EG14227A - N-phenoxyalkyl imidazoles as selective infibitors of the thermoboxane synthetase enzyme,pharmaceutical compositions thereof and process for their preparation - Google Patents

N-phenoxyalkyl imidazoles as selective infibitors of the thermoboxane synthetase enzyme,pharmaceutical compositions thereof and process for their preparation

Info

Publication number
EG14227A
EG14227A EG743/79A EG74379A EG14227A EG 14227 A EG14227 A EG 14227A EG 743/79 A EG743/79 A EG 743/79A EG 74379 A EG74379 A EG 74379A EG 14227 A EG14227 A EG 14227A
Authority
EG
Egypt
Prior art keywords
thermoboxane
infibitors
phenoxyalkyl
imidazoles
selective
Prior art date
Application number
EG743/79A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10501705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG14227(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG14227A publication Critical patent/EG14227A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EG743/79A 1978-12-13 1979-12-12 N-phenoxyalkyl imidazoles as selective infibitors of the thermoboxane synthetase enzyme,pharmaceutical compositions thereof and process for their preparation EG14227A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7848367 1978-12-13

Publications (1)

Publication Number Publication Date
EG14227A true EG14227A (en) 1983-12-31

Family

ID=10501705

Family Applications (1)

Application Number Title Priority Date Filing Date
EG743/79A EG14227A (en) 1978-12-13 1979-12-12 N-phenoxyalkyl imidazoles as selective infibitors of the thermoboxane synthetase enzyme,pharmaceutical compositions thereof and process for their preparation

Country Status (34)

