EA200000416A1 - Новые арилоксиалкилдиалкиламины - Google Patents
Новые арилоксиалкилдиалкиламиныInfo
- Publication number
- EA200000416A1 EA200000416A1 EA200000416A EA200000416A EA200000416A1 EA 200000416 A1 EA200000416 A1 EA 200000416A1 EA 200000416 A EA200000416 A EA 200000416A EA 200000416 A EA200000416 A EA 200000416A EA 200000416 A1 EA200000416 A1 EA 200000416A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- independently selected
- group
- aryloxylkydialkylamines
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Detergent Compositions (AREA)
Abstract
Настоящее изобретение предусматривает соединения, полезные в синтезе биологически активных соединений, и способы для их получения, соединения, имеющие формулу (I), где Rи Rнезависимо выбраны из H; C-Cалкила или C-Cперфторированного алкила; X представляет собой отщепляемую группу; A является O или S; m является целым числом от 1 до 3, предпочтительно 2; R, R, Rи Rнезависимо выбраны из H, галогена, -NO, алкила, алкокси, C-Cперфторированного алкила, OH или их C-Cсложных эфиров или алкиловых простых эфиров, -CN, -O-R, -O-Ar, -S-R, -S-Ar, -SO-R, -SO-Ar, -SO-R, -SO-Ar, -CO-R, -CO-Ar, -CO-Rили -CO-Ar; и Y выбирают из а) остатка (i), где Rи Rнезависимо выбраны из группы H, C-Cалкила или фенила; или b) необязательно замещенного пяти-, шести- или семичленного насыщенного, ненасыщенного или частично ненасыщенного гетероцикла или бициклического гетероцикла, включающего вплоть до двух гетероатомов, выбранных из группы, состоящей из -O-, -NH-, -N (C-Cалкил)-, -N= и -S(O)-.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95081897A | 1997-10-15 | 1997-10-15 | |
| US09/161,653 US6005102A (en) | 1997-10-15 | 1998-09-28 | Aryloxy-alkyl-dialkylamines |
| PCT/US1998/021609 WO1999019293A1 (en) | 1997-10-15 | 1998-10-14 | Novel aryloxy-alkyl-dialkylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000416A1 true EA200000416A1 (ru) | 2000-10-30 |
| EA003937B1 EA003937B1 (ru) | 2003-10-30 |
Family
ID=26858006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000416A EA003937B1 (ru) | 1997-10-15 | 1998-10-14 | Новые арилоксиалкилдиалкиламины |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP1025077B1 (ru) |
| JP (1) | JP2001519410A (ru) |
| KR (1) | KR100669836B1 (ru) |
| CN (1) | CN1231458C (ru) |
| AR (1) | AR015183A1 (ru) |
| AT (1) | ATE355264T1 (ru) |
| AU (1) | AU757630C (ru) |
| BR (1) | BR9813069A (ru) |
| CA (1) | CA2306343C (ru) |
| CY (1) | CY1106497T1 (ru) |
| DE (1) | DE69837210T2 (ru) |
| DK (1) | DK1025077T3 (ru) |
| EA (1) | EA003937B1 (ru) |
| EE (1) | EE200000225A (ru) |
| ES (1) | ES2281937T3 (ru) |
| HK (1) | HK1026889A1 (ru) |
| HU (1) | HUP0004419A3 (ru) |
| ID (1) | ID24417A (ru) |
| IL (2) | IL135343A0 (ru) |
| NO (1) | NO20001938L (ru) |
| NZ (1) | NZ503793A (ru) |
| PL (1) | PL198443B1 (ru) |
| PT (1) | PT1025077E (ru) |
| SI (1) | SI1025077T1 (ru) |
| SK (1) | SK286460B6 (ru) |
| TR (1) | TR200001012T2 (ru) |
| WO (1) | WO1999019293A1 (ru) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515431A (ja) * | 1998-05-15 | 2002-05-28 | アメリカン・ホーム・プロダクツ・コーポレイション | エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| EA005371B1 (ru) * | 1999-09-13 | 2005-02-24 | Уайт | Глюкопиранозидные конъюгаты 2-(4-гидроксифенил)-1-[4-(2-амин-1-илэтокси)бензил]-1h-индол-5-олов |
| EP1656938A1 (en) | 2000-07-06 | 2006-05-17 | Wyeth | Combinations of SSRI and estrogenic agents |
| AR029539A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Combinaciones de estatinas y agentes estrogenicos |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
| US6509332B2 (en) | 2000-07-06 | 2003-01-21 | Wyeth | Methods of treating excessive intraocular pressure |
| US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| JP2004502729A (ja) | 2000-07-06 | 2004-01-29 | ワイス | Ｓｓｒｉおよびエストロゲン剤の組み合わせ |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| US6358991B2 (en) | 2000-07-06 | 2002-03-19 | American Home Products Corporation | Methods of treating neuropeptide Y-related conditions |
| CA2441080A1 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| PT1401446E (pt) | 2001-05-22 | 2005-05-31 | Lilly Co Eli | Derivados de tetrahidroquinolina para a inibicao de doencas associadas com a privacao de estrogenio ou com uma resposta fisiologica aberrante ao estrogenio endogeno |
| ATE321754T1 (de) | 2001-05-22 | 2006-04-15 | Lilly Co Eli | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
