IL135343A0 - Novel aryloxy-alkyl-dialkylamines - Google Patents

Novel aryloxy-alkyl-dialkylamines

Info

Publication number
IL135343A0
IL135343A0 IL13534398A IL13534398A IL135343A0 IL 135343 A0 IL135343 A0 IL 135343A0 IL 13534398 A IL13534398 A IL 13534398A IL 13534398 A IL13534398 A IL 13534398A IL 135343 A0 IL135343 A0 IL 135343A0
Authority
IL
Israel
Prior art keywords
dialkylamines
alkyl
novel aryloxy
aryloxy
novel
Prior art date
Application number
IL13534398A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/161,653 external-priority patent/US6005102A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL135343A0 publication Critical patent/IL135343A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Detergent Compositions (AREA)
IL13534398A 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines IL135343A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95081897A 1997-10-15 1997-10-15
US09/161,653 US6005102A (en) 1997-10-15 1998-09-28 Aryloxy-alkyl-dialkylamines
PCT/US1998/021609 WO1999019293A1 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines

Publications (1)

Publication Number Publication Date
IL135343A0 true IL135343A0 (en) 2001-05-20

Family

ID=26858006

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13534398A IL135343A0 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines
IL135343A IL135343A (en) 1997-10-15 2000-03-29 Aryloxy-alkyl-dialkylamines, their preparation and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL135343A IL135343A (en) 1997-10-15 2000-03-29 Aryloxy-alkyl-dialkylamines, their preparation and pharmaceutical preparations containing them

Country Status (27)

Country Link
EP (2) EP1777214A3 (pt)
JP (1) JP2001519410A (pt)
KR (1) KR100669836B1 (pt)
CN (1) CN1231458C (pt)
AR (1) AR015183A1 (pt)
AT (1) ATE355264T1 (pt)
AU (1) AU757630C (pt)
BR (1) BR9813069A (pt)
CA (1) CA2306343C (pt)
CY (1) CY1106497T1 (pt)
DE (1) DE69837210T2 (pt)
DK (1) DK1025077T3 (pt)
EA (1) EA003937B1 (pt)
EE (1) EE200000225A (pt)
ES (1) ES2281937T3 (pt)
HK (1) HK1026889A1 (pt)
HU (1) HUP0004419A3 (pt)
ID (1) ID24417A (pt)
IL (2) IL135343A0 (pt)
NO (1) NO20001938L (pt)
NZ (1) NZ503793A (pt)
PL (1) PL198443B1 (pt)
PT (1) PT1025077E (pt)
SI (1) SI1025077T1 (pt)
SK (1) SK286460B6 (pt)
TR (1) TR200001012T2 (pt)
WO (1) WO1999019293A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
TR200003377T2 (tr) * 1998-05-15 2001-03-21 American Home Products Corporation Estrojenler ile bütünleşik 2-fenil-1-[4-(2-aminoetoksi)benzil]-indol
EP1212335B1 (en) * 1999-09-13 2006-01-18 Wyeth Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1- 4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols
AU2001271782A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted insole compounds for treating excessive intraocular pressure
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
EP1656938A1 (en) 2000-07-06 2006-05-17 Wyeth Combinations of SSRI and estrogenic agents
WO2002003975A2 (en) 2000-07-06 2002-01-17 Wyeth Combinations of ssri and estrogenic agents
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
AU2001273144A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
EP1379493A2 (en) * 2001-03-23 2004-01-14 Eli Lilly and Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
ES2236536T3 (es) 2001-05-22 2005-07-16 Eli Lilly And Company Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos.
EP1395563B1 (en) 2001-05-22 2006-03-29 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
TW200418825A (en) 2002-12-16 2004-10-01 Hoffmann La Roche Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives
JP2007532560A (ja) 2004-04-07 2007-11-15 ワイス バゼドキシフェンアセテートの結晶多形
TW200536845A (en) * 2004-04-07 2005-11-16 Wyeth Corp Crystalline polymorph of bazedoxifene acetate
US7504394B2 (en) 2004-04-08 2009-03-17 Wyeth Bazedoxifene ascorbate
MX2007001506A (es) * 2004-08-05 2007-03-27 Wyeth Corp Polimorfo cristalino del clorhidrato de pipindoxifeno monohidratado.
AR055837A1 (es) * 2005-01-13 2007-09-12 Wyeth Corp Procedimientos para la preparacion de alc0holes aminoetoxibencilicos
US20100087661A1 (en) * 2007-02-12 2010-04-08 Josef Jirman Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole
WO2009102771A1 (en) * 2008-02-11 2009-08-20 Wyeth Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate
AU2010237209A1 (en) 2009-04-13 2011-09-01 Sandoz Ag Processes for the synthesis of bazedoxifene acetate and intermediates thereof
US8569483B2 (en) 2011-06-21 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of bazedoxifene acetate and intermediates thereof
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
WO2014186325A1 (en) 2013-05-15 2014-11-20 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH448121A (de) 1963-03-13 1967-12-15 Hoffmann La Roche Verfahren zur Herstellung substituierter Hydrazinverbindungen
WO1991007107A1 (en) * 1989-11-13 1991-05-30 Pfizer Inc. Oxazolidinedione hypoglycemic agents
GB9326332D0 (en) 1993-12-23 1994-02-23 Karo Bio Indole derivatives
WO1998000137A1 (en) * 1996-07-01 1998-01-08 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
SK115899A3 (en) * 1997-02-27 2000-05-16 American Cyanamid Co N-hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
EP1011666A4 (en) * 1997-04-30 2004-03-31 Lilly Co Eli ANTITHROMBOTIC AGENTS

Also Published As

Publication number Publication date
SI1025077T1 (sl) 2007-06-30
EE200000225A (et) 2001-06-15
EP1777214A2 (en) 2007-04-25
DK1025077T3 (da) 2007-05-07
WO1999019293A1 (en) 1999-04-22
CN1281429A (zh) 2001-01-24
AU757630C (en) 2006-10-26
CA2306343C (en) 2010-08-03
EP1777214A3 (en) 2007-05-09
HUP0004419A2 (hu) 2001-07-30
PT1025077E (pt) 2007-05-31
AU757630B2 (en) 2003-02-27
HK1026889A1 (en) 2000-12-29
KR100669836B1 (ko) 2007-01-18
KR20010024505A (ko) 2001-03-26
NO20001938L (no) 2000-06-07
AR015183A1 (es) 2001-04-18
EP1025077A1 (en) 2000-08-09
CA2306343A1 (en) 1999-04-22
NZ503793A (en) 2002-10-25
DE69837210T2 (de) 2007-12-27
HUP0004419A3 (en) 2002-01-28
ATE355264T1 (de) 2006-03-15
IL135343A (en) 2007-12-03
EA200000416A1 (ru) 2000-10-30
AU1083199A (en) 1999-05-03
EP1025077B1 (en) 2007-02-28
ES2281937T3 (es) 2007-10-01
CN1231458C (zh) 2005-12-14
CY1106497T1 (el) 2012-01-25
TR200001012T2 (tr) 2000-09-21
NO20001938D0 (no) 2000-04-13
JP2001519410A (ja) 2001-10-23
PL339908A1 (en) 2001-01-15
EA003937B1 (ru) 2003-10-30
SK286460B6 (sk) 2008-10-07
ID24417A (id) 2000-07-20
BR9813069A (pt) 2000-08-22
SK5372000A3 (en) 2000-11-07
DE69837210D1 (de) 2007-04-12
PL198443B1 (pl) 2008-06-30

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Legal Events

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FF Patent granted
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