EG23843A - Modified pictet-spengler reaction and products prepared therefrom - Google Patents

Modified pictet-spengler reaction and products prepared therefrom

Info

Publication number
EG23843A
EG23843A EGNA2005000016A EG23843A EG 23843 A EG23843 A EG 23843A EG NA2005000016 A EGNA2005000016 A EG NA2005000016A EG 23843 A EG23843 A EG 23843A
Authority
EG
Egypt
Prior art keywords
prepared therefrom
spengler reaction
products prepared
modified pictet
pictet
Prior art date
Application number
Other languages
English (en)
Inventor
Mark W Orme
Original Assignee
Lilly Icos Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31191375&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG23843(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc
Application granted granted Critical
Publication of EG23843A publication Critical patent/EG23843A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Confectionery (AREA)
  • Indole Compounds (AREA)
  • Dental Preparations (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EGNA2005000016 2002-07-31 2005-01-29 Modified pictet-spengler reaction and products prepared therefrom EG23843A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40038602P 2002-07-31 2002-07-31
US46016103P 2003-04-03 2003-04-03
PCT/US2003/022039 WO2004011463A1 (en) 2002-07-31 2003-07-14 Modified pictet-spengler reaction and products prepared therefrom

Publications (1)

Publication Number Publication Date
EG23843A true EG23843A (en) 2007-10-17

Family

ID=31191375

Family Applications (1)

Application Number Title Priority Date Filing Date
EGNA2005000016 EG23843A (en) 2002-07-31 2005-01-29 Modified pictet-spengler reaction and products prepared therefrom

Country Status (19)

Country Link
US (2) US7550479B2 (ru)
EP (1) EP1546149B1 (ru)
JP (2) JP2005536567A (ru)
KR (1) KR100937915B1 (ru)
CN (1) CN100430395C (ru)
AT (1) ATE415402T1 (ru)
AU (1) AU2003256539B2 (ru)
BR (1) BR0313070B1 (ru)
CA (1) CA2492540C (ru)
DE (1) DE60324949D1 (ru)
EA (1) EA008666B1 (ru)
EG (1) EG23843A (ru)
ES (1) ES2318175T3 (ru)
IL (2) IL166255A (ru)
MX (1) MXPA05001139A (ru)
NO (1) NO331775B1 (ru)
NZ (1) NZ537784A (ru)
PL (1) PL216529B1 (ru)
WO (1) WO2004011463A1 (ru)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005116030A1 (en) * 2004-05-31 2005-12-08 Matrix Laboratories Ltd A process for the preparation of tadalafil
EP2216329A1 (en) * 2004-10-28 2010-08-11 Dr. Reddy's Laboratories Ltd. Processes for the preparation of tadalafi
US20060111571A1 (en) * 2004-11-02 2006-05-25 Shlomit Wizel Tadalafil crystal forms and processes for preparing them
CA2596667A1 (en) * 2005-02-25 2006-08-31 Teva Pharmaceutical Industries Ltd. Process of synthesizing tadalafil
WO2006091974A1 (en) * 2005-02-25 2006-08-31 Teva Pharmaceutical Industries Ltd. Tadalafil having a large particle size and a process for preparation thereof
KR20070099034A (ko) * 2005-02-25 2007-10-08 테바 파마슈티컬 인더스트리즈 리미티드 타달라필의 정제 방법
ES2278552T1 (es) * 2005-04-12 2007-08-16 Teva Pharmaceutical Industries Ltd Preparacion de intermediarios de tadalafil.
WO2007052283A1 (en) * 2005-10-31 2007-05-10 Alembic Limited An improved process for preparing tadalafil and its intermediate
WO2007110734A1 (en) * 2006-03-24 2007-10-04 Glenmark Pharmaceuticals Limited Process for the preparation of tadalafil
KR101035742B1 (ko) * 2006-09-28 2011-05-20 신에쓰 가가꾸 고교 가부시끼가이샤 신규 광산 발생제 및 이것을 이용한 레지스트 재료 및 패턴형성 방법
US20080194529A1 (en) * 2007-02-12 2008-08-14 Auspex Pharmaceuticals, Inc. HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
KR20100027170A (ko) 2007-06-29 2010-03-10 랜박시 래보러터리스 리미티드 테트라사이클릭 화합물의 중간체의 제조 방법
ITMI20080285A1 (it) * 2008-02-22 2009-08-23 Endura Spa Procedimento per la preparazione di esteri di acidi tetraidro-1h-betacarbolin-3-carbossilici
EP2107059A1 (en) 2008-03-31 2009-10-07 LEK Pharmaceuticals D.D. Conversion of tryptophan into ß-carboline derivatives
PL385356A1 (pl) * 2008-06-03 2009-12-07 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób wytwarzania tadalafilu
CN101906103A (zh) * 2010-08-08 2010-12-08 浙江华海药业股份有限公司 四氢-β-咔啉化合物合成方法的改进
US8829023B2 (en) 2011-02-10 2014-09-09 Interquim, S.A. Process for obtaining compounds derived from tetrahydro-β-carboline
CN102367253B (zh) * 2011-09-20 2016-04-06 浙江华海药业股份有限公司 一种制备他达拉非晶型a的方法
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
CN103980275B (zh) * 2014-05-14 2016-09-28 湖北省医药工业研究院有限公司 磷酸二酯酶5抑制剂他达拉非的制备方法
CN104151313B (zh) * 2014-07-13 2019-04-09 浙江华海药业股份有限公司 一种纯化他达拉非中间体的方法
SI3466951T1 (sl) * 2014-07-23 2022-05-31 Krka, D.D., Novo Mesto Proces za pripravo zaviralca CGMP-fosfodiesteraze in oralne farmacevtske formulacije, ki obsega koprecipitate tadalafila
CN105842350B (zh) * 2015-05-14 2018-11-13 湖北生物医药产业技术研究院有限公司 利用高效液相色谱分析他达拉非合成中间体的方法
CN105061428B (zh) * 2015-08-26 2019-12-27 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN106674223A (zh) * 2016-06-29 2017-05-17 浙江华海药业股份有限公司 一种精制他达拉非的方法
CN107663210A (zh) * 2016-07-28 2018-02-06 常州爱诺新睿医药技术有限公司 一种新的制备无水他达拉非晶型i的方法
CN106279155B (zh) * 2016-08-02 2019-03-19 扬子江药业集团四川海蓉药业有限公司 他达拉非的杂质对照品及其制备方法
CN109053724A (zh) * 2018-08-22 2018-12-21 上海青平药业有限公司 一种制备他达拉非过程中的杂质及该杂质的制备方法和他达拉非的纯化方法以及用途
CN110437228B (zh) * 2019-07-22 2022-06-14 山东省药学科学院 一种他达拉非及其中间体的制备方法
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
CN110790764B (zh) * 2019-11-27 2021-04-06 四川省通园制药集团有限公司 一种一锅法制备他达拉非的方法
CN114057738A (zh) * 2021-12-14 2022-02-18 京博农化科技有限公司 一种氯吲哚酰肼的合成方法
CN114805345B (zh) * 2022-04-27 2023-11-10 山东省药学科学院 一种他达拉非中间体顺式四氢咔啉盐酸盐的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514465D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
GB9401090D0 (en) * 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
GB9514473D0 (en) * 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds
ES2271080T3 (es) * 2000-11-06 2007-04-16 Lilly Icos Llc Derivados de indol como inhibidores de pde5.
DE60226970D1 (de) * 2001-06-05 2008-07-17 Lilly Icos Llc Pyrazinoä1',2':1,6ü-pyridoä3,4-bü indole-1,4-dionderivate

