitrogen-enthaltende Heterozyklen - Google Patents
3-Aminopiperidinderivate und verwandte Nitrogen-enthaltende Heterozyklen Download PDFInfo
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- EP0436334A2 EP0436334A2 EP90313680A EP90313680A EP0436334A2 EP 0436334 A2 EP0436334 A2 EP 0436334A2 EP 90313680 A EP90313680 A EP 90313680A EP 90313680 A EP90313680 A EP 90313680A EP 0436334 A2 EP0436334 A2 EP 0436334A2
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- methoxybenzylamino
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- phenylpiperidine
- piperidine
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Definitions
- the present invention relates to novel 3-aminopiperidine derivatives and related compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment and prevention of inflammatory and central nervous system disorders, as well as several other disorders.
- the pharmaceutically active compounds of this invention are substance P antagonists.
- This invention also relates to novel intermediates used in the synthesis of such substance P antagonists.
- Substance P is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being named because of their prompt stimulatory action on smooth muscle tissue. More specifically, substance P is a pharmacologically active neuropeptide that is produced in mammals (having originally been isolated from gut) and possesses a characteristic amino acid sequence that is illustrated by D. F. Veber et al . in U.S. Patent No. 4,680,283. The wide involvement of substance P and other tachykinins in the pathophysiology of numerous diseases has been amply demonstrated in the art. For instance, substance P has recently been shown to be involved in the transmission of pain or migraine (see B.E.B.
- the present invention relates to compounds of the formula wherein Y is (CH2) n wherein n is an integer from 1 to 4, and wherein any one of the carbon-carbon single bonds in said (CH2) n may optionally be replaced by a carbon-carbon double bond, and wherein any one of the carbon atoms of said (CH2) n may optionally be substituted with R4, and wherein any one of the carbon atoms of said (CH2) n may optionally be substituted with R7;
- Z is (CH2) m wherein m is an integer from 0 to 6, and wherein any one of the carbon-carbon single bonds of (CH2) m may optionally be replaced by a carbon-carbon double bond or a carbon-carbon triple bond, and any one of the carbon atoms of said (CH2) m may optionally be substituted with R8;
- R1 is hydrogen or (C1-C8) alkyl optionally substituted with hydroxy, (C1-C4)alkoxy or fluoro;
- R2 is a radical selected from
- the present invention also relates to the pharmaceutically acceptable acid addition salts of compounds of the formula I.
- the acids which are used to prepare the pharmaceutically acceptable acid addition salts of the aforementioned base compounds of this invention are those which form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, such as the hydrochloride, hydrobromide, hydroiodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, acetate, lactate, citrate, acid citrate, tartrate, bitartrate, succinate, maleate, fumarate, gluconate, saccharate, benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, p-toluenesulfonate and pamoate [ i- e., 1,1'-methylene-bis-(2-hydroxy-3- naphthoate)]salts.
- the present invention also relates to compounds of the formula wherein R1, R2, R3, R4, R5 and R7 are as defined for compounds of the formula I.
- the compounds of the formula VII are novel intermediates used in the synthesis of compounds of the formula I.
- the present invention also relates to the compound 3-amino-2-phenylpiperidine.
- halo as used herein, unless otherwise indicated, includes chloro, fluoro, bromo and iodo.
- alkyl as used herein, unless otherwise indicated, includes saturated monovalent hydrocarbon radicals having straight, branched or cyclic moieties or combinations thereof.
- one or more substituents includes from one to the maximum number of substituents possible based on the number of available bonding sites.
- Preferred compounds of the formula I are those wherein R1, R4, R5 R6 and R7 are hydrogen, R2 is phenyl, R3 is 2-methoxyphenyl,wherein the phenyl moiety may optionally be substituted with chlorine, fluorine, methyl, (C1-C6)alkoxy or trifluoromethane, m is 0 and n is 3 or 4.
- Specific preferred compounds of the formula I are: cis-3-(2-chlorobenzylamino)-2-phenylpiperidine; cis-3-(2-trifluoromethylbenzylamino)-2-phenylpiperidine; cis-3-(2-methoxybenzylamino)-2-(2-fluorophenyl)-piperidine; cis-3-(2-methoxybenzylamino)-2-(2-chlorophenyl)-piperidine; cis-3-(2-methoxybenzylamino)-2-(2-methylphenyl)-piperidine; cis-3-(2-methoxybenzylamino)-2-(3-methoxyphenyl)-piperidine; cis-3-(2-methoxybenzylamino)-2-(3-fluorophenyl)-piperidine; cis-3-(2-methoxybenzylamino)-2-(3-fluorophenyl)-piperidine;
- the present invention also relates to a pharmaceutical composition
- a pharmaceutical composition comprising a compound of the formula I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable diluent or carrier.
- the present invention also relates to the use of a compound of formula I for treating or preventing a condition selected from the group consisting of inflammatory diseases (e.g., arthritis, psoriasis, asthma and inflammatory bowel disease), anxiety, depression or dysthymic disorders, colitis, psychosis, pain, allergies such as eczema and rhinitis, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina, migraine and Reynaud's disease, fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, peripheral neuropathy, neuralgia, neuropathological disorders such as Alzheimer's disease, AIDS related dementia, diabetic neuropathy and multiple sclerosis, disorders related to immune enhancement or suppression such as systemic lupus erythematosus, and rhe
- the compounds of the present invention are also of value in a method of antagonizing the effects of substance P in a mammal, including a human, which comprises administering to said mammal a substance P antagonizing amount of compound of the formula I, or a pharmaceutically acceptable salt thereof.
- the compounds of the present invention are also of value in a method of treating or preventing a disorder in a mammal, including a human, resulting from an excess of substance P, which comprises administering to said mammal a substance P antagonizing amount of a compound of the formula I, or a pharmaceutically acceptable salt thereof.