Country Link
US (2) US4602016A (sv)
JP (1) JPS585197B2 (sv)
KR (1) KR830001243B1 (sv)
AR (1) AR227637A1 (sv)
AT (1) AT373879B (sv)
AU (1) AU517892B2 (sv)
BE (1) BE880584A (sv)
CA (1) CA1108137A (sv)
CH (1) CH644597A5 (sv)
CS (1) CS216517B2 (sv)
DD (1) DD147943A5 (sv)
DE (1) DE2950019A1 (sv)
DK (1) DK471479A (sv)
EG (1) EG14227A (sv)
ES (1) ES486782A0 (sv)
FI (1) FI70888C (sv)
FR (1) FR2444031A1 (sv)
GB (1) GB2038821B (sv)
GR (1) GR73003B (sv)
HU (1) HU183016B (sv)
IE (1) IE49318B1 (sv)
IL (1) IL58917A (sv)
IT (1) IT1194900B (sv)
LU (1) LU81985A1 (sv)
NL (1) NL177749C (sv)
NO (1) NO153135C (sv)
NZ (1) NZ192360A (sv)
PH (1) PH15056A (sv)
PL (1) PL134005B1 (sv)
PT (1) PT70571A (sv)
SE (1) SE444937B (sv)
SU (1) SU878195A3 (sv)
YU (1) YU301879A (sv)
ZA (1) ZA796708B (sv)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350696A (en) * 1980-03-08 1982-09-21 Pfizer Inc. Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
US4444775A (en) * 1981-06-22 1984-04-24 Ciba-Geigy Corporation Substituted imidazo[1,5-A]pyridines
DE3148291A1 (de) * 1981-12-05 1983-06-09 Basf Ag, 6700 Ludwigshafen Harnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
JPS58113178A (ja) * 1981-12-28 1983-07-05 Yamanouchi Pharmaceut Co Ltd 「お」−（１−イミダゾリル）アルキルオキシ（またはチオ）ベンゼン誘導体
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
NL8301550A (nl) * 1983-05-03 1984-12-03 Gist Brocades Nv Imidazolethanol esters.
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
PH22076A (en) * 1983-08-25 1988-05-20 Daiichi Seiyaku Co Benzocycloalkane derivative
IT1212791B (it) * 1983-11-24 1989-11-30 Medea Res Srl Derivato imidazolico adattivita' vasodilatatrice ed antitrombotica, sua preparazione e composizioni farmaceutiche che lo contengono.
ES8601148A1 (es) * 1984-12-10 1985-11-16 Ferrer Int Procedimiento de obtencion de nuevos derivados imidazoliletoxiindanicos.
US4894385A (en) * 1985-01-16 1990-01-16 Sankyo Company Limited Imidazole derivatives as inhibitors of TXA2 synthesis
US4847272A (en) 1986-01-28 1989-07-11 Sankyo Company Limited Thianaphthene derivatives
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
JPS63179840A (ja) * 1986-07-24 1988-07-23 Yamanouchi Pharmaceut Co Ltd 新規化学物質
ATE57925T1 (de) * 1987-04-03 1990-11-15 Cl Pharma Neue 2-thienyloxyessigsaeurederivate, ein verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
JPH01125372A (ja) * 1988-09-12 1989-05-17 Yamanouchi Pharmaceut Co Ltd イミダゾリルアルキルオキシベンゼン誘導体
DE4204686A1 (de) * 1992-02-17 1993-08-19 Gruenenthal Gmbh Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln
WO1999045905A2 (en) * 1998-03-13 1999-09-16 Pozen Inc. Prophylaxis and treatment of migraine headaches with thromboxane synthetase inhibitors and/or receptor antagonists
ES2172436B1 (es) 2000-10-31 2004-01-16 Almirall Prodesfarma Sa Derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
US20050020657A1 (en) * 2002-07-09 2005-01-27 B.M.R.A. Corporation B.V. Compositions and methods involving the combination of a thromboxane A2 receptor antagonist and an inhibitor of cyclooxygenase-2
EP1660076A1 (en) * 2003-08-07 2006-05-31 B.M.R.A. Corporation B.V. Compositions and methods involving the combination of a thromboxane a2 receptor antagonist and an inhibitor of cyclooxigenase-1
KR101275814B1 (ko) * 2006-06-23 2013-06-18 삼성에스디아이 주식회사 분산제 화합물 및 그의 제조방법
EP2234608A2 (en) 2007-12-11 2010-10-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
CN101811974B (zh) * 2010-04-15 2012-12-12 合肥医工医药有限公司 4-(3-(二甲氨基)丙氧基)-3,5-二甲氧基苯甲酸、其制法及医药用途
CN101851209B (zh) * 2010-06-21 2012-09-19 合肥医工医药有限公司 咪唑乙基香草酸醚、其制备方法及其医药用途
MX2014014234A (es) * 2012-05-22 2015-05-07 Genentech Inc Benzamidas n-sustituidas y su uso en el tratamiento del dolor.
KR20150074123A (ko) 2012-10-26 2015-07-01 머크 샤프 앤드 돔 코포레이션 전압-게이팅 나트륨 채널에서 선택적 활성을 갖는 n-치환된 인다졸 술폰아미드 화합물
WO2023240378A1 (zh) * 2022-06-13 2023-12-21 南京医工医药技术有限公司 咪唑烷基香草酸醚衍生物及其用途
CN114736161B (zh) * 2022-06-13 2022-09-13 南京医工医药技术有限公司 咪唑烷基香草酸醚衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534061A (en) * 1967-12-04 1970-10-13 Parke Davis & Co N-(alpha-(p-methoxyphenyl)-beta-nitrostyryl)-phenoxyalkyl pyrroles
US4085209A (en) * 1975-02-05 1978-04-18 Rohm And Haas Company Preparation and safening effect of 1-substituted imidazole metal salt complexes
US4078071A (en) * 1976-03-08 1978-03-07 Syntex (U.S.A.) Inc. Derivatives of substituted N-alkyl imidazoles
JPS5951943B2 (ja) * 1978-08-21 1984-12-17 キツセイ薬品工業株式会社 新規なイミダゾ−ル誘導体

