EE04992B1 - Kinoloonantibiootikume viivitatult vabastavad preparaadid ja nende valmistamise meetod - Google Patents

Kinoloonantibiootikume viivitatult vabastavad preparaadid ja nende valmistamise meetod

Info

Publication number
EE04992B1
EE04992B1 EEP200200707A EEP200200707A EE04992B1 EE 04992 B1 EE04992 B1 EE 04992B1 EE P200200707 A EEP200200707 A EE P200200707A EE P200200707 A EEP200200707 A EE P200200707A EE 04992 B1 EE04992 B1 EE 04992B1
Authority
EE
Estonia
Prior art keywords
preparation
release formulations
delayed release
quinolone antibiotics
quinolone
Prior art date
Application number
EEP200200707A
Other languages
English (en)
Estonian (et)
Inventor
Kanikanti Venkata-Rangarao
Rupp Roland
Weber Wolfgang
Deuringer Peter
Henck Jan-Olav
Stass Heino
Nishioka Takaaki
Katakawa Yoshifumi
Taniguchi Chika
Ichihashi Hitoshi
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of EE200200707A publication Critical patent/EE200200707A/xx
Publication of EE04992B1 publication Critical patent/EE04992B1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EEP200200707A 2000-06-26 2001-06-13 Kinoloonantibiootikume viivitatult vabastavad preparaadid ja nende valmistamise meetod EE04992B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10031043A DE10031043A1 (de) 2000-06-26 2000-06-26 Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
PCT/EP2001/006695 WO2002000219A1 (de) 2000-06-26 2001-06-13 Retard-zubereitungen von chinolon-antibiotika und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
EE200200707A EE200200707A (et) 2004-08-16
EE04992B1 true EE04992B1 (et) 2008-04-15

Family

ID=7646816

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200707A EE04992B1 (et) 2000-06-26 2001-06-13 Kinoloonantibiootikume viivitatult vabastavad preparaadid ja nende valmistamise meetod

Country Status (41)

Country Link
US (3) US7709022B2 (bg)
EP (1) EP1296685B1 (bg)
JP (1) JP4958373B2 (bg)
KR (1) KR100939617B1 (bg)
CN (1) CN1273138C (bg)
AR (1) AR029688A1 (bg)
AT (1) ATE355062T1 (bg)
AU (1) AU2001270573A1 (bg)
BG (1) BG65914B1 (bg)
BR (1) BRPI0111911B8 (bg)
CA (1) CA2414271C (bg)
CU (1) CU23264B7 (bg)
CY (1) CY1107574T1 (bg)
CZ (1) CZ301812B6 (bg)
DE (2) DE10031043A1 (bg)
DK (1) DK1296685T3 (bg)
DO (1) DOP2001000199A (bg)
EE (1) EE04992B1 (bg)
ES (1) ES2282270T3 (bg)
GT (1) GT200100126A (bg)
HK (1) HK1058479A1 (bg)
HN (1) HN2001000132A (bg)
HR (1) HRP20030050B1 (bg)
HU (1) HU229806B1 (bg)
IL (2) IL153333A0 (bg)
MA (1) MA25761A1 (bg)
MX (1) MXPA02012727A (bg)
MY (1) MY140994A (bg)
NO (1) NO325415B1 (bg)
NZ (1) NZ523352A (bg)
PE (1) PE20020207A1 (bg)
PL (1) PL203710B1 (bg)
PT (1) PT1296685E (bg)
RU (1) RU2332204C2 (bg)
SI (1) SI1296685T1 (bg)
SK (1) SK287384B6 (bg)
SV (1) SV2002000505A (bg)
TW (1) TWI279232B (bg)
UA (1) UA83616C2 (bg)
WO (1) WO2002000219A1 (bg)
ZA (1) ZA200210350B (bg)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US7491768B2 (en) * 2002-06-25 2009-02-17 Woong-Sig Moon Polymer resin formulation having anti-microbial or anti-coagulability and preparation method thereof
BRPI0407368A (pt) * 2003-02-10 2006-02-14 Bayer Healthcare Ag tratamento de doenças bacterianas dos órgãos respiratórios mediante aplicação local e fluor-quinolonas.
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
US7278982B2 (en) 2003-03-27 2007-10-09 Bioactis Limited Powder medicine applicator for nasal cavity
EP1652522A4 (en) * 2003-08-04 2008-11-26 Kyorin Seiyaku Kk PROLONGED RELEASE TABLET FOR ORAL ADMINISTRATION
US7943585B2 (en) * 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
WO2006007323A2 (en) * 2004-06-28 2006-01-19 Alza Corporation Dosage forms for low solubility and/or low dissolution rate free acid pharmaceutical agents
US20080206329A1 (en) * 2004-12-03 2008-08-28 Sanjay Verma Modified Release Ciprofloxacin Compositions
PT1868581E (pt) * 2005-04-11 2012-06-22 Abbott Lab Composições farmacêuticas que possuem perfis de dissolução melhorados para fármacos pouco solúveis
ATE460934T1 (de) * 2006-07-19 2010-04-15 Tabuk Pharmaceutical Mfg Co Pharmazeutische zubereitungen von ciprofloxacin
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
NZ588695A (en) * 2008-03-21 2012-11-30 Mylan Pharmaceuticals Inc Extended release forumulation containing a wax and ciprofloxacin
PL2395840T3 (pl) * 2009-02-13 2020-09-07 Romark Laboratories, L.C. Preparaty farmaceutyczne nitazoksanidu o kontrolowanym uwalnianiu
EP2429495A4 (en) * 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS
US11033624B2 (en) * 2010-06-02 2021-06-15 Novaflux Inc. Medical item for prevention and treatment of ear infection
CN102247313A (zh) * 2010-06-11 2011-11-23 北京润德康医药技术有限公司 一种以莫西沙星为活性成分的口服缓释固体制剂
US10285865B2 (en) 2014-05-02 2019-05-14 Novaflux Inc. Drug-releasing device usable in mucosal body cavities
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951792A (en) * 1959-11-18 1960-09-06 Smith Kline French Lab Sustained release pharmaceutical tablets
FR2100858B1 (bg) 1970-07-03 1975-06-06 Daiichi Seiyaku Co
US4122157A (en) * 1977-03-04 1978-10-24 Richardson-Merrell Inc. Nitrofurantoin sustained release tablet
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
FR2470599A1 (fr) * 1979-12-07 1981-06-12 Panoz Donald Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4370313A (en) * 1981-10-26 1983-01-25 Eaton Laboratories, Inc. Nitrofurantoin dosage form
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
US4530928A (en) * 1982-01-13 1985-07-23 Merck & Co., Inc. Quinoline carboxylic acid complexes with guanidinium carbonate
US4440740A (en) * 1982-04-26 1984-04-03 Merck & Co., Inc. α-Keto aldehydes as enhancing agents of gastro-intestinal drug absorption
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
IT1198386B (it) 1982-07-06 1988-12-21 Lepetit Spa Un prodotto a rilascio protratto contenente il suloctidile
IL70071A (en) 1982-11-01 1987-12-31 Merrell Dow Pharma Multilayered sustained release pharmaceutical tablets having non-uniform distribution of active ingredient
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4639458A (en) * 1985-01-22 1987-01-27 Merck & Co., Inc. Tablet and formulation
NL8500724A (nl) * 1985-03-13 1986-10-01 Univ Groningen Inrichtingen voor geregelde afgifte van werkzame stoffen, alsmede werkwijze ter vervaardiging daarvan.
FR2585246A1 (fr) * 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
IT1188212B (it) * 1985-12-20 1988-01-07 Paolo Colombo Sistema per il rilascio a velocita' controllata di sostanze attive
DE3601566A1 (de) * 1986-01-21 1987-07-23 Bayer Ag Pharmazeutische zubereitungen von ciprofloxacin
US5286754A (en) * 1986-01-21 1994-02-15 Bayer Aktiengesellschaft Pharmaceutical formulations of ciprofloxacin
JPS62195323A (ja) * 1986-02-24 1987-08-28 Eisai Co Ltd 胃内滞留型粒子
ATE71293T1 (de) 1986-09-18 1992-01-15 London Pharmacy Innovation Arzneiformulierung.
US4869908A (en) * 1987-01-09 1989-09-26 K.V. Pharmaceutical Co. Fibre formulations
US4786503A (en) * 1987-04-06 1988-11-22 Alza Corporation Dosage form comprising parallel lamine
US5200193A (en) * 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
DE3720757A1 (de) * 1987-06-24 1989-01-05 Bayer Ag Dhp-manteltablette
US5472710A (en) * 1988-04-16 1995-12-05 Schwarz Pharma Ag Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
US5032406A (en) * 1989-02-21 1991-07-16 Norwich Eaton Pharmaceuticals, Inc. Dual-action tablet
US5007790A (en) * 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
US5085865A (en) * 1989-04-12 1992-02-04 Warner-Lambert Company Sustained release pharmaceutical preparations containing an analgesic and a decongestant
DK469989D0 (da) * 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
IT1237904B (it) * 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
JPH0624959A (ja) * 1991-10-04 1994-02-01 Bayer Yakuhin Kk 胃内浮遊型薬物徐放性固形製剤
DE4200821A1 (de) * 1992-01-15 1993-07-22 Bayer Ag Geschmacksmaskierte pharmazeutische mittel
JP2958731B2 (ja) * 1992-02-14 1999-10-06 日本特殊陶業株式会社 酸化アルミニウム基焼結体及びその製造方法
US5582837A (en) * 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
IT1256393B (it) * 1992-11-17 1995-12-04 Inverni Della Beffa Spa Forme matriciali multistrato per il rilascio controllato di principi attivi
JP2686215B2 (ja) 1993-04-28 1997-12-08 信越化学工業株式会社 徐放性錠剤
IT1264696B1 (it) 1993-07-09 1996-10-04 Applied Pharma Res Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata
DE4406424A1 (de) * 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5464633A (en) * 1994-05-24 1995-11-07 Jagotec Ag Pharmaceutical tablets releasing the active substance after a definite period of time
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
CN1048628C (zh) 1995-07-06 2000-01-26 东北制药总厂 环丙沙星注射液的制备方法
US5705190A (en) * 1995-12-19 1998-01-06 Abbott Laboratories Controlled release formulation for poorly soluble basic drugs
IT1282650B1 (it) * 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
CA2290624C (en) * 1997-06-06 2006-12-05 John W. Shell Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs
IN186245B (bg) * 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
CN1895233A (zh) * 1997-09-25 2007-01-17 拜尔公司 控释活性化合物的药物制剂
PA8466701A1 (es) * 1998-01-21 2000-09-29 Pfizer Prod Inc Comprimido de mesilato de trovafloxacino
WO2000015198A1 (en) 1998-09-14 2000-03-23 Ranbaxy Laboratories Limited Orally administered controlled drug delivery system providing temporal and spatial control
EP1790334A3 (en) 1999-11-02 2008-02-20 Depomed, Inc. Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
PT1251832E (pt) 2000-02-04 2007-01-31 Depomed Inc Forma de dosagem constituída por invólucro-e-núcleo que conduz a uma libertação do fármaco de ordem zero
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US6780057B2 (en) * 2001-12-21 2004-08-24 Intel Corporation Coaxial dual pin sockets for high speed I/O applications