- the compounds of the present invention are also of value in a method of treating or preventing a condition selected from the group consisting of inflammatory diseases (e.g., arthritis, psoriasis, asthma and inflammatory bowel disease), anxiety, depression or dysthymic disorders, colitis, psychosis, pain, allergies such as eczema and rhinitis, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina, migraine and Reynaud's disease, fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, peripheral neuropathy, neuralgia, neuropathological disorders such as Alzheimer's disease, AIDS related dementia, diabetic neuropathy and multiple sclerosis, disorders related to immune enhancement or suppression such as systemic lupus erythematosus, and rheumatic
- the compounds of the present invention are also of value in a method of treating or preventing a disorder in mammal, including a human, the treatment or prevention of which is effected or facilitated by a decrease in substance P mediated neurotransmission which comprises administering to said mammal an amount of a compound of the formula I, or a pharmaceutically acceptable salt thereof, effective in antagonizing the effect of substance P at its receptor site.
- the compounds of the present invention are also of value in a method of treating or preventing a disorder in mammal, including a human, the treatment or prevention of which is effected or facilitated by a decrease in substance P mediated neurotransmission which comprises administering to said mammal an amount of a compound of the formula I, or a pharmaceutically acceptable salt thereof, effective in treating or preventing such disorder.
- the invention includes compounds of the formula: wherein R2 to R8 and Z are as previously defined; compounds of the formula: wherein R2 to R7 are as previously defined; compounds of the formula: wherein R1 to R5 and R7 are as previously defined; and the 2S, 3S enantiomers of compounds of the formula I of the formula: wherein R2 to R5 and R7 are as previously defined.
- the compounds of the formula I have chiral centers and therefore exist in different enantiomeric forms.
- This invention relates to all optical isomers and all stereoisomers of compounds of the formula I, and mixtures thereof.
- Formulae I and VII above include compounds identical to those depicted but for the fact that one or more hydrogen or carbon atoms are replaced by radioactive isotopes thereof.
- Such radiolabelled compounds are useful as research and diagnostic tools in metabolism pharmokinetic studies and in binding assays. Specific applications in research include radioligand binding assays, autoradiography studies and in vivo binding studies, while specific applications in the diagnostic area include studies of the substance P receptor in the human brain in in vivo binding in the relevant tissues for inflammation, e.g. immune-type cells or cells that are directly involved in inflammatory bowel disorders and the like. Included among the radiolabelled forms of compounds of the formulae I and VII are the tritium and C14 isotopes thereof.
- the compounds of the formula I may be prepared as described in the following reaction schemes and discussion. Each of the formulae designated IA, IB, IC, and ID represents a different group of compounds having the general formula I. Unless otherwise indicated, R1, R2, R3, R4, R5, R6, R7, R8, Y,Z,n and m in the reaction schemes and discussion that follow are defined as above.
- Scheme 1 illustrates the preparation of compounds of the formulae IA, IB and IC.
- Formula IA represents compounds of the formula I wherein each of R1 and R6 is hydrogen, m is 0 and n is 3, with the proviso that R2 is not benzhydryl and neither R4 nor R7 is attached to the "6" position of the piperidine ring.
- Formula IB represents compounds of the formula I wherein R1 is hydrogen and n is 3, with the proviso that R2 is not benzhydryl and neither R4 nor R7 is attached to the "6" position of the piperidine ring.
- Formula IC represents compounds of the formula I wherein R6 is hydrogen, m is 0 and n is 3, with the proviso that R2 is not benzhydryl and neither R4 nor R7 is attached to the "6" position of the piperidine ring.
- a compound of the formula II is reacted with a compound of the formula in the presence of ammonium acetate, in a polar solvent such as ethanol, acetic acid or dimethyl sulfoxide.
- a polar solvent such as ethanol, acetic acid or dimethyl sulfoxide.
- Ethanol is the preferred solvent.
- Temperatures from about room temperature to about 150°C are suitable, with the reflux temperature of the solvent being preferred.
- This reaction yields, by intramolecular condensation, a compound of the formula III (Von M. Muhlstadt and B. Schulze, J. Prak. Chem , 317, 919 (1975)).
- the condensation product of formula III is then converted, via a Nef reaction, to an oxime of the formula IV.
- This reaction may be carried out using reagents such as aqueous Ti(III) chloride, potassium permanganate, pyridine/hexamethylphosphoramide complex of molybdenum pentoxide, tributylphosphinediphenyl disulphide or ozone in the presence of a base. Suitable temperatures range from about -100°C to about 0°C.
- the reaction is performed by bubbling ozone through the reaction mixture in the presence of potassium t-butoxide at about -78°C, and then quenching the reaction mixture with hydroxylamine hydrochloride at ambient temperature.
- the oxime of formula IV is then reduced to yield both the cis and trans isomers of a compound of the formula V.
- Suitable reducing agents include Raney nickel/hydrogen, 10% palladium on charcoal/hydrogen, and aluminum amalgam.
- the reduction is carried out using Raney nickel in ethanol under a hydrogen gas pressure of about 3 atm and at a temperature of about 25°C. Temperatures from about 10°C to about 60°C and pressures from about 1 to about 10 atmospheres are also suitable.
- Reductive amination of the mixture of cis and trans isomers of the compound of the formula V from the above step with sodium cyanoborohydride or sodium triacetoxyborohydride and a compound of the formula R3CHO yields a mixture of the cis and trans isomers of a compound of the formula VI.
- This reaction is typically carried out in a polar solvent such as acetic acid or a lower alkanol, at a temperature from about 0°C to about 50°C. Methanol is the preferred solvent and about 25°C is the preferred temperature. It is also preferable that the pH of the reaction mixture be about 4 to about 5.
- the cis and trans isomers of the compound of the formula VI so formed can be easily separated by using silica-gel flash chromatography, eluting with 3% methanol in methylene chloride.
- Suitable reducing agents include borane dimethylsulfide in tetrahydrofuran ("THF"), lithium aluminum hydride, borane in THF and sodium borohydride-titanium (IV) chloride. Best results are obtained by using borane dimethylsulfide in THF.
- THF tetrahydrofuran
- IV sodium borohydride-titanium
- the compound of formula IA so formed may be converted to a compound of the formula IB having the same stereochemistry, as illustrated in scheme 1, by reacting it with a compound of the formula R6-( Z ) -X, wherein X is halo, Z is (CH2) m and wherein one of the carbon-carbon single bond of said (CH2) m may optionally be replaced by a carbon-carbon double bond, and wherein on, of the carbons of said (CH2) m may optionally be substituted with R8.
- This reaction is typically carried out in the presence of a base such as triethylamine or potassium t-butoxide, in a polar solvent such as methylene chloride or dichloroethane, and at a temperature from about room temperature to about 150°C.
- a base such as triethylamine or potassium t-butoxide
- a polar solvent such as methylene chloride or dichloroethane
- the reaction is carried out at the reflux temperature in methylene chloride in the presence of triethylamine.
- a compound of the formula VI is reacted with a compound of the formula R1X, wherein X is halo, to yield a compound of the formula VII having the same stereochemistry (e.g. cis, trans or a mixture thereof).
- This reaction is typically carried out in the presence of a base such as triethylamine or potassium t-butoxide in a polar solvent such as methylene chloride or dichloroethane, at a temperature from about room temperature to about 150°C.
- a base such as triethylamine or potassium t-butoxide
- a polar solvent such as methylene chloride or dichloroethane
- Reduction of the compound of formula VII so formed yields a compound of the formula IC having the same stereochemistry.
- suitable reducing agents are lithium aluminum-hydride, borane dimethylsulfide in THF, borane in THF and sodium borohydride-titanium (IV) chloride. Best results are obtained using borane dimethylsulfide in THF.
- the reaction may be carried out at temperatures from about room temperature to about 150°C, and is preferably carried out at the reflux temperature of the solvent.
- Scheme 2 illustrates an alternate method of preparing compounds of the formula IB.
- the starting material for this method is a compound of the formula VI, which is illustrated in scheme 1.
- the basic nitrogen of the starting material is protected with a group such as t-butoxycarbonyl (Boc), trifluoroacetyl, carbobenzyloxy or carboethoxy, by reacting it, respectively, with di-t-butyl dicarbonate, trifluoroacetic anhydride, benzyl chloroformate or ethylchloroformate.
- t-butoxycarbonyl is illustrated in scheme 2.
- the reaction of the starting material with di-t-butyl dicarbonate is typically carried out in a polar solvent such as THF, dichloromethane or chloroform, at a temperature from about 0°C to about 100°C.
- a polar solvent such as THF, dichloromethane or chloroform
- the preferred solvent is dichloromethane and the preferred temperature is room temperature.
- the reaction is generally carried out for about 0.5 to 72 hours. This reaction yields a compound of the formula VIII having the same stereo- chemistry as the starting material.
- the compound of formula VIII so formed is then reacted with a compound of the formula X-( z ) -R6 wherein X is halo, or CH3SO2O-( Z ) -R6, to form a compound of the formula IX having the same stereochemistry.
- Z is (CH2) m and any one of the carbons of said (CH2) m may optionally be substituted with R8 and one of the carbon-carbon single bonds of said (CH2) m may optionally be replaced with a carbon-carbon double bond or a carbon-carbon triple bond.
- This reaction is generally carried out in the presence of a base such as potassium hydroxide, potassium t-butoxide, lithium diisopropylamine or sodium methoxide, in a polar solvent such as t-butanol or DMF, for about 0.5 to about 24 hours.
- a base such as potassium hydroxide, potassium t-butoxide, lithium diisopropylamine or sodium methoxide
- a polar solvent such as t-butanol or DMF
- Reaction temperatures will generally range from about -25°C to about 150°C.
- the preferred temperature is generally the reflux temperature of the solvent.
- the protecting group is then removed from the compound of formula IX by reacting it with an acid such as hydrochloric acid, trifluoroacetic acid or perchloric acid, to yield a compound of the formula X having the same stereochemistry.
- an acid such as hydrochloric acid, trifluoroacetic acid or perchloric acid
- Appropriate solvents for this reaction include polar solvents such as methylene chloride, dioxane, ether or THF, preferably dioxane.
- the reaction is typically run at a temperature from about -10°C to about 50°C, preferably about 25°C, for about 0.5 to about 24 hours.
- Scheme 3 illustrates a method of preparing compounds of the formula ID.
- Formula ID represents compounds of the formula I wherein each of R1 and R6 are hydrogen, m is 0 and n is 2, 3 or 4. This group of compounds includes those of the formula IA.
- the method of scheme 3 can be used to prepare the pure 2S,3S enantiomer, the pure 2R,3R enantiomer, or a racemic mixture of a compound of the formula ID, depending on whether the starting material is, respectively, the R-enantiomer, the S-enantiomer, or a racemic mixture of the starting material of formula XI.
- formula ID includes compounds of the formula IA
- the method of scheme 3 can be used to prepare compounds of the formula IA wherein R4 is attached to the "6" position of the nitrogen containing ring.
- the method of scheme 3 can also be used to prepare compounds of the formula ID wherein R2 is benzhydryl.
- compounds of the formula ID may be prepared as follows.
- the pure R-enantiomer, S-enantiomer or a racemic mixture of a compound of the formula XI is reacted with a nitrogen-protecting reagent such as t-butyldimethylsilyl chloride (TBDMS-Cl), t-butyldimethylsilyl triflate (TBDMS-OTf) or benzyl bromide/t-butoxide, preferably TBDMS-Cl, to form a compound of the formula XII.
- This reaction is typically carried out in a polar solvent such as DMF or triethyl- amine, preferably triethylamine, at a temperature of from about 0 to about 140°C. Room temperature is preferred.
- the above reaction is followed by a stereospecific alkylation of the compound of formula XII to form the trans stereoisomer of a compound of the formula XIII.
- the compound of formula XII is reacted with lithium diethylamide in a polar solvent such as ether or THF, preferably THF, at a temperature from about -100°C to about room temperature, preferably about -78°C.
- a compound of the formula is added to the reaction mixture to produce the trans isomer of a compound of the formula XIII.
- the cyclization of the compound of formula XIV to produce a compound of the formula XV is accomplished by heating the crude product of formula XIV from the foregoing reaction at a temperature from about 80°C to about 140°C, preferably at about 100°C, for about 5 minutes to about 2 days, preferably for about 15 minutes, in a high boiling solvent such as DMF or toluene, preferably in DMF. Generally, this reaction is conducted in the presence of sodium iodide and sodium bicarbonate. In the compound of formula XV produced by this reaction, R2 and -COOCH3 are cis to each other.
- the compound of formula XV is then treated with benzylchloroformate in a polar solvent such as water, water/acetone, chloroform, dichloroethane or ethyl acetate, in the presence of a base such as triethylamine or sodium bicarbonate, to yield the N-carbobenzyloxy piperidine (N-Cbz piperidine) of formula XVI having the same stereochemistry (i.e., wherein R2 and -COOCH3 are in the cis configuration).
- This reaction may be carried out at temperatures from about 0°C to about 100°C, preferably about 25°C, for about 5 minutes to 18 hours.
- reaction temperatures may range from about room temperature to about 100°C, with about 50°C being preferred.
- the conversion of the carboxamide group of the compound of formula XVII to form a compound of the formula XVIII having the same stereochemistry may be accomplished by a Hoffmann degradation using reagents such as bromine/sodium methoxide in methanol, lead tetraacetate in t-butyl alcohol, tin (IV) chloride, iodobenzene bis(trifluoroacetate) in aqueous acetonitrile, sodium bromide or benzyltrimethyl ammonium tribromide.
- the compound of formula XVII is treated with lead tetraacetate in t-butanol.
- This reaction is typically carried out at a temperature from about room temperature to the reflux temperature of the solvent, preferably at the reflux temperature, for about 15 minutes to about 10 hours, preferably for about 3 to about 5 hours.
- Reaction of the compound of formula XVIII with an acid such as hydrochloric acid, trifluroacetic acid or perchloric acid yields a compound of the formula XIX having the same stereochemistry.
- the solvent is typically a polar solvent such as methylene chloride, dioxane, ether or THF, preferably dioxane.
- This reaction is typically carried out at a temperature from about -10 to about 50°C, preferably at about 25°C, for about 0.5 to 24 hours.
- Reductive amination of the compound of the formula XIX from the above step with sodium cyanoborohydride or sodium triacetoxyborohydride and a compound of the formula R3CHO yields a compound of the formula XX having the same stereochemistry.
- This reaction is generally carried out in a polar solvent such as acetic acid or a lower alkanol, at a temperature from about 0 to about 50°C. Methanol is the preferred solvent and about 25°C is the preferred temperature. It is also preferred that the pH of the reaction mixture be about 4 to about 5.
- the compound of formula XX is converted into a compound of the formula ID wherein R2 and the amino group are cis to each other by reacting it with ammonium formate in the presence of palladium on charcoal (e.g. 10% palladium on charcoal).
- palladium on charcoal e.g. 10% palladium on charcoal
- a polar solvent such as ethyl acetate or a lower alkanol is used, and the reaction is run at a temperature from about room temperature to about 150°C for about 0.5 to about 24 hours.
- the reaction is conducted in ethanol at room temperature for about 3 to about 24 hours.
- the trans isomer of a compound of the formula ID may be prepared by the same procedure described above for obtaining the cis isomer, with the following modification.
- To prepare the trans isomer either the compound of formula XV or the compound of formula XVI, after its formation as described above, is treated with potassium t-butoxide or a lithium dialkylamide.
- the solvent for this reaction is generally a polar solvent such as THF or ether, and the reaction is generally conducted at a temperature from about -78°C to room temperature, preferably at about 0°C, for about 5 minutes to about 10 hours.
- Scheme 4 illustrates a preferred method of preparing compounds of the formula ID wherein n is 2.
- a compound of the formula XXI is treated with hydrogen gas in the presence of a metal catalyst such a palladium on charcoal, platinum on charcoal or platinum dioxide, preferably palladium on charcoal, and in the presence of an acid such as trifluroacetic acid or hydrochloric acid, to produce a compound of the formula XXII.
- a polar inert solvent is generally used.
- the preferred solvent is ethanol.
- This reaction is typically carried out at a pressure of about 1.5 atm to about 5 atm, preferably at about 3.0 atm, at a temperature from about 0°C-60°C, preferably at about 25°C.
- the compound of formula XXII so formed is then converted to a compound of the formula ID by the procedure illustrated in scheme 3 and described above.
- Enantiomerically pure compounds of the formula IC may be prepared as follows.
- a compound of the formula XX, prepared as described above, is alkylated by reacting it with a compound of the formula R1X, wherein X is halo.
- This reaction is usually conducted in the presence of a base such as triethylamine or potassium t-butoxide, in a polar solvent such as methylene chloride or dichloroethane, and at a temperature from about room temperature to about 200°C.
- a base such as triethylamine or potassium t-butoxide
- a polar solvent such as methylene chloride or dichloroethane
- the alkylated product which has the same stereochemistry as the starting material of formula XX, is then converted to a compound of the formula IC having the same stereochemistry, by reacting it with ammonium formate in the presence of palladium on charcoal (e.g. 10% palladium on charcoal).
- palladium on charcoal e.g. 10% palladium on charcoal
- a polar solvent such as ethyl acetate or a lower alkanol is used, and the reaction is run at a temperature from about room temperature to about 80°C for about 3 to about 24 hours.
- the reaction is preferably conducted in ethanol at room temperature for about 0.5 to about 24 hours.
- Enantiomerically pure compounds of the formula IB may be prepared by reacting the analogous compound of the formula ID, having the same stereochemistry, with a compound of the formula R6-( Z ) -X, wherein X is halo or mesylate.
- R6-( Z ) -R6 and CH3SO2O- ( Z ) -R6 Z is (CH2) m and one of the carbons of said (CH2) m may optionally be substituted with R8 and one of the carbon-carbon single bonds of said (CH2) m may optionally be replaced with a carbon-carbon double bond.
- Z is (CH2) m and one of the carbons of said (CH2) m may optionally be substituted with R8 and one of the carbon-carbon single bonds of said (CH2) m may optionally be replaced with a carbon-carbon double bond.
- the reaction is performed in the same manner as described above for converting compounds of the formula IA into compounds of the formula IB.
- the hydrogenolysis reaction is usually carried out using a catalyst such as palladium on carbon or palladium hydroxide, in an inert solvent such as acetic acid or an alcoholic solvent, at a temperature from about 0°C to about 50°C. It is preferably carrier out at about room temperature in a methanol/ethanol solvent. It is also preferable to conduct this reaction in the presence of a mineral acid such as hydrochloric or sulfuric acid.
- a catalyst such as palladium on carbon or palladium hydroxide
- an inert solvent such as acetic acid or an alcoholic solvent
- An alternative method of preparing racemic 3-amino-2-phenylpiperidine is by reducing 3-amino-2-phenylpyridine.
- This reduction is generally accomplished using either sodium in alcohol, lithium aluminum hydride/aluminum trichloride, electrolytic reduction or hydrogen in the presence of a metal catalyst.
- the reduction with sodium is generally conducted in a boiling alcohol, preferably butanol, at a temperature from about 20°C to about the reflux temperature of the solvent, preferably at about 120°C.
- the reduction with lithium aluminum hydride/aluminum trichloride is usually carried out in ether, THF or dimethoxyethane, preferably ether, at a temperature from about 25°C to about 100°C, preferably at about room temperature.
- the electrolytic reduction is conducted, preferably, at room temperature, but temperatures from about 10°C to about 60°C are also suitable.
- Hydrogenation in the presence of a metal catalyst is the preferred method of reduction.
- Suitable hydrogenation catalysts include palladium, platinum, nickel and rhodium.
- the preferred catalyst for hydrogenation is platinum oxide.
- the reaction temperature may range from about 10°C to about 50°C, with about 25°C being preferred.
- the hydrogenation is generally carried out at a pressure from about 1.5 to about 4 atmospheres, preferably at about 3.0 atmospheres.
- the reaction of 3-amino-2-phenylpyridine with a compound of the formula R3CHO to produce the pyridine analog of the piperidine of formula IA is typically carried out in the presence of a reducing agent such as sodium cyanoborohydride, sodium triacetoxyborohydride, sodium borohydride, hydrogen and a metal catalyst, zinc and hydrochloric acid, or formic acid at a temperature from about -60°C to about 50°C.
- Suitable reaction inert solvents for this reaction include lower alcohols (e.g., methanol, ethanol and isopropanol), acetic acid and THF.
- the solvent is methanol
- the temperature is about 25°C
- the reducing agent is sodium cyanoborohydride.
- the reaction of 3-amino-2-phenylpyridine with a compound of the formula R3CHO may be carried out in the presence of a drying agent or using an apparatus designed to remove azeotropically the water generated, to produce an imine of the formula which is then reacted with a reducing agent as described above, preferably with sodium triacetoxyborohydride at about room temperature.
- the preparation of the imine is generally carried out in a reaction inert solvent such as benzene, xylene or toluene, preferably toluene, at a temperature from about 25°C to about 110°C, preferably at about the reflux temperature of the solvent.
- Suitable drying agents/solvent systems include titanium tetrachloride/dichloromethane and molecular sieves/THF. Titanium tetrachloride/dichloromethane is preferred.
- reaction of 3-amino-2-phenylpyridine with a compound of the formula R3CH2X is typically carried out in a reaction inert solvent such as dichloromethane or THF, preferably dichloromethane, at a temperature from about 0°C to about 60°C, preferably at about 25°C.
- a reaction inert solvent such as dichloromethane or THF, preferably dichloromethane
- the pyridine so formed is then reduced to form the desired piperidine of formula IA by the procedure described above for reducing 3-amino-2-phenylpyridine.
- pressure is not critical unless otherwise indicated. Pressures from about 0.5 atmospheres to about 5 atmospheres are generally acceptable, and ambient pressure, i.e. about 1 atmosphere, is preferred as a matter of convenience.
- novel compounds of the formula I and the pharmaceutically acceptable salts thereof are useful as substance P antagonists, i.e., they possess the ability to antagonize the effects of substance P at its receptor site in mammals, and therefore they are able to function as therapeutic agents in the treatment of the aforementioned disorders and diseases in an afflicted mammal.
- the compounds of the formula I which are basic in nature are capable of forming a wide variety of different salts with various inorganic and organic acids. Although such salts must be pharmaceutically acceptable for administration to animals, it is often desirable in practice to initially isolate a compound of the Formula I from the reaction mixture as a pharmaceutically unacceptable salt and then simply convert the latter back to the free base compound by treatment with an alkaline reagent and subsequently convert the latter free base to a pharmaceutically acceptable acid addition salt.
- the acid addition salts of the base compounds of this invention are readily prepared by treating the base compound with a substantially equivalent amount of the chosen mineral or organic acid in an aqueous solvent medium or in a suitable organic solvent, such as methanol or ethanol. Upon careful evaporation of the solvent, the desired solid salt is readily obtained.
- the compounds of Formula I and their pharmaceutically acceptable salts exhibit substance P receptor-binding activity and therefore are of value in the treatment and prevention of a wide variety of clinical conditions the treatment or prevention of which are effected or facilitated by a decrease in substance P mediated neurotransmission.
- Such conditions include inflammatory diseases (e.g., arthritis, psoriasis, asthma and inflammatory bowel disease), anxiety, depression or dysthymic disorders, colitis, psychosis, pain, allergies such as eczema and rhinitis, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina, migraine and Reynaud's disease, fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, peripheral neuropathy, neuralgia, neuropathological disorders such as Alzheimer's disease, AIDS related dementia, diabetic neuropathy and multiple sclerosis, disorders related to immune enhancement or suppression such as systemic lupus erythematosus, and rheumatic diseases such as fibrositis.
- these compounds are readily adapted to therapeutic use as substance P antagonists for
- the compounds of the formula I and the pharmaceutically acceptable salts thereof can be administered via either the oral, parenteral or topical routes.
- these compounds are most desirably administered in dosages ranging from about 5.0 mg up to about 1500 mg per day, although variations will necessarily occur depending upon the weight and condition of the subject being treated and the particular route of administration chosen.
- a dosage level that is in the range of about 0.07 mg to about 21 mg per kg of body weight per day is most desirably employed. Variations may nevertheless occur depending upon the species of animal being treated and its individual response to said medicament, as well as on the type of pharmaceutical formulation chosen and the time period and interval at which such administration is carried out.
- dosage levels below the lower limit of the aforesaid range may be more than adequate, while in other cases still larger doses may be employed without causing any harmful side effect, provided that such larger doses are first divided into several small doses for administration throughout the day.
- the compounds of the invention may be administered alone or in combination with pharmaceutically acceptable carriers or diluents by either of the three routes previously indicated, and such administration may be carried out in single or multiple doses.
- the novel therapeutic agents of this invention can be administered in a wide variety of different dosage forms, i.e., they may be combined with various pharmaceutically acceptable inert carriers in the form of tablets, capsules, lozenges, troches, hard candies, powders, sprays, creams, salves, suppositories, jellies, gels, pastes, lotions, ointments, aqueous suspensions, injectable solutions, elixirs, syrups, and the like.
- Such carriers include solid diluents or fillers, sterile aqueous media and various non-toxic organic solvents, etc.
- oral pharmaceutical compositions can be suitably sweetened and/or flavored.
- the therapeutically-effective compounds of this invention are present in such dosage forms at concentration levels ranging from about 5.0% to about 70% by weight.
- tablets containing various excipients such as microcrystalline cellulose, sodium citrate, calcium carbonate, dicalcium phosphate and glycine may be employed along with various disintegrants such as starch (and preferably corn, potato or tapioca starch), alginic acid and certain complex silicates, together with granulation binders like polyvinylpyrrolidone, sucrose, gelatin and acacia.
- disintegrants such as starch (and preferably corn, potato or tapioca starch), alginic acid and certain complex silicates, together with granulation binders like polyvinylpyrrolidone, sucrose, gelatin and acacia.
- lubricating agents such as magnesium stearate, sodium lauryl sulfate and talc are often very useful for tabletting purposes.
- compositions of a similar type may also be employed as fillers in gelatin capsules, preferred materials in this connection also include lactose or milk sugar as well as high molecular weight polyethylene glycols.
- lactose or milk sugar as well as high molecular weight polyethylene glycols.
- the active ingredient may be combined with various sweetening or flavoring agents, coloring matter or dyes, and, if so desired, emulsifying and/or suspending agents as well, together with such diluents as water, ethanol, propylene glycol, glycerin and various like combinations thereof.
- solutions of a therapeutic compound of the present invention in either sesame or peanut oil or in aqueous propylene glycol may be employed.
- the aqueous solutions should be suitably buffered (preferably pH greater than 8) if necessary and the liquid diluent first rendered isotonic.
- These aqueous solutions are suitable for intravenous injection purposes.
- the oily solutions are suitable for intraarticular, intramuscular and subcutaneous injection purposes. The preparation of all these solutions under sterile conditions is readily accomplished by standard pharmaceutical techniques well known to those skilled in the art.
- the activity of the compounds of the present invention as substance P antagonists is determined by their ability to inhibit the binding of substance P at its receptor sites in bovine caudate tissue, employing radioactive ligands to visualize the tachykinin receptors by means of autoradiography.
- the substance P antagonizing activity of the herein described compounds may be evaluated by using the standard assay procedure described by M. A. Cascieri et al., as reported in the Journal of Biological Chemistry , Vol. 258, p. 5158 (1983). This method essentially involves determining the concentration of the individual compound required to reduce by 50% the amount of radiolabelled substance P ligands at their receptor sites in said isolated cow tissues, thereby affording characteristic IC50 values for each compound tested.
- bovine caudate tissue is removed from a -70°C freezer and homogenized in 50 volumes (w./v.) of an ice-cold 50 mM Tris (i.e., trimethamine which is 2-amino-2-hydroxymethyl-1,3-propanediol) hydrochloride buffer having a pH of 7.7.
- Tris i.e., trimethamine which is 2-amino-2-hydroxymethyl-1,3-propanediol
- the homogenate is centrifuged at 30,000 x G for a period of 20 minutes.
- the pellet is resuspended in 50 volumes of Tris buffer, rehomogenized and then recentrifuged at 30,000 x G for another twenty- minute period.