| US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
| US7098241B2 (en) | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
| JP2007532560A (ja) | 2004-04-07 | 2007-11-15 | ワイス | バゼドキシフェンアセテートの結晶多形 |
| KR20070004815A (ko) | 2004-04-07 | 2007-01-09 | 와이어쓰 | 바제독시펜 아세테이트의 결정질 다형체 |
| WO2005100315A1 (en) | 2004-04-08 | 2005-10-27 | Wyeth | Bazedoxifene ascorbate as selective estrogen receptor modulator |
| CN1993322A (zh) * | 2004-08-05 | 2007-07-04 | 惠氏公司 | 哌多昔芬盐酸盐一水合物的结晶多晶型物 |
| BRPI0606659A2 (pt) * | 2005-01-13 | 2009-07-07 | Wyeth Corp | processos para a preparação de álcoois aminoetoxibenzìlicos |
| US20100087661A1 (en) * | 2007-02-12 | 2010-04-08 | Josef Jirman | Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole |
| US20100016582A1 (en) * | 2008-02-11 | 2010-01-21 | Wyeth | Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate |
| WO2010118997A1 (en) * | 2009-04-13 | 2010-10-21 | Sandoz Ag | Processes for the synthesis of bazedoxifene acetate and intermediates thereof |
| US8569483B2 (en) | 2011-06-21 | 2013-10-29 | Divi's Laboratories, Ltd. | Process for the preparation of bazedoxifene acetate and intermediates thereof |
| CN104151265B (zh) * | 2013-05-13 | 2016-10-05 | 上海医药工业研究院 | 醋酸巴多昔芬中间体的制备方法 |
| US9751835B2 (en) | 2013-05-15 | 2017-09-05 | Indiana University Research And Technology Corporation | Processes and intermediates for preparing indole pharmaceuticals |
| IT201800006562A1 (it) * | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli | |
| IT201900001923A1 (it) | 2019-02-11 | 2020-08-11 | Erregierre Spa | Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH448121A (de) | 1963-03-13 | 1967-12-15 | Hoffmann La Roche | Verfahren zur Herstellung substituierter Hydrazinverbindungen |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| GB9326332D0 (en) | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
| WO1998000137A1 (en) * | 1996-07-01 | 1998-01-08 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| GEP20022626B (en) * | 1997-02-27 | 2002-02-25 | American Cyanamid Company Us | N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl Sulfanyl, Sulfinil or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase Inhibitors |
| EP1011666A4 (en) * | 1997-04-30 | 2004-03-31 | Lilly Co Eli | ANTITHROMBOTIC AGENTS |
-
1998
- 1998-10-14 EA EA200000416A patent/EA003937B1/ru not_active IP Right Cessation
- 1998-10-14 KR KR1020007004031A patent/KR100669836B1/ko not_active IP Right Cessation
- 1998-10-14 HU HU0004419A patent/HUP0004419A3/hu unknown
- 1998-10-14 DK DK98953459T patent/DK1025077T3/da active
- 1998-10-14 CN CNB988121492A patent/CN1231458C/zh not_active Expired - Fee Related
- 1998-10-14 AU AU10831/99A patent/AU757630C/en not_active Ceased
- 1998-10-14 EP EP98953459A patent/EP1025077B1/en not_active Expired - Lifetime
- 1998-10-14 NZ NZ503793A patent/NZ503793A/xx unknown
- 1998-10-14 PL PL339908A patent/PL198443B1/pl not_active IP Right Cessation
- 1998-10-14 BR BR9813069-2A patent/BR9813069A/pt not_active Application Discontinuation
- 1998-10-14 TR TR2000/01012T patent/TR200001012T2/xx unknown
- 1998-10-14 PT PT98953459T patent/PT1025077E/pt unknown
- 1998-10-14 AR ARP980105112A patent/AR015183A1/es unknown
- 1998-10-14 SK SK537-2000A patent/SK286460B6/sk not_active IP Right Cessation
- 1998-10-14 AT AT98953459T patent/ATE355264T1/de not_active IP Right Cessation
- 1998-10-14 SI SI9830877T patent/SI1025077T1/sl unknown
- 1998-10-14 EP EP07003195A patent/EP1777214A3/en not_active Withdrawn
- 1998-10-14 CA CA2306343A patent/CA2306343C/en not_active Expired - Fee Related
- 1998-10-14 IL IL13534398A patent/IL135343A0/xx active IP Right Grant
- 1998-10-14 ID IDW20000680A patent/ID24417A/id unknown
- 1998-10-14 JP JP2000515866A patent/JP2001519410A/ja active Pending
- 1998-10-14 DE DE69837210T patent/DE69837210T2/de not_active Expired - Lifetime
- 1998-10-14 EE EEP200000225A patent/EE200000225A/xx unknown
- 1998-10-14 ES ES98953459T patent/ES2281937T3/es not_active Expired - Lifetime
- 1998-10-14 WO PCT/US1998/021609 patent/WO1999019293A1/en active IP Right Grant
-
2000
- 2000-03-29 IL IL135343A patent/IL135343A/en not_active IP Right Cessation
- 2000-04-13 NO NO20001938A patent/NO20001938L/no not_active Application Discontinuation
- 2000-09-26 HK HK00106079A patent/HK1026889A1/xx not_active IP Right Cessation
-
2007
- 2007-04-05 CY CY20071100491T patent/CY1106497T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |