EE04233B1 - E-2-[4-(4-kloro-1,2-difenüül-but-1-enüül)fenoksü]etanool ja selle farmatseutilised koostised - Google Patents

E-2-[4-(4-kloro-1,2-difenüül-but-1-enüül)fenoksü]etanool ja selle farmatseutilised koostised

Info

Publication number
EE04233B1
EE04233B1 EEP200000473A EEP200000473A EE04233B1 EE 04233 B1 EE04233 B1 EE 04233B1 EE P200000473 A EEP200000473 A EE P200000473A EE P200000473 A EEP200000473 A EE P200000473A EE 04233 B1 EE04233 B1 EE 04233B1
Authority
EE
Estonia
Prior art keywords
enyl
phenoxy
diphenyl
chloro
ethanol
Prior art date
Application number
EEP200000473A
Other languages
English (en)
Estonian (et)
Inventor
Marketta Kalapudas Arja
S�dervall Marja-Liisa
Viitanen Antti
M�ntyl� Eero
Original Assignee
Orion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corporation filed Critical Orion Corporation
Publication of EE200000473A publication Critical patent/EE200000473A/xx
Publication of EE04233B1 publication Critical patent/EE04233B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP200000473A 1998-02-19 1999-02-19 E-2-[4-(4-kloro-1,2-difenüül-but-1-enüül)fenoksü]etanool ja selle farmatseutilised koostised EE04233B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9803521.5A GB9803521D0 (en) 1998-02-19 1998-02-19 New compounds and pharmaceutical compositions thereof
PCT/FI1999/000137 WO1999042427A1 (en) 1998-02-19 1999-02-19 E-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EE200000473A EE200000473A (et) 2001-12-17
EE04233B1 true EE04233B1 (et) 2004-02-16

Family

ID=10827263

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000473A EE04233B1 (et) 1998-02-19 1999-02-19 E-2-[4-(4-kloro-1,2-difenüül-but-1-enüül)fenoksü]etanool ja selle farmatseutilised koostised

Country Status (33)

Country Link
US (1) US6395785B1 (es)
EP (1) EP1056701B1 (es)
JP (1) JP2002503713A (es)
KR (1) KR100755918B1 (es)
CN (1) CN1161314C (es)
AR (1) AR014961A1 (es)
AT (1) ATE252531T1 (es)
AU (1) AU755798B2 (es)
BG (1) BG64471B1 (es)
BR (1) BR9907688A (es)
CA (1) CA2321122C (es)
CZ (1) CZ294315B6 (es)
DE (1) DE69912247T2 (es)
DK (1) DK1056701T3 (es)
EA (1) EA002919B1 (es)
EE (1) EE04233B1 (es)
ES (1) ES2211038T3 (es)
GB (1) GB9803521D0 (es)
GE (1) GEP20022794B (es)
HR (1) HRP20000545A2 (es)
HU (1) HUP0101354A3 (es)
ID (1) ID26857A (es)
IL (1) IL137214A (es)
NO (1) NO325595B1 (es)
NZ (1) NZ505637A (es)
PL (1) PL193315B1 (es)
PT (1) PT1056701E (es)
RS (1) RS49660B (es)
SK (1) SK285940B6 (es)
TR (1) TR200002037T2 (es)
UA (1) UA57132C2 (es)
WO (1) WO1999042427A1 (es)
ZA (1) ZA991232B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW593256B (en) * 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
SI1235776T1 (sl) * 1999-11-16 2006-06-30 Hormos Medical Corp Trifenilalkenski derivati in njihova uporaba kot selektivni estrogenski receptorski modulatorji
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
CN101448490A (zh) 2006-05-22 2009-06-03 霍尔莫斯医疗有限公司 治疗慢性非细菌性前列腺炎的选择性雌激素受体调节剂或者芳香酶抑制剂
EP2121553B1 (en) 2007-02-14 2012-06-27 Hormos Medical Ltd. Method for the preparation of therapeutically valuable triphenylbutene derivatives
US7504530B2 (en) 2007-02-14 2009-03-17 Hormos Medical Ltd. Methods for the preparation of fispemifene from ospemifene
CN102770402B (zh) 2010-01-19 2016-01-20 坎布雷卡尔斯库加公司 制造二苯甲酮衍生物的新方法
JP6174156B2 (ja) 2012-10-19 2017-08-02 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
US20150321983A1 (en) * 2012-10-19 2015-11-12 Fermion Oy A process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126576B (en) 1982-06-25 1985-06-19 Farmos Group Limited Alkane and alkene derivatives
GB9418067D0 (en) 1994-09-07 1994-10-26 Orion Yhtymae Oy Triphenylethylenes for the prevention and treatment of osteoporosis
GB9604577D0 (en) * 1996-03-04 1996-05-01 Orion Yhtymae Oy Serum cholesterol lowering agent

Also Published As

Publication number Publication date
SK285940B6 (sk) 2007-11-02
BG104713A (en) 2001-03-30
HRP20000545A2 (en) 2001-02-28
YU51000A (sh) 2002-11-15
PL193315B1 (pl) 2007-01-31
IL137214A0 (en) 2001-07-24
US6395785B1 (en) 2002-05-28
CA2321122A1 (en) 1999-08-26
DE69912247T2 (de) 2004-07-29
CZ294315B6 (cs) 2004-11-10
EP1056701A1 (en) 2000-12-06
BG64471B1 (bg) 2005-04-30
ZA991232B (en) 1999-09-17
JP2002503713A (ja) 2002-02-05
UA57132C2 (uk) 2003-06-16
HUP0101354A3 (en) 2002-05-28
PL342445A1 (en) 2001-06-04
ATE252531T1 (de) 2003-11-15
KR20010040985A (ko) 2001-05-15
TR200002037T2 (tr) 2001-02-21
EP1056701B1 (en) 2003-10-22
NZ505637A (en) 2002-10-25
NO20003987D0 (no) 2000-08-07
CN1161314C (zh) 2004-08-11
AR014961A1 (es) 2001-04-11
ES2211038T3 (es) 2004-07-01
PT1056701E (pt) 2004-03-31
GB9803521D0 (en) 1998-04-15
WO1999042427A1 (en) 1999-08-26
KR100755918B1 (ko) 2007-09-06
GEP20022794B (en) 2002-09-25
CZ20002927A3 (cs) 2000-12-13
DE69912247D1 (de) 2003-11-27
CA2321122C (en) 2008-02-12
IL137214A (en) 2005-05-17
NO325595B1 (no) 2008-06-23
EA200000851A1 (ru) 2001-02-26
SK12052000A3 (sk) 2001-01-18
BR9907688A (pt) 2000-11-14
AU2524499A (en) 1999-09-06
HUP0101354A2 (hu) 2002-03-28
EA002919B1 (ru) 2002-10-31
RS49660B (sr) 2007-09-21
AU755798B2 (en) 2002-12-19
CN1291178A (zh) 2001-04-11
EE200000473A (et) 2001-12-17
ID26857A (id) 2001-02-15
DK1056701T3 (da) 2004-02-02
NO20003987L (no) 2000-08-07

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

MM4A Lapsed by not paying the annual fees

Effective date: 20090219