NO914577L - Fremgangsmaate for fremstilling av heterocyklisk substituerte piperazinoalkylbenzoksazin- og -tiazinforbindelser - Google Patents
Fremgangsmaate for fremstilling av heterocyklisk substituerte piperazinoalkylbenzoksazin- og -tiazinforbindelserInfo
- Publication number
- NO914577L NO914577L NO91914577A NO914577A NO914577L NO 914577 L NO914577 L NO 914577L NO 91914577 A NO91914577 A NO 91914577A NO 914577 A NO914577 A NO 914577A NO 914577 L NO914577 L NO 914577L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- compounds
- halogen
- carbon atoms
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Forbindelser med den generelle formel I ;-R hvor X betyr oksygen eller svovel, Y betyr oksygen eller svovel, R1 betyr hydrogen eller lavere alkyl. R2 betyr hydrogen, lavere alkyl, halogen, lavere alkoksy, hydroksy, nitro eller tri- fluormetyl, og R3 betyr hydrogen, lavere alkyl, halogen eller lavere alkoksy, eller R2 og R3 er bundet til nabokarbonatomer og betyr til sammen en alkylendioksygruppe med 1-2 karbon- atomer, n står for et helt tall fra O til 4, og R4 står for en umettet, heterosyklisk 6-ring som inneholder l eller 2 nitrogenatomer som ikke er bundet direkte til piperazinringen, som eventuelt kan være substituert med 1-2 substituenter fra gruppen lavere alkyl, lavere alkoksy og halogen, som er bundet til karbonatomer, og syreaddi- sjonssalter derav. Forbindelsene er terapeutisk aktive. Fremstillingen av forbindelsene er beskrevet. Forbindelser med den generelle formel IV iv hvor X betyr oksygen eller svovel, R1 betyr hydrogen eller lavere alkyl, R2' betyr hydrogen, lavere alkyl, halogen, lavere alkoksy, nitro eller trifluor- metyl, R betyr hydrogen, lavere alkyl, halogen eller lavere alkoksy, eller R2' og R er bundet til nabostilte karbon- atomer og betyr til sammen en alkylen- dioksygruppe med 1-2 karbonatomer, og n står for et helt tall fra O til 4, kan anvendes som mellomprodukter ved fremstillingen av forbindelser med formel I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4037427A DE4037427A1 (de) | 1990-11-24 | 1990-11-24 | Heterocyclisch substituierte piperazinoalkylbenzoxazin und -thiazin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO914577D0 NO914577D0 (no) | 1991-11-22 |
| NO914577L true NO914577L (no) | 1992-05-25 |
Family
ID=6418854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO91914577A NO914577L (no) | 1990-11-24 | 1991-11-22 | Fremgangsmaate for fremstilling av heterocyklisk substituerte piperazinoalkylbenzoksazin- og -tiazinforbindelser |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0488008A1 (no) |
| JP (1) | JPH05140156A (no) |
| KR (1) | KR920009826A (no) |
| CN (1) | CN1062140A (no) |
| AU (1) | AU644496B2 (no) |
| CA (1) | CA2056009A1 (no) |
| DE (1) | DE4037427A1 (no) |
| FI (1) | FI915518A (no) |
| HU (1) | HUT62004A (no) |
| IE (1) | IE914074A1 (no) |
| IL (1) | IL99949A0 (no) |
| MX (1) | MX9102192A (no) |
| NO (1) | NO914577L (no) |
| PT (1) | PT99570A (no) |
| TW (1) | TW218876B (no) |
| ZA (1) | ZA918341B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2667068B1 (fr) * | 1990-09-26 | 1994-09-09 | Adir | Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| AU638154B2 (en) * | 1990-10-04 | 1993-06-17 | Suntory Limited | Benzoxazine derivative and herbicide containing same as an active ingredient |
| AU5979494A (en) * | 1993-02-05 | 1994-08-29 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzoxazine derivative, medicine containing the same, and intermediate therefor |
| FR2702477B1 (fr) * | 1993-03-08 | 1995-04-28 | Synthelabo | Dérivés de benzoxazine, leur préparation et leur application en thérapeutique. |
| FR2755690B1 (fr) * | 1996-11-08 | 1998-12-18 | Adir | Nouveaux derives aminomethyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1244481A (en) * | 1967-11-08 | 1971-09-02 | Wyeth John & Brother Ltd | Benzothiazine derivatives and the preparation thereof |
| EP0186310A1 (en) * | 1984-11-28 | 1986-07-02 | Takeda Chemical Industries, Ltd. | 1,4-Benzothiazine Derivatives, their production and use |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| FR2667068B1 (fr) * | 1990-09-26 | 1994-09-09 | Adir | Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1990
- 1990-11-24 DE DE4037427A patent/DE4037427A1/de not_active Withdrawn
-
1991
- 1991-10-18 ZA ZA918341A patent/ZA918341B/xx unknown
- 1991-11-04 IL IL99949A patent/IL99949A0/xx unknown
- 1991-11-06 HU HU913482A patent/HUT62004A/hu unknown
- 1991-11-09 CN CN91110541A patent/CN1062140A/zh not_active Withdrawn
- 1991-11-18 EP EP91119624A patent/EP0488008A1/de not_active Withdrawn
- 1991-11-21 PT PT99570A patent/PT99570A/pt not_active Application Discontinuation
- 1991-11-21 TW TW080109147A patent/TW218876B/zh active
- 1991-11-22 IE IE407491A patent/IE914074A1/en not_active Application Discontinuation
- 1991-11-22 FI FI915518A patent/FI915518A/fi not_active Application Discontinuation
- 1991-11-22 MX MX9102192A patent/MX9102192A/es not_active IP Right Cessation
- 1991-11-22 CA CA002056009A patent/CA2056009A1/en not_active Abandoned
- 1991-11-22 NO NO91914577A patent/NO914577L/no unknown
- 1991-11-22 JP JP3307362A patent/JPH05140156A/ja active Pending
- 1991-11-22 AU AU88091/91A patent/AU644496B2/en not_active Ceased
- 1991-11-23 KR KR1019910021008A patent/KR920009826A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2056009A1 (en) | 1992-05-25 |
| IE914074A1 (en) | 1992-06-03 |
| DE4037427A1 (de) | 1992-05-27 |
| EP0488008A1 (de) | 1992-06-03 |
| FI915518A (fi) | 1992-05-25 |
| ZA918341B (en) | 1992-07-29 |
| KR920009826A (ko) | 1992-06-25 |
| HUT62004A (en) | 1993-03-29 |
| CN1062140A (zh) | 1992-06-24 |
| MX9102192A (es) | 1994-08-31 |
| JPH05140156A (ja) | 1993-06-08 |
| TW218876B (no) | 1994-01-11 |
| PT99570A (pt) | 1992-10-30 |
| NO914577D0 (no) | 1991-11-22 |
| AU8809191A (en) | 1992-05-28 |
| IL99949A0 (en) | 1992-08-18 |
| HU913482D0 (en) | 1992-01-28 |
| AU644496B2 (en) | 1993-12-09 |
| FI915518A0 (fi) | 1991-11-22 |
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