HK1026889A1 - Novel aryloxy-alkyl-dialkylamines - Google Patents

Novel aryloxy-alkyl-dialkylamines

Info

Publication number
HK1026889A1
HK1026889A1 HK00106079A HK00106079A HK1026889A1 HK 1026889 A1 HK1026889 A1 HK 1026889A1 HK 00106079 A HK00106079 A HK 00106079A HK 00106079 A HK00106079 A HK 00106079A HK 1026889 A1 HK1026889 A1 HK 1026889A1
Authority
HK
Hong Kong
Prior art keywords
dialkylamines
alkyl
novel aryloxy
aryloxy
novel
Prior art date
Application number
HK00106079A
Other languages
English (en)
Inventor
Panolil Raveendranath
Joseph Zeldis
Galina Vid
John Richard Potoski
Jianxin Ren
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/161,653 external-priority patent/US6005102A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of HK1026889A1 publication Critical patent/HK1026889A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
HK00106079A 1997-10-15 2000-09-26 Novel aryloxy-alkyl-dialkylamines HK1026889A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95081897A 1997-10-15 1997-10-15
US09/161,653 US6005102A (en) 1997-10-15 1998-09-28 Aryloxy-alkyl-dialkylamines
PCT/US1998/021609 WO1999019293A1 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines

Publications (1)

Publication Number Publication Date
HK1026889A1 true HK1026889A1 (en) 2000-12-29

Family

ID=26858006

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00106079A HK1026889A1 (en) 1997-10-15 2000-09-26 Novel aryloxy-alkyl-dialkylamines

Country Status (27)

Country Link
EP (2) EP1025077B1 (xx)
JP (1) JP2001519410A (xx)
KR (1) KR100669836B1 (xx)
CN (1) CN1231458C (xx)
AR (1) AR015183A1 (xx)
AT (1) ATE355264T1 (xx)
AU (1) AU757630C (xx)
BR (1) BR9813069A (xx)
CA (1) CA2306343C (xx)
CY (1) CY1106497T1 (xx)
DE (1) DE69837210T2 (xx)
DK (1) DK1025077T3 (xx)
EA (1) EA003937B1 (xx)
EE (1) EE200000225A (xx)
ES (1) ES2281937T3 (xx)
HK (1) HK1026889A1 (xx)
HU (1) HUP0004419A3 (xx)
ID (1) ID24417A (xx)
IL (2) IL135343A0 (xx)
NO (1) NO20001938L (xx)
NZ (1) NZ503793A (xx)
PL (1) PL198443B1 (xx)
PT (1) PT1025077E (xx)
SI (1) SI1025077T1 (xx)
SK (1) SK286460B6 (xx)
TR (1) TR200001012T2 (xx)
WO (1) WO1999019293A1 (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515431A (ja) * 1998-05-15 2002-05-28 アメリカン・ホーム・プロダクツ・コーポレイション エストロゲンと組み合わせる２−フェニル−１−［４−（２−アミノエトキシ）ベンジルオキシ］インドール
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
CN1196708C (zh) * 1999-09-13 2005-04-13 惠氏公司 2－(4－羟基－苯基)－1－[4－(2－氨－1－基－乙氧基)－苄基]－1h－吲哚－5－酚的吡喃葡糖苷轭合物
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
MXPA03000170A (es) 2000-07-06 2003-05-27 Wyeth Corp Combinaciones de un inhibidor de recaptacion de serotonina selectivo y agentes estrogenicos.
AU2001273144A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
EP1656938A1 (en) 2000-07-06 2006-05-17 Wyeth Combinations of SSRI and estrogenic agents
US6509332B2 (en) 2000-07-06 2003-01-21 Wyeth Methods of treating excessive intraocular pressure
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
CA2441080A1 (en) * 2001-03-23 2002-10-03 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
JP2004531559A (ja) 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体
ATE321754T1 (de) 2001-05-22 2006-04-15 Lilly Co Eli 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
GT200500080A (es) * 2004-04-07 2005-10-31 Polimorfo cristalino de acetato de bazedoxifeno
BRPI0509191A (pt) * 2004-04-07 2007-09-25 Wyeth Corp polimorfo cristalino, composição, métodos de preparar forma a polimórfica de acetato de bazedoxifeno, de tratar um mamìfero possuindo uma doença ou sìndrome associada com deficiência de estrogênio ou excesso de estrogênio, e com proliferação ou desenvolvimento anormal de tecidos endometriais, cáncer de mama em um mamìfero, e uma mulher pós-menopausal para um ou vários distúrbios vasomotores, de abaixar colesterol em um mamìfero, e de inibir perda óssea em um mamìfero, e, forma a polimorfa cristalina de acetato de bazedoxifeno
US7504394B2 (en) 2004-04-08 2009-03-17 Wyeth Bazedoxifene ascorbate
WO2006017639A2 (en) * 2004-08-05 2006-02-16 Wyeth Crystalline polymorph of pipindoxifene hydrochloride monohydrate
SG158860A1 (en) * 2005-01-13 2010-02-26 Wyeth Corp Processes for the preparation of aminoethoxybenzyl alcohols
US20100087661A1 (en) * 2007-02-12 2010-04-08 Josef Jirman Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole
US20100016582A1 (en) * 2008-02-11 2010-01-21 Wyeth Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate
RU2011145811A (ru) 2009-04-13 2013-05-20 Сандоз Аг Способы синтеза базедоксифенацетата и его промежуточных продуктов
US8569483B2 (en) 2011-06-21 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of bazedoxifene acetate and intermediates thereof
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
US9751835B2 (en) 2013-05-15 2017-09-05 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH448121A (de) 1963-03-13 1967-12-15 Hoffmann La Roche Verfahren zur Herstellung substituierter Hydrazinverbindungen
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9326332D0 (en) 1993-12-23 1994-02-23 Karo Bio Indole derivatives
CA2259487A1 (en) * 1996-07-01 1998-01-08 Margaret Mary Faul Hypoglycemic and hypolipidemic compounds
PL335286A1 (en) * 1997-02-27 2000-04-10 American Cyanamid Co N-hydroxy-2-(alkyl, aryl or heteroaryl sulphanyl sulphinyl or sulphonyl)-3-substituted alkyl, aryl or heteroaryl amides as inhibitors of intercellular metaloproteases
AU7170798A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Antithrombotic agents

