EE200000225A - Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon - Google Patents

Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon

Info

Publication number
EE200000225A
EE200000225A EEP200000225A EEP200000225A EE200000225A EE 200000225 A EE200000225 A EE 200000225A EE P200000225 A EEP200000225 A EE P200000225A EE P200000225 A EEP200000225 A EE P200000225A EE 200000225 A EE200000225 A EE 200000225A
Authority
EE
Estonia
Prior art keywords
dialkylamines
aryloxyalkyl
preparation
methods
pharmaceutical composition
Prior art date
Application number
EEP200000225A
Other languages
English (en)
Estonian (et)
Inventor
Raveendranath Panolil
Zeldis Joseph
Vid Galina
Richard Potoski John
Ren Jianxin
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/161,653 external-priority patent/US6005102A/en
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of EE200000225A publication Critical patent/EE200000225A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Detergent Compositions (AREA)
EEP200000225A 1997-10-15 1998-10-14 Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon EE200000225A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95081897A 1997-10-15 1997-10-15
US09/161,653 US6005102A (en) 1997-10-15 1998-09-28 Aryloxy-alkyl-dialkylamines
PCT/US1998/021609 WO1999019293A1 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines

Publications (1)

Publication Number Publication Date
EE200000225A true EE200000225A (et) 2001-06-15

Family

ID=26858006

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000225A EE200000225A (et) 1997-10-15 1998-10-14 Arüüloksüalküüldialküülamiinid, nende valmistamismeetodid ja farmatseutiline kompositsioon

Country Status (27)

Country Link
EP (2) EP1025077B1 (pt)
JP (1) JP2001519410A (pt)
KR (1) KR100669836B1 (pt)
CN (1) CN1231458C (pt)
AR (1) AR015183A1 (pt)
AT (1) ATE355264T1 (pt)
AU (1) AU757630C (pt)
BR (1) BR9813069A (pt)
CA (1) CA2306343C (pt)
CY (1) CY1106497T1 (pt)
DE (1) DE69837210T2 (pt)
DK (1) DK1025077T3 (pt)
EA (1) EA003937B1 (pt)
EE (1) EE200000225A (pt)
ES (1) ES2281937T3 (pt)
HK (1) HK1026889A1 (pt)
HU (1) HUP0004419A3 (pt)
ID (1) ID24417A (pt)
IL (2) IL135343A0 (pt)
NO (1) NO20001938L (pt)
NZ (1) NZ503793A (pt)
PL (1) PL198443B1 (pt)
PT (1) PT1025077E (pt)
SI (1) SI1025077T1 (pt)
SK (1) SK286460B6 (pt)
TR (1) TR200001012T2 (pt)
WO (1) WO1999019293A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
EA005932B1 (ru) * 1998-05-15 2005-08-25 Уайт 2-фенил-1-[4-(2-аминоэтокси)бензил]индол в комбинации с эстрогенами
EP1212335B1 (en) * 1999-09-13 2006-01-18 Wyeth Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1- 4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols
EP1656938A1 (en) 2000-07-06 2006-05-17 Wyeth Combinations of SSRI and estrogenic agents
AU2001271782A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted insole compounds for treating excessive intraocular pressure
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
AU2001273144A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
EP1990051A1 (en) 2000-07-06 2008-11-12 Wyeth Combinations of SSRI and estrogenic agents
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
JP2004532834A (ja) * 2001-03-23 2004-10-28 イーライ・リリー・アンド・カンパニー ヒスタミンh3受容体アンタゴニストである非イミダゾール系アリールアルキルアミン化合物、その製造および治療的使用
US7056931B2 (en) 2001-05-22 2006-06-06 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
EP1401446B1 (en) 2001-05-22 2005-02-09 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
JP2007532548A (ja) 2004-04-07 2007-11-15 ワイス バゼドキシフェンアセテートの結晶質多形体
RU2006132180A (ru) * 2004-04-07 2008-05-20 Вайет (Us) Кристаллический полиморф базедоксифен ацетата
AU2005233128A1 (en) 2004-04-08 2005-10-27 Wyeth Bazedoxifene ascorbate as selective estrogen receptor modulator
CN1993322A (zh) * 2004-08-05 2007-07-04 惠氏公司 哌多昔芬盐酸盐一水合物的结晶多晶型物
AR055837A1 (es) * 2005-01-13 2007-09-12 Wyeth Corp Procedimientos para la preparacion de alc0holes aminoetoxibencilicos
US20100087661A1 (en) * 2007-02-12 2010-04-08 Josef Jirman Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole
US20100016582A1 (en) * 2008-02-11 2010-01-21 Wyeth Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate
RU2011145811A (ru) * 2009-04-13 2013-05-20 Сандоз Аг Способы синтеза базедоксифенацетата и его промежуточных продуктов
US8569483B2 (en) 2011-06-21 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of bazedoxifene acetate and intermediates thereof
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
WO2014186325A1 (en) 2013-05-15 2014-11-20 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH448121A (de) 1963-03-13 1967-12-15 Hoffmann La Roche Verfahren zur Herstellung substituierter Hydrazinverbindungen
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9326332D0 (en) 1993-12-23 1994-02-23 Karo Bio Indole derivatives
EP0925063A4 (en) * 1996-07-01 2000-12-27 Lilly Co Eli Blood-glucose-lowering and lipid-lowering compounds
PT970046E (pt) * 1997-02-27 2004-04-30 Wyeth Corp N-hidroxi-2-(alquil, aril, ou heteroaril sulfanil, sulfinil ou sulfonil)-alquil, aril ou heteroaril amidas substituidas em 3 como inibidores de metaloproteinase de matriz
WO1998048797A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents

Also Published As

Publication number Publication date
JP2001519410A (ja) 2001-10-23
CY1106497T1 (el) 2012-01-25
ATE355264T1 (de) 2006-03-15
KR20010024505A (ko) 2001-03-26
CN1231458C (zh) 2005-12-14
IL135343A0 (en) 2001-05-20
DE69837210D1 (de) 2007-04-12
EA200000416A1 (ru) 2000-10-30
CN1281429A (zh) 2001-01-24
IL135343A (en) 2007-12-03
TR200001012T2 (tr) 2000-09-21
SI1025077T1 (sl) 2007-06-30
NO20001938D0 (no) 2000-04-13
NZ503793A (en) 2002-10-25
EP1777214A2 (en) 2007-04-25
HUP0004419A3 (en) 2002-01-28
AU757630C (en) 2006-10-26
HUP0004419A2 (hu) 2001-07-30
CA2306343C (en) 2010-08-03
SK5372000A3 (en) 2000-11-07
ES2281937T3 (es) 2007-10-01
DK1025077T3 (da) 2007-05-07
CA2306343A1 (en) 1999-04-22
PL339908A1 (en) 2001-01-15
PT1025077E (pt) 2007-05-31
HK1026889A1 (en) 2000-12-29
EP1025077A1 (en) 2000-08-09
NO20001938L (no) 2000-06-07
AR015183A1 (es) 2001-04-18
AU1083199A (en) 1999-05-03
KR100669836B1 (ko) 2007-01-18
DE69837210T2 (de) 2007-12-27
AU757630B2 (en) 2003-02-27
SK286460B6 (sk) 2008-10-07
EP1025077B1 (en) 2007-02-28
BR9813069A (pt) 2000-08-22
PL198443B1 (pl) 2008-06-30
EA003937B1 (ru) 2003-10-30
EP1777214A3 (en) 2007-05-09
WO1999019293A1 (en) 1999-04-22
ID24417A (id) 2000-07-20

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