EE04018B1 - Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised - Google Patents

Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised

Info

Publication number
EE04018B1
EE04018B1 EEP199900539A EEP9900539A EE04018B1 EE 04018 B1 EE04018 B1 EE 04018B1 EE P199900539 A EEP199900539 A EE P199900539A EE P9900539 A EEP9900539 A EE P9900539A EE 04018 B1 EE04018 B1 EE 04018B1
Authority
EE
Estonia
Prior art keywords
pyrimidinediones
thieno
pharmaceutical compositions
compositions containing
preparation
Prior art date
Application number
EEP199900539A
Other languages
English (en)
Estonian (et)
Inventor
Cheshire David
Cooke Andrew
Cooper Martin
Donald David
Furber Mark
Perry Matthew
Thorne Philip
Original Assignee
Astra Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceuticals Limited filed Critical Astra Pharmaceuticals Limited
Publication of EE9900539A publication Critical patent/EE9900539A/xx
Publication of EE04018B1 publication Critical patent/EE04018B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Liquid Crystal (AREA)
EEP199900539A 1997-05-28 1998-05-18 Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised EE04018B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
PCT/SE1998/000935 WO1998054190A1 (fr) 1997-05-28 1998-05-18 Nouveaux composes

Publications (2)

Publication Number Publication Date
EE9900539A EE9900539A (et) 2000-06-15
EE04018B1 true EE04018B1 (et) 2003-04-15

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900539A EE04018B1 (et) 1997-05-28 1998-05-18 Tieno[2,3-d]pürimidiindioonid, nende valmistamisemeetod ja neid sisaldavad ravimkoostised

Country Status (28)

Country Link
US (2) US6180635B1 (fr)
EP (1) EP0991653B1 (fr)
JP (1) JP2002500666A (fr)
KR (1) KR100561988B1 (fr)
CN (1) CN1122037C (fr)
AT (1) ATE226205T1 (fr)
AU (1) AU723708B2 (fr)
BR (1) BR9809481A (fr)
CA (1) CA2289509C (fr)
CZ (1) CZ297536B6 (fr)
DE (1) DE69808765T2 (fr)
DK (1) DK0991653T3 (fr)
EE (1) EE04018B1 (fr)
ES (1) ES2184270T3 (fr)
HU (1) HU226627B1 (fr)
ID (1) ID28432A (fr)
IL (2) IL132763A0 (fr)
IS (1) IS1983B (fr)
NO (1) NO323752B1 (fr)
NZ (1) NZ500853A (fr)
PL (1) PL199567B1 (fr)
PT (1) PT991653E (fr)
RU (1) RU2225410C2 (fr)
SE (1) SE9702001D0 (fr)
SK (1) SK283589B6 (fr)
TR (1) TR199902904T2 (fr)
UA (1) UA61111C2 (fr)
WO (1) WO1998054190A1 (fr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
EP1280806B1 (fr) * 2000-05-04 2004-08-04 AstraZeneca AB Thieno 2,3-d]pyrimidinediones et leur utilisation en tant que produits pharmaceutiques
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
MXPA03004926A (es) * 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
CZ2004747A3 (cs) * 2001-12-21 2004-11-10 Novo Nordisk A/S Deriváty amidů jako GK aktivátory
MXPA05000130A (es) * 2002-06-27 2005-02-17 Novo Nordisk As Derivados de aril-carbonilo como agentes terapeuticos.
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
NZ541218A (en) * 2003-01-17 2008-05-30 Astrazeneca Ab Thienopyrimidinediones and their use in modulation of autoimmune disease
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
CA2551324C (fr) * 2004-01-06 2012-11-27 Novo Nordisk A/S Heteroaryl-urees et leur utilisation en tant qu'activateurs de glucokinase
EP1904466A1 (fr) * 2005-07-08 2008-04-02 Novo Nordisk A/S Activateurs de dicycloalkylurée glucokinase
WO2007006761A1 (fr) * 2005-07-08 2007-01-18 Novo Nordisk A/S Dicycloalkylcarbamoylurées en tant qu’activateurs de glucokinase
JP4960355B2 (ja) 2005-07-14 2012-06-27 ノボ・ノルデイスク・エー／エス ウレア型グルコキナーゼ活性化剤
CA2644996A1 (fr) * 2006-03-02 2007-09-13 Cv Therapeutics, Inc. Antagonistes du recepteur a2a de l'adenosine
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
CA2670788A1 (fr) * 2006-12-01 2008-06-12 Cv Therapeutics, Inc. Antagonistes du recepteur d'adenosine a2a
WO2008084043A1 (fr) * 2007-01-09 2008-07-17 Novo Nordisk A/S Activateurs de la glucokinase à base d'urée
US8318778B2 (en) 2007-01-11 2012-11-27 Novo Nordisk A/S Urea glucokinase activators
EP2008656A1 (fr) 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions pour le traitement d'hyperphénylalaninémie
PL2411395T3 (pl) * 2009-03-23 2013-10-31 Glenmark Pharmaceuticals Sa Pochodne furopirymidynodionu jako modulatory TRPA1
CA2855372C (fr) * 2011-11-11 2022-03-22 Nimbus Apollo, Inc. Derives de 2,4-dioxo-thieno-[2,3-d]pyrimidinyle et compositions pharmaceutiques connexes utilisees comme inhibiteurs d'acc
JP6268093B2 (ja) * 2012-09-14 2018-01-24 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
CN105793267B (zh) * 2013-10-07 2018-02-06 拜耳制药股份公司 环状噻吩并尿嘧啶甲酰胺类及其用途
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
KR20180082557A (ko) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 트리아졸 acc 억제제 및 그의 용도
KR20180082556A (ko) 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 피라졸 acc 억제제 및 그의 용도
SI3379933T1 (sl) 2015-11-25 2023-07-31 Gilead Apollo, Llc Fungicidni sestavki, ki vsebujejo derivate 2,4-diokso-1,4-dihidrotieno (2,3-d)pirimidina
HUE053175T2 (hu) 2015-11-25 2021-06-28 Gilead Apollo Llc ACC-gátló észterek és azok alkalmazása
JP6944462B2 (ja) 2016-03-02 2021-10-06 ギリアド アポロ， エルエルシー チエノピリミジンジオンａｃｃ阻害剤の固体形態およびその生成のための方法
WO2018041771A1 (fr) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft Thiéno-uraciles substitués par un groupe (1-méthylcyclopropyl)méthyle et leur utilisation
CA3037642A1 (fr) * 2016-09-23 2018-03-29 Bayer Aktiengesellschaft Thieno-uraciles a substitution n 3 -cyclique et leur utilisation
CN110461328A (zh) 2017-03-28 2019-11-15 吉利德科学公司 治疗肝疾病的治疗组合
EP3806852A1 (fr) 2018-06-12 2021-04-21 vTv Therapeutics LLC Utilisations thérapeutiques d'activateurs de glucokinase en combinaison avec de l'insuline ou des analogues d'insuline

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989002432A1 (fr) * 1987-09-16 1989-03-23 Taiho Pharmaceutical Company, Limited Derives de thienopyrimidine
TW276256B (fr) * 1993-08-26 1996-05-21 Takeda Pharm Industry Co Ltd
FR2750862B1 (fr) * 1996-07-12 1998-10-16 Dupin Jean Pierre Utilisation d'heterocycles diazotes fusionnes avec un systeme aromatique ou heteroaromatique pour le traitement des maladies thrombo-emboliques

Also Published As

Publication number Publication date
CZ297536B6 (cs) 2007-01-03
PL337126A1 (en) 2000-07-31
HU226627B1 (en) 2009-05-28
CN1264382A (zh) 2000-08-23
ATE226205T1 (de) 2002-11-15
IL132763A0 (en) 2001-03-19
PT991653E (pt) 2003-02-28
NZ500853A (en) 2001-05-25
NO323752B1 (no) 2007-07-02
IL132763A (en) 2007-03-08
US6342502B1 (en) 2002-01-29
EE9900539A (et) 2000-06-15
ID28432A (id) 2001-05-24
TR199902904T2 (xx) 2000-06-21
EP0991653A1 (fr) 2000-04-12
KR100561988B1 (ko) 2006-03-17
EP0991653B1 (fr) 2002-10-16
SK283589B6 (sk) 2003-10-07
ES2184270T3 (es) 2003-04-01
JP2002500666A (ja) 2002-01-08
IS1983B (is) 2005-01-14
NO995810D0 (no) 1999-11-26
DE69808765D1 (de) 2002-11-21
HUP0003355A2 (hu) 2001-02-28
US6180635B1 (en) 2001-01-30
AU7680898A (en) 1998-12-30
PL199567B1 (pl) 2008-10-31
NO995810L (no) 2000-01-27
UA61111C2 (uk) 2003-11-17
DE69808765T2 (de) 2003-07-24
HUP0003355A3 (en) 2003-03-28
CA2289509C (fr) 2007-10-02
IS5264A (is) 1999-11-23
SK151399A3 (en) 2000-05-16
SE9702001D0 (sv) 1997-05-28
CA2289509A1 (fr) 1998-12-03
CN1122037C (zh) 2003-09-24
RU2225410C2 (ru) 2004-03-10
CZ420199A3 (cs) 2000-07-12
AU723708B2 (en) 2000-09-07
WO1998054190A1 (fr) 1998-12-03
DK0991653T3 (da) 2003-01-06
KR20010013107A (ko) 2001-02-26
BR9809481A (pt) 2000-06-20

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

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