Also Published As

Publication number Publication date
DE69837210D1 (de) 2007-04-12
KR20010024505A (ko) 2001-03-26
EP1777214A2 (en) 2007-04-25
PT1025077E (pt) 2007-05-31
NO20001938D0 (no) 2000-04-13
NZ503793A (en) 2002-10-25
EA003937B1 (ru) 2003-10-30
EP1777214A3 (en) 2007-05-09
DK1025077T3 (da) 2007-05-07
PL339908A1 (en) 2001-01-15
NO20001938L (no) 2000-06-07
JP2001519410A (ja) 2001-10-23
ES2281937T3 (es) 2007-10-01
CA2306343A1 (en) 1999-04-22
WO1999019293A1 (en) 1999-04-22
TR200001012T2 (tr) 2000-09-21
ID24417A (id) 2000-07-20
KR100669836B1 (ko) 2007-01-18
AU757630B2 (en) 2003-02-27
CY1106497T1 (el) 2012-01-25
SK5372000A3 (en) 2000-11-07
BR9813069A (pt) 2000-08-22
HUP0004419A2 (hu) 2001-07-30
DE69837210T2 (de) 2007-12-27
IL135343A (en) 2007-12-03
PL198443B1 (pl) 2008-06-30
AR015183A1 (es) 2001-04-18
HUP0004419A3 (en) 2002-01-28
SK286460B6 (sk) 2008-10-07
EP1025077B1 (en) 2007-02-28
CN1231458C (zh) 2005-12-14
IL135343A0 (en) 2001-05-20
SI1025077T1 (sl) 2007-06-30
AU1083199A (en) 1999-05-03
EA200000416A1 (ru) 2000-10-30
CA2306343C (en) 2010-08-03
CN1281429A (zh) 2001-01-24
EP1025077A1 (en) 2000-08-09
AU757630C (en) 2006-10-26
ATE355264T1 (de) 2006-03-15
EE200000225A (et) 2001-06-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101014