Also Published As

Publication number Publication date
NL7908899A (nl) 1980-06-17
IE49318B1 (en) 1985-09-18
BE880584A (fr) 1980-06-12
KR830001242A (ko) 1983-04-29
IT1194900B (it) 1988-09-28
AT373879B (de) 1984-02-27
US4602016A (en) 1986-07-22
FI793868A (fi) 1980-06-14
FR2444031A1 (fr) 1980-07-11
ATA783379A (de) 1983-07-15
AU5372579A (en) 1980-06-19
HU183016B (en) 1984-04-28
US4636500A (en) 1987-01-13
NL177749B (nl) 1985-06-17
LU81985A1 (fr) 1980-04-22
PH15056A (en) 1982-06-03
JPS585197B2 (ja) 1983-01-29
NL177749C (nl) 1985-11-18
AU517892B2 (en) 1981-09-03
YU301879A (en) 1983-01-21
ES8101556A1 (es) 1980-12-16
CS216517B2 (en) 1982-11-26
CH644597A5 (de) 1984-08-15
SU878195A3 (ru) 1981-10-30
GB2038821A (en) 1980-07-30
GB2038821B (en) 1982-12-08
DK471479A (da) 1980-06-14
NO153135B (no) 1985-10-14
PL134005B1 (en) 1985-07-31
DD147943A5 (de) 1981-04-29
NO153135C (no) 1986-01-22
NO794069L (no) 1980-06-16
IE792403L (en) 1980-06-13
JPS5585572A (en) 1980-06-27
SE444937B (sv) 1986-05-20
IL58917A0 (en) 1980-03-31
ES486782A0 (es) 1980-12-16
PT70571A (en) 1980-01-01
KR830001243B1 (ko) 1983-06-27
FI70888C (fi) 1986-10-27
FR2444031B1 (sv) 1983-06-10
SE7910204L (sv) 1980-06-14
FI70888B (fi) 1986-07-18
ZA796708B (en) 1981-08-26
AR227637A1 (es) 1982-11-30
CA1108137A (en) 1981-09-01
GR73003B (sv) 1984-01-24
IT7941669A0 (it) 1979-12-11
DE2950019A1 (de) 1980-07-10
IL58917A (en) 1984-03-30
NZ192360A (en) 1982-02-23
PL220351A1 (sv) 1980-12-01

Similar Documents

Publication Publication Date Title
EG14227A (en) N-phenoxyalkyl imidazoles as selective infibitors of the thermoboxane synthetase enzyme,pharmaceutical compositions thereof and process for their preparation
IL56734A0 (en) Phemoxyalkylcarboxylic acid derivatives,process for their preparation and pharmaceutical compositions containing thesame
DE3068020D1 (en) Aminoalkylbenzene derivatives, process for their preparation and pharmaceutical compositions
DE2962122D1 (en) 17-alkylcarbonates of corticoids, process for their preparation and their use as medicines against dermatoses
PT70707A (en) Process for preparing n-benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions
ZA794472B (en) Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof
DE3062586D1 (en) 2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same
DE2960954D1 (en) 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
DE3161260D1 (en) Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
DE2963573D1 (en) Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
IL58377A (en) 4-phenyl-1,3-benzodiazepines,method of preparing the same and pharmaceutical compositions comprising them
DE2964209D1 (en) Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
DE3062884D1 (en) Spiro-hydantoin derivatives, process for their preparation and pharmaceutical compositions thereof
GB2019837A (en) N-Oxacyclic-alkylpiperidyl-diazacompounds, process for their manufacture and pharmaceutical compositions containing them
IL57229A (en) Hydroxypropyl-imidazole derivatives,their production and pharmaceutical compositions containing them
DE2966413D1 (en) Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them
DE2862404D1 (en) Hydantoin derivatives, their preparation and pharmaceutical compositions containing them
DE3060894D1 (en) Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them
SG7985G (en) N-phenylindoline derivatives,their production and pharmaceutical compositions containing them
DE3060079D1 (en) Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof
IL62747A0 (en) 2-guanidinothiazole derivatives,process for the preparation thereof and pharmaceutical compositions comprising the same
IL57533A (en) 17alpha-acetylene derivatives of androst-4-ene,process for preparing them and pharmaceutical compositions containing them
DE2966043D1 (en) Process for the preparation of oside derivatives, derivatives so obtained and their biological applications
DE3368933D1 (en) Phosphate derivatives, process for preparation thereof and pharmaceutical compositions of the same
DE2966639D1 (en) Benzodiazepine derivatives, process for their preparation and pharmaceutical compositions containing them