Also Published As

Publication number Publication date
US20040024018A1 (en) 2004-02-05
EE200200707A (et) 2004-08-16
HN2001000132A (es) 2001-09-11
CZ301812B6 (cs) 2010-06-30
CN1438889A (zh) 2003-08-27
BG107372A (bg) 2003-09-30
CY1107574T1 (el) 2013-03-13
PE20020207A1 (es) 2002-04-27
HUP0300953A2 (hu) 2003-08-28
HU229806B1 (en) 2014-07-28
SK287384B6 (sk) 2010-08-09
US7780986B2 (en) 2010-08-24
SK18212002A3 (sk) 2003-04-01
PT1296685E (pt) 2007-05-31
PL203710B1 (pl) 2009-11-30
ES2282270T3 (es) 2007-10-16
US20070237824A1 (en) 2007-10-11
CA2414271A1 (en) 2002-12-23
HRP20030050B1 (en) 2011-07-31
JP2004504278A (ja) 2004-02-12
CZ20024216A3 (cs) 2003-04-16
IL153333A0 (en) 2003-07-06
US8187632B2 (en) 2012-05-29
IL153333A (en) 2010-05-31
US20070065509A1 (en) 2007-03-22
KR20030023883A (ko) 2003-03-20
BR0111911A (pt) 2003-05-13
SV2002000505A (es) 2002-12-02
WO2002000219A1 (de) 2002-01-03
DOP2001000199A (es) 2002-05-15
TWI279232B (en) 2007-04-21
DK1296685T3 (da) 2007-05-07
CU23264B7 (es) 2008-03-14
BRPI0111911B1 (pt) 2015-08-25
US7709022B2 (en) 2010-05-04
HUP0300953A3 (en) 2009-04-28
MXPA02012727A (es) 2003-05-14
CN1273138C (zh) 2006-09-06
JP4958373B2 (ja) 2012-06-20
BRPI0111911B8 (pt) 2021-05-25
MY140994A (en) 2010-02-12
DE50112123D1 (de) 2007-04-12
NO20026160L (no) 2002-12-20
EP1296685A1 (de) 2003-04-02
ATE355062T1 (de) 2006-03-15
NZ523352A (en) 2004-08-27
PL360632A1 (en) 2004-09-20
KR100939617B1 (ko) 2010-02-01
DE10031043A1 (de) 2002-02-14
MA25761A1 (fr) 2003-04-01
AR029688A1 (es) 2003-07-10
HK1058479A1 (en) 2004-05-21
BG65914B1 (bg) 2010-05-31
AU2001270573A1 (en) 2002-01-08
HRP20030050A2 (en) 2004-06-30
SI1296685T1 (sl) 2007-06-30
EP1296685B1 (de) 2007-02-28
ZA200210350B (en) 2004-02-10
UA83616C2 (uk) 2008-08-11
CA2414271C (en) 2005-09-27
NO20026160D0 (no) 2002-12-20
GT200100126A (es) 2002-01-31
RU2332204C2 (ru) 2008-08-27
NO325415B1 (no) 2008-04-21

Similar Documents

Publication Publication Date Title
EE200200707A (et) Kinoloonantibiootikume viivitatult vabastavad preparaadid ja nende valmistamise meetod
EE200300207A (et) Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
NO20016173D0 (no) Gipssammensetninger og fremgangsmåter ved fremstilling derav
NO20004741L (no) Farmasöytiske blandinger for forlenget peptidfrigjöring og fremstillingsmetode
CY2013011I2 (el) Μεθοδος χορηγησης διφωσφονικων
IL154031A0 (en) Substituted sulfonylaminomethylbenzoic acid derivatives and preparation
GB2385524B (en) Compositions and methods of use for extracts of magnoliaceae
AR026045A1 (es) Formulaciones de liberacion prolongada de derivados de eritromocina
EE200200328A (et) Multši kompositsioon ja meetod
PT1150966E (pt) Metodo de preparacao de 5-cianoftalido
DK1949936T3 (da) Sammensætning til kontrolleret frigivelse og fremgangsmåde til fremstilling deraf
EE04717B1 (et) Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
EE200200105A (et) Radiofarmatseutilised saadused ja nende valmistamise meetod
AU2001288961A1 (en) Lipoteichoic acid immunogenic compositions and methods of making and using thereof
IL211958A0 (en) Lactone formulations and method of use
HUP0303731A3 (en) Sulfonylguanidines and their use for preparation of pharmaceutical compositions
AU2002221273A1 (en) Delayed and sustained release formulations and method of use thereof
EP1501352A4 (en) METHOD AND COMPOSITIONS FOR PROTRACTED ACTIVE SUBSTANCE
AU2001247196A1 (en) Methods and compositions for detection of disease
AU2001286852A1 (en) Quinoline antibacterial compounds and methods of use thereof
FI20010816A (fi) Menetelmä vastaanottimen tahdistamisessa ja vastaanotin
AU2001295672A1 (en) Vaccine composition and stabilisation method
EE04553B1 (et) 15-llilised 8a- ja 9a-laktaamid ning nende valmistamismeetod
AUPQ760400A0 (en) Herbical formulations and methods of use thereof
NO20011921D0 (no) Sulfidoamidokarboksylsyrer, metoder for fremstilling derav og anvendelser derav

Legal Events

Date Code Title Description
GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20081231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20101231