Also Published As

Publication number Publication date
IL200692A0 (en) 2010-05-17
NO20051022L (no) 2005-04-22
IL200692A (en) 2011-11-30
ES2318175T3 (es) 2009-05-01
CN100430395C (zh) 2008-11-05
JP4994427B2 (ja) 2012-08-08
WO2004011463A1 (en) 2004-02-05
BR0313070B1 (pt) 2014-09-09
US20090312548A1 (en) 2009-12-17
JP2009235096A (ja) 2009-10-15
PL216529B1 (pl) 2014-04-30
EA200500264A1 (ru) 2005-08-25
JP2005536567A (ja) 2005-12-02
KR100937915B1 (ko) 2010-01-21
CA2492540C (en) 2010-05-04
MXPA05001139A (es) 2005-05-16
AU2003256539B2 (en) 2010-03-04
IL166255A (en) 2010-04-29
IL166255A0 (en) 2006-01-15
EP1546149A1 (en) 2005-06-29
EA008666B1 (ru) 2007-06-29
NZ537784A (en) 2008-01-31
US7550479B2 (en) 2009-06-23
AU2003256539A1 (en) 2004-02-16
ATE415402T1 (de) 2008-12-15
EP1546149B1 (en) 2008-11-26
DE60324949D1 (de) 2009-01-08
NO331775B1 (no) 2012-03-26
BR0313070A (pt) 2005-06-28
KR20050030961A (ko) 2005-03-31
PL375092A1 (en) 2005-11-14
US20060004203A1 (en) 2006-01-05
CN1671706A (zh) 2005-09-21
CA2492540A1 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
EG23843A (en) Modified pictet-spengler reaction and products prepared therefrom
WO2003014336A1 (fr) Procede de preparation de cellules souches hematopoietiques multipotentes
WO2002092756A3 (en) Insulin producing cells derived from human embryonic stem cells
WO2006116949A8 (fr) Nouvelle souche du bacillus subtilis et son utilisation dans la préparation de médicament pour traiter la thrombose
EP2253746A3 (en) Coloured diamond
AU2003268522A1 (en) Apparatus and process for production of high purity hydrogen
MXPA04000449A (es) Procedimiento para preparacion de derivados de amidina.
AU2003211697A1 (en) Process for producing l-threonine with the use of bacterium beloniging to the genus escherichia
MXPA04006677A (es) Procedimiento para la preparacion de esteres de escopina.
AU2003258157A1 (en) Mutant e. coli appa phytase enzymes
AU2002242633A1 (en) Fermentation process including the use of enzymes
AU2003248117A1 (en) Novel enzyme forming peptide, microorganism producing the same and process for producing dipeptide using them
AU2003261327A1 (en) Base assemblies, methods of production and uses thereof
AU2002368368A1 (en) Process for producing diamond, graphite or mixture of diamond and graphite
WO2005012498A3 (en) Production of porphyrins
AU2003295110A1 (en) Production process of gamma-cyhalothrin
AU2002241277A1 (en) Functional plant, promoter to be used for producing the functional plant and method of using the same
AU2002229706A1 (en) Process for the fermentative production of d-pantothenic acid
AU2003206934A1 (en) Fermentation process
AU2002336564A1 (en) Method of enzyme production by microorganisms
YU67203A (sh) Derivati caloporosida, postupak za njihovu proizvodnju i njihova primena
AU2003227487A1 (en) Novel pickle and sesoning liquor and process for producing the same
AU2003263604A1 (en) Method of producing laminates, and laminates
TW200500466A (en) Process for manufacturing tricholoma matsutake mycelia
UA55331C2 (ru) ШТАММ (ТКСТ) BLAKESLEA TRISPORA ІМВ F-100022-ПРОДУЦЕНТ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--КАРОТИНА