- the pellet is then resuspended in 40 volumes of ice-cold 50 mM Tris buffer (pH 7.7) containing 2 mM of calcium chloride, 2 mM of magnesium chloride, 40 g/ml of bacitracin, 4 ⁇ g/ml of leupeptin, 2 ⁇ g of chymostatin and 200 g/ml of bovine serum albumin. This step completes the production of the tissue preparation.
- the radioligand binding procedure is then carried out in the following manner, viz., by initiating the reaction via the addition of 100 ⁇ l of the test compound made up to a concentration of 1 ⁇ M, followed by the addition of 100 ⁇ l of radioactive ligand made up to a final concentration 0.5 mM and then finally by the addition of 800 ⁇ l of the tissue preparation produced as described above.
- the final volume is thus 1.0 ml, and the reaction mixture is next vortexed and incubated at room temperature ( ca . 20°C) for a period of 20 minutes.
- the tubes are then filtered using a cell harvester, and the glass fiber filters (Whatman GF/B) are washed four times with 50 mM of Tris buffer (pH 7.7), with the filters having previously been presoaked for a period of two hours prior to the filtering procedure. Radioactivity is then determined in a Beta counter at 53% counting efficiency, and the IC50 values are calculated by using standard statistical methods.
- the glass fiber filters (Whatman GF/B) are washed four times with 50 mM of Tris buffer (pH 7.7), with the filters having previously been presoaked for a period of two hours prior to the filtering procedure. Radioactivity is then determined in a Beta counter at 53% counting efficiency, and the IC50 values are calculated by using standard statistical methods.
- the anti-psychotic activity of the compounds of the present invention as neuroleptic agents for the control of various psychotic disorders is determined primarily by a study of their ability to suppress substance P-induced or substance P agonist induced hypermotility in guinea pigs. This study is carried out by first dosing the guinea pigs with a control compound or with an appropriate test compound of the present invention, then injecting the guinea pigs with substance P or a substance P agonist by intracerebral administration via canula and thereafter measuring their individual locomotor response to said stimulus.
- reaction mixture was filtered through diatomaceous earth (Celite (trademark)) and the filtrate was concentrated using a rotary evaporator. The residue was suspended in water and the pH made basic. The aqueous phase was extracted with methylene chloride (4 x 200 ml) washed with water, brine, and then dried (anhyd. magnesium sulfate) and concentrated to give an oil (47.0 gms) which was flash chromatographed. Elution with 3% methanol in methylene chloride afforded a white solid (19.6 gms, m.p. 122°C).
- the mixture was partitioned between methylene chloride and aqueous sodium bicarbonate, the layers were separated and the aqueous phase was extracted with three portions of methylene chloride.
- the combined organic fractions were dried (sodium sulfate) and concentrated with a rotary evaporator.
- the crude material was purified by flash column chromatography using 3:97 methanol/chloroform as the eluant to obtain 42 mg of cis-N-ethyl-5-(2-methoxybenzylamino)- 2-oxo-6-phenylpiperidine.
- the crude material was purified by flash column chromatography (7 g of silica gel) using 3:97 methanol/chlorform as the eluant to obtain 44 mg of cis-3-(N,N-methyl-(2-methoxybenzylamino) -2-phenylpiperidin-6-one.
- the hydrochloride salt of this material was prepared by treating a methylene chloride solution of the product with ether saturated with hydrogen chloride, concentrating, triturating with ether, scratching and repeating the concentration from ether. M.p. 176-178°C (HCl salt, dec).
- Examples 56-60 have the following general formula and were prepared by a procedure similar to that described in Example 1.
- Example 61-62 have the following general formula and were prepared by a procedure similar to that described in Example 1.
- Cis-methyl-2-phenylpiperidine-3-carboxylate (1.54 gm, 7.0 mmole), triethylamine (1.5 ml, 11.0 mmole) and benzyl chloroformate (1.5 ml, 11.0 mmole) were mixed in methylene chloride (45 ml) at 25C and stirred for 15 hours. At the end of this period, the reaction mixture was taken up in ether (100 ml), washed with water (2 x 50 ml) and dried (anhyd. magnesium sulfate). The solvent was removed under reduced pressure to afford a residue which was chromatographed on a flash SiO2-gel column. Elution with 1:1 ethyl acetate/hexane afforded cis-methyl 2-phenylpiperidine-1-(benzyloxycarbonyl)-3-carboyxlate as an oil (1.91 gm, 77%).
- Cis-2-phenylpiperidine-1-(benzyloxycarbonyl)-3-carboxami-de (1.4 gm, 4.1 mmole) was dissoved in dry tert.-butanol (40 ml) at 50°C, and lead tetraacetate (1.9 gm, 4.3 mmole) was added. The resulting brown reaction mixture was refluxed for 0.5 hours. Additional lead tetraacetate (1.9 gm, 4.3 mmole) was added over a period of 1 hour. At the end of this period, the reaction mixture was poured into cold 1N hydrochloric acid and filtered through diatomaceous earth (Celite (trademark)).
- aqueous phase was extracted with ethyl acetate (3 x 100 ml) and the combined organic layers were washed successively with water, 5% aqueous sodium hydroxide, water, and brine and dried (anhyd. magnesium sulfate). Evaporation of the solvent under reduced pressure afforded a residue which was chromatographed on a SiO2-gel column. Elution with 25% ethyl acetate in hexane afforded chromato- graphically homogeneous cis-1-(benzoyloxycarbonyl)-3-(N-tert-butoxycarbonyl)-2-phenylpiperidine (1.1 gm) as oil.
- Cis-1-(benzyloxycarbonyl)-3-amino-2-phenylpiperidine (0.78 gm, 2.5 mmole) was dissolved in methanol (25 ml) and the pH of the medium was adjusted to 5 with the help of methanolic hydrochloric acid.
- crushed molecular sieves 1.0 gm
- sodium cyanoborohydride 0.163 gm, 2.5 mmole
- o-methoxybenzaldehyde 0.411 gm, 3.0 mmole
- reaction mixture was filtered through diatomaceous earth (Celite (trademark)) and the filtrate was taken up in aqueous ammonium hydroxide.
- the aqueous phase was extracted with methylene chloride (3 x 60 ml) and dried (anhyd. magnesium sulfate). The solvents were removed under reduced pressure to afford an oily residue (1.18 gm). This was dissolved in ethanol (27 ml) and 10% palladium on carbon (1.2 gm) and ammonium formate (0.864 gm, 14 mmole) were added. The resulting reaction mixture was stirred at 25C for 16 hrs.
- reaction mixture was filtered through diatomaceous earth (Celite (trademark)), which was washed with ethanol (50 ml) and methylene chloride (100 ml). The solvents were removed under vacuum to afford a solid which was taken up in aqueous ammonium hydroxide and extracted with methylene chloride (3 x 60 ml). The organic extracts were combined and dried (anhyd. magnesium sulfate). Evaporation of the solvents under pressure afforded a yellow oil from which cis-3-(2-methoxybenzylamino)- 2-phenylpiperidine (728 mg, 83%) was isolated as white solid by treatment with ether-HCl. This was crystallized from ethanol/methanol to afford the hydrochloride salt of the title compound (0.58 mg, m.p. 250C).
- HRMS Calc'd for C24H26N2: 342.2096. Found: 342.2057.
- Examples 71-75 have the following general formula and were prepared by a procedure similar to that described in Example 1.
- Examples 77-81 have the following general formula and were prepared similar to that described in Example 1.
- Example 85-89 The title compounds of Example 85-89 were prepared by a procedure similar to that described in Example 1.
- the hydrochloric acid extracts were basified with 1M aqueous sodium hydroxide and extracted with methylene chloride.
- the methylene chloride extracts were dried (sodium sulfate) and concentated to obtain 528 mg of colorless oil.
- the oil was dissolved in methylene chloride, and ether saturated with hydrogen chloride was added to the solution.
- the resulting white solid was collected by filtration and stirred in isopropanol at 60°C for 2 hours. Filtration afforded 414 mg of the title compound as its hydrochloride.
- the title compound was prepared by a procedure analogous to that of Example 2, replacing allyl bromide with 4-bromobutyronitrile.
- Example 93 The title compound of Example 93 (1.9 g) was dissolved in 10 ml of acetic acid in a bottle. To the system was added 1.9 g of 5% platinum/carbon (60% water), and the mixture was shaken under hydrogen (40 p.s.i.) for 4 hours. The mixture was diluted with ethanol, filtered through diatomaceous earth (Celite (trademark)) and the filtrate was concentrated. Saturated aqueous sodium bicarbonate was added to the residue until the pH of the mixture was ca . 8, and the mixture was extracted with chloroform. The chloroform extracts were dried (sodium sulfate) and concentrated to obtain 1.6 g of the title compound as an oil.
- Example 95 The title compound of Example 95 is treated with borane dimethylsulfide, employing conditions analogous to those described in Example 1B, to obtain the title compound.
- the title compound was prepared by a procedure analogous to that described in Example 2, replacing allyl bromide with ethyl 6-bromohexanoate.
- the title compound was prepared by a procedure analogous to that described in Example 2, replacing allyl bromide with 4-iodobutyl-4-fluorophenylketone.
- the mixture was extracted with chloroform, dried (sodium sulfate) and concentrated to obtain 500 mg of an oil.
- the crude product was purified by flash column chromatography (20 g of silica gel) using 1:19 methanol/chloroform as the eluant to obtain 295 mg of the title compound, which was converted to its methanesulfonic acid salt.
- the title compound was prepared by a procedure analogous to that described in Example 2, replacing allyl bromide with 5,6-dimethylenedioxy-1-methylsulfonyloxyhexane.
- the title compound was prepared by a procedure similar to that described in Example 101.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 95.
- the title compound was prepared by a procedure similar to that described in Example 95.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 101.
- the title compound was prepared by a procedure similar to that described in Example 102.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 104.
- the title compound was prepared by a procedure similar to that described in Example 104.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 91.
- the title compound was prepared by a procedure similar to that described in Example 63.
- the title compound was prepared by a procedure similar to that described in Example 95.
- the title compound was prepared by a procedure similar to that described in Example 93.
- the title compound was prepared by a procedure similar to that described in Example 101.
- the title compound was prepared by a procedure similar to that described in Example 95.
- the title compound was prepared by a procedure similar to that described in Example 95.
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PCT/US1990/000116 WO1991009844A1 (en) | 1990-01-04 | 1990-01-04 | Substance p antagonists |
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EP19930201034 Division EP0558156A3 (de) | 1990-01-04 | 1990-12-14 | 3-Aminopiperidinzwischenprodukte |
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CA (1) | CA2033497C (de) |
CZ (1) | CZ289485B6 (de) |
DE (1) | DE69014848T2 (de) |
DK (1) | DK0436334T3 (de) |
ES (1) | ES2064667T3 (de) |
FI (2) | FI114096B (de) |
GR (1) | GR3014940T3 (de) |
HU (5) | HU222724B1 (de) |
IE (1) | IE63770B1 (de) |
IL (3) | IL112348A (de) |
MY (1) | MY105438A (de) |
NO (1) | NO178187C (de) |
NZ (1) | NZ236581A (de) |
PL (5) | PL164244B1 (de) |
PT (1) | PT96405B (de) |
RU (1) | RU2105758C1 (de) |
UA (1) | UA41251C2 (de) |
WO (1) | WO1991009844A1 (de) |
YU (1) | YU48026B (de) |
ZA (1) | ZA9136B (de) |
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